Treatment With Lisdexamfetamine Dimesylate Improves Self- and Informant-Rated Executive Function Behaviors and Clinician- and Informant-Rated ADHD Symptoms in Adults: Data From a Randomized, Double-Blind, Placebo-Controlled Study
Abstract
Objective: To examine the level of agreement between self- and observer-reported ratings of ADHD symptoms and executive function (EF) behaviors in adults with moderate to severe ADHD and EF deficits. Method: During a 10-week, randomized, double-blind, placebo-controlled study, the effect of lisdexamfetamine dimesylate (LDX) on EF was assessed by self-report and informant report (Behavior Rating Inventory of Executive Function–Adult Version), and ADHD symptoms were assessed by clinician- and informant-rated scales (ADHD Rating Scale IV with adult prompts and Conners’ Adult ADHD Rating Scales–Observer Report: Short Version, respectively). Post hoc analysis used Pearson correlations to assess relationships between self- and informant-rated EF and clinician- and informant-rated ADHD symptoms. Results: Correlations between self-ratings versus informant ratings and clinician versus informant ratings were greater at Week 10/early termination (EF: placebo [0.5231–0.6085], LDX [0.3543–0.5167]; ADHD symptoms: placebo [0.4169], LDX [0.4004]) versus baseline (EF: placebo [0.3208–0.5023], LDX [0.2852–0.3439]; ADHD symptoms: placebo [0.1511], LDX [–0.0408]). Conclusion: LDX improved EF and ADHD symptoms, based on participant, informant, and clinician ratings. Increased rater agreement over time may reflect improved symptom awareness.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,767 · see citing works
Kessler, R. C., Adler, L., Barkley, R., Biederman, J., Conners, C. K., Demler, O., Faraone, S. V., Greenhill, L. L., Howes, M. J., Secnik, K., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.4.716 · Cited by 3,886 · see citing works
Self-citationMorbidity and Mortality Weekly Report
(2010) · Wilderness and Environmental Medicine · doi:10.1016/j.wem.2010.09.015 · Cited by 2,976 · see citing works
(1998) · Cited by 2,026 · see citing works
Pliszka, S. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318054e724 · Cited by 1,765 · see citing works
Biederman, J. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.816 · Cited by 1,498 · see citing works
Barkley, R. A., Fischer, M., Smallish, L., & Fletcher, K. (2002) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.111.2.279 · Cited by 1,199 · see citing works
Barkley, R. A., & Murphy, K. R. (2010) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acq014 · Cited by 468 · see citing works
(2010) · PsycEXTRA Dataset · doi:10.1037/e664852010-002 · Cited by 456 · see citing works
Sandra Kooij, J. J., Marije Boonstra, A., Swinkels, S. H. N., Bekker, E. M., de Noord, I., & Buitelaar, J. K. (2008) · Journal of Attention Disorders · doi:10.1177/1087054707299367 · Cited by 388 · see citing works
Diagnosis and evaluation of adults with attention-deficit/hyperactivity disorder
Adler, L., & Cohen, J. (2004) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2003.12.003 · Cited by 290 · see citing works
Self-citationBrown, T. E. (2006) · International Journal of Disability, Development and Education · doi:10.1080/10349120500510024 · Cited by 215 · cited 1× · see citing works
“Brown (2006) found that most adults with ADHD may also exhibit deficits in executive function (EF).”
Behavior Rating Inventory of Executive Function, Adult Version
National Cancer Institute (2020) · Definitions · doi:10.32388/xlccsc · Cited by 212 · see citing works
Validation of the ADHD Rating Scale as a clirlician administered and scored instrument
Faries, D. E., Yalcin, I., Harder, D. F., & Heiligenstein, J. H. (2001) · Journal of Attention Disorders · doi:10.1177/108705470100500204 · Cited by 183 · see citing works
Adler, L. A., Liebowitz, M., Kronenberger, W., Qiao, M., Rubin, R., Hollandbeck, M., Deldar, A., Schuh, K., & Durell, T. (2009) · Depression and Anxiety · doi:10.1002/da.20549 · Cited by 176 · see citing works
Self-citationZucker, M., Morris, M. K., Ingram, S. M., Morris, R. D., & Bakeman, R. (2002) · Psychological Assessment · doi:10.1037/1040-3590.14.4.379 · Cited by 163 · see citing works
Brown, T. E., & Landgraf, J. M. (2010) · Postgraduate Medicine · doi:10.3810/pgm.2010.09.2200 · Cited by 160 · see citing works
Weisler, R. H., Biederman, J., Spencer, T. J., Wilens, T. E., Faraone, S. V., Chrisman, A. K., Read, S. C., & Tulloch, S. J. (2006) · CNS Spectrums · doi:10.1017/s1092852900013687 · Cited by 158 · see citing works
Self-citationAdler, L. A., Spencer, T. J., Milton, D. R., Moore, R. J., & Michelson, D. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0304 · Cited by 157 · see citing works
Self-citationPredictors of the accuracy of self assessment of everyday functioning in people with schizophrenia
Sabbag, S. A., Twamley, E. W., Vella, L., Heaton, R. K., Patterson, T. L., & Harvey, P. D. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.02.002 · Cited by 125 · see citing works
Okonkwo, O. C., Wadley, V. G., Griffith, H. R., et al. (2008) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31817e8a9d · Cited by 122 · see citing works
Long-term efficacy and safety outcomes with OROS-MPH in adults with ADHD
Buitelaar, J., Trott, G., Hofecker, M., Waechter, S., Berwaerts, J., Dejonkheere, J., & Schäuble, B. (2011) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001131 · Cited by 110 · see citing works
Validation of the Adult ADHD Investigator Symptom Rating Scale (AISRS)
Spencer, T. J., Adler, L. A., Qiao, M., Saylor, K. E., Brown, T. E., Holdnack, J. A., Schuh, K. J., Trzepacz, P. T., & Kelsey, D. K. (2009) · Journal of Attention Disorders · doi:10.1177/1087054709347435 · Cited by 109 · see citing works
Self-citationThe reliability and validity of self-and investigator ratings of ADHD in adults
Adler, L. A., Faraone, S. V., Spencer, T. J., Michelson, D., Reimherr, F. W., Glatt, S. J., Marchant, B. K., & Biederman, J. (2008) · Journal of Attention Disorders · doi:10.1177/1087054707308503 · Cited by 108 · cited 3× · see citing works
“…end of the study, and change scores; however, investigator total symptom ratings at the end of the study were lower than those reported in self-ratings and endpoint score was more accurately predicted by baseline score when both measures were reported by the investigator (Adler et al., 2008).”
Retz, W., Rösler, M., Ose, C., Scherag, A., Alm, B., Philipsen, A., Fischer, R., Ammer, R., & The Study Group (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.540257 · Cited by 79 · see citing works
Low self-awareness of ADHD in adults using a self-report screening questionnaire
Manor, I., Vurembrandt, N., Rozen, S., Gevah, D., Weizman, A., & Zalsman, G. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2010.08.013 · Cited by 78 · see citing works
Biederman, J., Mick, E., Fried, R., Wilner, N., Spencer, T. J., & Faraone, S. V. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.11.005 · Cited by 67 · see citing works
Durell, T. M., Adler, L. A., Williams, D. W., Deldar, A., McGough, J. J., Glaser, P. E., Rubin, R. L., Pigott, T. A., Sarkis, E. H., & Fox, B. K. (2013) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31827d8a23 · Cited by 64 · see citing works
Self-citationAdler, L. A., Dirks, B., Deas, P. F., Raychaudhuri, A., Dauphin, M. R., Lasser, R. A., & Weisler, R. H. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m08144 · Cited by 62 · cited 16× · see citing works
“As previously reported (Adler et al., 2013), common TEAEs with LDX included decreased appetite, dry mouth, headache, feeling jittery, and insomnia; in addition, small, clinically non-significant increases in blood pressure and pulse were observed.”
InfluentialSelf-citationParent–Child Agreement in the Assessment of Obsessive-Compulsive Disorder
Canavera, K. E., Wilkins, K. C., Pincus, D. B., & Ehrenreich, J. T. (2009) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374410903258975 · Cited by 56 · see citing works
Reliability and Validity of Self- and Other-Ratings of Symptoms of ADHD in Adults
Voorhees, E. E. V., Hardy, K. K., & Kollins, S. H. (2010) · Journal of Attention Disorders · doi:10.1177/1087054709356163 · Cited by 55 · see citing works
Mattos, P., Louzã, M. R., Palmini, A. L. F., Oliveira, I. R. D., & Rocha, F. L. (2013) · Journal of Attention Disorders · doi:10.1177/1087054711434772 · Cited by 47 · see citing works
Buitelaar, J. K., Casas, M., Philipsen, A., Kooij, J. J. S., Ramos‐Quiroga, J. A., Dejonckheere, J., van Oene, J. C., & Schäuble, B. (2011) · Psychological Medicine · doi:10.1017/s0033291711000845 · Cited by 28 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Adler L. A., 2004, The Adult ADHD Clinical Diagnostic Scale (ACDS) v1.2
- Brown T. E., 1996, Brown Attention-Deficit Hyperactivity Disorder Scales for Adolescents and Adults
- Conners C. K., 1999, Conners’ Adult ADHD Rating Scales (CAARS) Technical Manual
- Weisler R., 2012, Poster presented at the American Psychiatric Association 165th Annual Meeting
Cited by
Sorted by citations
Matveychuk, D., Thomas, R. K., Swainson, J., Khullar, A., MacKay, M.-A., Baker, G. B., & Dursun, S. M. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320916657 · Cited by 209 · see citing works
Adler, L. A., Alperin, S., Leon, T., & Faraone, S. V. (2017) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2016.0121 · Cited by 28 · see citing works
Self-citationReview of Lisdexamfetamine Dimesylate in Adults With Attention-Deficit/Hyperactivity Disorder
Najib, J., Wimer, D., Zeng, J., Lam, K. W., Romanyak, N., Paige Morgan, E., & Thadavila, A. (2017) · Journal of Central Nervous System Disease · doi:10.1177/1179573517728090 · Cited by 17 · see citing works
- Authors
- Weisler, R., Ginsberg, L., Dirks, B., Deas, P., Adeyi, B., & Adler, L. A.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Red Oak Psychiatry Associates, P.A., Houston, TX, USA
- Shire Development LLC, Wayne, PA, USA
- VA NY Harbor Healthcare System (US)
- Venue
- Journal of Attention Disorders
- Publisher
- SAGE Publications
- Published
- 2014-01-24
- Volume
- 21
- Issue
- 14
- Pages
- 1198-1207
- ISSN
- 1087-0547 (ISSN-L)
- 1557-1246
- OpenAlex
- W2318134686
- Semantic Scholar
- dfec2664929d64e4cace1c04ded6147a4b108bf2
- Cited by
- 15
- References
- 33
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Attention Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- lisdexamfetamine dimesylate, adult ADHD, executive function, rater agreement, ADHD symptom severity, stimulant medication, ADHD Rating Scale-IV
- MeSH terms
- Lisdexamfetamine Dimesylate, Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Awareness, Double-Blind Method, Female, Humans, Male, Treatment Outcome, Young Adult, Executive Function, Self Report
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review