The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Role of Dopamine in the Motivational and Cognitive Control of Behavior
Abstract
Brain dopamine has often been implicated in impulsive and/or inflexible behaviors, which may reflect failures of motivational and/or cognitive control. However, the precise role of dopamine in such failures of behavioral control is not well understood, not least because they implicate paradoxical changes in distinct dopamine systems that innervate dissociable neural circuits. In addition, there are large individual differences in the response to dopaminergic drugs with some individuals benefiting from and others being impaired by the same drug. This complicates progress in the understanding of dopamine's role in behavioral control processes, but also provides a major problem for neuropsychiatry, where some individuals are disproportionately vulnerable to the adverse effects of dopamine-enhancing drugs on motivation and cognition. Recent progress is reviewed from cognitive and behavioral neuroscience research on motivation and cognitive control, which begins to elucidate the factors that mediate the complex roles of mesolimbic, mesocortical, and nigrostriatal dopamine in behavioral control.
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In the citing paper
“Dopamine signaling in the striatum is part of a larger system that mediates impulsive behavior, which includes the prefrontal cortex (Cools, 2008; Dalley et al., 2011; George and Koob, 2010; Groman and Jentsch, 2012).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Cools, 2008
In the citing paper
“Cognitive control deficits are often associated with alterations in dopamine transmission in prefrontal cortex and striatum (Arnsten et al., 1994; Cai and Arnsten, 1997; Cools, 2008; Cools and D'Esposito, 2011; Landau et al., 2009; Vernaleken et al., 2007)”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Cools, 2008
In the citing paper
“Frontostriatal circuits subserving affective, cognitive, and motor processes are significantly modulated by the neurotransmitter dopamine (DA) (for reviews see (Schultz 2002; Wise 2004; Cools 2008), through facilitation of the direct pathway via the action of excitatory DA receptors (D1-like) and inhibition of the indirect pathway via the action of inhibitory DA receptors (D2-like).”
From Developmental imaging genetics: Linking dopamine function to adolescent behavior (2014) · cites this paper as Cools 2008
Citations
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Flagged first, then by citations
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Cited by
Sorted by citations
The dual pathway to creativity model: Creative ideation as a function of flexibility and persistence
Nijstad, B. A., Dreu, C. K. W. D., Rietzschel, E. F., & Baas, M. (2010) · European Review of Social Psychology · doi:10.1080/10463281003765323 · Cited by 1,145
“Within cognitive psychology this has been described as a trade-off between flexibility and stability (e.g., Cools, 2008; Dreisbach & Goschke, 2004; Dreisbach et al., 2005; Müller et al., 2007).”
BackgroundThe neural mechanisms of inter-temporal decision-making: understanding variability
Peters, J., & Büchel, C. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.03.002 · Cited by 693
Neurophysiology of performance monitoring and adaptive behavior
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“Generally, the FRN might be affected later in the course of disease progression than the ERN because the ventral striatum, relevant for reward processing, seems to be affected by dopamine depletion only at more severe stages of PD (104, 105).”
BackgroundAn Integrative Model of the Maturation of Cognitive Control
Luna, B., Marek, S., Larsen, B., Tervo-Clemmens, B., & Chahal, R. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-034054 · Cited by 550
“Owing to its role in motivational processing underlying learning, memory, cognition, emotion, and reward processing (Cools 2008, Schultz 2002), DA function has been of keen interest regarding adolescence sensation seeking (for reviews, see Padmanabhan & Luna 2013, Spear 2000, Wahlstrom et al. 2010).”
BackgroundPsychopathology and the Human Connectome: Toward a Transdiagnostic Model of Risk For Mental Illness
Buckholtz, J. W., & Meyer‐Lindenberg, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.002 · Cited by 449
“The linkage between DRD2 variation and these seemingly diverse phenotypes may be driven by an effect on frontostriatal circuitry for flexible, value-based action selection (Cools, 2008; Balleine and O’Doherty, 2010).”
Metadata
- Authors
- Cools, R.
- Affiliations
- Radboud University Nijmegen (NL)
- Corresponding author
- Cools, Roshan
- ORCID
- Cools, Roshan
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2008-08
- Volume
- 14
- Issue
- 4
- Pages
- 381-395
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- OpenAlex
- W2147381727
- Cited by
- 352
- References
- 91
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 14 · 2023: 19 · 2022: 17 · 2021: 12 · 2020: 13 · 2019: 32 · 2018: 13 · 2017: 16 · 2016: 20 · 2015: 26 · 2014: 19 · 2013: 26 · 2012: 32
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Neuroscientist (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- dopamine, motivation, cognitive control, impulsive behavior, mesolimbic dopamine system, mesocortical dopamine system, nigrostriatal dopamine system, neuropsychiatry
- MeSH terms
- Animals, Behavior, Brain, Brain Mapping, Cognition, Dopamine, Humans, Motivation, Dopamine Agents
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