Visual hallucinations in Parkinson’s disease: spotlight on central cholinergic dysfunction
Open accessAbstract
Visual hallucinations are a common non-motor feature of Parkinson’s disease and have been associated with accelerated cognitive decline, increased mortality and early institutionalization. Despite their prevalence and negative impact on patient outcomes, the repertoire of treatments aimed at addressing this troubling symptom is limited. Over the past two decades, significant contributions have been made in uncovering the pathological and functional mechanisms of visual hallucinations, bringing us closer to the development of a comprehensive neurobiological framework. Convergent evidence now suggests that degeneration within the central cholinergic system may play a significant role in the genesis and progression of visual hallucinations. Here, we outline how cholinergic dysfunction may serve as a potential unifying neurobiological substrate underlying the multifactorial and dynamic nature of visual hallucinations. Drawing upon previous theoretical models, we explore the impact that alterations in cholinergic neurotransmission has on the core cognitive processes pertinent to abnormal perceptual experiences. We conclude by highlighting that a deeper understanding of cholinergic neurobiology and individual pathophysiology may help to improve established and emerging treatment strategies for the management of visual hallucinations and psychotic symptoms in Parkinson’s disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Previous research has shown that the thalamus plays a role in VH in PD.
“Previous research has shown that the thalamus plays a role in VH in PD54,55”
From Deviations in effective connectivity explain different hallucination subtypes in Parkinson's disease psychosis (2026) · cites this paper as [54]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Control of goal-directed and stimulus-driven attention in the brain
Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881 · see citing works
Complex brain networks: graph theoretical analysis of structural and functional systems
Bullmore, E., & Sporns, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2575 · Cited by 11,820 · see citing works
The brain's default mode network
Raichle, M. E. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014030 · Cited by 3,904 · see citing works
Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030
Dorsey, E. R., Constantinescu, R., Thompson, J. P., Biglan, K., Holloway, R. G., Kieburtz, K. D., Marshall, F. J., Ravina, B. M., Schifitto, G., Siderowf, A. D., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000247740.47667.03 · Cited by 2,479 · see citing works
Mesulam, M. ‐., Mufson, E. J., Levey, A. I., & Wainer, B. H. (1983) · Journal of Comparative Neurology · doi:10.1002/cne.902140206 · Cited by 1,962 · see citing works
Lees, A. J., Hardy, J., & Revesz, T. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60492-x · Cited by 1,956 · see citing works
Uncertainty, Neuromodulation, and Attention
Yu, A. J., & Dayan, P. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.026 · Cited by 1,774 · see citing works
Mammalian nicotinic acetylcholine receptors: from structure to function
Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00015.2008 · Cited by 1,724 · see citing works
The role of acetylcholine in learning and memory
Hasselmo, M. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.002 · Cited by 1,693 · see citing works
Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404 · see citing works
Dimensionality reduction for large-scale neural recordings
Cunningham, J. P., & Yu, B. M. (2014) · Nature Neuroscience · doi:10.1038/nn.3776 · Cited by 1,219 · see citing works
Controllability of structural brain networks
Gu, S., Pasqualetti, F., Cieslak, M., Telesford, Q. K., Yu, A. B., Kahn, A. E., Medaglia, J. D., Vettel, J. M., Miller, M. B., Grafton, S. T., et al. (2015) · Nature Communications · doi:10.1038/ncomms9414 · Cited by 912 · see citing works
Efferent connections of the habenular nuclei in the rat
Herkenham, M. A., & Nauta, W. J. H. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901870103 · Cited by 855 · see citing works
Parkinson's Disease and Parkinsonism: Neuropathology
Dickson, D. W. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a009258 · Cited by 847 · see citing works
Predictors of Nursing Home Placement in Parkinson's Disease: A Population‐Based, Prospective Study
Aarsland, D., Larsen, J. P., Tandberg, E., & Laake, K. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb06891.x · Cited by 811 · see citing works
Spreading of pathology in neurodegenerative diseases: a focus on human studies
Brettschneider, J., Tredici, K. D., Lee, V. M.-Y., & Trojanowski, J. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3887 · Cited by 790 · see citing works
Short latency inhibition of human hand motor cortex by somatosensory input from the hand
Tokimura, H., Lazzaro, V. D., Tokimura, Y., Oliviero, A., Profice, P., Insola, A., Mazzone, P., Tonali, P., & Rothwell, J. C. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00503.x · Cited by 771 · see citing works
Shen, W., Plotkin, J. L., Francardo, V., Ko, W. K. D., Xie, Z., Li, Q., Fieblinger, T., Wess, J., Neubig, R. R., Lindsley, C. W., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.039 · Cited by 713 · see citing works
Bodick, N. C., Offen, W., Levey, A. I., Cutler, N. R., Gauthier, S. G., Satlin, A., Shannon, H. E., Tollefson, G. D., Rasmussen, K., Bymaster, F. P., et al. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550160091022 · Cited by 687 · see citing works
The thalamic reticular nucleus: structure, function and concept
Pinault, D. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.04.008 · Cited by 683 · see citing works
Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain
Selden, N. (1998) · Brain · doi:10.1093/brain/121.12.2249 · Cited by 657 · see citing works
Prefrontal Acetylcholine Release Controls Cue Detection on Multiple Timescales
Parikh, V., Kozak, R., Martinez, V., & Sarter, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.025 · Cited by 623 · see citing works
Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe
Harding, A., Broe, G. A., & Halliday, G. M. (2002) · Brain · doi:10.1093/brain/awf033 · Cited by 608 · see citing works
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?
Compta, Y., Parkkinen, L., O’Sullivan, S. S., Vandrovcová, J., Holton, J. L., Collins, C., Lashley, T., Kallis, C., Williams, D. R., de Silva, R., et al. (2011) · Brain · doi:10.1093/brain/awr031 · Cited by 585 · see citing works
Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia
Shekhar, A., Potter, W. Z., Lightfoot, J., Lienemann, J., Dubé, S., Mallinckrodt, C. H., Bymaster, F. P., McKinzie, D. L., & Felder, C. C. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.06091591 · Cited by 563 · see citing works
Friston, K. J., Kahan, J., Biswal, B., & Razi, A. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.12.009 · Cited by 553 · see citing works
Mesulam, M. M., & Geula, C. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902750205 · Cited by 520 · see citing works
Thalamic functions in distributed cognitive control
Halassa, M. M., & Kästner, S. (2017) · Nature Neuroscience · doi:10.1038/s41593-017-0020-1 · Cited by 513 · see citing works
Structural and functional diversity of native brain neuronal nicotinic receptors
Gotti, C., Clementi, F., Fornari, A., Gaimarri, A., Guiducci, S., Manfredi, I., Moretti, M., Pedrazzi, P., Pucci, L., & Zoli, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.05.024 · Cited by 469 · see citing works
Acetylcholine contributes through muscarinic receptors to attentional modulation in V1
Herrero, J. L., Roberts, M. J., Delicato, L. S., Gieselmann, M. A., Dayan, P., & Thiele, A. (2008) · Nature · doi:10.1038/nature07141 · Cited by 459 · see citing works
Representation of Non-Spatial and Spatial Information in the Lateral Entorhinal Cortex
Deshmukh, S. S., & Knierim, J. J. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00069 · Cited by 454 · see citing works
Clinical correlates of selective pathology in the amygdala of patients with Parkinson’s disease
Harding, A. J., Stimson, E., Henderson, J. M., & Halliday, G. M. (2002) · Brain · doi:10.1093/brain/awf251 · Cited by 445 · see citing works
Sarter, M., & Bruno, J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00487-x · Cited by 440 · see citing works
Hallucinations, REM sleep, and Parkinson’s disease
Arnulf, I., Bonnet, A.-M., Damier, P., Bejjani, B.-P. W., Seilhean, D., Derenne, J., & Agid, Y. (2000) · Neurology · doi:10.1212/wnl.55.2.281 · Cited by 439 · see citing works
Collerton, D., Perry, E. K., & McKeith, I. G. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000130 · Cited by 437 · see citing works
Vandecasteele, M., Varga, V., Berényi, A., Papp, E., Barthó, P., Venance, L., Freund, T. F., & Buzsáki, G. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411233111 · Cited by 409 · see citing works
A 12-Year Population-Based Study of Psychosis in Parkinson Disease
Forsaa, E. B., Larsen, J. P., Wentzel‐Larsen, T., Goetz, C. G., Stebbins, G. T., Aarsland, D., & Alves, G. W. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.166 · Cited by 400 · see citing works
The pedunculopontine nucleus in Parkinson's disease
Zweig, R. M., Jankel, W. R., Hedreen, J. C., Mayeux, R. P., & Price, D. L. (1989) · Annals of Neurology · doi:10.1002/ana.410260106 · Cited by 388 · see citing works
A central role for the lateral prefrontal cortex in goal-directed and stimulus-driven attention
Asplund, C. L., Todd, J. J., Snyder, A. P., & Marois, R. (2010) · Nature Neuroscience · doi:10.1038/nn.2509 · Cited by 384 · see citing works
Mechanism of Deep Brain Stimulation
Chiken, S., & Nambu, A. (2015) · The Neuroscientist · doi:10.1177/1073858415581986 · Cited by 375 · see citing works
Liu, A. K. L., Chang, R. C., Pearce, R. K. B., & Gentleman, S. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1392-5 · Cited by 365 · see citing works
Alves, P. N., Foulon, C., Karolis, V., Bzdok, D., Margulies, D. S., Volle, E., & Thiebaut de Schotten, M. (2019) · Communications Biology · doi:10.1038/s42003-019-0611-3 · Cited by 357 · see citing works
Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo
Klein, J. C., Eggers, C., Kalbe, E., Weisenbach, S., Hohmann, C., Vollmar, S., Baudrexel, S., Diederich, N. J., Heiß, W.-D., & Hilker, R. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d55f61 · Cited by 355 · see citing works
The psychosis spectrum in Parkinson disease
ffytche, D. H., Creese, B., Politis, M., Chaudhuri, K. R., Weintraub, D., Ballard, C., & Aarsland, D. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.200 · Cited by 355 · see citing works
Thiele, A., & Bellgrove, M. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.008 · Cited by 350 · see citing works
New evidence on the management of Lewy body dementia
Taylor, J.-P., McKeith, I. G., Burn, D. J., Boeve, B. F., Weintraub, D., Bamford, C., Allan, L. M., Thomas, A. J., & O'Brien, J. T. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30153-x · Cited by 347 · see citing works
Dautan, D., Huerta-Ocampo, I., Witten, I. B., Deisseroth, K. A., Bolam, J. P., Gerdjikov, T. V., & Mena‐Segovia, J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5071-13.2014 · Cited by 335 · see citing works
Free Energy, Precision and Learning: The Role of Cholinergic Neuromodulation
Moran, R. J., Campo, P., Symmonds, M., Stephan, K. E., Dolan, R. J., & Friston, K. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4255-12.2013 · Cited by 312 · see citing works
Hallucinations in Parkinson disease
Diederich, N. J., Fénelon, G., Stebbins, G., & Goetz, C. G. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.62 · Cited by 312 · see citing works
Burn, D. J., Emre, M., McKeith, I. G., Deyn, P. P. D., Aarsland, D., Hsu, C., & Lane, R. M. (2006) · Movement Disorders · doi:10.1002/mds.21077 · Cited by 310 · see citing works
Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches
Bohnen, N. I., Yarnall, A. J., Weil, R. S., Moro, E., Moehle, M. S., Borghammer, P., Bédard, M., & Albin, R. L. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00377-x · Cited by 309 · see citing works
Hall, H., Reyes, S., Landeck, N., Bye, C. R., Leanza, G., Double, K. L., Thompson, L. H., Halliday, G. M., & Kirik, D. (2014) · Brain · doi:10.1093/brain/awu193 · Cited by 306 · see citing works
Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep
Van Dort, C. J., Zachs, D. P., Kenny, J. D., Zheng, S., Goldblum, R. R., Gelwan, N. A., Ramos, D. M., Nolan, M. A., Wang, K., Weng, F.-J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423136112 · Cited by 296 · see citing works
Diederich, N. J., Goetz, C. G., & Stebbins, G. T. (2004) · Movement Disorders · doi:10.1002/mds.20308 · Cited by 290 · see citing works
Perry, E. K., & Perry, R. H. (1995) · Brain and Cognition · doi:10.1006/brcg.1995.1255 · Cited by 277 · see citing works
Ward, A. M., Schultz, A. P., Huijbers, W., Dijk, K. R. A. V., Hedden, T., & Sperling, R. A. (2013) · Human Brain Mapping · doi:10.1002/hbm.22234 · Cited by 271 · see citing works
Hippocampal sharp-wave ripples linked to visual episodic recollection in humans
Norman, Y., Yeagle, E. M., Khuvis, S., Harel, M., Mehta, A. D., & Malach, R. (2019) · Science · doi:10.1126/science.aax1030 · Cited by 270 · see citing works
Jones, B. E. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0444-2 · Cited by 265 · see citing works
Attentional modulation of thalamic reticular neurons
McAlonan, K., Cavanaugh, J., & Wurtz, R. H. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5602-05.2006 · Cited by 261 · see citing works
Rethinking the Pedunculopontine Nucleus: From Cellular Organization to Function
Mena‐Segovia, J., & Bolam, J. P. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.027 · Cited by 249 · see citing works
Linking pattern completion in the hippocampus to predictive coding in visual cortex
Hindy, N. C., Ng, F. Y., & Turk-Browne, N. B. (2016) · Nature Neuroscience · doi:10.1038/nn.4284 · Cited by 246 · see citing works
Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system
Shen, J., & Yakel, J. L. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.64 · Cited by 242 · see citing works
Pacchetti, C., Manni, R., Zangaglia, R., Mancini, F., Marchioni, E., Tassorelli, C., Terzaghi, M., Ossola, M., Martignoni, E., Moglia, A., et al. (2005) · Movement Disorders · doi:10.1002/mds.20582 · Cited by 242 · see citing works
Topographical Organization of the Pedunculopontine Nucleus
Martinez‐Gonzalez, C., Bolam, J. P., & Mena‐Segovia, J. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00022 · Cited by 240 · see citing works
Minor hallucinations occur in drug‐naive Parkinson's disease patients, even from the premotor phase
Pagonabarraga, J., Martinez‐Horta, S., Fernández de Bobadilla, R., Pérez, J., Ribosa‐Nogué, R., Marín, J., Pascual‐Sedano, B., García, C., Gironell, A., & Kulisevsky, J. (2016) · Movement Disorders · doi:10.1002/mds.26432 · Cited by 236 · see citing works
Gateways of Ventral and Dorsal Streams in Mouse Visual Cortex
Wang, Q., Gao, E., & Burkhalter, A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3488-10.2011 · Cited by 232 · see citing works
Neurotransmission in Parkinson’s disease: beyond dopamine
Barone, P. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02900.x · Cited by 222 · see citing works
Prediction and memory: A predictive coding account
Barron, H. C., Auksztulewicz, R., & Friston, K. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101821 · Cited by 220 · see citing works
Kurosawa, M., Sato, A., & Sato, Y. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90371-6 · Cited by 212 · see citing works
An acetylcholine-activated microcircuit drives temporal dynamics of cortical activity
Chen, N., Sugihara, H., & Sur, M. (2015) · Nature Neuroscience · doi:10.1038/nn.4002 · Cited by 210 · see citing works
Shine, J. M., Halliday, G. M., Naismith, S. L., & Lewis, S. J. G. (2011) · Movement Disorders · doi:10.1002/mds.23896 · Cited by 205 · see citing works
Self-citationCerebral blood flow predicts differential neurotransmitter activity
Dukart, J., Holiga, Š., Chatham, C. H., Hawkins, P. C. T., Forsyth, A., McMillan, R. L., Myers, J., Lingford-Hughes, A. R., Nutt, D., Merlo‐Pich, E., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22444-0 · Cited by 203 · see citing works
Hallucinations and perceptual inference
Friston, K. J. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05290131 · Cited by 196 · see citing works
Reality monitoring and visual hallucinations in Parkinson’s disease
Barnes, J., Boubert, L., Harris, J., Lee, A., & David, A. S. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(02)00182-3 · Cited by 192 · see citing works
Cholinergic nucleus basalis neurons may influence the cortex via the thalamus
Levey, A. I., Hallanger, A. E., & Wainer, B. H. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90042-5 · Cited by 189 · see citing works
Ruivo, L. M. T.-G., Baker, K. L., Conway, M. W., Kinsley, P. J., Gilmour, G., Phillips, K. G., Isaac, J. T. R., Lowry, J. P., & Mellor, J. R. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.085 · Cited by 175 · see citing works
Basal forebrain acetylcholine release during REM sleep is significantly greater than during waking
Vazquez, J. M., & Baghdoyan, H. A. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.2.r598 · Cited by 173 · see citing works
Localization of nicotinic receptor subunit mRNAs in monkey brain by in situ hybridization
Quik, M., Polonskaya, Y., Gillespie, A. J., Jakowec, M. W., Lloyd, G. K., & Langston, J. W. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000911)425:1 · Cited by 172 · see citing works
Hallucinations and sleep disorders in PD
Goetz, C. G., Wuu, J., Curgian, L. M., & Leurgans, S. E. (2005) · Neurology · doi:10.1212/01.wnl.0000148479.10865.fe · Cited by 171 · see citing works
Intravenous levodopa in hallucinating Parkinson's disease patients
Goetz, C. G., Pappert, E. J., Blasucci, L. M., Stebbins, G. T., Ling, Z. D., Nora, M. V., & Carvey, P. M. (1998) · Neurology · doi:10.1212/wnl.50.2.515 · Cited by 170 · see citing works
Constructing, Perceiving, and Maintaining Scenes: Hippocampal Activity and Connectivity
Zeidman, P., Mullally, S. L., & Maguire, E. A. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu266 · Cited by 169 · see citing works
Borghammer, P., Chakravarty, M., Jonsdottir, K., Sato, N., Matsuda, H., Ito, K., Arahata, Y., Kato, T., & Gjedde, A. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0246-0 · Cited by 160 · see citing works
Meyer, P., Strecker, K., Kendziorra, K., Becker, G., Hesse, S., Woelpl, D., Hensel, A., Patt, M., Sorger, D., Wegner, F., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.106 · Cited by 158 · see citing works
Tricks of the mind: Visual hallucinations as disorders of attention
Shine, J. M., O’Callaghan, C., Halliday, G. M., & Lewis, S. J. G. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.01.004 · Cited by 157 · see citing works
Self-citationDonepezil in the treatment of hallucinations and delusions in Parkinson’s disease
Fabbrini, G., Barbanti, P., Aurilia, C., Pauletti, C., Lenzi, G. L., & Meco, G. (2002) · Neurological Sciences · doi:10.1007/s100720200022 · Cited by 154 · see citing works
Goldman, J. G., Stebbins, G. T., Dinh, V., Bernard, B. A., Merkitch, D., deToledo‐Morrell, L., & Goetz, C. G. (2014) · Brain · doi:10.1093/brain/awt360 · Cited by 152 · see citing works
The Cholinergic Brain in Parkinson's Disease
Pasquini, J., Brooks, D. J., & Pavese, N. (2021) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.13319 · Cited by 149 · see citing works
Dementia and visual hallucinations associated with limbic pathology in Parkinson's disease
Kalaitzakis, M. E., Christian, L., Moran, L. B., Graeber, M. B., Pearce, R. K. B., & Gentleman, S. (2008) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2008.05.007 · Cited by 146 · see citing works
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity
Lohani, S., Moberly, A. H., Benisty, H., Landa, B., Jing, M., Li, Y., Higley, M. J., & Cardin, J. A. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01202-6 · Cited by 146 · see citing works
M1 Receptors Mediate Cholinergic Modulation of Excitability in Neocortical Pyramidal Neurons
Gulledge, A. T., Bucci, D. J., Zhang, S. S., Matsui, M., & Yeh, H. H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1366-09.2009 · Cited by 143 · see citing works
Mufson, E. J., Martin, T. L., Mash, D. C., Wainer, B. H., & Mesulam, M. M. (1986) · Brain Research · doi:10.1016/0006-8993(86)91114-5 · Cited by 141 · see citing works
Bilateral Deep Brain Stimulation of the Nucleus Basalis of Meynert for Parkinson Disease Dementia
Gratwicke, J., Zrinzo, L. U., Kahan, J., Peters, A., Beigi, M., Akram, H., Hyam, J. A., Oswal, A., Day, B. L., Mancini, L., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.3762 · Cited by 141 · see citing works
Norman, Y., Raccah, O., Liu, S., Parvizi, J., & Malach, R. (2021) · Neuron · doi:10.1016/j.neuron.2021.06.020 · Cited by 140 · see citing works
Davis, A. A., Fritz, J. J., Wess, J., Lah, J. J., & Levey, A. I. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6393-09.2010 · Cited by 137 · see citing works
Regional cerebral blood flow in Parkinson disease with nonpsychotic visual hallucinations
Oishi, N., Udaka, F., Kameyama, M., Sawamoto, N., Hashikawa, K., & Fukuyama, H. (2005) · Neurology · doi:10.1212/01.wnl.0000187116.13370.e0 · Cited by 137 · see citing works
Moran, S. P., Maksymetz, J., & Conn, P. J. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.10.007 · Cited by 137 · see citing works
Muscarinic Signaling in the Brain
Thiele, A. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170433 · Cited by 136 · see citing works
Hippocampal head atrophy predominance in Parkinson’s disease with hallucinations and with dementia
Ibarretxe‐Bilbao, N., Ramírez‐Ruiz, B., Tolosa, E., Martı́, M. J., Valldeoriola, F., Bargalló, N., & Junqué, C. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0885-8 · Cited by 134 · see citing works
Boucetta, S., Salimi, A., Dadar, M., Jones, B. E., Collins, D. L., & Dang‐Vu, T. T. (2016) · Scientific Reports · doi:10.1038/srep26782 · Cited by 134 · see citing works
Shine, J. M., Halliday, G. M., Gilat, M., Matar, E., Bolitho, S., Carlos, M., Naismith, S. L., & Lewis, S. J. G. (2013) · Human Brain Mapping · doi:10.1002/hbm.22321 · Cited by 133 · see citing works
Self-citationIbarretxe‐Bilbao, N., Ramírez‐Ruiz, B., Junqué, C., Martí, M. J., Valldeoriola, F., Bargalló, N., Juanes, S., & Tolosa, E. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.179655 · Cited by 133 · see citing works
Grothe, M. J., Heinsen, H., Amaro, E., Grinberg, L. T., & Teipel, S. J. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv062 · Cited by 128 · see citing works
Lange, K. W., Wells, F. R., Jenner, P. G., & MARSDEN, C. D. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb05838.x · Cited by 125 · see citing works
Separate elements of episodic memory subserved by distinct hippocampal-prefrontal connections
Barker, G. R. I., Banks, P. J., Scott, H., Ralph, G. S., Mitrophanous, K. A., Wong, L.-F., Bashir, Z. I., Uney, J. B., & Warburton, E. C. (2017) · Nature Neuroscience · doi:10.1038/nn.4472 · Cited by 124 · see citing works
Metabolic Alterations in Patients With Parkinson Disease and Visual Hallucinations
Boecker, H., Ceballos-Baumann, A., Volk, D., Conrad, B., Förstl, H., & Häussermann, P. (2007) · Archives of Neurology · doi:10.1001/archneur.64.7.984 · Cited by 123 · see citing works
Nucleus basalis of Meynert neuronal activity during a delayed response task in monkey
Richardson, R. T., & DeLong, M. R. (1986) · Brain Research · doi:10.1016/0006-8993(86)91529-5 · Cited by 122 · see citing works
Manganelli, F., Vitale, C., Santangelo, G., Pisciotta, C., Iodice, R., Cozzolino, A., Dubbioso, R., Picillo, M., Barone, P., & Santoro, L. (2009) · Brain · doi:10.1093/brain/awp166 · Cited by 122 · see citing works
Janzen, J., Ent, D. V. ‘., Lemstra, A. W., Berendse, H. W., Barkhof, F., & Foncke, E. M. J. (2011) · Journal of Neurology · doi:10.1007/s00415-011-6149-z · Cited by 120 · see citing works
Hallucinations in Parkinson's disease: A follow‐up study
de Maindreville, A. D., Fénelon, G., & Mahieux, F. (2004) · Movement Disorders · doi:10.1002/mds.20263 · Cited by 119 · see citing works
What is the link between hallucinations, dreams, and hypnagogic–hypnopompic experiences?
Waters, F., Blom, J. D., Dang-Vu, T. T., Cheyne, A. J., Alderson-Day, B., Woodruff, P., & Collerton, D. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw076 · Cited by 119 · see citing works
Wallace, W., Ahlers, S. T., Gotlib, J. R., Bragin, V., Sugar, J., Gluck, R., SHEA, P. A., Davis, K. L., & Haroutunian, V. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8712 · Cited by 118 · see citing works
Inglis, W. L., Olmstead, M. C., & Robbins, T. W. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00181-4 · Cited by 112 · see citing works
Forebrain Cholinergic Signaling: Wired and Phasic, Not Tonic, and Causing Behavior
Sarter, M. F., & Lustig, C. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1305-19.2019 · Cited by 110 · see citing works
Lenka, A., Jhunjhunwala, K. R., Saini, J., & Pal, P. K. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.04.005 · Cited by 106 · see citing works
Shine, J. M., Muller, A. J., O’Callaghan, C., Hornberger, M., Halliday, G. M., & Lewis, S. J. (2015) · npj Parkinson's Disease · doi:10.1038/npjparkd.2015.3 · Cited by 106 · see citing works
Self-citationVisual hallucination in Parkinson's disease with FDG PET
Nagano‐Saito, A., Washimi, Y., Arahata, Y., Iwai, K., Kawatsu, S., Ito, K., Nakamura, A., Abe, Y., Yamada, T., Kato, T., et al. (2004) · Movement Disorders · doi:10.1002/mds.20129 · Cited by 105 · see citing works
Cognitive Changes in Parkinson’s Disease Patients with Visual Hallucinations
Ramírez‐Ruiz, B., Junqué, C., Martı́, M. J., Valldeoriola, F., & TOLOSA, E. S. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000100850 · Cited by 104 · see citing works
Callahan, P. M., Hutchings, E. J., Kille, N. J., Chapman, J., & Terry, A. V. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.10.019 · Cited by 102 · see citing works
The integrative role of the pedunculopontine nucleus in human gait
Lau, B., Welter, M., Belaïd, H., Fernández-Vidal, S., Bardinet, É., Grabli, D., & Karachi, C. (2015) · Brain · doi:10.1093/brain/awv047 · Cited by 101 · see citing works
Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease
Fujita, M., Ichise, M., Zoghbi, S. S., Liow, J., Ghose, S., Vines, D. C., Sangare, J., Lu, J., Cropley, V., Iida, H., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20688 · Cited by 100 · see citing works
Shapiro, M. S., Loose, M. D., Hamilton, S. E., Nathanson, N. M., Gomeza, J., Wess, J., & Hille, B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10899 · Cited by 99 · see citing works
Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations
Papapetropoulos, S., McCorquodale, D. S., Gonzalez, J., Jean-Gilles, L., & Mash, D. C. (2005) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2005.10.005 · Cited by 98 · see citing works
Effects of scopolamine on MEG spectral power and coherence in elderly subjects
Osipova, D. V., Ahveninen, J., Kaakkola, S., Jääskeläinen, I. P., Huttunen, J., & Pekkonen, E. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00165-2 · Cited by 97 · see citing works
Rasmusson, D. D., Clow, K. A., & Szerb, J. C. (1992) · Brain Research · doi:10.1016/0006-8993(92)91041-c · Cited by 96 · see citing works
Ruffmann, C., Calboli, F. C. F., Bravi, I., Gveric, D. O., Curry, L. K., de Smith, A. J., Pavlou, S., Buxton, J. L., Blakemore, A. I. F., Takousis, P., et al. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12294 · Cited by 96 · see citing works
Cholinergic Denervation Patterns Across Cognitive Domains in Parkinson's Disease
van der Zee, S., Müller, M. L. T. M., Kanel, P., van Laar, T., & Bohnen, N. I. (2020) · Movement Disorders · doi:10.1002/mds.28360 · Cited by 96 · see citing works
Risk factors for early psychosis in PD: insights from the Parkinson's Progression Markers Initiative
Ffytche, D. H., Pereira, J. B., Ballard, C. G., Chaudhuri, К. R., Weintraub, D. A., & Aarsland, D. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-314832 · Cited by 94 · see citing works
Crouse, R. B., Kim, K. K. O., Batchelor, H. M., Girardi, E., Kamaletdinova, R., Chan, J., Rajebhosale, P., Pittenger, S. T., Role, L. W., Talmage, D. A., et al. (2020) · eLife · doi:10.7554/elife.57335 · Cited by 92 · see citing works
Hallucinations and sleep-wake cycle in PD
Manni, R., Pacchetti, C., Terzaghi, M., Sartori, I., Mancini, F., & Nappi, G. (2002) · Neurology · doi:10.1212/01.wnl.0000038351.32678.4a · Cited by 91 · see citing works
T he pedunculopontine tegmental nucleus— A functional hypothesis from the comparative literature
Gut, N. K., & Winn, P. (2016) · Movement Disorders · doi:10.1002/mds.26556 · Cited by 89 · see citing works
Hallucinations and sleep disorders in PD
Goetz, C. G., Ouyang, B., Negron, A., & Stebbins, G. T. (2010) · Neurology · doi:10.1212/wnl.0b013e3181fd6158 · Cited by 88 · see citing works
Zhang, F., Xu, S., & Iadecola, C. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00302-y · Cited by 87 · see citing works
Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis
Yang, J.-S., Seo, S. W., Jang, S., Jung, G. Y., & Kim, S. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002612 · Cited by 87 · see citing works
Visual hallucinations in Parkinson's disease: Theoretical models
Muller, A. J., Shine, J. M., Halliday, G. M., & Lewis, S. J. G. (2014) · Movement Disorders · doi:10.1002/mds.26004 · Cited by 85 · see citing works
Self-citationShin, S., Lee, J. E., Hong, J. Y., Sunwoo, M.-K., Sohn, Y. H., & Lee, P. H. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303391 · Cited by 83 · see citing works
Khundakar, A. A., Hanson, P. S., Erskine, D., Lax, N. Z., Roscamp, J., Karyka, E., Tsefou, E., Singh, P., Cockell, S., Gribben, A., et al. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0334-3 · Cited by 83 · see citing works
Understanding visual hallucinations: A new synthesis
Collerton, D., Barnes, J., Diederich, N. J., Dudley, R., ffytche, D., Friston, K., Goetz, C. G., Goldman, J. G., Jardri, R., Kulisevsky, J., et al. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105208 · Cited by 83 · see citing works
Self-citationBorghammer, P., Cumming, P. D., Aanerud, J., & GJEDDE, A. H. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.042 · Cited by 82 · see citing works
Zarkali, A., McColgan, P., Leyland, L., Lees, A. J., Rees, G. E., & Weil, R. S. (2021) · Communications Biology · doi:10.1038/s42003-020-01622-9 · Cited by 82 · see citing works
Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep
Ni, K.-M., Hou, X., Yang, C.-H., Dong, P., Li, Y., Zhang, Y., Jiang, P., Berg, D. K., Duan, S., & Li, X. (2016) · eLife · doi:10.7554/elife.10382 · Cited by 81 · see citing works
Role of the locus coeruleus and basal forebrain in arousal and attention
Maness, E. B., Burk, J. A., McKenna, J. T., Schiffino, F. L., Strecker, R. E., & McCoy, J. G. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.07.014 · Cited by 81 · see citing works
Hallucinations, somatic‐functional disorders of PD‐DLB as expressions of thalamic dysfunction
ONOFRJ, M. C., Espay, A. J., Bonanni, L., Pizzi, S. D., & Sensi, S. L. (2019) · Movement Disorders · doi:10.1002/mds.27781 · Cited by 79 · see citing works
Basal forebrain contributes to default mode network regulation
Nair, J., Klaassen, A.-L., Arato, J., Vyssotski, A. L., Harvey, M., & Rainer, G. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712431115 · Cited by 77 · see citing works
Noradrenergic and cholinergic systems take centre stage in neuropsychiatric diseases of ageing
Orlando, I. F., Shine, J. M., Robbins, T. W., Rowe, J. B., & O’Callaghan, C. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105167 · Cited by 77 · see citing works
Intermittent Stimulation of the Nucleus Basalis of Meynert Improves Working Memory in Adult Monkeys
Liu, R., Crawford, J., Callahan, P. M., Terry, A. V., Constantinidis, C., & Blake, D. T. (2017) · Current Biology · doi:10.1016/j.cub.2017.07.021 · Cited by 76 · see citing works
Bejr‐Kasem, H., Pagonabarraga, J., Martínez‐Horta, S., Sampedro, F., Marín‐Lahoz, J., Horta‐Barba, A., Aracil‐Bolaños, I., Pérez‐Pérez, J., Boti, M. A., Campolongo, A., et al. (2018) · Movement Disorders · doi:10.1002/mds.27557 · Cited by 76 · see citing works
Regional vulnerability of hippocampal subfields and memory deficits in Parkinson's disease
Pereira, J. B., Junqué, C., David Bartrés-faz, A., Ramírez‐Ruiz, B., Martı́, M. J., & TOLOSA, E. S. (2013) · Hippocampus · doi:10.1002/hipo.22131 · Cited by 74 · see citing works
Hypoperfusion of the visual pathway in parkinsonian patients with visual hallucinations
Matsui, H., Nishinaka, K., Oda, M., Hara, N., Komatsu, K., Kubori, T., & Udaka, F. (2006) · Movement Disorders · doi:10.1002/mds.21140 · Cited by 73 · see citing works
Network effects of deep brain stimulation
Alhourani, A., McDowell, M. M., Randazzo, M. J., Wozny, T. A., Kondylis, E. D., Lipski, W. J., Beck, S., Karp, J. F., Ghuman, A. S., & Richardson, R. M. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00275.2015 · Cited by 72 · see citing works
O’Callaghan, C., Walpola, I. C., & Shine, J. M. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0699 · Cited by 72 · see citing works
Differences in Response to Muscarinic Activation Between First and Higher Order Thalamic Relays
Varela, C., & Sherman, S. M. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00578.2007 · Cited by 71 · see citing works
What do phasic cholinergic signals do?
Sarter, M. F., Lustig, C., Berry, A. S., Gritton, H. J., Howe, W. M., & Parikh, V. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.02.008 · Cited by 71 · see citing works
Neuroimaging in Parkinson’s disease dementia: connecting the dots
Weil, R. S., Hsu, J. K., Darby, R. R., Soussand, L., & Fox, M. D. (2019) · Brain Communications · doi:10.1093/braincomms/fcz006 · Cited by 71 · see citing works
Diverse Spatiotemporal Scales of Cholinergic Signaling in the Neocortex
Disney, A. A., & Higley, M. J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1306-19.2019 · Cited by 71 · see citing works
d’Angremont, E., Begemann, M. J. H., van Laar, T., & Sommer, I. E. C. (2023) · JAMA Neurology · doi:10.1001/jamaneurol.2023.1835 · Cited by 71 · see citing works
Nardone, R., Bergmann, J., Brigo, F., Christova, M., Kunz, A. B., Seidl, M., Tezzon, F., Trinka, E., & Golaszewski, S. M. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0888-6 · Cited by 69 · see citing works
Molecular Imaging of the Cholinergic System in Parkinson's Disease
Bohnen, N. I., Kanel, P., & Müller, M. L. T. M. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.027 · Cited by 69 · see citing works
Intralaminar nuclei of the thalamus in Lewy body diseases
Brooks, D., & Halliday, G. M. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.08.014 · Cited by 66 · see citing works
Dencker, D., Wörtwein, G., Weikop, P., Jeon, J., Thomsen, M., Sager, T. N., Mørk, A., Woldbye, D. P. D., Wess, J., & Fink‐Jensen, A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0370-11.2011 · Cited by 65 · see citing works
Classics in Chemical Neuroscience: Xanomeline
Bender, A. M., Jones, C. K., & Lindsley, C. W. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00001 · Cited by 65 · see citing works
Increased weighting on prior knowledge in Lewy body-associated visual hallucinations
Zarkali, A., Adams, R. A., Psarras, S., Leyland, L., Rees, G. E., & Weil, R. S. (2019) · Brain Communications · doi:10.1093/braincomms/fcz007 · Cited by 65 · see citing works
Liu, Q., Zhu, Z., Teipel, S. J., Yang, J., Xing, Y., Tang, Y., & Jia, J. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00047 · Cited by 64 · see citing works
Cholinergic double duty: cue detection and attentional control
Sarter, M., & Lustig, C. (2019) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2018.12.026 · Cited by 64 · see citing works
Gratwicke, J., Zrinzo, L. U., Kahan, J., Peters, A., Brechany, U., McNichol, A., Beigi, M., Akram, H., Hyam, J. A., Oswal, A., et al. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.04.010 · Cited by 64 · see citing works
Baseline symptoms and basal forebrain volume predict future psychosis in early Parkinson disease
Barrett, M. J., Blair, J. C., Sperling, S. A., Smolkin, M. E., & Druzgal, T. J. (2018) · Neurology · doi:10.1212/wnl.0000000000005421 · Cited by 63 · see citing works
Multimodal MRI of the hippocampus in Parkinson’s disease with visual hallucinations
Yao, N., Cheung, C., Pang, S. Y.-Y., Chang, R. S., Lau, K. K., John Suckling, A., Yu, K., Mak, H. K., Chua, S. E., Ho, S., et al. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0907-5 · Cited by 62 · see citing works
Synaptic Proteins and Choline Acetyltransferase Loss in Visual Cortex in Dementia With Lewy Bodies
Mukaetova‐Ladinska, E. B., Andras, A., Milne, J., Abdel‐All, Z., Borr, I., Jaros, E., Perry, R. H., Honer, W. G., Cleghorn, A., Doherty, J., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31827c5710 · Cited by 62 · see citing works
Brain atrophy in Parkinson’s disease with polysomnography-confirmed REM sleep behavior disorder
Rahayel, S., Gaubert, M., Postuma, R. B., Montplaisir, J. Y., Carrier, J., Monchi, O., Rémillard-Pelchat, D., Bourgouin, P.-A., Panisset, M., Chouinard, S., et al. (2019) · SLEEP · doi:10.1093/sleep/zsz062 · Cited by 62 · see citing works
Muscarinic acetylcholine receptors act in synergy to facilitate learning and memoryPreprint
Leaderbrand, K., Chen, H. J., Corcoran, K. A., Guedea, A. L., Jovasevic, V., Wess, J., & Radulović, J. (2016) · Learning & Memory · doi:10.1101/lm.043133.116 · Cited by 58 · see citing works
Jacobson, S. A., Morshed, T., Dugger, B. N., Beach, T. G., Hentz, J. G., Adler, C. H., Shill, H. A., Sabbagh, M. N., Belden, C. M., Sue, L. I., et al. (2014) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2014.06.018 · Cited by 57 · see citing works
Zarkali, A., McColgan, P., Ryten, M., Reynolds, R. H., Leyland, L., Lees, A. J., Rees, G. E., & Weil, R. S. (2020) · Brain · doi:10.1093/brain/awaa270 · Cited by 57 · see citing works
The Pharmacology of Visual Hallucinations in Synucleinopathies
Russo, M., Carrarini, C., Dono, F., Rispoli, M. G., Pietro, M. D., Stefano, V. D., Ferri, L., Bonanni, L., Sensi, S. L., & ONOFRJ, M. C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01379 · Cited by 56 · see citing works
Sutherland, M. T., Ray, K. L., Riedel, M. C., Yanes, J. A., Stein, E. A., & Laird, A. R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.021 · Cited by 55 · see citing works
Investigating visual misperceptions in Parkinson's disease: A novel behavioral paradigm
Shine, J. M., Halliday, G. M., Carlos, M., Naismith, S. L., & Lewis, S. J. G. (2012) · Movement Disorders · doi:10.1002/mds.24900 · Cited by 53 · see citing works
Self-citationHepp, D. H., Ruiter, A. M., Galis, Y., Voorn, P., Rozemüller, A. J. M., Berendse, H. W., Foncke, E. M. J., & van de Berg, W. D. J. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000014 · Cited by 52 · see citing works
Structural and molecular cholinergic imaging markers of cognitive decline in Parkinson’s disease
Schumacher, J., Kanel, P., Dyrba, M., Storch, A., Bohnen, N. I., Teipel, S. J., & Grothe, M. J. (2023) · Brain · doi:10.1093/brain/awad226 · Cited by 50 · see citing works
Regulation of cerebral cortical blood flow by the basal forebrain cholinergic fibers and aging
Sato, A., Sato, Y., & Uchida, S. (2002) · Autonomic Neuroscience · doi:10.1016/s1566-0702(01)00367-8 · Cited by 49 · see citing works
Hallucinations and sleep disturbances in Parkinson’s disease
Kulisevsky, J., & Gerschcovich, E. R. (2004) · Neurology · doi:10.1212/wnl.63.8_suppl_3.s28 · Cited by 48 · see citing works
Quantification of nicotinic acetylcholine receptors in Parkinson's disease with 123I-5IA SPECT
Oishi, N., Hashikawa, K., Yoshida, H., Ishizu, K., Ueda, M., Kawashima, H., Saji, H., & Fukuyama, H. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.02.014 · Cited by 48 · see citing works
Cholinergic and perfusion brain networks in Parkinson disease dementia
Colloby, S. J., McKeith, I. G., Burn, D. J., Wyper, D. J., O'Brien, J. T., & Taylor, J. (2016) · Neurology · doi:10.1212/wnl.0000000000002839 · Cited by 48 · see citing works
Effect of Rivastigmine on Behavioral and Psychiatric Symptoms of Parkinson’s Disease Dementia
Oh, Y., Kim, J., & Lee, P. H. (2015) · Journal of Movement Disorders · doi:10.14802/jmd.15041 · Cited by 47 · see citing works
Dugger, B. N., & Dickson, D. W. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0739-1 · Cited by 47 · see citing works
Kim, K., Müller, M. L. T. M., Bohnen, N. I., Sarter, M. F., & Lustig, C. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.006 · Cited by 46 · see citing works
Hepp, D. H., Foncke, E. M. J., Berendse, H. W., Wassenaar, T. M., Dubbelink, K. T. E. O., Groenewegen, H. J., van de Berg, W. D. J., & Schoonheim, M. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-10146-y · Cited by 45 · see citing works
Kurosawa, M., Sato, A., & Sato, Y. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90684-8 · Cited by 43 · see citing works
Sabec, M. H., Wonnacott, S., Warburton, E. C., & Bashir, Z. I. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.016 · Cited by 42 · see citing works
Vignando, M., ffytche, D., Lewis, S. J. G., Lee, P. H., Chung, S. J., Weil, R. S., Hu, M. T., Mackay, C. E., Griffanti, L., Pins, D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28087-0 · Cited by 42 · see citing works
Self-citationTaylor, N. L., D’Souza, A., Munn, B., Lv, J., Záborszky, L., Müller, E. J., Wainstein, G., Calamante, F., & Shine, J. M. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119455 · Cited by 42 · see citing works
Walpola, I. C., Muller, A. J., Hall, J. M., Andrews‐Hanna, J. R., Irish, M., Lewis, S. J. G., Shine, J. M., & O’Callaghan, C. (2020) · Cortex · doi:10.1016/j.cortex.2019.12.023 · Cited by 41 · see citing works
Self-citationMapping Cholinergic Synaptic Loss in Parkinson’s Disease: An [18F]FEOBV PET Case-Control Study
Horsager, J., Okkels, N., Hansen, A. K., Damholdt, M. F., Andersen, K. H., Fedorova, T. D., Munk, O. L., Danielsen, E. H., Pavese, N., Brooks, D. J., et al. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-223489 · Cited by 41 · see citing works
Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators
Manetti, D., Dei, S., Arias, H. R., Braconi, L., Gabellini, A., Teodori, E., & Romanelli, M. N. (2023) · Molecules · doi:10.3390/molecules28031270 · Cited by 41 · see citing works
Griffiths, B., Zaehle, T., Repplinger, S., Schmitt, F. C., Voges, J., Hanslmayr, S., & Staudigl, T. (2022) · Nature Communications · doi:10.1038/s41467-022-31407-z · Cited by 40 · see citing works
The structural connectivity mapping of the intralaminar thalamic nuclei
Kumar, V., Scheffler, K., & Grodd, W. (2023) · Scientific Reports · doi:10.1038/s41598-023-38967-0 · Cited by 39 · see citing works
Manni, R., Terzaghi, M., Ratti, P., Repetto, A., Zangaglia, R., & Pacchetti, C. (2010) · Consciousness and Cognition · doi:10.1016/j.concog.2010.10.009 · Cited by 38 · see citing works
Blautzik, J., Keeser, D., Paolini, M., Kirsch, V., Berman, A., Coates, U., Reiser, M. F., Teipel, S. J., & Meindl, T. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.006 · Cited by 38 · see citing works
Nizari, S., Wells, J. A., Carare, R. O., Romero, I. A., & Hawkes, C. A. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01108-z · Cited by 38 · see citing works
Thomas, G. E. C., Zeidman, P., Sultana, T., Zarkali, A., Razi, A., & Weil, R. S. (2022) · Brain Communications · doi:10.1093/braincomms/fcac329 · Cited by 38 · see citing works
Dotigny, F., Amor, A. Y. B., Burke, M., & Vaucher, E. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.030 · Cited by 37 · see citing works
Progression of regional cortical cholinergic denervation in Parkinson’s disease
Bohnen, N. I., Roytman, S., Kanel, P., Müller, M. L. T. M., Scott, P. J. H., Frey, K. A., Albin, R. L., & Koeppe, R. A. (2022) · Brain Communications · doi:10.1093/braincomms/fcac320 · Cited by 37 · see citing works
Visual Hallucinations and Cognitive Impairment in Parkinson's Disease
Park, H. K., Kim, J. S., Im, K. C., Kim, M. J., Lee, J., Lee, M. C., Kim, J., & Chung, S. J. (2013) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100014888 · Cited by 36 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Redefining Non-Motor Symptoms in Parkinson’s Disease
Peña-Zelayeta, L., Delgado-Minjares, K. M., Villegas-Rojas, M. M., León‐Arcia, K., Santiago-Balmaseda, A., Andrade-Guerrero, J., Pérez-Segura, I., Ortega‐Robles, E., Soto-Rojas, L. O., & Arias-Carrión, Ó. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15050172 · Cited by 76 · see citing works
Neuropsychiatric disorders in Parkinson’s disease
Heim, B., & Djamshidian, A. (2025) · Therapeutic Advances in Neurological Disorders · doi:10.1177/17562864251356062 · Cited by 24 · see citing works
Dik, D., Halliday, G. M., Sytnyk, V., & Shepherd, C. E. (2025) · Brain · doi:10.1093/brain/awaf305 · Cited by 8 · see citing works
Churchill, L., Ignatavicius, A., Konuri, A., Anderson, J., Taylor, N. L., Lewis, S. J. G., & Matar, E. (2025) · Movement Disorders · doi:10.1002/mds.70025 · Cited by 7 · see citing works
Self-citationMapping the neural and molecular basis underlying fatigue in Parkinson’s disease
Yang, F., Shen, J.-Y., Sun, Z.-Q., Tan, L., Yang, R., Zhu, L., Mo, Y., Shao, H., Hou, J., Sun, Z., et al. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01216-4 · Cited by 4 · see citing works
Core Clinical Features Associated With Survival in Patients With Dementia With Lewy Bodies
McCarter, S. J., Ferman, T. J., Grant, K. M., Aakre, J. A., Knopman, D. S., Graff‐Radford, N. R., Forsberg, L. K., Fields, J. A., Day, G. S., Miyagawa, T., et al. (2025) · Neurology · doi:10.1212/wnl.0000000000214197 · Cited by 4 · see citing works
The challenges with the identification of Parkinson’s disease subtypes
Rigon, L., Popławska-Domaszewicz, K., Metta, V., Fogliano, C. A., Nasi, M. L., Sauerbier, A., Dafsari, H., Leta, V., Falup‐Pecurariu, C., Odin, P., et al. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2611250 · Cited by 3 · see citing works
Basal Forebrain Volume Predicts Disease Conversion in Prodromal Synucleinopathy
Churchill, L., Konuri, A., Ignatavicius, A., Anderson, J., Lewis, S. J. G., & Matar, E. (2025) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.70242 · Cited by 4 · see citing works
Self-citationIgnatavicius, A., Churchill, L., Anderson, J., Konuri, A., O’Callaghan, C., Lewis, S. J. G., & Matar, E. (2025) · Movement Disorders · doi:10.1002/mds.70011 · Cited by 3 · see citing works
Self-citationZhang, H., Zhao, Y., Chen, Y., Feng, Y., Shen, B., Dong, S., Zhu, J., Jiang, X., Li, D., Chen, Y., et al. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01106-9 · Cited by 3 · see citing works
Imposter in the brain: aetiological, clinical and neuroimaging characteristics of Capgras syndrome
Hiroyuki, W., Whitwell, J. L., Bhaskaran, J. G., Lowe, V. J., & Josephs, K. A. (2025) · Brain · doi:10.1093/brain/awaf378 · Cited by 2 · see citing works
Comparing phenotypic features between Parkinson’s disease dementia and dementia with Lewy bodies
Gunawardana, C. W., Burke, P. G. R., Ignatavicius, A., Matar, E., & Lewis, S. J. G. (2026) · Journal of Neurology · doi:10.1007/s00415-026-13649-9 · Cited by 2 · see citing works
Self-citationSleep-like slow waves during wakefulness uncover a malignant form of Parkinson’s diseasePreprint
Bernasconi, F., Andrillon, T., Farah, J. C., Arnulf, I., Schwartz, S., Potheegadoo, J., Martínez‐Horta, S., Pagonabarraga, J., Kulisevsky, J., & Blanke, O. (2025) · medRxiv · doi:10.1101/2025.08.29.25334276 · Cited by 2 · see citing works
Liu, J., Yu, D., Liu, Y., Yong, Y., Wang, Z., Fan, P., & Yang, X. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107316 · Cited by 1 · see citing works
Mantovani, E., Bertoncello, E., Filippetti, M., Picelli, A., Tinazzi, M., & Tamburin, S. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-026-03127-x · Cited by 1 · see citing works
Iqbal, S., Zhong, X., Khan, M. A., Wu, Z., Almujally, N. A., Liu, W., Cambria, E., & Hussain, A. (2026) · Information Fusion · doi:10.1016/j.inffus.2026.104483 · Cited by 3 · see citing works
Data-driven trajectories of atrophy explain clinical heterogeneity across Lewy body diseases
Konuri, A., Leal, G. C., Zebarjadi, N., Habich, A., Castellanos-Perilla, N., González, M. C., Taylor, J., Firbank, M., Alcolea, D. A., Bejanin, A., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106400 · Cited by 1 · see citing works
Self-citationAbnormal intrinsic brain functional network dynamics in amnestic mild cognitive impairment
Li, L., Wu, J., Zheng, M., Xue, X., Ma, J., Hua, X., & Xu, J. (2025) · Brain Conflux · doi:10.71321/bgaxq397 · Cited by 1 · see citing works
Vignando, M., Ffytche, D., Mazibuko, N., Palma, G., Bhat, A., Montagnese, M., Dave, S., Tai, Y. F., Batzu, L., Leta, V., et al. (2026) · Nature Mental Health · doi:10.1038/s44220-026-00669-7
“Previous research has shown that the thalamus plays a role in VH in PD 54,55 , and a recent proposal 56 views the thalamus as a driver of unbalanced network recruitment, suggesting that it may induce decoupling between the default mode network and task-positive networks.”
Disrupted functional brain network associated with presence of hallucinations in Parkinson’s disease
Montagnese, M., Mehta, M. A., Ffytche, D. H., Firbank, M., Lawson, R. A., Taylor, J., Bullmore, E. T., & Morgan, S. E. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf185
Youssef, P., Chua, M., Andersson, L. I., Galper, J., Gunawardana, C. W., Matar, E., Halliday, G. M., Lewis, S. J. G., & Dzamko, N. L. (2025) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2025.108094
Self-citationNecpál, J., Grofik, M., Patarák, M., Jeleňová, B., Bebjaková, V., & Baranová, L. (2025) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/s44411-025-00414-z
Pisani, S., Váša, F., Velayudhan, L., & Bhattacharyya, S. (2026) · Movement Disorders · doi:10.1002/mds.70222
Physicochemical balancing facilitates fast cyclic immunolabeling in centimeter-scale FFPE tissuesPreprint
Lin, Y., Huang, C.-Y., Chen, Y.-H., Chen, Y., Ko, P., Hsu, H., Tung, Y., Chen, Y.-F., Chen, Y.-F., Chiang, A.-S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.09.710440
Rivastigmine for Behavioural Symptoms in Parkinson's Disease: Evidence and Open Questions
Luca, A. (2026) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.70049
She, L., Xiong, W., Cai, H. R., Zhou, L. H., Li, Z., & Pan, Y. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1858348
Liu, H., Shen, W., Zhou, H., Gao, Y., & Li, X. (2026) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000005442
Isolated visual hallucinations as the first sign of lacunar infarcts: A late-onset psychosis mimic
Unni, N., Longkumer, I., & Bhosale, M. S. (2026) · Journal of Medical Society · doi:10.4103/jms.jms_45_26
Inflammation and neuropsychiatric symptoms in Parkinson's disease: a genetic association
Gonçalves, A. R., Mendes, A., Damásio, J., Vila‐Chã, N., Boleixa, D., Santos, C., Leal, B., & Cavaco, S. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1877657
Monopoli, G., Tomaiuolo, F., Sestieri, C., Punzi, M., Marino, S., Gambi, F., Perrucci, M. G., Ferretti, A., Sensi, S. L., & Pizzi, S. D. (2026) · Brain Communications · doi:10.1093/braincomms/fcag357
Non-motor symptoms of parkinson's disease and their pharmacological management
El-Jaafary, S. I. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27702-3.00019-4
(2026) · Psychiatry and Behavioral Sciences · doi:10.5455/pbs.20260305045651
- Authors
- Ignatavicius, A., Matar, E., & Lewis, S. J. G.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Matar, Elie
- Lewis, Simon J G
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2024-09-10
- Volume
- 148
- Issue
- 2
- Pages
- 376-393
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC11788216
- OpenAlex
- W4402428806
- Cited by
- 32
- References
- 239
- Citations by year
- 2026: 16 · 2025: 16
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council (2008565)
- United States Department of Defense (PD220061, 1195830)
- Australian Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- visual hallucinations, Parkinson's disease, cholinergic neurotransmission, non-motor symptoms, cognitive decline, perceptual disorders, hallucination treatment, psychotic symptoms
- MeSH terms
- Acetylcholine, Hallucinations, Humans, Parkinson Disease, Cholinergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review