The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Visual dysfunction in multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell layer thickness than peripapillary retinal nerve fiber layer thickness
Abstract
Background: Post-mortem analyses of multiple sclerosis (MS) eyes demonstrate prominent retinal neuronal ganglion cell layer (GCL) loss, in addition to related axonal retinal nerve fiber layer (RNFL) loss. Despite this, clinical correlations of retinal neuronal layers remain largely unexplored in MS. Objectives: To determine if MS patients exhibit in vivo retinal neuronal GCL loss, deeper retinal neuronal loss, and investigate correlations between retinal layer thicknesses, MS clinical subtype and validated clinical measures. Methods: Cirrus HD-optical coherence tomography (OCT), utilizing automated intra-retinal layer segmentation, was performed in 132 MS patients and 78 healthy controls. MS classification, Expanded Disability Status Scale (EDSS) and visual function were recorded in study subjects. Results: GCL+inner plexiform layer (GCIP) was thinner in relapsing–remitting MS (RRMS; n = 96, 71.6 µm), secondary progressive MS (SPMS; n = 20, 66.4 µm) and primary progressive MS (PPMS; n = 16, 74.1 µm) than in healthy controls (81.8 µm; p < 0.001 for all). GCIP thickness was most decreased in SPMS, and although GCIP thickness correlated significantly with disease duration, after adjusting for this, GCIP thickness remained significantly lower in SPMS than RRMS. GCIP thickness correlated significantly, and better than RNFL thickness, with EDSS, high-contrast, 2.5% low-contrast and 1.25% low-contrast letter acuity in MS. 13.6% of patients also demonstrated inner or outer nuclear layer thinning. Conclusions: OCT segmentation demonstrates in vivo GCIP thinning in all MS subtypes. GCIP thickness demonstrates better structure-function correlations (with vision and disability) in MS than RNFL thickness. In addition to commonly observed RNFL/GCIP thinning, retinal inner and outer nuclear layer thinning occur in MS.
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Citations
Cites
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011
Huang, D., Swanson, E. A., Lin, C. P., Schuman, J. S., Stinson, W. G., Chang, W., Hee, M. R., Flotte, T., Gregory, K., Puliafito, C. A., et al. (1991) · Science · doi:10.1126/science.1957169 · Cited by 13,788
Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”
Polman, C. H., Reingold, S. C., Edan, G., Filippi, M., Hartung, H., Kappos, L., Lublin, F. D., Metz, L. M., McFarland, H. F., O'Connor, P. W., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20703 · Cited by 5,017
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Defining the clinical course of multiple sclerosis: Results of an international survey
Lublin, F. D., Reingold, S. C., & National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis* (1996) · Neurology · doi:10.1212/wnl.46.4.907 · Cited by 3,686
(1985) · Archives of Ophthalmology · doi:10.1001/archopht.1985.01050120030015 · Cited by 2,540
Optical coherence tomography for ultrahigh resolution in vivo imaging
Fujimoto, J. G. (2003) · Nature Biotechnology · doi:10.1038/nbt892 · Cited by 1,033
Detection of Macular Ganglion Cell Loss in Glaucoma by Fourier-Domain Optical Coherence Tomography
Tan, O., Chopra, V., Lu, A. T.-H., Schuman, J. S., Ishikawa, H., Wollstein, G., Varma, R., & Huang, D. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2009.05.025 · Cited by 665
Relation of Visual Function to Retinal Nerve Fiber Layer Thickness in Multiple Sclerosis
FISHER, J., JACOBS, D., MARKOWITZ, C., GALETTA, S., VOLPE, N., NANOSCHIAVI, M., BAIER, M., FROHMAN, E., WINSLOW, H., & FROHMAN, T. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2005.10.040 · Cited by 658
Self-citationThree-dimensional Retinal Imaging with High-Speed Ultrahigh-Resolution Optical Coherence Tomography
Wojtkowski, M., Srinivasan, V., Fujimoto, J. G., Ko, T., Schuman, J. S., Kowalczyk, A., & Duker, J. S. (2005) · Ophthalmology · doi:10.1016/j.ophtha.2005.05.023 · Cited by 640
Cited by
Microcystic macular oedema in multiple sclerosis is associated with disease severity
Gelfand, J. M., Nolan, R., Schwartz, D. M., Graves, J., & Green, A. J. (2012) · Brain · doi:10.1093/brain/aws098 · Cited by 331
Ganglion Cell Loss in Relation to Visual Disability in Multiple Sclerosis
Walter, S. D., Ishikawa, H., Galetta, K. M., Sakai, R. E., Feller, D. J., Henderson, S. B., Wilson, J. A., Maguire, M. G., Galetta, S. L., Frohman, E., et al. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2011.11.032 · Cited by 294
Self-citationNeuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography
Bennett, J., de Seze, J., Lana-Peixoto, M., Palace, J., Waldman, A., Schippling, S., Tenembaum, S., Banwell, B., Greenberg, B., Levy, M., et al. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458514567216 · Cited by 252
Nolan‐Kenney, R. C., Liu, M., Akhand, O., Calabresi, P. A., Paul, F., Petzold, A., Balk, L., Brandt, A. U., Martínez‐Lapiscina, E. H., Saidha, S., et al. (2019) · Annals of Neurology · doi:10.1002/ana.25462 · Cited by 164
Self-citationStructured layer surface segmentation for retina OCT using fully convolutional regression networks
He, Y., Carass, A., Liu, Y., Jedynak, B. M., Solomon, S. D., Saidha, S., Calabresi, P. A., & Prince, J. L. (2021) · Medical Image Analysis · doi:10.1016/j.media.2020.101856 · Cited by 104
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Metadata
- Authors
- Saidha, S., Syc, S. B., Durbin, M. K., Eckstein, C., Oakley, J. D., Meyer, S. A., Conger, A., Frohman, T. C., Newsome, S., Ratchford, J. N., Frohman, E. M., & Calabresi, P. A.
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2011-08-24
- Volume
- 17
- Issue
- 12
- Pages
- 1449-1463
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2006175679
- Cited by
- 296
- References
- 31
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Saidha, S., Syc, S. B., Durbin, M. K., Eckstein, C., Oakley, J. D., Meyer, S. A., Conger, A., Frohman, T. C., Newsome, S., Ratchford, J. N., Frohman, E. M., & Calabresi, P. A. (2011). Visual dysfunction in multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell layer thickness than peripapillary retinal nerve fiber layer thickness. Multiple Sclerosis Journal. https://doi.org/10.1177/1352458511418630
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