The DOI matches its Crossref record; 202 of the 203 references it cites were found in a registry or an index.
Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects
Open accessAbstract
Regulatory and functional aspects of the kynurenine (K) pathway (KP) of tryptophan (Trp) degradation are reviewed. The KP accounts for ~95% of dietary Trp degradation, of which 90% is attributed to the hepatic KP. During immune activation, the minor extrahepatic KP plays a more active role. The KP is rate-limited by its first enzyme, Trp 2,3-dioxygenase (TDO), in liver and indoleamine 2,3-dioxygenase (IDO) elsewhere. TDO is regulated by glucocorticoid induction, substrate activation and stabilization by Trp, cofactor activation by heme, and end-product inhibition by reduced nicotinamide adenine dinucleotide (phosphate). IDO is regulated by IFN-γ and other cytokines and by nitric oxide. The KP disposes of excess Trp, controls hepatic heme synthesis and Trp availability for cerebral serotonin synthesis, and produces immunoregulatory and neuroactive metabolites, the B 3 “vitamin” nicotinic acid, and oxidized nicotinamide adenine dinucleotide. Various KP enzymes are undermined in disease and are targeted for therapy of conditions ranging from immunological, neurological, and neurodegenerative conditions to cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The Trp-Kyn-AhR pathway, in which the essential amino acid tryptophan is converted to Kyn and other secondary metabolites, is the primary route of tryptophan catabolism (19).”
From Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis (2019) · cites this paper as [19]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism
Munn, D. H., Zhou, M., Attwood, J. T., Bondarev, I. E., Conway, S. J., Marshall, B., Brown, C. C., & Mellor, A. L. (1998) · Science · doi:10.1126/science.281.5380.1191 · Cited by 2,589
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature · doi:10.1038/nature10491 · Cited by 1,898
An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells
Mezrich, J. D., Fechner, J. H., Zhang, X., Johnson, B. P., Burlingham, W. J., & Bradfield, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903670 · Cited by 1,674
Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism
Taylor, M. W., & Feng, G. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.11.1907934 · Cited by 1,060
Neuropharmacology of quinolinic and kynurenic acids.
Stone, T. W. (1993) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00441-7 · Cited by 949
Role of Poly(ADP-ribose) Polymerase (PARP) Cleavage in Apoptosis
Boulares, A. H., Yakovlev, A. G., Ivanova, V. S., Stoica, B. A., Wang, G., Iyer, S., & Smulson, M. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.22932 · Cited by 898
Tryptophan and the immune response
Moffett, J., & Namboodiri, M. (2003) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2003.t01-1-01177.x · Cited by 765
Chausmer, A. B. (1998) · Journal of the American College of Nutrition · doi:10.1080/07315724.1998.10718735 · Cited by 734
Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion
Platten, M., Wick, W., & den Eynde, B. J. V. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0569 · Cited by 725
Nguyen, N. T., Kimura, A., Nakahama, T., Chinen, I., Masuda, K., Nohara, K., Fujii‐Kuriyama, Y., & Kishimoto, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014465107 · Cited by 705
Research works printed but not linked: 13
- Verjee ZHM, 1975, Acta Vitaminol Enzymol (Milano), 29, 198
- Shibata K, 1986, Agr Biol Chem, 50, 3037
- Murakami Y, 2013, Int J Tryptophan Res, 6, 47
- Nakamura T, 1987, J Biol Chem, 262, 723
- Yamamoto M, 1982, Biochem Int, 5, 747
- Carlson MG, 1993, J Clin Endocrinol Metab, 77, 11
- Chiancone FM, 1964, Ital J Biochem, 13, 1
- Badawy AA-B, 1983, Alcohol Alcohol, 18, 369
- Chouinard G, 1978, Commun Psychopharmacol, 2, 21
- Oxenkrug G, 2016, Ann Psychiatry Ment Health, 4
- Ikeda S, 1986, Ital J Biochem, 35, 232
- Fukuwatari T, 2013, Int J Tryptophan Res, 6, 3
- Zhang LQ, 2011, J Bioanal Biomed, 7, 13
Cited by
Sorted by citations
Items 301–400 of 1,000
Serotonin, Kynurenine, and Indole Pathways of Tryptophan Metabolism in Humans in Health and Disease
Holeček, M. (2026) · Nutrients · doi:10.3390/nu18030507 · Cited by 30
Tryptophan as a Central Hub for Host/Microbial Symbiosis
Borghi, M., Puccetti, M., Pariano, M., Renga, G., Stincardini, C., Ricci, M., Giovagnoli, S., Costantini, C., & Romani, L. R. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920919755 · Cited by 30
Tryptophan and kynurenine stimulate human decidualization via activating Aryl hydrocarbon receptor
Wang, P., Chen, S., Hong, Z.-K., Li, S., Yang, Z., Quan, S., & Yang, Z. (2020) · Reproductive Toxicology · doi:10.1016/j.reprotox.2020.07.011 · Cited by 29
The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Su, A. H., Ling, F. W., Vaganay, C., Sodaro, G., Benaksas, C., Bello, R. D., Forget, A., Pardieu, B., Lin, K., Rutter, J. C., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0970 · Cited by 29
Kwiatkowska, I., Hermanowicz, J. M., Myśliwiec, M., & Pawlak, D. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6656033 · Cited by 30
IFN-γ and CD38 in Hyperprogressive Cancer Development
Angelicola, S., Ruzzi, F., Landuzzi, L., Scalambra, L., Gelsomino, F., Ardizzoni, A., Nanni, P., Lollini, P., & Palladini, A. (2021) · Cancers · doi:10.3390/cancers13020309 · Cited by 30
Hersi, F., Elgendy, S. M., Shamma, S. A. A., Altell, R. T., Sadiek, O., & Omar, H. A. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120573 · Cited by 29
Calella, P., Dio, M. D., Cerullo, G., Onofrio, V. D., Gallé, F., & Liguori, G. (2022) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2022.2137785 · Cited by 29
Han, J., Gong, S., Bian, X., Qian, Y., Wang, G., Li, N., & Wu, J. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.06.009 · Cited by 29
The evolution of small molecule enzyme activators
Dow, L. F., Case, A. M., Paustian, M. P., Pinkerton, B. R., Simeon, P., & Trippier, P. C. (2023) · RSC Medicinal Chemistry · doi:10.1039/d3md00399j · Cited by 29
Anhedonic-like behavior correlates with IFNγ serum levels in a two-hit model of depression
Géa, L. P., Colombo, R., da Rosa, E. D., Antqueviezc, B., de Aguiar, É. Z., Hizo, G. H., Schmidt, G. B., de Oliveira, L. F., Stein, D. J., & Rosa, A. R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112076 · Cited by 30
Al‐Hakeim, H. K., Twayej, A. J., Al-Dujaili, A. H., & Maes, M. H. J. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319666200102100307 · Cited by 30
Kimmel, M., Verosky, B. G., Chen, H. J., Davis, O., & Gur, T. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.11.014 · Cited by 30
Curtasu, M. V., Knudsen, K. E. B., Callesen, H., Purup, S., Stagsted, J., & Hedemann, M. S. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00264 · Cited by 28
Inhibiting Sialidase-Induced TGF-β1 Activation Attenuates Pulmonary Fibrosis in Mice
Karhadkar, T. R., Meek, T. D., & Gomer, R. H. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000258 · Cited by 28
Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
Wang, X., Mehra, S., Kaushal, D., Veazey, R. S., & Xu, H. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.666227 · Cited by 29
Hamilton, M. M., Mseeh, F., McAfoos, T. J., Leonard, P. G., Reyna, N. J., Harris, A. L., Xu, A., Han, M., Soth, M., Czakó, B., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00679 · Cited by 28
Bifarin, O. O., Gaul, D. A., Sah, S., Arnold, R. S., Ogan, K., Master, V. A., Roberts, D. L., Bergquist, S. H., Petros, J. A., Edison, A. S., et al. (2021) · Cancers · doi:10.3390/cancers13246253 · Cited by 28
de Oliveira, L. R. S., Machado, F. S. M., Dias, I. R., Magalhães, C. O. D. E., Sousa, R. A. L. D., & Cassilhas, R. C. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07156-z · Cited by 30
Shi, T., Shi, Y., Gao, H., Ma, Y., Wang, Q., Shen, S., Shao, X., Gong, W., Chen, X., Qin, J., et al. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.03.003 · Cited by 29
Nadour, Z., Simian, C., Laprévôte, O., Loriot, M., Larabi, I. A., & Pallet, N. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.07.009 · Cited by 28
Nguyen, D. T., Kleczko, E. K., Dwivedi, N., Monaghan, M. T., Gitomer, B. Y., Chonchol, M. B., Clambey, E. T., Nemenoff, R. A., Klawitter, J., & Hopp, K. (2022) · JCI Insight · doi:10.1172/jci.insight.154773 · Cited by 28
Lai, W., Huang, Z., Li, S., Li, X.-G., & Luo, D. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109840 · Cited by 28
The serotonin hypothesis of depression: both long discarded and still supported?
Moncrieff, J., Cooper, R. E., Stockmann, T., Amendola, S., Hengartner, M. P., Plöderl, M., & Horowitz, M. A. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02094-z · Cited by 28
Anesi, A., Berding, K., Clarke, G. A., Stanton, C., Cryan, J. F., Caplice, N. M., Ross, R. P., Doolan, A., Vrhovšek, U., & Mattivi, F. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00946 · Cited by 28
Yang, P., & Zhang, J. (2023) · Biomedicines · doi:10.3390/biomedicines11071988 · Cited by 28
Kynurenic Acid Plays a Protective Role in Hepatotoxicity Induced by HFPO-DA in Male Mice
Hu, J., Dai, J., & Sheng, N. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c08033 · Cited by 29
mRNA-delivery of IDO1 suppresses T cell-mediated autoimmunity
Kenney, L. L., Chiu, R. S.-Y., Dutra, M. N., Wactor, A., Honan, C., Shelerud, L. M., Corrigan, J. J., Yu, K. J., Ferrari, J. D., Jeffrey, K. L., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101717 · Cited by 28
Damerell, V., Klaassen‐Dekker, N., Brezina, S., Ose, J., Ulvik, A., van Roekel, E. H., Holowatyj, A. N., Baierl, A., Böhm, J., Bours, M. J. L., et al. (2024) · International Journal of Cancer · doi:10.1002/ijc.35183 · Cited by 27
Trisal, A., Singh, I., Garg, G., Jorwal, K., & Singh, A. K. (2024) · 3 Biotech · doi:10.1007/s13205-024-04187-0 · Cited by 27
Kang, I. M., Theodoropoulos, G., & Wangpaichitr, M. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2024.1524651 · Cited by 28
Templeman, J. R., Mansilla, W. D., Fortener, L., & Shoveller, A. K. K. (2019) · Journal of Animal Science · doi:10.1093/jas/skz142 · Cited by 27
Current state on tryptophan 2,3-dioxygenase inhibitors: a patent review
Kozlova, A., & Frédérick, R. (2018) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2019.1556638 · Cited by 28
The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro
Sborchia, M., Prez, E. G. D., Antoine, M., Bienfait, L., Indra, R., Valbuena, G. N., Phillips, D. H., Nortier, J., Stiborová, M., Keun, H. C., et al. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02578-4 · Cited by 27
Sadok, I., Jędruchniewicz, K., Rawicz‐Pruszyński, K., & Staniszewska, M. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136972 · Cited by 27
Intestinal Dysbiosis, the Tryptophan Pathway and Nonalcoholic Steatohepatitis
Chen, J., Vitetta, L., Henson, J. D., & Hall, S. (2022) · International Journal of Tryptophan Research · doi:10.1177/11786469211070533 · Cited by 27
Dawood, S., Bano, S., & Badawy, A. A. ‐. (2022) · Bioscience Reports · doi:10.1042/bsr20220426 · Cited by 27
Self-citationPark, J., Lee, J.-M., Lee, E.-J., Kim, D.-J., & Hwang, W.-B. (2018) · Oncology Reports · doi:10.3892/or.2018.6266 · Cited by 28
Flieger, J., Święch-Zubilewicz, A., Śniegocki, T., Dolar-Szczasny, J., & Pizoń, M. (2018) · Molecules · doi:10.3390/molecules23113012 · Cited by 27
Indoleamine 2,3-Dioxygenase as a Therapeutic Target for Alzheimer’s Disease and Geriatric Depression
Savonije, K., Meek, A. R., & Weaver, D. F. (2023) · Brain Sciences · doi:10.3390/brainsci13060852 · Cited by 27
de Gomes, M. G., Souza, L. C., Goes, A. T. R., Fabbro, L. D., Filho, C. B., Donato, F., Prigol, M., Luchese, C., Roman, S. S., Puntel, R. L., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.05.002 · Cited by 26
Kynurenine induces an age-related phenotype in bone marrow stromal cells
Patel, D., Potter, M. L., Anaya, J. M., McGee‐Lawrence, M. E., Hamrick, M. W., Hill, W., Isales, C. M., & Fulzele, S. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111464 · Cited by 26
Tryptophan catabolism is dysregulated in leiomyomas
Chuang, T., Quintanilla, D., Boos, D., & Khorram, O. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.05.081 · Cited by 26
Rengasamy, M. L., Marsland, A. L., Spada, M. L., Hsiung, K. S., Kovats, T., & Price, R. B. (2021) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2021.100177 · Cited by 29
Effect of microbiota metabolites on the progression of chronic hepatitis B virus infection
Sun, X. L., Pan, C. Q., & Xing, H. (2021) · Hepatology International · doi:10.1007/s12072-021-10230-6 · Cited by 26
Metabolic Snapshot of Plasma Samples Reveals New Pathways Implicated in SARS-CoV-2 Pathogenesis
Albóniga, O. E., Jiménez, D., Sánchez‐Conde, M., Vizcarra, P., Ron, R., Herrera, S., Martínez‐Sanz, J., Moreno, E., Moreno, S., Barbas, C., et al. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00786 · Cited by 26
Chojnacki, C. J., Konrad, P., Błońska, A., Mędrek-Socha, M., Przybyłowska-Sygut, K., Chojnacki, J., & Popławski, T. (2022) · Nutrients · doi:10.3390/nu14153217 · Cited by 31
Identification and characterization of the kynurenine pathway in the pond snail Lymnaea stagnalis
Benatti, C., Rivi, V., Alboni, S., Andrea, G., Sara, C., Luca, P., Brunello, N., Johanna, B., Bicciato, S., & Tascedda, F. (2022) · Scientific Reports · doi:10.1038/s41598-022-19652-0 · Cited by 26
Milosavljevic, S., Smith, A. A., Wright, C. J., Valafar, H., & Pocivavsek, A. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02399-1 · Cited by 28
Ren, X., Wei, Y., Zhao, H., Shao, J., Zeng, F., Wang, Z., & Li, L. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1261832 · Cited by 26
Tryptophan Metabolism via Kynurenine Pathway: Role in Solid Organ Transplantation
Žulpaitė, R., Miknevicius, P., Leber, B., Strupas, K., Stiegler, P., & Schemmer, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041921 · Cited by 28
Relation of the kynurenine pathway with normal age: A systematic review
Bakker, L., Choe, K., Eussen, S. J. P. M., Ramakers, I. H. G. B., van den Hove, D., Kenis, G., Rutten, B. P. F., Verhey, F. R. J., & Köhler, S. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111890 · Cited by 27
The role of gut microbiota-derived metabolites in modulating poultry immunometabolism
Oke, O. E., Fasasi, L. O., Opowoye, I. O., & Akosile, O. A. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1700406 · Cited by 27
An integrative atlas of chicken long non-coding genes and their annotations across 25 tissues
Jehl, F., Muret, K., Bernard, M., Boutin, M., Lagoutte, L., Désert, C., Déhais, P., Esquerré, D., Acloque, H., Giuffra, E., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-77586-x · Cited by 27
Scarale, M. G., Mastroianno, M., Prehn, C. P., Copetti, M., Salvemini, L., Adamski, J., Cosmo, S. D., Trischitta, V., & Menzaghi, C. (2022) · Diabetes · doi:10.2337/db22-0095 · Cited by 26
Tomaszewski, M., Morris, A. P., Howson, J. M. M., Franceschini, N., Eales, J., Xu, X., Dikalov, S., Guzik, T. J., Humphreys, B. D., Harrap, S. B., et al. (2022) · Kidney International · doi:10.1016/j.kint.2022.04.045 · Cited by 26
IDO1 and inflammatory neovascularization: bringing new blood to tumor-promoting inflammation
Muller, A. J., Mondal, A., Dey, S., & Prendergast, G. C. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1165298 · Cited by 25
The connection between gut microbiota and its metabolites with neurodegenerative diseases in humans
Fabi, J. P. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01369-w · Cited by 27
Kynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia
Solvang, S.-E. H., Nordrehaug, J. E., Aarsland, D., Lange, J., Ueland, P. M., McCann, A., Midttun, Ø., Tell, G. S., & Giil, L. M. (2019) · International Journal of Tryptophan Research · doi:10.1177/1178646919877883 · Cited by 25
Clinical insights into the kynurenine pathway in age-related diseases
Kim, B., Lee, S. H., & Koh, J. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110793 · Cited by 26
Lee, K. B., Ang, L., Yau, W., & Seow, W. J. (2020) · Metabolites · doi:10.3390/metabo10090362 · Cited by 25
Role of Natural Killer Cells in Uveal Melanoma
Javed, A., & Milhem, M. M. (2020) · Cancers · doi:10.3390/cancers12123694 · Cited by 25
Kale, D., Fatangare, A., Phapale, P. B., & Sickmann, A. (2023) · Cells · doi:10.3390/cells12242796 · Cited by 24
Resistance Exercise Modulates Kynurenine Pathway in Pancreatic Cancer Patients
Pal, A., Zimmer, P., Clauss, D., Schmidt, M. E., Ulrich, C. M., Wiskemann, J., & Steindorf, K. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1186-1009 · Cited by 24
Serotonergic Regulation of Hepatic Energy Metabolism
Park, J., Jeong, W., Yun, C., Kim, H., & Oh, C. (2021) · Endocrinology and Metabolism · doi:10.3803/enm.2021.1331 · Cited by 24
Rafiq, T., Stearns, J. C., Shanmuganathan, M., Azab, S. M., Anand, S. S., Thabane, L., Beyene, J., Williams, N. C., Morrison, K. M., Teo, K. K., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16651 · Cited by 24
Petrozzi, B. P., Marszałek‐Grabska, M., Kozub-Pędrak, A., Szałaj, K., Trzpil, A., Stachniuk, A., Lamadé, E. K., Gilles, M., Deuschle, M., Turski, W. A., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-39774-3 · Cited by 24
Kynurenine pathway and its role in neurologic, psychiatric, and inflammatory bowel diseases
Sheibani, M., Shayan, M., Khalilzadeh, M., Soltani, Z. E., Jafari‐Sabet, M., Ghasemi, M., & Dehpour, A. R. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08859-7 · Cited by 24
Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders
Kondo, T., Okada, Y., Saika, S., Yamaguchi, N., Hatakeyama, S., & Maruyama, K. (2024) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2024.151418 · Cited by 24
The roles of the kynurenine pathway in COVID-19 neuropathogenesis
Dehhaghi, M., Heydari, M., Panahi, H. K. S., Lewin, S. R., Heng, B., Brew, B. J., & Guillemin, G. J. (2024) · Infection · doi:10.1007/s15010-024-02293-y · Cited by 25
The Impact of Protein Acetylation/Deacetylation on Systemic Lupus Erythematosus
Ren, J., Panther, E. J., Liao, X., Grammer, A. C., Lipsky, P. E., & Reilly, C. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124007 · Cited by 25
Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia
Martino, L. D., Tosello, V., Peroni, E., & Piovan, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168738 · Cited by 25
Shokr, M. M., Eladawy, R. M., Azar, Y. O., & Raish, S. M. A. (2025) · Foods · doi:10.3390/foods14172926 · Cited by 25
The gut microbiota and its metabolites: novel therapeutic targets for inflammatory bowel disease
Shen, X. Z., Li, Y., Wang, D., & Sun, K. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1690279 · Cited by 25
Dahmani, M., Anderson, J. F., Sultana, H., & Neelakanta, G. (2020) · Cellular Microbiology · doi:10.1111/cmi.13237 · Cited by 23
Ze, L., Xu, P., Kang, W., Wu, J., Jin, L., Anjum, A. A., & Li, G. (2021) · Amino Acids · doi:10.1007/s00726-021-03009-4 · Cited by 23
Electrochemical Determination of Kynurenine Pathway Metabolites—Challenges and Perspectives
Sadok, I., & Staniszewska, M. M. (2021) · Sensors · doi:10.3390/s21217152 · Cited by 24
Brown, S. J., Brown, A. M., Purves-Tyson, T. D., Huang, X., Weickert, C. S., & Newell, K. A. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.12.039 · Cited by 23
An anxious relationship between Autism Spectrum Disorder and Gut Microbiota: A tangled chemistry?
Vellingiri, B., Aishwarya, S. Y., Jancy, S. B., Abhishek, G. S., Babu, H. W. S., Vijayakumar, P., Narayanasamy, A., Mariappan, S., Sangeetha, R., Gopalakrishnan, A. V., et al. (2022) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2022.03.003 · Cited by 23
Yoshioka, S., Ikeda, T., Fukuchi, S., Kawai, Y., Ohta, K., Murakami, H., Ogo, N., Muraoka, D., Takikawa, O., & Asai, A. (2022) · International Journal of Tryptophan Research · doi:10.1177/11786469221138456 · Cited by 23
Measurement of kynurenine pathway metabolites by tandem mass spectrometry
Abuşoğlu, S., Onmaz, D. E., Abuşoğlu, G., Yerlikaya, F. H., & Ünlü, A. (2023) · Journal of Mass Spectrometry and Advances in the Clinical Lab · doi:10.1016/j.jmsacl.2023.04.003 · Cited by 23
Zhang, J., Chen, M., Yang, Y., Liu, Z., Guo, W., Xiang, P., Zeng, Z., Wang, D., & Xiong, W. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31349 · Cited by 23
Skorobogatov, K., Picker, L. D., Wu, C., Foiselle, M., Richard, J., Boukouaci, W., Bouassida, J., Laukens, K., Meysman, P., Corvoisier, P. L., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.08.013 · Cited by 23
Gazi, M. A., Das, S., Siddique, M. A., Alam, M. A., Fahim, S. M., Hasan, M. M., Hossaini, F., Kabir, M. M., Noor, Z., Haque, R., et al. (2020) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.20-0049 · Cited by 23
Campos, B., Rivetti, C., Tauler, R., Piña, B., & Barata, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-39987-5 · Cited by 22
Wang, J., Behl, T., Rana, T., Sehgal, A., Wal, P., Saxena, B., Yadav, S., Mohan, S., Anwer, M. K., Chigurupati, S., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155466 · Cited by 23
Characteristics of Nutrition and Metabolism in Dogs and Cats
Li, P., & Wu, G. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-54192-6_4 · Cited by 25
Wen, H., Liu, Y., Wang, S., Wang, T., Zhang, G., Chen, X., Li, Y., Cui, H., Lai, F., & Li, S. (2019) · Molecules · doi:10.3390/molecules24112124 · Cited by 22
Templeman, J. R., Thornton, E., Cargo-Froom, C. L., Squires, E. J., Swanson, K. S., & Shoveller, A. K. K. (2020) · Journal of Animal Science · doi:10.1093/jas/skaa128 · Cited by 24
Brewitz, L., Tumber, A., Thalhammer, A., Salah, E., Christensen, K. E., & Schofield, C. J. (2020) · ChemMedChem · doi:10.1002/cmdc.202000147 · Cited by 22
Suento, W. J., Kunisawa, K., Wulaer, B., Kosuge, A., Iida, T., Fujigaki, S., Fujigaki, H., Yamamoto, Y., Tanra, A. J., Saito, K., et al. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15222 · Cited by 22
Kitada, M., Araki, S., & Koya, D. (2023) · Cells · doi:10.3390/cells12040595 · Cited by 21
Guerrero-Esperanza, M., Wróbel, K., Ojeda, A. G., Garay‐Sevilla, M. E., Escobosa, A. R. C., Barrientos, E. Y., & Wróbel, K. (2020) · European Journal of Mass Spectrometry · doi:10.1177/1469066720964632 · Cited by 21
Multi-omics approach to COVID-19: a domain-based literature review
Montaldo, C., Messina, F., Abbate, I., Antonioli, M., Bordoni, V., Aiello, A., Ciccosanti, F., Colavita, F., Farroni, C., Fard, S. N., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03168-8 · Cited by 21
Chilosi, M., Doglioni, C., Ravaglia, C., Martignoni, G., Salvagno, G. L., Pizzolo, G., Bronte, V., & Poletti, V. E. (2022) · Biomedicines · doi:10.3390/biomedicines10061332 · Cited by 22
Chojnacki, C. J., Popławski, T., Konrad, P., Fila, M., Błasiak, J., & Chojnacki, J. (2022) · Nutrition & Metabolism · doi:10.1186/s12986-022-00700-5 · Cited by 23
Potential Inflammatory Biomarker in Patients with Attention Deficit Hyperactivity Disorder
Park, J. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113054 · Cited by 22
Mangoni, A. A., & Zinellu, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1257159 · Cited by 21
The Role of Amino Acids in Non-Enzymatic Antioxidant Mechanisms in Cancer: A Review
Dyachenko, E. I., & Bel’skaya, L. V. (2023) · Metabolites · doi:10.3390/metabo14010028 · Cited by 21
Li, H., Zheng, N., Guo, A., Tang, W., Li, M., Cao, Y., Ma, X., Cao, H., Ma, Y., Wang, H., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06469-0 · Cited by 22
Metadata
- Authors
- Badawy, A. A.-B.
- Affiliations
- Cardiff Metropolitan University (GB)
- Corresponding author
- Badawy, Abdulla A-B
- ORCID
- Badawy, Abdulla A-B
- Venue
- International Journal of Tryptophan Research
- Publisher
- SAGE Publications
- Published
- 2017-01-01
- Volume
- 10
- Pages
- 1178646917691938-1178646917691938
- ISSN
- 1178-6469 (ISSN-L)
- PMC
- PMC5398323
- OpenAlex
- W2598111690
- Cited by
- 1,158
- References
- 203
- Citations by year
- 2026: 147 · 2025: 179 · 2024: 137 · 2023: 153 · 2022: 148 · 2021: 148 · 2020: 119 · 2019: 75 · 2018: 45 · 2017: 7
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Tryptophan Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Keywords
- kynurenine pathway, tryptophan metabolism, tryptophan 2,3-dioxygenase, indoleamine 2,3-dioxygenase, glucocorticoid regulation, nitric oxide, NADP+ inhibition, heme biosynthesis, serotonin synthesis, NAD+, immune regulation, neuroactive metabolites, neurodegenerative diseases, cancer therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
