Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

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An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

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An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

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Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

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Neuropharmacology of quinolinic and kynurenic acids.

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Role of Poly(ADP-ribose) Polymerase (PARP) Cleavage in Apoptosis

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Tryptophan and the immune response

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Zinc, Insulin and Diabetes

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Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion

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Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

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REDOX proteomics reveals energy metabolism alterations in the liver of M. spretus mice exposed to p, p′-DDE

Morales‐Prieto, N., & Abril, N. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.08.057 · Cited by 24

Neuroendocrine Abnormalities in Major Depression: An Insight Into Glucocorticoids, Cytokines, and the Kynurenine Pathway

Nikkheslat, N., Pariante, C. M., & Zunszain, P. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811073-7.00003-9 · Cited by 23

AhR Activation in Pharmaceutical Development: Applying Liver Gene Expression Biomarker Thresholds to Identify Doses Associated With Tumorigenic Risks in Rats

Qin, C., Aslamkhan, A. G., Pearson, K., Tanis, K. Q., Podtelezhnikov, A. A., Frank, E., Pacchione, S. J., Pippert, T. R., Glaab, W. E., & Sistare, F. D. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz125 · Cited by 21

Engineered Biosynthesis of Fungal 4-Quinolone Natural Products

Liu, M., Ōhashi, M., & Tang, Y. (2020) · Organic Letters · doi:10.1021/acs.orglett.0c02426 · Cited by 21

Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder

Bi̇lgi̇ç, A., Abuşoğlu, S., Sadıç, Ç. Ç., Oflaz, M. B., Akça, Ö. F., Sivrikaya, A., Baysal, T., & Ünlü, A. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1841187 · Cited by 21

Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline

Hasegawa, M., Kunisawa, K., Wulaer, B., Kubota, H., Kurahashi, H., Sakata, T., Ando, H., Fujigaki, S., Fujigaki, H., Yamamoto, Y., et al. (2024) · British Journal of Pharmacology · doi:10.1111/bph.17407 · Cited by 20

Curcumin-loaded lipid-core nanocapsules attenuates the immune challenge LPS-induced in rats: Neuroinflammatory and behavioral response in sickness behavior

de Gomes, M. G., Teixeira, F. E. G., de Carvalho, F. B., Pacheco, C. O., Neto, M. R. D. S., Giacomeli, R., Ramalho, J. B., dos Santos, R. B., Domingues, W. B., Campos, V. F., et al. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577270 · Cited by 20

Modulation of the Nitric Oxide/BH4 Pathway Protects Against Irradiation-Induced Neuronal Damage

Thabet, N. M., Rashed, E. R., Abdel-Rafei, M. K., & Moustafa, E. M. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03306-0 · Cited by 20

Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

Klaessens, S., Stroobant, V., Hoffmann, D., Gyrd‐Hansen, M., Pilotte, L., Vigneron, N., Plaen, E. D., & den Eynde, B. J. V. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2022447118 · Cited by 21

Nutraceuticals as Potential Targets for the Development of a Functional Beverage for Improving Sleep Quality

Bulman, A., D'Cunha, N. M., Marx, W., McKune, A. J., Jani, R., & Naumovski, N. (2021) · Beverages · doi:10.3390/beverages7020033 · Cited by 22

Predicting lupus membranous nephritis using reduced picolinic acid to tryptophan ratio as a urinary biomarker

Anekthanakul, K., Manocheewa, S., Chienwichai, K., Poungsombat, P., Limjiasahapong, S., Wanichthanarak, K., Jariyasopit, N., Mathema, V. B., Kuhakarn, C., Reutrakul, V., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103355 · Cited by 20

Distinct post-sepsis induced neurochemical alterations in two mouse strains

Browne, C. A., Clarke, G. A., Fitzgerald, P., O’Sullivan, J. B., Dinan, T. G., & Cryan, J. F. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.05.005 · Cited by 20

The Kynurenine Pathway in Obese Middle-Aged Women with Normoglycemia and Type 2 Diabetes

Kubacka, J., Staniszewska, M. M., Sadok, I., Sypniewska, G., & Stefańska, A. (2022) · Metabolites · doi:10.3390/metabo12060492 · Cited by 20

New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals

Stuehr, D. J., Dai, Y., Biswas, P., Sweeny, E. A., & Ghosh, A. (2022) · Biological Chemistry · doi:10.1515/hsz-2022-0197 · Cited by 20

Diagnostic, Prognostic and Mechanistic Biomarkers of COVID-19 Identified by Mass Spectrometric Metabolomics

Bourgin, M., Durand, S., & Kroemer, G. (2023) · Metabolites · doi:10.3390/metabo13030342 · Cited by 21

Dynamic urinary metabolomics analysis based on UHPLC-Q-TOF/MS to investigate the potential biomarkers of blood stasis syndrome and the effects of Danggui Sini decoction

Huang, H., Wu, J., Lu, R., Liu, X., Chin, B., Zhu, H., Yin, C., Cheng, B., Wu, Z., Chen, X., et al. (2019) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2019.112986 · Cited by 20

Metabolomic Profiling of Biological Reference Materials using a Multiplatform High-Resolution Mass Spectrometric Approach

Aristizabal‐Henao, J. J., Lemas, D. J., Griffin, E. K., Costa, K. A., Camacho, C. G., & Bowden, J. A. (2021) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.1c00194 · Cited by 20

Proteomic and Metabolomic Profiling in Soft Tissue Sarcomas

Chadha, M., & Huang, P. H. (2022) · Current Treatment Options in Oncology · doi:10.1007/s11864-022-00947-3 · Cited by 20

Association of plasma kynurenine pathway metabolite concentrations with metabolic health risk in prepubertal Asian children

Tan, K. M. L., Tint, M. T., Narasimhan, K., Yap, F. K. P., Godfrey, K. M., Lee, Y. S., Tan, K. H., Gluckman, P. D., Chong, Y. S., Chong, M. F., et al. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01085-4 · Cited by 20

Dual Effect of Tryptamine on Prostate Cancer Cell Growth Regulation: A Pilot Study

Li, Z., Ding, B., Ali, M. R. K., Zhao, L., Zang, X., & Lv, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911087 · Cited by 20

HDACi combination therapy with IDO1i remodels the tumor microenvironment and boosts antitumor efficacy in colorectal cancer with microsatellite stability

Liang, R., Ding, D., Li, Y., Lan, T., Ryabtseva, S., Huang, S., Ren, J., Huang, H., & Wei, B. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02936-0 · Cited by 20

Reshaping the tumor microenvironment of cold soft-tissue sarcomas with anti-angiogenics: a phase 2 trial of regorafenib combined with avelumab

Toulmonde, M., Guégan, J., Ceruso, M. S., Valentin, T., Bahleda, R., Peyraud, F., Rey, C., Kind, M., Cantarel, C., Bellera, C. A., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02278-9 · Cited by 19

Production, Mechanisms, and Therapeutic Strategies of Tryptophan Metabolites in CNS Diseases

Shi, C., Dong, J., Hui, X., Xu, Z., Zhao, Z., & Dong, L. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05538-5 · Cited by 19

IDO family: the metabolic crossroads connecting immunity, nerves and tumors

Wang, X., Chen, Z., Chen, L., & Qiu, C. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07758-2 · Cited by 19

Changes in Immune Activation During Pregnancy and the Postpartum Period in Treated HIV Infection

Schnittman, S. R., Byakwaga, H., Boum, Y., Kabakyenga, J. K., Matthews, L. T., Burdo, T. H., Huang, Y., Tracy, R. P., Haberer, J. E., Kembabazi, A., et al. (2021) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofab245 · Cited by 19

Metabolomic profiling demonstrates evidence for kidney and urine metabolic dysregulation in a piglet model of cardiac surgery-induced acute kidney injury

Davidson, J. A., Robison, J., Khailova, L. S., Frank, B. S., Jaggers, J. J., Ing, R. J., Lawson, S., Iguidbashian, J., Ali, E. A., Treece, A. L., et al. (2022) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00039.2022 · Cited by 19

Effect of apigenin on tryptophan metabolic key enzymes expression in lipopolysaccharide-induced microglial cells and its mechanism

Kurniati, D., Hirai, S., & Egashira, Y. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e12743 · Cited by 19

Overlooked Contribution of the Indole Moiety to the Formation of Haloacetonitrile Disinfection Byproducts

Kralles, Z. T., Werner, C. A., & Dai, N. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c01080 · Cited by 19

High phthalate exposure increased urinary concentrations of quinolinic acid, implicated in the pathogenesis of neurological disorders: Is this a potential missing link?

Nassan, F. L., Gunn, J. A., Hill, M. M., Coull, B. A., & Hauser, R. B. (2019) · Environmental Research · doi:10.1016/j.envres.2019.02.034 · Cited by 19

Acute hypertrophic but not maximal strength loading transiently enhances the kynurenine pathway towards kynurenic acid

Joisten, N., Schumann, M., Schenk, A., Walzik, D., Freitag, N., Knoop, A., Thevis, M., Bloch, W., & Zimmer, P. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04375-9 · Cited by 20

The role of the neuroinflammation and stressors in premenstrual syndrome/premenstrual dysphoric disorder: a review

Cheng, M. T., Jiang, Z., Yang, J., Sun, X., Song, N., Du, C., Luo, Z.-L., & Zhang, Z. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1561848 · Cited by 19

Serotonin dysfunction in ADHD

Jackson, E. F., Riley, T. B., & Overton, P. G. (2025) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-025-09610-y · Cited by 20

Tryptophan metabolism: From physiological functions to key roles and therapeutic targets in cancer (Review)

Zhao, J., Bai, X., Du, J., Chen, Y., Guo, X., Zhang, J., Gan, J., Wu, P., Chen, S., Zhang, X., et al. (2025) · Oncology Reports · doi:10.3892/or.2025.8919 · Cited by 20

Development and validation of a liquid chromatography method using UV/fluorescence detection for the quantitative determination of metabolites of the kynurenine pathway in human urine: Application to patients with heart failure

Sousa, A. C., Ribeiro, C. M. R., Gonçalves, V. M. F., Barbosa, J., Peixoto, B., Andrade, A., Silva, P. M. A., Andrade, J. P., & Leal, S. M. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.113997 · Cited by 18

Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status

Hutchinson, A. P., Yin, P., Neale, I., Coon, J. S., Kujawa, S. A., Liu, S., & Bulun, S. E. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00852-y · Cited by 18

High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis

Rong, G., Zhang, T., Xu, Y., Zhang, Z., Gui, B., Hu, K., Zhang, J., Tang, Z., & Shen, C. (2022) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-022-05567-4 · Cited by 18

Effect of Zanthoxylum bungeanum essential oil on rumen enzyme activity, microbiome, and metabolites in lambs

Zhang, H., Lang, X., Li, X., Chen, G., & Wang, C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0272310 · Cited by 21

Kynurenine Pathway of Tryptophan Metabolism Is Associated with Hospital Mortality in Patients with Acute Respiratory Distress Syndrome: A Prospective Cohort Study

Chiu, L., Tang, H.-Y., Fan, C.-M., Lo, C.-J., Hu, H., Kao, K., & Cheng, M. (2022) · Antioxidants · doi:10.3390/antiox11101884 · Cited by 19

IDO1 Is a Therapeutic Target for Pancreatic Cancer–Associated Depression

Hue, J. J., Graor, H. J., Zarei, M., Katayama, E., Ji, K., Hajihassani, O., Loftus, A. W., Gohar, A. V., & Winter, J. M. (2022) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-22-0055 · Cited by 18

Linking nervous and immune systems in psychiatric illness: A meta-analysis of the kynurenine pathway

Sales, P. M. G., Schrage, E., Coico, R., & Pato, M. T. (2022) · Brain Research · doi:10.1016/j.brainres.2022.148190 · Cited by 20

Protective effects of Descurainia sophia seeds extract and its fractions on pulmonary edema by untargeted urine and serum metabolomics strategy

Zhang, J., Zhou, N., Wang, Y., Liu, T., Cao, Y.-M., Feng, W., & Zheng, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1080962 · Cited by 18

Metabolomics of head and neck cancer in biofluids: an integrative systematic review

Chuchueva, N., Carta, F., Nguyen, H. N., Luevano, J., Lewis, I. A., Ríos-Castillo, I., Fanos, V., King, E. V., Swistushkin, V., Reshetov, I. V., et al. (2023) · Metabolomics · doi:10.1007/s11306-023-02038-2 · Cited by 18

Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Kavyani, B., Ahn, S. B., Missailidis, D., Annesley, S. J., Fisher, P. R., Schloeffel, R., Guillemin, G. J., Lovejoy, D. B., & Heng, B. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03784-z · Cited by 18

CD103+ dendritic cell–fibroblast crosstalk via TLR9, TDO2, and AHR signaling drives lung fibrogenesis

Carter, H. M., Costa, R. M., Adams, T. S., Gilchrist, T. M., Emch, C. E., Bame, M., Oldham, J. M., Huang, S. K., Linderholm, A., Noth, I., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.177072 · Cited by 18

The oral administration of silver nanoparticles activates the kynurenine pathway in rat brain independently of oxidative stress

Adeyemı, O. S., Uloko, R. A., Awakan, O. J., Adeyanju, A. A., & Otohinoyi, D. A. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.01.034 · Cited by 18

HLA‐G, HLA‐E, and IDO overexpression predicts a worse survival of Tunisian patients with vulvar squamous cell carcinoma

Boujelbène, N., Yahia, H. B., Babay, W., Gadria, S., Zemni, I., Azaiez, H., Dhouioui, S., Zidi, N., Mchiri, R., Mrad, K., et al. (2019) · HLA · doi:10.1111/tan.13536 · Cited by 18

3-Hydroxykynurenine in Regulation of Drosophila Behavior: The Novel Mechanisms for Cardinal Phenotype Manifestations

Zhuravlev, A. V., Vetrovoy, O. V., Ivanova, P. N., & Savvateeva-Popova, E. V. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00971 · Cited by 18

Pomegranate Metabolites Impact Tryptophan Metabolism in Humans and Mice

Yang, J., Guo, Y., Lee, R., Henning, S. M., Wang, J., Pan, Y., Qing, T., Hsu, M., Nguyen, A., Siddarth, P., et al. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzaa165 · Cited by 18

Kynurenine to tryptophan ratio as a biomarker of acute stress in fish

Wish, J. V., Bulloch, P., Oswald, L., Halldorson, T. H. J., Raine, J. C., Jamshed, L., Märvin, C. H., Thomas, P. J., Holloway, A. C., & Tomy, G. T. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.132522 · Cited by 18

Novel taste, sickness, and memory: Lipopolysaccharide to induce a Garcia-like effect in inbred and wild strains of Lymnaea stagnalis

Rivi, V., Batabyal, A., Benatti, C., Blom, J. M. C., Tascedda, F., & Lukowiak, K. D. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114137 · Cited by 18

Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis

Hui, Y., Jiao, X., Yang, L., Lu, D., Han, Y., Yang, W., Cao, Y., Miao, Y., Gong, S., & Wei, M. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.04.022 · Cited by 18

Tryptophan metabolism at the crossroads of the neuro-immuno-microbial axis: implications for precision medicine in chronic diseases

Xia, H.-H., & Huang, J. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1707850 · Cited by 18

Moxibustion alleviates depression-like behavior in rats with Crohn’s disease by inhibiting the kynurenine pathway metabolism in the gut-brain axis

Bao, C., Huang, J., Wu, H., Ma, Y., Zhou, H., Chen, L., Yang, D., Liu, H., Shi, Y., & Lu, Y. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1019590 · Cited by 17

Kynurenine pathway in type 2 diabetes: Role of metformin

Al-Qahtani, Z., Al-Kuraishy, H. M., Ali, N. H., Elewa, Y. H. A., & Batiha, G. E. (2024) · Drug Development Research · doi:10.1002/ddr.22243 · Cited by 17

Understanding immune system dysfunction and its context in mood disorders: psychoneuroimmunoendocrinology and clinical interventions

Ortega, M. A., Fraile‐Μartinez, O., Montero, C. G., Díaz, R., López-González, L., Monserrat, J., Barrena-Blázquez, S., Álvarez-Mon, M. Á., Lahera, G., & Álvarez‐Mon, M. (2024) · Military Medical Research · doi:10.1186/s40779-024-00577-w · Cited by 21

Chronic dietary supplementation with kynurenic acid, a neuroactive metabolite of tryptophan, decreased body weight without negative influence on densitometry and mandibular bone biomechanical endurance in young rats

Tomaszewska, E., Muszyński, S., Kuc, D., Dobrowolski, P., Lamorski, K., Smolińska, K., Donaldson, J., Świetlicka, I., Mielnik−Błaszczak, M., Paluszkiewicz, P., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226205 · Cited by 17

Association of urinary concentrations of phthalate metabolites with quinolinic acid among women: A potential link to neurological disorders

Nassan, F. L., Gunn, J. A., Hill, M. M., Williams, P. L., & Hauser, R. B. (2020) · Environment International · doi:10.1016/j.envint.2020.105643 · Cited by 18

Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase

Brewitz, L., Tumber, A., Zhang, X., & Schofield, C. J. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115675 · Cited by 17

Advances in kynurenine analysis

Mrštná, K., Krčmová, L. K., & Švec, F. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117441 · Cited by 17

Merging metabolomics and genomics provides a catalog of genetic factors that influence molecular phenotypes in pigs linking relevant metabolic pathways

Bovo, S., Ribani, A., Fanelli, F., Galimberti, G., Martelli, P. L., Trevisi, P., Bertolini, F., Bolner, M., Casadio, R., Dall’Olio, S., et al. (2025) · Genetics Selection Evolution · doi:10.1186/s12711-025-00960-8 · Cited by 16

The role of Akkermansia muciniphila in the regulation of inflammatory bowel disease: intestinal immunity and metabolism

Wang, X., Li, A., Jing, H., Zhang, X., Dong, X., Song, Z., Wu, N., & Zheng, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1653472 · Cited by 16

Tryptophan 2,3-dioxygenase, a novel therapeutic target for Parkinson’s disease

Boros, F. A., & Vécsei, L. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1999928 · Cited by 16

Machine learning approaches to the human metabolome in sepsis identify metabolic links with survival

Kosyakovsky, L. B., Somerset, E., Rogers, A. J., Sklar, M. C., Mayers, J. R., Toma, A., Szekely, Y., Soussi, S., Wang, B., Fan, C. S., et al. (2022) · Intensive Care Medicine Experimental · doi:10.1186/s40635-022-00445-8 · Cited by 16

Simultaneous quantification of tryptophan metabolites by liquid chromatography tandem mass spectrometry during early human pregnancy

van Zundert, S. K. M., Griffioen, P. H., van Rossem, L., Willemsen, S. P., de Rijke, Y. B., van Schaik, R. H. N., Steegers‐Theunissen, R. P. M., & Mirzaian, M. (2022) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2022-0790 · Cited by 16

First trimester maternal tryptophan metabolism and embryonic and fetal growth: the Rotterdam Periconceptional Cohort (Predict Study)

van Zundert, S. K. M., van Egmond, N. C. M., van Rossem, L., Willemsen, S. P., Griffioen, P. H., van Schaik, R. H. N., Mirzaian, M., & Steegers‐Theunissen, R. P. M. (2024) · Human Reproduction · doi:10.1093/humrep/deae046 · Cited by 16

Kynurenine, 3-OH-kynurenine, and anthranilate are nutrient metabolites that alter H3K4 trimethylation and H2AS40 O-GlcNAcylation at hypothalamus-related loci

Hayakawa, K., Nishitani, K., & Tanaka, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-56341-x · Cited by 16

The aryl hydrocarbon receptor facilitates the human cytomegalovirus-mediated G1/S block to cell cycle progression

Naseri-Nosar, P., Nogalski, M. T., & Shenk, T. E. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2026336118 · Cited by 16

TDO2 overexpression correlates with poor prognosis, cancer stemness, and resistance to cetuximab in bladder cancer

Phạm, Q. T., Taniyama, D., Akabane, S., Harada, K., Babasaki, T., Sekino, Y., Hayashi, T., Sakamoto, N., Sentani, K., Oue, N., et al. (2021) · Cancer Reports · doi:10.1002/cnr2.1417 · Cited by 16

Determination of Vitamin B3 Vitamer (Nicotinamide) and Vitamin B6 Vitamers in Human Hair Using LC-MS/MS

Sallabi, S. M., Alhmoudi, A., Alshekaili, M., & Shah, I. (2021) · Molecules · doi:10.3390/molecules26154487 · Cited by 16

Different endurance exercises modulate NK cell cytotoxic and inhibiting receptors

Pal, A., Schneider, J., Schlüter, K., Steindorf, K., Wiskemann, J., Rosenberger, F., & Zimmer, P. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-021-04735-z · Cited by 16

Perivascular brown adipocytes-derived kynurenic acid relaxes blood vessel via endothelium PI3K-Akt-eNOS pathway

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Identification of Biomarkers for the Diagnosis of Sepsis-Associated Acute Kidney Injury and Prediction of Renal Recovery in the Intensive Care Unit

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From Monoamines to Systems Psychiatry: Rewiring Depression Science and Care (1960s–2025)

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Whole Exome Sequencing Enhanced Imputation Identifies 85 Metabolite Associations in the Alpine CHRIS Cohort

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The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a systematic review and meta-analysis of cerebrospinal fluid studies

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Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective

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Animal and plant protein intake association with mental health, tryptophan metabolites pathways, and gut microbiota in healthy women: a cross-sectional study

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Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway

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Do Acute Exercise-Induced Activations of the Kynurenine Pathway Induce Regulatory T-Cells on the Long-Term? - A Theoretical Frame Work Supported by Pilot Data.

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Evaluation of the andrographolides role and its indoleamine 2,3-dioxygenase inhibitory potential and attendant molecular mechanism against STZ-induced diabetic rats

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Flavivirus-Mediating B Cell Differentiation Into Antibody-Secreting Cells in Humans Is Associated With the Activation of the Tryptophan Metabolism

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Stem cell transplantation uncovers TDO-AHR regulation of lung dendritic cells in herpesvirus-induced pathology

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The Kynurenine Pathway Metabolites in Cord Blood Positively Correlate With Early Childhood Adiposity

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Pretreatment of umbilical cord derived MSCs with IFN-γ and TNF-α enhances the tumor-suppressive effect on acute myeloid leukemia

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Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression?

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Further characterization of tryptophan metabolism and its dysregulation in fibroids

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Hydrocortisone Affects Fatigue and Physical Functioning Through Metabolism of Tryptophan: A Randomized Controlled Trial

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Tryptophan metabolism is differently regulated between large and small dogs

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The Role of Amino Acids in the Crosstalk Between Mesenchymal Stromal Cells and Neoplastic Cells in the Hematopoietic Niche

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Amino acid transporter LAT1 (SLC7A5) promotes metabolic rewiring in TNBC progression through the L-Trp/QPRT/NAD+ pathway

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Optimizing human performance in extreme environments through precision medicine: From spaceflight to high-performance operations on Earth

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Phytoconstituent Profiles Associated with Relevant Antioxidant Potential and Variable Nutritive Effects of the Olive, Sweet Almond, and Black Mulberry Gemmotherapy Extracts

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Kynurenine pathway dysregulation as a mechanistic link between cognitive impairment and brain damage: Implications for multiple sclerosis

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Immunomodulatory mechanisms driving tumor escape in glioblastoma: The central role of IDO and tryptophan metabolism in local and systemic immunotolerance

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Early detection of feline chronic kidney disease via 3-hydroxykynurenine and machine learning

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Kynurenines and Mitochondrial Disturbances in Multiple Sclerosis

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Urinary Excretion of N1-Methylnicotinamide, as a Biomarker of Niacin Status, and Mortality in Renal Transplant Recipients

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Influence of the presence of the heme cofactor on the JK-loop structure in indoleamine 2,3-dioxygenase 1

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The role of tryptophan metabolic pathway in children with attention deficit hyperactivity disorder with and without comorbid oppositional defiant disorder and conduct disorder

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Perioperative changes in the plasma metabolome of patients receiving general anesthesia for pancreatic cancer surgery

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Overview of the Kynurenine Pathway of Tryptophan Metabolism

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Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice

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Simultaneous Measurement of Kynurenine and Tryptophan in Human Plasma and Supernatants of Cultured Human Cells by HPLC with Coulometric Detection

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Tryptophan and indole metabolism in immune regulation

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