The Effects of Lisdexamfetamine Dimesylate on Emotional Lability in Children 6 to 12 Years of Age With ADHD in a Double-Blind Placebo-Controlled Trial
Abstract
Objective: To evaluate the effect of lisdexamfetamine dimesylate (LDX) on emotional lability (EL) in children with ADHD. Method: Post hoc analyses of a placebo-controlled trial of LDX-stratified children (aged 6-12 years) with ADHD to prominent and not prominent EL at baseline (score >3 or ≤3, respectively, on Conners’ Parent Rating Scale [CPRS] items of anger, loss of temper, and irritability). Efficacy was assessed by change in CPRS EL scores and ADHD Rating Scale-IV (ADHD-RS-IV) total and subscale scores. Safety measures included treatment-emergent adverse events (TEAEs). Results: LDX showed improvement versus placebo ( p < .0005) for EL item least squares (LS) mean change scores at endpoint and throughout the day. At baseline, 138 and 73 participants randomized to LDX treatment and having baseline and endpoint CPRS scores were categorized with CPRS-derived prominent and not prominent baseline EL, respectively; 41 and 31 participants randomized to placebo were categorized with CPRS-derived prominent and not prominent baseline EL, respectively. ADHD-RS-IV total and subscale scores decreased with LDX regardless of baseline EL severity. TEAEs included decreased appetite, insomnia, upper abdominal pain, headache, and irritability. Conclusion: EL and ADHD symptoms improved with LDX regardless of baseline EL symptom severity. LDX demonstrated a safety profile consistent with long-acting psychostimulant use.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Meta-analyses suggest that stimulants' effect size on diagnostic ADHD symptoms ranges from 0.6 to 0.8.
“meta-analyses suggest a range of 0.6–0.8 [36, 37]”
From Using Stimulants to Treat ADHD-Related Emotional Lability (2014) · cites this paper as [36]
Some studies have reported improvements in EL with stimulant treatment, including MPH.
“some studies have reported improvements in EL with stimulant treatment, including MPH (Baweja et al., 2021; A. C. Childress et al., 2014; López et al., 2017).”
From A Post-Hoc Analysis of Emotional Lability With Delayed-Release/Extended-Release Methylphenidate in Children Aged 6 to 12 Years of Age Participating in Two Phase 3 Clinical Trials (2024) · cites this paper as A. C. Childress et al., 2014
Cites
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,767 · see citing works
Jacobson, N. S., & Truax, P. (1991) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.59.1.12 · Cited by 7,770 · see citing works
(2005) · JAMA · doi:10.1001/jama.294.19.2423-c · Cited by 2,325 · see citing works
Conners, C. K., Sitarenios, G., Parker, J. D. A., & Epstein, J. N. (1998) · Journal of Abnormal Child Psychology · doi:10.1023/a:1022602400621 · Cited by 1,772 · see citing works
ADHD Comorbidity Findings From the MTA Study: Comparing Comorbid Subgroups
JENSEN, P. S., HINSHAW, S. P., KRAEMER, H. C., LENORA, N., NEWCORN, J. H., ABIKOFF, H. B., MARCH, J. S., ARNOLD, L. E., CANTWELL, D. P., CONNERS, C. K., et al. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200102000-00009 · Cited by 974 · cited 2× · see citing works
“…National Institute of Mental Health (NIMH) Collaborative Multisite Multimodal Treatment Study of Children with ADHD, comorbid ODD, CD, and/or anxiety were found to display variable symptom profiles and treatment responses when compared with children without either comorbidity (Jensen et al., 2001).”
BackgroundGreenhill, L. L., Pliszka, S., & Dulcan, M. K. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200202001-00003 · Cited by 927 · see citing works
Gioia, G. A., Isquith, P. K., Retzlaff, P. D., & Espy, K. A. (2002) · Child Neuropsychology · doi:10.1076/chin.8.4.249.13513 · Cited by 608 · see citing works
Biederman, J., Krishnan, S., Zhang, Y., McGough, J. J., & Findling, R. L. (2007) · Clinical Therapeutics · doi:10.1016/s0149-2918(07)80083-x · Cited by 404 · see citing works
Sobanski, E., Banaschewski, T., Asherson, P., Buitelaar, J., Chen, W., Franke, B., Holtmann, M., Krumm, B., Sergeant, J., Sonuga‐Barke, E., et al. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02217.x · Cited by 365 · see citing works
Gillberg, C. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830210105014 · Cited by 340 · see citing works
Stein, M. A., Sarampote, C. S., Waldman, I. D., Robb, A. S., Conlon, C. J., Pearl, P. L., Black, D. O., Seymour, K. E., & Newcorn, J. H. (2003) · PEDIATRICS · doi:10.1542/peds.112.5.e404 · Cited by 229 · see citing works
Placebo-Controlled Evaluation of Ritalin Side Effects
Ahmann, P. A., Waltonen, S. J., Theye, F. W., Olson, K. A., & Van Erem, A. J. (1993) · Pediatrics · doi:10.1542/peds.91.6.1101 · Cited by 178 · cited 3× · see citing works
“Medications for ADHD may also affect expression of emotions; blunted emotionality and increased irritability have been reported as side effects of psychostimulants (Ahmann et al., 1993; Gillberg et al., 1997; Greenhill et al., 2002; Perwien et al., 2008).”
BackgroundMania and ADHD: comorbidity or confusion
Carlson, G. A. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00179-7 · Cited by 164 · see citing works
Manic symptoms in psychiatrically hospitalized children – what do they mean?
Carlson, G. A., & Kelly, K. L. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00211-0 · Cited by 142 · see citing works
ADHD Treatment With Once-Daily OROS Methylphenidate: Final Results From a Long-Term Open-Label Study
Wilens, T. E., McBurnett, K., Stein, M. A., Lerner, M., Spencer, T. J., & Wolraich, M. L. (2005) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000173291.28688.e7 · Cited by 120 · see citing works
McGough, J. J., Biederman, J., Wigal, S. B., López, F. A., McCracken, J. T., Spencer, T. J., Zhang, Y., & Tulloch, S. J. (2005) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000157550.94702.a2 · Cited by 89 · see citing works
A Prospective Study of Stimulant Response in Preschool Children: Insights From ROC Analyses
Short, E. J., Manos, M. J., Findling, R. L., & Schubel, E. A. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200403000-00005 · Cited by 56 · see citing works
Findling, R. L., Ginsberg, L. D., Jain, R., & Gao, J. (2009) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2008.0165 · Cited by 45 · see citing works
Silva, R. R., Muniz, R., Pestreich, L., Childress, A., Brams, M., Lopez, F. A., & Wang, J. (2006) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2006.16.239 · Cited by 44 · see citing works
Self-citationKratochvil, C. J., Faries, D., Vaughan, B., Perwien, A., Busner, J., Saylor, K., Kaplan, S., Buermeyer, C., & Swindle, R. (2007) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2006.0018 · Cited by 32 · see citing works
Duration of effect of oral long-acting stimulant medications for ADHD throughout the day
Brams, M., Moon, E., Pucci, M., & López, F. A. (2010) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.488553 · Cited by 30 · see citing works
Changes in Emotions Related to Medication Used to Treat ADHD. Part I: Literature Review
Manos, M. J., Brams, M., Childress, A. C., Findling, R. L., López, F. A., & Jensen, P. S. (2011) · Journal of Attention Disorders · doi:10.1177/1087054710381230 · Cited by 28 · see citing works
Self-citationEmotional Expression in Children Treated With ADHD Medication
Perwien, A. R., Kratochvil, C. J., Faries, D. E., Vaughan, B. S., Busner, J., Saylor, K. E., Buermeyer, C. M., Kaplan, S. L., & Swindle, R. W. (2007) · Journal of Attention Disorders · doi:10.1177/1087054707306117 · Cited by 25 · see citing works
Turgay, A., Ginsberg, L., Sarkis, E., Jain, R., Adeyi, B., Gao, J., Dirks, B., Babcock, T., Scheckner, B., Richards, C., et al. (2010) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2009.0110 · Cited by 23 · see citing works
Self-citationLópez, F. A., Ginsberg, L. D., & Arnold, V. K. (2008) · Postgraduate Medicine · doi:10.3810/pgm.2008.09.1910 · Cited by 22 · see citing works
Self-citationSilva, R., Tilker, H. A., Cecil, J. T., Kowalik, S. C., Khetani, V. D., Faleck, H. J., & Patin, J. R. (2004) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2004.14.555 · Cited by 18 · see citing works
Katic, A., Ginsberg, L., Jain, R., Adeyi, B., Dirks, B., Babcock, T., Scheckner, B., Richards, C., Lasser, R., Turgay, A., et al. (2012) · Journal of Attention Disorders · doi:10.1177/1087054710389990 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Emotion Dysregulation in Attention Deficit Hyperactivity Disorder
Shaw, P., Stringaris, A., Nigg, J., & Leibenluft, E. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13070966 · Cited by 1,232 · see citing works
Faraone, S. V., Rostain, A. L., Blader, J., Busch, B., Childress, A. C., Connor, D. F., & Newcorn, J. H. (2019) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12899 · Cited by 400 · see citing works
Self-citationHulvershorn, L. A., Mennes, M., Castellanos, F. X., Di Martino, A., Milham, M. P., Hummer, T. A., & Roy, A. K. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.11.012 · Cited by 138 · see citing works
Using Stimulants to Treat ADHD-Related Emotional Lability
Posner, J., Kass, E., & Hulvershorn, L. (2014) · Current psychiatry reports · doi:10.1007/s11920-014-0478-4 · Cited by 66 · see citing works
Cerrillo-Urbina, A. J., García-Hermoso, A., Pardo-Guijarro, M. J., Sánchez-López, M., Santos-Gómez, J. L., & Martínez-Vizcaíno, V. (2018) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2017.0151 · Cited by 44 · see citing works
Maneeton, N., Maneeton, B., Likhitsatian, S., Suttajit, S., Narkpongphun, A., Srisurapanont, M., & Woottiluk, P. (2015) · Drug Design, Development and Therapy · doi:10.2147/dddt.s79071 · Cited by 23 · see citing works
Katic, A., Dirks, B., Babcock, T., Scheckner, B., Adeyi, B., Richards, C., & Findling, R. L. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2012.0104 · Cited by 10 · see citing works
Self-citationArnold, V. K., López, F. A., Childress, A. C., Po, M. D., Uchida, C. L., Cuthbertson, L., Sallee, F. R., & Incledon, B. (2024) · Journal of Attention Disorders · doi:10.1177/10870547241243155 · Cited by 1 · see citing works
“Stimulant medications such as methylphenidate (MPH) are known to be effective treatments for ADHD (Biederman et al., 2003) and some studies have reported improvements in EL with stimulant treatment, including MPH (Baweja et al., 2021; A. C. Childress et al., 2014; López et al., 2017).”
BackgroundSelf-citation
- Authors
- Childress, A. C., Arnold, V., Adeyi, B., Dirks, B., Babcock, T., Scheckner, B., Lasser, R., & Lopez, F. A.
- Affiliations
- Center for Psychiatry and Behavioral Medicine (US)
- University of Tennessee System (US)
- Shire Development LLC, Wayne, PA, USA
- Children’s Developmental Center, Winter Park, FL, USA
- Venue
- Journal of Attention Disorders
- Publisher
- SAGE Publications
- Published
- 2012-06-26
- Volume
- 18
- Issue
- 2
- Pages
- 123-132
- ISSN
- 1087-0547 (ISSN-L)
- 1557-1246
- OpenAlex
- W2035130341
- Semantic Scholar
- 65bb241295237e3733845687d27292a234e8b210
- Cited by
- 33
- References
- 27
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 7 · 2013: 2
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Attention Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- lisdexamfetamine dimesylate, emotional lability, attention deficit hyperactivity disorder, children, psychostimulants, irritability, anger, treatment-emergent adverse events, ADHD symptom severity, Conners' Parent Rating Scale, ADHD Rating Scale-IV
- MeSH terms
- Lisdexamfetamine Dimesylate, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Dextroamphetamine, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Emotions, Female, Humans, Male, Parents, Personality Assessment, Treatment Outcome, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
