Cited by 352Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesParkinson's Disease Mechanisms and Treatments

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Role of Dopamine in the Motivational and Cognitive Control of Behavior

Cools, Roshan·2008·The Neuroscientist

DOI 10.1177/1073858408317009

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Abstract

Brain dopamine has often been implicated in impulsive and/or inflexible behaviors, which may reflect failures of motivational and/or cognitive control. However, the precise role of dopamine in such failures of behavioral control is not well understood, not least because they implicate paradoxical changes in distinct dopamine systems that innervate dissociable neural circuits. In addition, there are large individual differences in the response to dopaminergic drugs with some individuals benefiting from and others being impaired by the same drug. This complicates progress in the understanding of dopamine's role in behavioral control processes, but also provides a major problem for neuropsychiatry, where some individuals are disproportionately vulnerable to the adverse effects of dopamine-enhancing drugs on motivation and cognition. Recent progress is reviewed from cognitive and behavioral neuroscience research on motivation and cognitive control, which begins to elucidate the factors that mediate the complex roles of mesolimbic, mesocortical, and nigrostriatal dopamine in behavioral control.

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See all 352

Authors: Cools, R.
Affiliations: Radboud University Nijmegen (NL)
Corresponding author: Cools, Roshan
ORCID: Cools, Roshan
Venue: The Neuroscientist
Publisher: SAGE Publications
Published: 2008-08
Volume: 14
Issue: 4
Pages: 381-395
ISSN: 1073-8584 (ISSN-L)
1089-4098
DOI: 10.1177/1073858408317009
OpenAlex: W2147381727
Cited by: 352
References: 91
Citations by year: 2026: 8 · 2025: 14 · 2024: 14 · 2023: 19 · 2022: 17 · 2021: 12 · 2020: 13 · 2019: 32 · 2018: 13 · 2017: 16 · 2016: 20 · 2015: 26 · 2014: 19 · 2013: 26 · 2012: 32
FWCI: 10.23
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: The Neuroscientist (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: dopamine, motivation, cognitive control, impulsive behavior, mesolimbic dopamine system, mesocortical dopamine system, nigrostriatal dopamine system, neuropsychiatry
MeSH terms: Animals, Behavior, Brain, Brain Mapping, Cognition, Dopamine, Humans, Motivation, Dopamine Agents

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Role of Dopamine in the Motivational and Cognitive Control of Behavior

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