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Cited by 99Stress Responses and CortisolAdrenal Hormones and DisordersBirth, Development, and Health

Ethnic differences in adrenocorticotropic hormone, cortisol and corticotropin-releasing hormone during pregnancy

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Glynn, Laura M., Schetter, Christine Dunkel, Chicz-DeMet, Aleksandra, Hobel, Calvin J., Sandman, Curt A.·2007·Peptides
DOI 10.1016/j.peptides.2007.04.005
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Abstract

Significant ethnic disparities exist in reproductive outcomes. A potential contributing factor may be the functioning of the hypothalamic-pituitary-adrenal (HPA) axis and placenta during pregnancy. In the present study, levels of cortisol, ACTH and CRH were determined longitudinally from the plasma of 310 African American, Hispanic and non-Hispanic White women at 18-20, 24-26 and 30-32 weeks' gestation. During pregnancy, African American women exhibited lower levels of cortisol than non-Hispanic women and higher levels of ACTH than Hispanic women. The trajectory of CRH increase also differed by ethnicity, with African Americans exhibiting the lowest levels both early and late in pregnancy. Higher levels of cortisol at 18-20 weeks were associated with higher levels of CRH at 30-32 weeks among the African American and Hispanic women, but not among non-Hispanic women. Ethnic differences persisted when adjusting statistically for sociodemographic and biomedical factors. The findings are consistent with the possibility that ethnic disparities in adverse birth outcomes may be due, in part, to differences in HPA axis and placental function.

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Crossref · 10.1016/j.peptides.2007.04.005

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  • African American women are more likely than white women to show maternal stress in the context of preterm birth and to have pregnancy-associated cortisol patterns that differ significantly from white women.

    “Of additional importance is the fact that African American women are significantly more likely to show evidence of maternal stress in the context of PTB as well as pregnancy associated maternal cortisol patterns that differ significantly from white women (Christian et al., 2016; Glynn et al., 2007).”

    From Childhood stress and birth timing among African American women: cortisol as biological mediator (2017) · cites this paper as Glynn et al., 2007

  • HPA markers tend to correlate well during pregnancy, and each has been linked to early birth in prior work.

    “Markers tend to correlate well during pregnancy (e.g., Glynn et al., 2007; O’Keane et al., 2011), with each linked to early birth in prior work”

    From Childhood stress and birth timing among African American women: cortisol as biological mediator (2017) · cites this paper as Glynn et al., 2007

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Authors
Glynn, L. M., Schetter, C. D., Chicz-DeMet, A., Hobel, C. J., & Sandman, C. A.
Affiliations
  • University of California, Irvine (US)
  • University of California, Los Angeles (US)
  • Cedars-Sinai Medical Center (US)
Corresponding author
Glynn, Laura M.
ORCID
Venue
Peptides
Publisher
Elsevier BV
Published
2007-06
Volume
28
Issue
6
Pages
1155-1161
ISSN
0196-9781 (ISSN-L)
DOI
10.1016/j.peptides.2007.04.005
OpenAlex
W2145337001
Cited by
99
References
36
Citations by year
2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 10
FWCI
2.34
Type
journal article
Language
en
Open access
Licence
Locations
  • Peptides (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (NS-41298;, R01NS041298)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD028413, R01-HD28413, R01HD040967, R01 HD-40967)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
ethnic disparities, pregnancy, ACTH, cortisol, corticotropin-releasing factor, hypothalamic-pituitary-adrenal axis, placental function, African American women, Hispanic women, non-Hispanic white women, birth outcomes
MeSH terms
Adrenocorticotropic Hormone, Black or African American, Corticotropin-Releasing Hormone, Female, Gestational Age, Hispanic or Latino, Humans, Hydrocortisone, Pregnancy, Pregnancy Trimester, First, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Black People, White People

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