The neural mechanisms of inter-temporal decision-making: understanding variability
Abstract
Humans and animals prefer immediate over delayed rewards (delay discounting). This preference for smaller-but-sooner over larger-but-later rewards shows substantial interindividual variability in healthy subjects. Moreover, a strong bias towards immediate reinforcement characterizes many psychiatric conditions such as addiction and attention-deficit hyperactivity disorder. We discuss the neural mechanisms underlying delay discounting and describe how interindividual variability (trait effects) in the neural instantiation of subprocesses of delay discounting (such as reward valuation, cognitive control and prospection) contributes to differences in behaviour. We next discuss different interventions that can partially remedy impulsive decision-making (state effects). Although the precise neural mechanisms underlying many of these modulating influences are only beginning to be unravelled, they point towards novel treatment approaches for disorders of impulse control.
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Delay discounting recruits corticostriatal circuitry.
“Neuroimaging studies have consistently shown that delay discounting recruits corticostriatal circuitry (19).”
From Adolescent impatience decreases with increased frontostriatal connectivity (2015) · cites this paper as [19]
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“, 2013); conversely, improved top-down cognitive control over the striatum by prefrontal cortical regions may reduce impulsivity (Peters and Büchel, 2011).”
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“Indeed, studies of delay discounting using fMRI have directly implicated the ventral striatum in delay discounting, among a number of other regions, including subunits of prefrontal cortex, posterior cingulate cortex, anterior insula, and anterior cingulate (24; 49).”
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Diminished Cortical Thickness Is Associated with Impulsive Choice in Adolescence
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Naudé, J., Dongelmans, M., & Faure, P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.021 · Cited by 39 · see citing works
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Decision making: effects of methylphenidate on temporal discounting in nonhuman primates
Rajala, A. Z., Jenison, R. L., & Populin, L. C. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00278.2015 · Cited by 25 · see citing works
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- Authors
- Peters, J., & Büchel, C.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Peters, Jan
- Venue
- Trends in Cognitive Sciences
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 15
- Issue
- 5
- Pages
- 227-239
- ISSN
- 1364-6613 (ISSN-L)
- OpenAlex
- W2082648681
- Semantic Scholar
- 62f30915986589056d24a19d33d82f81599ff90b
- Cited by
- 693
- References
- 166
- Citations by year
- 2026: 27 · 2025: 44 · 2024: 57 · 2023: 37 · 2022: 42 · 2021: 51 · 2020: 88 · 2019: 47 · 2018: 39 · 2017: 39 · 2016: 40 · 2015: 57 · 2014: 52 · 2013: 34 · 2012: 29
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cognitive Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- delay discounting, intertemporal choice, interindividual variability, impulsivity, reward valuation, cognitive control, prospection, addiction, attention deficit hyperactivity disorder, impulse control disorders, neural mechanisms, therapeutic interventions
- MeSH terms
- Animals, Brain Mapping, Cognition, Computer Simulation, Decision Making, Humans, Models, Neurological, Nerve Net, Reward, Temporal Lobe, Behavior, Addictive, Comprehension
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