Cited by 15Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

Treatment With Lisdexamfetamine Dimesylate Improves Self- and Informant-Rated Executive Function Behaviors and Clinician- and Informant-Rated ADHD Symptoms in Adults: Data From a Randomized, Double-Blind, Placebo-Controlled Study

Weisler, Richard, Ginsberg, Lawrence, Dirks, Bryan, Deas, Patrick, Adeyi, Ben, Adler, Lenard A.·2017·Journal of Attention Disorders

Abstract

Objective: To examine the level of agreement between self- and observer-reported ratings of ADHD symptoms and executive function (EF) behaviors in adults with moderate to severe ADHD and EF deficits. Method: During a 10-week, randomized, double-blind, placebo-controlled study, the effect of lisdexamfetamine dimesylate (LDX) on EF was assessed by self-report and informant report (Behavior Rating Inventory of Executive Function–Adult Version), and ADHD symptoms were assessed by clinician- and informant-rated scales (ADHD Rating Scale IV with adult prompts and Conners’ Adult ADHD Rating Scales–Observer Report: Short Version, respectively). Post hoc analysis used Pearson correlations to assess relationships between self- and informant-rated EF and clinician- and informant-rated ADHD symptoms. Results: Correlations between self-ratings versus informant ratings and clinician versus informant ratings were greater at Week 10/early termination (EF: placebo [0.5231–0.6085], LDX [0.3543–0.5167]; ADHD symptoms: placebo [0.4169], LDX [0.4004]) versus baseline (EF: placebo [0.3208–0.5023], LDX [0.2852–0.3439]; ADHD symptoms: placebo [0.1511], LDX [–0.0408]). Conclusion: LDX improved EF and ADHD symptoms, based on participant, informant, and clinician ratings. Increased rater agreement over time may reflect improved symptom awareness.

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Crossref · 10.1177/1087054713518242

Cites

33 of 33 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 4

  1. Adler L. A., 2004, The Adult ADHD Clinical Diagnostic Scale (ACDS) v1.2
  2. Brown T. E., 1996, Brown Attention-Deficit Hyperactivity Disorder Scales for Adolescents and Adults
  3. Conners C. K., 1999, Conners’ Adult ADHD Rating Scales (CAARS) Technical Manual
  4. Weisler R., 2012, Poster presented at the American Psychiatric Association 165th Annual Meeting

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Authors
Weisler, R., Ginsberg, L., Dirks, B., Deas, P., Adeyi, B., & Adler, L. A.
Affiliations
  • University of North Carolina at Chapel Hill (US)
  • Red Oak Psychiatry Associates, P.A., Houston, TX, USA
  • Shire Development LLC, Wayne, PA, USA
  • VA NY Harbor Healthcare System (US)
Venue
Journal of Attention Disorders
Published
2014-01-24
Volume
21
Issue
14
Pages
1198-1207
ISSN
  • 1087-0547 (ISSN-L)
  • 1557-1246
OpenAlex
W2318134686
Cited by
15
References
33
Citations by year
2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1
FWCI
1.12
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Attention Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
lisdexamfetamine dimesylate, adult ADHD, executive function, rater agreement, ADHD symptom severity, stimulant medication, ADHD Rating Scale-IV
MeSH terms
Lisdexamfetamine Dimesylate, Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Awareness, Double-Blind Method, Female, Humans, Male, Treatment Outcome, Young Adult, Executive Function, Self Report

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