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Cited by 91Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Dissecting the Components of Long-Term Potentiation

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Blundon, Jay A., Zakharenko, Stanislav S.·2008·The Neuroscientist
DOI 10.1177/1073858408320643PMC PMC2655119
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Abstract

The formation of memories relies in part on plastic changes at synapses between neurons. Although the mechanisms of synaptic plasticity have been studied extensively over several decades, many aspects of this process remain controversial. The cellular locus of expression of long-term potentiation (LTP), a major form of synaptic plasticity, is one of the most important unresolved phenomena. In this article, some recent advances in this area made possible by the development of new imaging tools are summarized. These studies have demonstrated that LTP is compound in nature and consists of both presynaptic and postsynaptic components. Some features of presynaptic and postsynaptic changes during compound LTP are also reviewed.

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  • LTP is compound in nature, involving both increased presynaptic release probability and enhanced postsynaptic conductance.

    “However, evidence indicates that LTP is compound in nature, involving both increased presynaptic release probability and enhanced postsynaptic conductance [65].”

    From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [65]

    The section “A summary of LTP mechanisms” describes compound LTP at CA3–CA1 synapses as having presynaptic and postsynaptic components, with their contributions depending on the stimulation protocol. The section “The evolution of fluorescent probes of presynaptic activity” reports more effective neurotransmitter release after compound LTP. Our copy does not establish that the presynaptic change specifically increases release probability or that the postsynaptic change specifically enhances conductance. (LLM, conf=0.83)

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Authors
Blundon, J. A., & Zakharenko, S. S.
Affiliations
  • Rhodes College (US)
  • St. Jude Children's Research Hospital (US)
Corresponding author
Zakharenko, Stanislav S.
ORCID
Venue
The Neuroscientist
Publisher
SAGE Publications
Published
2008-12
Volume
14
Issue
6
Pages
598-608
ISSN
  • 1073-8584 (ISSN-L)
  • 1089-4098
DOI
10.1177/1073858408320643
PMC
PMC2655119
OpenAlex
W2104085571
Cited by
91
References
11
Citations by year
2026: 7 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 7 · 2019: 1 · 2018: 2 · 2017: 9 · 2016: 2 · 2015: 5 · 2014: 9 · 2013: 9 · 2012: 10
FWCI
2.60
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • The Neuroscientist (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R01MH079079)
  • National Cancer Institute (P30CA021765)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
long-term potentiation, synaptic plasticity, memory formation, presynaptic plasticity, postsynaptic plasticity
MeSH terms
Animals, Dose-Response Relationship, Radiation, Electric Stimulation, Humans, Memory, Models, Biological, Neurons, Synapses, Long-Term Potentiation

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