Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works

Copper, iron and zinc in Alzheimer's disease senile plaques

Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00092-6 · Cited by 2,120 · see citing works

Translating cell biology into therapeutic advances in Alzheimer's disease

Selkoe, D. J. (1999) · Nature · doi:10.1038/399a023 · Cited by 1,588 · see citing works

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478 · see citing works

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., et al. (2004) · Science · doi:10.1126/science.1091230 · Cited by 1,303 · see citing works

Mitochondria and neuronal survival

Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243 · see citing works

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

Manczak, M., Anekonda, T. S., Henson, E., Park, B. S., Quinn, J., & Reddy, P. H. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl066 · Cited by 1,104 · see citing works

Mitochondria take center stage in aging and neurodegeneration

Beal, M. F. (2005) · Annals of Neurology · doi:10.1002/ana.20624 · Cited by 957 · see citing works

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction

Devi, L., Prabhu, B. M., Galati, D. F., Avadhani, N. G., & Anandatheerthavarada, H. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1469-06.2006 · Cited by 792 · see citing works

Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

Caspersen, C., Wang, N., Yao, J., Sosunov, A., Chen, X., Lustbader, J. W., Xu, H. W., Stern, D., McKhann, G., & Du Yan, S. (2005) · The FASEB Journal · doi:10.1096/fj.05-3735fje · Cited by 738 · see citing works

Characterization of the human heart mitochondrial proteome

Taylor, S. W., Fahy, E., Zhang, B., Glenn, G. M., Warnock, D. E., Wiley, S. E., Murphy, A. N., Gaucher, S. P., Capaldi, R., Gibson, B. W., et al. (2003) · Nature Biotechnology · doi:10.1038/nbt793 · Cited by 702 · see citing works

Mitochondrial dysfunction in neurodegenerative diseases

Beal, M. F. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00114-5 · Cited by 608 · see citing works

β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4042-03.2004 · Cited by 587 · see citing works

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

Anandatheerthavarada, H. K., Biswas, G., Robin, M.-A., & Avadhani, N. G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207030 · Cited by 571 · see citing works

MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS

Price, D. L., & Sisodia, S. S. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.479 · Cited by 568 · see citing works

Emerging functions of mammalian mitochondrial fusion and fission

Chen, H., & Chan, D. C. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi270 · Cited by 538 · see citing works

β‐Amyloid inhibits integrated mitochondrial respiration and key enzyme activities

Casley, C. S., Canevari, L., Land, J. M., Clark, J. B., & Sharpe, M. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00681.x · Cited by 485 · see citing works

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients

Maurer, I. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00112-3 · Cited by 475 · see citing works

Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice

David, D. C., Hauptmann, S., Scherping, I., Schuessel, K., Keil, U., Rizzu, P., Ravid, R., Dröse, S., Brandt, U., Müller, W. E., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500356200 · Cited by 447 · see citing works

Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

Busciglio, J., Pelsman, A., Wong, C., Pigino, G., Yuan, M., Mori, H., & Yankner, B. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00604-9 · Cited by 387 · see citing works

Amyloid precursor protein‐mediated free radicals and oxidative damage: Implications for the development and progression of Alzheimer's disease

Reddy, P. H. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03530.x · Cited by 356 · see citing works

Inflammation and neurodegenerative diseases

Griffin, W. S. T. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.470s · Cited by 351 · see citing works

Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease

Gouras, G. K., Almeida, C. G., & Takahashi, R. H. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.022 · Cited by 338 · see citing works

Copper-Dependent Inhibition of Human Cytochrome<i>c</i>Oxidase by a Dimeric Conformer of Amyloid-β_1-42

Crouch, P. J., Blake, R., Duce, J. A., Ciccotosto, G. D., Li, Q.-X., Barnham, K. J., Curtain, C. C., Cherny, R. A., Cappai, R., Dyrks, T., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4276-04.2005 · Cited by 327 · see citing works

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

Chang, S., Ma, T. R., Miranda, R. D., Balestra, M. E., Mahley, R. W., & Huang, Y. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508254102 · Cited by 319 · see citing works

Mitochondrial alterations in Alzheimer's disease

Baloyannis, S. J. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9204 · Cited by 318 · see citing works

Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons

Annaert, W. G., Lévesque, L., Craessaerts, K., Dierinck, I., Snellings, G., Westaway, D. A., George‐Hyslop, P. S., Cordell, B., Fraser, P., & Strooper, B. D. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.277 · Cited by 311 · see citing works

Localization of Amyloid β Protein Messenger RNA in Brains from Patients with Alzheimer's Disease

Bahmanyar, S., Higgins, G. A., Goldgaber, D., Lewis, D. A., Morrison, J. H., Wilson, M. C., Shankar, S. K., & Gajdusek, D. C. (1987) · Science · doi:10.1126/science.3299701 · Cited by 300 · see citing works

Are mitochondria critical in the pathogenesis of Alzheimer's disease?

Reddy, P. H., & Beal, M. F. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.03.004 · Cited by 289 · see citing works

Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis

Keil, U., Bonert, A., Marques, C. A., Scherping, I., Weyermann, J., Strosznajder, J. B., Müller-Spahn, F., Haass, C., Czech, C., Pradier, L., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405600200 · Cited by 287 · see citing works

Brain aluminum in aging and Alzheimer disease

MCDERMOTT, J. R., Smith, A. I., Iqbal, K., & Wı́sniewski, H. M. (1979) · Neurology · doi:10.1212/wnl.29.6.809 · Cited by 263 · see citing works

Nicastrin, Presenilin, APH-1, and PEN-2 Form Active γ-Secretase Complexes in Mitochondria

Hansson, C. A., Frykman, S., Farmery, M. R., Tjernberg, L. O., Nilsberth, C., Pursglove, S. E., Ito, A., Winblad, B., Cowburn, R. F., Thyberg, J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404500200 · Cited by 256 · see citing works

Cognitive and behavioral heterogeneity in Alzheimer's disease: seeking the neurobiological basis

Cummings, J. L. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00183-4 · Cited by 238 · see citing works

Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders

Loeffler, D. A., LeWitt, P. A., Juneau, P. L., Sima, A. A. F., Nguyen, H.-U., DeMaggio, A. J., Brickman, C. M., Brewer, G. J., Dick, R. D., Troyer, M. D., et al. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00782-2 · Cited by 237 · see citing works

Amyloid-β Peptides Are Cytotoxic to Oligodendrocytes

Xu, J., Chen, S., Ahmed, S. H., Chen, H., Ku, G., Goldberg, M. P., & Hsu, C. Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-j0001.2001 · Cited by 230 · see citing works

Neurotransmitter changes in alzheimer's disease: Implications to diagnostics and therapy

Reinikainen, K. J., Soininen, H. S., & Riekkinen, P. J. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490270419 · Cited by 230 · see citing works

Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease.

Basun, H., Forssell, L. G., Wetterberg, L., & Winblad, B. G. (1991) · PubMed · Cited by 228 · see citing works

Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex

Roesch, K. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.5.477 · Cited by 204 · see citing works

Degradation of the Amyloid β-Protein by the Novel Mitochondrial Peptidasome, PreP

Falkevall, A., Alikhani, N., Bhushan, S., Pavlov, P. F., Busch, K., Johnson, K. A., Eneqvist, T., Tjernberg, L. O., Ankarcrona, M., & Glaser, E. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602532200 · Cited by 202 · see citing works

Protein Kinase A-mediated Phosphorylation Modulates Cytochrome c Oxidase Function and Augments Hypoxia and Myocardial Ischemia-related Injury

Prabu, S. K., Anandatheerthavarada, H. K., Raza, H., Srinivasan, S., Spear, J. F., & Avadhani, N. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507741200 · Cited by 190 · see citing works

Transgenic mouse models of Alzheimer's disease

Janus, C., & Westaway, D. A. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00524-8 · Cited by 178 · see citing works

Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat

Stephenson, D. T., Rash, K. S., & Clemens, J. A. (1992) · Brain Research · doi:10.1016/0006-8993(92)91274-i · Cited by 164 · see citing works

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

Leissring, M. A., Farris, W., Wu, X., Christodoulou, D. C., Haigis, M. C., Guarente, L., & Selkoe, D. J. (2004) · Biochemical Journal · doi:10.1042/bj20041081 · Cited by 162 · see citing works

Functional cooperation and separation of translocators in protein import into mitochondria, the double-membrane bounded organelles

Endo, T., Yamamoto, H., & Esaki, M. (2003) · Journal of Cell Science · doi:10.1242/jcs.00667 · Cited by 160 · see citing works

Shaping the mitochondrial proteome

Gabaldón, T., & Huynen, M. A. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.07.011 · Cited by 150 · see citing works

Bimodal Targeting of Microsomal CYP2E1 to Mitochondria through Activation of an N-terminal Chimeric Signal by cAMP-mediated Phosphorylation

Robin, M., Anandatheerthavarada, H. K., Biswas, G., Sepuri, N. B. V., Gordon, D. M., Pain, D., & Avadhani, N. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203292200 · Cited by 147 · see citing works

Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle.

Askanas, V., McFerrin, J., Baqué, S., Alvarez, R. B., Sarkozi, E., & Engel, W. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1314 · Cited by 140 · see citing works

A postmortem study of amino acid neurotransmitters in Alzheimer's disease

Ellison, D. W., Beal, M. F., Mazurek, M. F., Bird, E. D., & Martin, J. B. (1986) · Annals of Neurology · doi:10.1002/ana.410200510 · Cited by 139 · see citing works

Targeting of NH2-terminal–processed Microsomal Protein to Mitochondria: A Novel Pathway for the Biogenesis of Hepatic Mitochondrial P450MT2

Addya, S., Anandatheerthavarada, H. K., Biswas, G., Bhagwat, S. V., Mullick, J., & Avadhani, N. G. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.3.589 · Cited by 137 · see citing works

Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP‐dependent phosphorylation at Ser128

Anandatheerthavarada, H. K., Biswas, G., Mullick, J., Sepuri, N. B. V., Otvos, L., Pain, D., & Avadhani, N. G. (1999) · The EMBO Journal · doi:10.1093/emboj/18.20.5494 · Cited by 132 · see citing works

Human Cortical Neuronal Cell Line: Establishment From a Patient with Unilateral Megalencephaly

Ronnett, G. V., Hester, L. D., Nye, J. S., Connors, K., & Snyder, S. H. (1990) · Science · doi:10.1126/science.1692158 · Cited by 127 · see citing works

Comprehensive and Neuropsychologic Evaluations

Mohs, R. C. (1996) · International Psychogeriatrics · doi:10.1017/s1041610296002578 · Cited by 106 · see citing works

Monoamine neurotransmitters and their metabolites in brain regions in alzheimer's disease: A postmortem study

Nazarali, A. J., & Reynolds, G. P. (1992) · Cellular and Molecular Neurobiology · doi:10.1007/bf00711237 · Cited by 105 · see citing works

The Role of Mitochondria in the Pathogenesis of Neurodegenerative Diseases

Manfredim, G., & Beal, M. F. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00278.x · Cited by 101 · see citing works

β-Amyloid Precursor Protein Is a Direct Cleavage Target of HtrA2 Serine Protease

Park, H., Kim, S. S., Seong, Y.-M., Kim, K., Goo, H. G., Yoon, E. J., Min, D. S., Kang, S., & Rhim, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603443200 · Cited by 95 · see citing works

The Mitochondrial Import Machinery for Preproteins

Rehling, P., Wiedemann, N., Pfanner, N., & Truscott, K. N. (2001) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/20014091074200 · Cited by 85 · see citing works

Cytochrome Oxidase Deficiency in Alzheimer's Diseasea

Parker, W. D. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb00191.x · Cited by 79 · see citing works

The role of presenilins in Alzheimer’s disease

Thinakaran, G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8728 · Cited by 65 · see citing works

Multiple Mechanisms Underlie Neurotoxicity by Different Types of Alzheimer's Disease Mutations of Amyloid Precursor Protein

Hashimoto, Y., Niikura, T., Ito, Y., & Nishimoto, I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005332200 · Cited by 64 · see citing works

Significance of intracellular A beta 42 accumulation in Alzheimer s disease

Tabira, T. (2002) · Frontiers in bioscience · doi:10.2741/tabira · Cited by 60 · see citing works

Ultrastructural localization of Alzheimer amyloid ?/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes

Yamaguchi, H., Yamazaki, T., Ishiguro, K., Shoji, M., Nakazato, Y., & Hirai, S. (1992) · Acta Neuropathologica · doi:10.1007/bf00304629 · Cited by 55 · see citing works

Energy metabolism, oxidative stress and neuronal degeneration in Alzheimer’s disease

Sims, N. R. (1996) · Neurodegeneration · doi:10.1006/neur.1996.0059 · Cited by 45 · see citing works

Mitochondrial abnormalities in neuroectodermal cells stably expressing human amyloid precursor protein (hAPP751)

Grant, S. M., Shankar, S. L., Chalmers-Redman, R. M. E., Tatton, W. G., Moshe Szyf, A., & Cuello, A. C. (1999) · Neuroreport · doi:10.1097/00001756-199901180-00008 · Cited by 44 · see citing works

Action of apomorphine, bromocriptine and lergotrile onγ-aminobutyric acid and acetylcholine release in nucleus accumbens and corpus striatum

de Belleroche, J., & Gardiner, I. M. (1983) · Journal of Neural Transmission · doi:10.1007/bf01252802 · Cited by 41 · see citing works

Transport of proteins into mitochondria

Truscott, K. N., Pfanner, N., & Voos, W. (2007) · Springer eBooks · doi:10.1007/bfb0115593 · Cited by 41 · see citing works

Neurobiology of Major Depression in Alzheimer's Disease

Zubenko, G. S. (2000) · International Psychogeriatrics · doi:10.1017/s1041610200007079 · Cited by 30 · see citing works

Age-related changes in the expression of Alzheimerʼs βAPP in the brain of senescence accelerated mouse (SAM)-P/10

Jeong, S., Kim, K., & Suh, Y. (1997) · Neuroreport · doi:10.1097/00001756-199705060-00033 · Cited by 23 · see citing works

Expression of amyloid precursor protein in human astrocytes in vitro: isoform-specific increases following heat shock

Shepherd, C. E., Bowes, S., Parkinson, D., Cambray-Deakin, M. A., & Pearson, R. C. A. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00197-4 · Cited by 23 · see citing works

Alzheimer’s disease: A Review

Siva Rami Reddy, E. (2019) · International Journal of Homoeopathic Sciences · doi:10.33545/26164485.2019.v3.i1a.52 · Cited by 18 · see citing works

Mitochondria and Mitochondrial Cascades in Alzheimer’s disease

Swerdlow, R. H. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170585 · Cited by 850 · see citing works

The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives

Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.010 · Cited by 786 · see citing works

VDAC, a multi-functional mitochondrial protein regulating cell life and death

Shoshan‐Barmatz, V., Pinto, V. D., Zweckstetter, M., Raviv, Z., Keinan, N., & Arbel, N. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.03.002 · Cited by 792 · see citing works

The Alzheimer’s Disease Mitochondrial Cascade Hypothesis

Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100339 · Cited by 562 · see citing works

Calcium Dysregulation and Homeostasis of Neural Calcium in the Molecular Mechanisms of Neurodegenerative Diseases Provide Multiple Targets for Neuroprotection

Zündorf, G., & Reiser, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3359 · Cited by 482 · see citing works

The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease

McManus, M. J., Murphy, M. P., & Franklin, J. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0552-11.2011 · Cited by 432 · see citing works

Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer’s Disease

Hroudová, J., Singh, N., & Fišar, Z. (2014) · BioMed Research International · doi:10.1155/2014/175062 · Cited by 319 · see citing works

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation

Leuner, K., Schütt, T., Kurz, C., Eckert, S. H., Schiller, C., Occhipinti, A., Mai, S., Jendrach, M., Eckert, G. P., Kruse, S. E., et al. (2012) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2011.4173 · Cited by 354 · see citing works

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

Reddy, P. H. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.042 · Cited by 264 · see citing works

Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains

Vaillant-Beuchot, L., Mary, A., Pardossi-Piquard, R., Bourgeois, A., Lauritzen, I., Eysert, F., Kinoshita, P. F., Cazareth, J., Badot, C., Fragaki, K., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-020-02234-7 · Cited by 263 · see citing works

Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis

Chakravorty, A., Jetto, C. T., & Manjithaya, R. R. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00311 · Cited by 219 · see citing works

Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease

Wang, H., Dey, K. K., Chen, P.-C., Li, Y., Niu, M., Cho, J.-H., Wang, X., Bai, B., Jiao, Y., Chepyala, S. R., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00384-6 · Cited by 210 · see citing works

The Alzheimer's disease mitochondrial cascade hypothesis: an update

Swerdlow, R. H., & Khan, S. M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.01.011 · Cited by 206 · see citing works

Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer's Disease

Swerdlow, R. H. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4149 · Cited by 203 · see citing works

Mitochondrial calcium homeostasis as potential target for mitochondrial medicine

Giorgi, C., Agnoletto, C., Bononi, A., Bonora, M., Marchi, E. D., Marchi, S., Missiroli, S., Patergnani, S., Poletti, F., Rimessi, A., et al. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.07.004 · Cited by 200 · see citing works

Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes

Prete, D. D., Suski, J., Oulès, B., Debayle, D., Gay, A.-S., Lacas-Gervais, S., Bussiere, R., Bauer, C., Pinton, P., Paterlini-Bréchot, P., et al. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160953 · Cited by 158 · see citing works

Convergence of Amyloid-β and Tau Pathologies on Mitochondria In Vivo

Eckert, A., Schulz, K. L., Rhein, V. F., & Götz, J. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8109-5 · Cited by 158 · see citing works

Physiology and pharmacology of amyloid precursor protein

Cho, Y., Bae, H., Okun, E., Arumugam, T. V., & Jo, D. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108122 · Cited by 145 · see citing works

Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders

Covarrubias‐Pinto, A., Acuña, A. I., Beltrán, F. A., Torres-Díaz, L., & Castro, M. A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226095 · Cited by 140 · see citing works

The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing

Liu, Y., Tan, Y., Zhang, Z., Yi, M., Zhu, L., & Peng, W. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00397-x · Cited by 144 · see citing works

Mitochondrial dysfunction and Alzheimer's disease

Maruszak, A., & Żekanowski, C. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.004 · Cited by 123 · see citing works

The Neurodegenerative Mitochondriopathies

Swerdlow, R. H. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1095 · Cited by 112 · see citing works

Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia

Zhang, H., Zheng, C. Y., Yan, H., Wang, Z. F., Tang, L. L., Gao, X., & Tang, X. C. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.04.049 · Cited by 111 · see citing works

Mitochondria, Cybrids, Aging, and Alzheimer's Disease

Swerdlow, R. H., Koppel, S., Weidling, I., Hayley, C., Ji, Y., & Wilkins, H. M. (2017) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2016.12.017 · Cited by 106 · see citing works

Mitochondrial respiration as a target for neuroprotection and cognitive enhancement

Gonzalez-Lima, F., Barksdale, B. R., & Rojas, J. C. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.11.010 · Cited by 105 · see citing works

Huperzine A protects isolated rat brain mitochondria against β-amyloid peptide

Gao, X., Zheng, C. Y., Yang, L., Tang, X. C., & Zhang, H. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.02.028 · Cited by 103 · see citing works

Protein folding diseases and neurodegeneration: Lessons learned from yeast

Winderickx, J., Delay, C., Vos, A. D., Klinger, H., Pellens, K., Vanhelmont, T., LEUVEN, F. V., & Zabrocki, P. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.020 · Cited by 102 · see citing works

Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis

Weidling, I. W., & Swerdlow, R. H. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113321 · Cited by 100 · see citing works

Alpha-synuclein and beta-amyloid – different targets, same players: calcium, free radicals and mitochondria in the mechanism of neurodegeneration

Angelova, P. R., & Abramov, A. Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.103 · Cited by 98 · see citing works

Genetic determinants at the interface of cancer and neurodegenerative disease

Morris, L. G. T., Veeriah, S., & Chan, T. A.-T. (2010) · Oncogene · doi:10.1038/onc.2010.127 · Cited by 97 · see citing works

Genetics of Alzheimer’s Disease

Ridge, P. G., Ebbert, M., & Kauwe, J. S. K. (2013) · BioMed Research International · doi:10.1155/2013/254954 · Cited by 96 · see citing works

Role of the mitochondrial sodium/calcium exchanger in neuronal physiology and in the pathogenesis of neurological diseases

Castaldo, P., Cataldi, M., Magi, S., Lariccia, V., Arcangeli, S., & Amoroso, S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.017 · Cited by 89 · see citing works

Multiple pathogenic proteins implicated in neuronopathic Gaucher disease mice

Xu, Y., Xu, K., Sun, Y., Liou, B., Quinn, B., Li, R.-H., Xue, L., Zhang, W., Setchell, K. D. R., Witte, D. P., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu105 · Cited by 89 · see citing works

The mitochondrial hypothesis: Dysfunction, bioenergetic defects, and the metabolic link to Alzheimer's disease

Swerdlow, R. H. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.01.008 · Cited by 88 · see citing works

The Alzheimer’s Disease Mitochondrial Cascade Hypothesis: A Current Overview

Swerdlow, R. H. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221286 · Cited by 83 · see citing works

Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation

Ma, B., Meng, X., Wang, J., Sun, J., Ren, X., Qin, M., Sun, J., Sun, G., & Sun, X. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.06.018 · Cited by 78 · see citing works

Improved mitochondrial function in brain aging and Alzheimer disease - the new mechanism of action of the old metabolic enhancer piracetam

Leuner, K. (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00044 · Cited by 70 · see citing works

Newly Developed Drugs for Alzheimer’s Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission

Korábečný, J., Nepovimová, E., Cikánková, T., Špilovská, K., Vašková, L., Mezeiová, E., Kuča, K., & Hroudová, J. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2017.06.034 · Cited by 64 · see citing works

Therapeutic and preventive effects of methylene blue on Alzheimer's disease pathology in a transgenic mouse model

Paban, V., Manrique, C., Filali, M., Maunoir-Regimbal, S., Fauvelle, F., & Alescio‐Lautier, B. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.033 · Cited by 58 · see citing works

Mitochondria and Alzheimer’s Disease: the Role of Mitochondrial Genetic Variation

Ridge, P. G., & Kauwe, J. S. K. (2018) · Current Genetic Medicine Reports · doi:10.1007/s40142-018-0132-2 · Cited by 57 · see citing works

Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer’s disease

Xu, L., Shen, Y., Wang, X., Wei, L., Wang, P., Yang, H., Wang, C.-F., Xie, Z., & Bi, J. (2017) · Neuroreport · doi:10.1097/wnr.0000000000000739 · Cited by 55 · see citing works

Mitochondria and Alzheimer’s disease: amyloid-β peptide uptake and degradation by the presequence protease, hPreP

Alikhani, N., Ankarcrona, M., & Glaser, E. G. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9244-4 · Cited by 55 · see citing works

Mitochondrial links between brain aging and Alzheimer’s disease

Wilkins, H., & Swerdlow, R. H. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00261-2 · Cited by 53 · see citing works

Mitochondrial Genomic Analysis of Late Onset Alzheimer’s Disease Reveals Protective Haplogroups H6A1A/H6A1B: The Cache County Study on Memory in Aging

Ridge, P. G., Maxwell, T. J., Corcoran, C. D., Norton, M. C., Tschanz, J. T., O’Brien, E., Kerber, R. A., Cawthon, R., Munger, R. G., & Kauwe, J. S. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045134 · Cited by 52 · see citing works

The effects of bioactive components from the rhizome of Salvia miltiorrhiza (Danshen) on the characteristics of Alzheimer’s disease

Chong, C., Su, H., Lu, J., & Wang, Y. (2019) · Chinese Medicine · doi:10.1186/s13020-019-0242-0 · Cited by 51 · see citing works

Mitochondrial medicine and the neurodegenerative mitochondriopathies

Swerdlow, R. H. (2009) · Pharmaceuticals · doi:10.3390/ph2030150 · Cited by 43 · see citing works

A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor

Kooistra, J., Milojevic, J., Melacini, G., & Ortega, J. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1037 · Cited by 43 · see citing works

IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity

Bjune, J.-I., Haugen, C., Gudbrandsen, O. A., Nordbø, O. P., Nielsen, H. J., Våge, V., Njølstad, P. R., Sagen, J. V., Dankel, S. N., & Mellgren, G. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0275-y · Cited by 40 · see citing works

Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506

Overk, C., Rockenstein, E. M., Florio, J. B., Cheng, Q., & Masliah, E. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.068 · Cited by 39 · see citing works

N-palmitoyl serotonin alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of BDNF and p-CREB in mice

Min, A. Y., Doo, C. N., Son, E. J., Sung, N. Y., Lee, K. J., Sok, D., & Kim, M. R. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.09.016 · Cited by 38 · see citing works

Mechanisms associated with the dysregulation of mitochondrial function due to lead exposure and possible implications on the development of Alzheimer’s disease

Bandaru, L. J. M., Ayyalasomayajula, N., Murumulla, L., & Challa, S. (2022) · BioMetals · doi:10.1007/s10534-021-00360-7 · Cited by 38 · see citing works

Applications of high‐resolution magic angle spinning MRS in biomedical studies I—cell line and animal models

Kaebisch, E. M., Fuss, T. L., Vandergrift, L. A., Toews, K., Habbel, P., & Cheng, L. L. (2017) · NMR in Biomedicine · doi:10.1002/nbm.3700 · Cited by 37 · see citing works

Mitochondrial Membrane Potential Influences Amyloid-β Protein Precursor Localization and Amyloid-β Secretion

Wilkins, H., Troutwine, B., Menta, B. W., Manley, S., Strope, T., Lysaker, C., & Swerdlow, R. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215280 · Cited by 36 · see citing works

Neuroprotection of Gastrodia elata polyphenols against H2O2-induced PC12 cell cytotoxicity by reducing oxidative stress

Tan, W., Zheng, Q., Feng, K., Feng, X., Zhong, W., Liao, C., Li, S., Liu, Y., & Hu, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1050775 · Cited by 35 · see citing works

Bioenergetics and metabolism: a bench to bedside perspective

Swerdlow, R. H. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13509 · Cited by 35 · see citing works

Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration

Schaefer, P., von Einem, B., Walther, P., Calzia, E., & Arnim, C. A. F. V. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168157 · Cited by 35 · see citing works

Mitochondria Dysfunction in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis: Lessons From Drosophila Models

Anoar, S., Woodling, N. S., & Niccoli, T. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.786076 · Cited by 34 · see citing works

Mitochondrial Complex I and β-Amyloid Peptide Interplay in Alzheimer’s Disease: A Critical Review of New and Old Little Regarded Findings

Atlante, A., & Valenti, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115951 · Cited by 32 · see citing works

Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives

Bhole, R. P., Chikhale, R. V., & Rathi, K. M. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.11.003 · Cited by 34 · see citing works

Biomechanistic insights into the roles of oxidative stress in generating complex neurological disorders

Yusuf, M., Khan, M., Robaian, M. A., & Khan, R. A. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0250 · Cited by 31 · see citing works

The organellar peptidasome, PreP: A journey from Arabidopsis to Alzheimer's disease

Glaser, E. G., & Alikhani, N. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.12.016 · Cited by 27 · see citing works

The PTEN inhibitor bpV(pic) promotes neuroprotection against amyloid β-peptide (25-35)-induced oxidative stress and neurotoxicity

Liu, X., Zhang, L., Chen, Z., & Liu, L. (2017) · Neurological Research · doi:10.1080/01616412.2017.1317916 · Cited by 27 · see citing works

Exercise and Syzygium aromaticum reverse memory deficits, apoptosis and mitochondrial dysfunction of the hippocampus in Alzheimer's disease

Panahzadeh, F., Mirnasuri, R., & Rahmati, M. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114871 · Cited by 26 · see citing works

Mitochondrial localization of NCXs: Balancing calcium and energy homeostasis

Magi, S., Piccirillo, S., Preziuso, A., Amoroso, S., & Lariccia, V. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102162 · Cited by 26 · see citing works

Effects of estrogens and androgens on mitochondria under normal and pathological conditions

Mohajeri, M., Martín-Jiménez, C., Barreto, G. E., & Sahebkar, A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.03.001 · Cited by 22 · see citing works

Mitochondrially-Targeted Therapeutic Strategies for Alzheimer’s Disease

Onyango, I. G., Bennett, J. P., & Stokin, G. B. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666211208125855 · Cited by 21 · see citing works

Genetic and biochemical studies of SNPs of the mitochondrial Aβ-degrading protease, hPreP

Pinho, C. M., Björk, B. F., Alikhani, N., Bäckman, H. G., Eneqvist, T., Fratiglioni, L., Glaser, E. G., & Graff, C. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.075 · Cited by 20 · see citing works

Metabotyping of Docosahexaenoic Acid - Treated Alzheimer’s Disease Cell Model

Bahety, P., Tan, Y. M., Hong, Y., Zhang, L., Chan, E. C. Y., & Ee, P. L. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090123 · Cited by 20 · see citing works

Discovery of Molecular Networks of Neuroprotection Conferred by Brahmi Extract in Aβ42-Induced Toxicity Model of Drosophila melanogaster Using a Quantitative Proteomic Approach

Deolankar, S. C., Najar, M. A., Ramesh, P., Kanichery, A., Kudva, A. K., Raghu, S. V., & Prasad, T. S. K. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03066-0 · Cited by 18 · see citing works

Mitochondrial optic neuropathy: In vivo model of neurodegeneration and neuroprotective strategies

Rojas (2010) · Eye and Brain · doi:10.2147/eb.s9363 · Cited by 18 · see citing works

Inhibition of 37/67kDa Laminin-1 Receptor Restores APP Maturation and Reduces Amyloid-β in Human Skin Fibroblasts from Familial Alzheimer’s Disease

Bhattacharya, A., Izzo, A., Mollo, N., Napolitano, F., Limone, A., Margheri, F., Mocali, A., Minopoli, G., Bianco, A. L., Maggio, F. D., et al. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10040232 · Cited by 17 · see citing works

Ginsenoside Rg1 attenuates β-amyloid-induced apoptosis in mutant PS1 M146L cells

Wei, C., Jia, J., Liang, P., & Guan, Y. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.07.089 · Cited by 17 · see citing works

Pharmacologic enrichment of exosome yields and mitochondrial cargo

Wang, X., Berkowicz, A., King, K., Menta, B. W., Gabrielli, A. P., Novikova, L., Troutwine, B., Pleen, J., Wilkins, H., & Swerdlow, R. H. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.04.001 · Cited by 16 · see citing works

Assembly of 809 whole mitochondrial genomes with clinical, imaging, and fluid biomarker phenotyping

Ridge, P. G., Wadsworth, M. E., Miller, J. B., Saykin, A. J., Green, R. C., Initiative, T. A. D. N., & Kauwe, J. S. K. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.11.013 · Cited by 15 · see citing works

Perspective on the calcium dyshomeostasis hypothesis in the pathogenesis of selective neuronal degeneration in animal models of Alzheimer's disease

Overk, C., & Masliah, E. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.01.005 · Cited by 14 · see citing works

Binding of divalent cations is essential for the activity of the organellar peptidasome in Arabidopsis thaliana, AtPreP

Bäckman, H. G., Pessoa, J., Eneqvist, T., & Glaser, E. G. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.040 · Cited by 9 · see citing works

Neurodegeneration, Mitochondria, and Antibiotics

Suarez-Rivero, J. M., López‐Pérez, J., Muela‐Zarzuela, I., Pastor‐Maldonado, C. J., Cilleros-Holgado, P., Gómez-Fernández, D., Álvarez-Córdoba, M., Munuera-Cabeza, M., Talaverón-Rey, M., Povea-Cabello, S., et al. (2023) · Metabolites · doi:10.3390/metabo13030416 · Cited by 8 · see citing works

Effects of Novel Tacrine Derivatives on Mitochondrial Energy Metabolism and Monoamine Oxidase Activity—In Vitro Study

Hroudová, J., Nováková, T., Korábečný, J., Maliňák, D., Górecki, L., & Fišar, Z. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02172-1 · Cited by 5 · see citing works

Insulin-like growth factor-1 inhibits STS-induced cell death and increases functional recovery of in vitro differentiated neurons

Pucci, B., Bertani, F. R., Indelicato, M., Sale, P., Lococo, E., Grassi, F., Pagani, F., Colafrancesco, V., Morgante, E., Tafani, M., et al. (2008) · Cell Cycle · doi:10.4161/cc.7.24.7261 · Cited by 4 · see citing works

Mitochondrial Function and Neurodegenerative Diseases

Wilkins, H. M., Weidling, I., Koppel, S., Wang, X., von Schulze, A., & Swerdlow, R. H. (2018) · The Molecular and Cellular Basis of Neurodegenerative Diseases · doi:10.1016/b978-0-12-811304-2.00013-4 · Cited by 2 · see citing works

Morphological and functional abnormalities in neuromuscular junctions of Drosophila melanogaster induced by human APP gene expression

Sarantseva, S. V., Kislik, G., Tkachenko, N., Vasiliev, A. N., & Schwarzman, A. L. (2012) · Cell and Tissue Biology · doi:10.1134/s1990519x12040104 · Cited by 2 · see citing works

Mitophagy Impairments as Culprit of Alzheimer’s Disease

Mani, S., Swargiary, G., Singh, M., & Rawal, M. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_5 · Cited by 1 · see citing works

EXPLORATIONS IN HOMEOVISCOUS ADAPTATION AND MASS SPECTRAL ANALYSIS OF MEMBRANE LIPIDS

Timmons, M. D. (2010) · UKnowledge (University of Kentucky)

Amyloid precursor protein with the Alzheimer´s disease 670/671 mutation : Animal and cellular models

Kloskowska, E. (2008) · Figshare

Strategies of neuroprotection in an in vivo model of retinal degeneration induced by mitochondrial dysfunction

Rojas-Martinez, J. C. (2009) · Texas ScholarWorks (Texas Digital Library)

Functional and structural studies of the Presequence protease, PreP

Bäckman, H. G. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Association studies on susceptibility genes in Alzheimer disease

Björk, B. F. (2008) · Figshare

Targeting Alzheimer's disease neuronal mitochondria as a therapeutic approach

Onyango, I. G., & Stokin, G. B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819621-2.00015-2

Modulation of Alzheimer’s Disease related APP Trafficking via Protein Kinase C

Vithana, R. (2012) · UA Campus Repository (The University of Arizona)

Hallucinogenic Therapy in Alzheimer’s Disease targeting Mitochondria-Associated Membranes

Minauro‐Sanmiguel, F., & Vargas-Pérez, H. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.02.028

Inhaled General Anesthetics in Alzheimer’s Disease Progression: Divergent Effects, Underlying Mechanisms, and Future Perspectives

Yang, L., Song, G., Parker, E., & Yang, L. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05832-w

Importance du contrôle qualité des mitochondries dans les maladies neurodégénératives : analyse cellulaire et génétique dans des modèles drosophile de la maladie de Huntington et de la sclérose latérale amyotrophique

Khalil, B. (2016) · theses.fr (ABES) · doi:10.70675/4446111fz4182z4737zae76z7f117887a893

Dérégulation de l’homéostasie calcique du réticulum endoplasmique dans la maladie d’Alzheimer : rôle du récepteur de la ryanodine et de l’isoforme SERCA1 tronquée

Bussiere, R. (2018) · theses.fr (ABES) · doi:10.70675/2334ca11z42bfz4e8bza53bz02e8bbacc38e

Implications de la signalisation de la protéine kinase activée par l’AMP (AMPK) dans les dysfonctions mitochondriales, la pathologie amyloïde et Tau, et la neuroinflammation dans la maladie d’Alzheimer

Mary, A. (2022) · theses.fr (ABES) · doi:10.70675/868e288ezd237z49c1z866fzf618e1462aab

The role of organochlorine pesticides as environmental factors in Alzheimer's disease in human studies: A systematic review and meta-analysis

Ghaedrahmat, Z., Almasi, H., Goushki, J. S., & Moghiseh, Z. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261465828

Mitochondrial Translocation of Amyloid Precursor Protein and its Cleaved Products: Relevance to Mitochondrial Dysfunction in Alzheimer's Disease

Anandatheerthavarada, H. K., & Devi, L. (2007) · Reviews in the Neurosciences · doi:10.1515/revneuro.2007.18.5.343 · Cited by 28 · see citing works

Amyloid-β peptide and mitochondrial dysfunction

Yang, A. J. T., & Wilkins, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45078-5.00022-1

Interactions between amyloid, amyloid precursor protein, and mitochondria

Wilkins, H. (2023) · Biochemical Society Transactions · doi:10.1042/bst20220518 · Cited by 38 · see citing works

Amyloid precursor protein and mitochondria

Strope, T. A., & Wilkins, H. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102651 · Cited by 34 · see citing works

Mitochondrial accumulation of APP and Aβ: significance for Alzheimer disease pathogenesis

Pavlov, P. F., Petersen, C. H., Glaser, E. G., & Ankarcrona, M. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00892.x · Cited by 82 · see citing works