The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons
Abstract
AMP-activated protein kinase (AMPK) constitutes a molecular hub for cellular metabolic control, common to all eukaryotic cells. Numerous reports have established how AMPK responds to changes in the AMP:ATP ratio as a measure of cellular energy levels. In this way, it integrates control over a number of metabolic enzymes and adapts cellular processes to the current energy status in various cell types, such as muscle and liver cells. The role of AMPK in the development, function, and maintenance of the nervous system, on the other hand, has only recently gained attention. Neurons, while highly metabolically active, have poor capacity for nutrient storage and are thus sensitive to energy fluctuations. Recent reports demonstrate that AMPK may have neuroprotective properties and is activated in neurons by resveratrol but also by metabolic stress in the form of ischemia/hypoxia and glucose deprivation. Novel studies on AMPK also implicate neuronal activity as a critical factor in neurodegeneration. Here we discuss the latest advances in the knowledge of AMPK's role in the metabolic control and survival of excitable cells.
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“It is a brain specific form of diabetes characterized by impaired insulin actions and neuronal insulin resistance [120] that leads to excessive generation and accumulation of amyloid oligomers, a key factor in the development of AD [121].”
From Metformin: An Old But Still the Best Treatment for Type 2 Diabetes (2013) · cites this paper as [120]
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1 retracted
RETRACTED: LKB1 and AMPK maintain epithelial cell polarity under energetic stress
Mirouse, V., Swick, L. L., Kazgan, N., Johnston, D. S., & Brenman, J. E. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702053 · Cited by 190
RetractedLiang, J., Shao, S. H., Xu, Z.-X., Hennessy, B. T., Ding, Z., Larrea, M. D., Kondo, S., Dumont, D. J., Gutterman, J. U., Walker, C. L., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1537 · Cited by 886
Resveratrol stimulates AMP kinase activity in neurons
Dasgupta, B., & Milbrandt, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610068104 · Cited by 723
Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
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Culmsee, C., monnig, J., Kemp, B. E., & Mattson, M. P. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:1:45 · Cited by 340
Xue, B., & Kahn, B. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113217 · Cited by 338
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke
McCullough, L. D., Zeng, Z., Li, H., Landree, L. E., McFadden, J., & Ronnett, G. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409985200 · Cited by 333
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AMP‐activated protein kinase: role in metabolism and therapeutic implications
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The Neurodegenerative Drosophila Melanogaster Ampk Mutant Loechrig
Cook, M. (2012) · Online Publication Service of Würzburg University (Würzburg University)
The effects of glucose-induced metabolic injury on microglia activity and survival
Kenawy, S. M. (2013) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3t12d
Hypothermia and the Evaluation of Combination Therapies for Neonatal Hypoxic-Ischemic Brain Damage
Przyslupski, A. (2016) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3bz61k3c
Hussey, R. C. (2013) · Trinity's Access to Research Output (TARA) (Trinity College Dublin)
AMPK Modulates Associative Learning via Neuronal Mitochondrial Fusion in C. elegansPreprint
Escoubas, C. C., Laversenne, V., Tabakovic, E., Weir, H. J. M., Clark, N., & Mair, W. B. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.05.370031
do Amaral, L. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2021.tde-27092021-115850
Leib, D., & Manivanh, R. V. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727582977.793533719
Taste receptor type 1 member 3 mediates diet-induced cognitive impairment in mice
Lee, K.-H., Song, J. W., Kim, C.-S., Seong, H., Shin, D., & Shon, W.-J. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122194
НЕЙРОПРОТЕКТОРНЫЕ ФУНКЦИИ МЕТФОРМИНА (ОБЗОР ЛИТЕРАТУРЫ)
Гридасова, Е. И., Плешкова, В. С., Чичкан, А. С., & Смирнова, П. Н. (2026) · Military and tactical medicine Emergency medicine · doi:10.55359/2782-3296.2026.81.44.009
Metadata
- Authors
- Spasić, M. R., Callaerts, P., & Norga, K. K.
- Affiliations
- Vlaams Instituut voor Biotechnologie (BE)
- Laboratory of Developmental Genetics, Flanders Institute for Biotechnology (VIB), Leuven, Belgium, , Pediatric Hematology and Oncology, Department of Woman & Child, K.U. Leuven, Leuven, Belgium
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2009-04-09
- Volume
- 15
- Issue
- 4
- Pages
- 309-316
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- OpenAlex
- W2014734035
- Cited by
- 109
- References
- 33
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2021: 6 · 2020: 5 · 2019: 2 · 2018: 11 · 2017: 5 · 2016: 12 · 2015: 12 · 2014: 14 · 2013: 12 · 2012: 10
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Neuroscientist (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaams Instituut voor Biotechnologie
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- AMPK, neuronal energy metabolism, neuroprotection, AMP/ATP ratio, resveratrol, hypoxia-ischemia, glucose deprivation, metabolic stress, neuronal activity, neurodegeneration, neuronal survival, excitable cells
- MeSH terms
- Animals, Brain, Brain Chemistry, Cell Survival, Energy Metabolism, Humans, Neurons, Stress, Physiological, Cytoprotection, Hypoxia-Ischemia, Brain, AMP-Activated Protein Kinases
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