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Cited by 22Multiple Sclerosis Research StudiesAdvanced MRI Techniques and ApplicationsNeuroinflammation and Neurodegeneration Mechanisms

Ultra-small superparamagnetic iron oxide enhancement is associated with higher loss of brain tissue structure in clinically isolated syndrome

Maarouf, Adil, Ferré, Jean-Christophe, Zaaraoui, Wafaa, Le Troter, Arnaud, Bannier, Elise, Berry, Isabelle, Guye, Maxime, Pierot, Laurent +6 more·2016·Multiple Sclerosis Journal
DOI 10.1177/1352458515607649
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Abstract

BACKGROUND: Macrophages are important components of inflammatory processes in multiple sclerosis, closely linked to axonal loss, and can now be observed in vivo using ultra-small superparamagnetic iron oxide (USPIO). In the present 1-year longitudinal study, we aimed to determine the prevalence and the impact on tissue injury of macrophage infiltration in patients after the first clinical event of multiple sclerosis. METHODS: Thirty-five patients, 32 years mean age, were imaged in a mean of 66 days after their first event using conventional magnetic resonance imaging, gadolinium (Gd) to probe blood-brain barrier integrity, USPIO to study macrophage infiltration and magnetization transfer ratio (MTR) to assess tissue structure integrity. Statistics were performed using two-group repeated-measures ANOVA. Any patient received treatment at baseline. RESULTS: At baseline, patients showed 17 USPIO-positive lesions reflecting infiltration of macrophages present from the onset. This infiltration was associated with local higher loss of tissue structure as emphasized by significant lower MTRnorm values (p<0.03) in USPIO(+)/Gd(+) lesions (n=16; MTRnormUSPIO(+)/Gd(+)=0.78 at baseline, MTRnormUSPIO(+)/Gd(+)=0.81 at M12) relative to USPIO(-)/Gd(+) lesions (n=67; MTRnormUSPIO(-)/Gd(+)=0.82 at baseline, MTRnormUSPIO(-)/Gd(+)=0.85 at M12). No interaction in MTR values was observed during the 12 months follow-up (lesion type × time). CONCLUSION: Infiltration of activated macrophages evidenced by USPIO enhancement, is present at the onset of multiple sclerosis and is associated with higher and persistent local loss of tissue structure. Macrophage infiltration affects more tissue structure while tissue recovery during the following year has a similar pattern for USPIO and Gd-enhanced lesions, leading to relative higher persistent local loss of tissue structure in lesions showing USPIO enhancement at baseline.

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  • Iron oxide nanoparticles have a key advantage over gadolinium-based contrast agents in MS imaging: they visualize monocyte/macrophage infiltration, which correlates with ongoing demyelination and disease progression.

    “In this context, a key advantage of using iron oxide nanoparticles over gadolinium-based contrast agents is the visualization of monocyte/macrophage infiltration by the former, which correlates with ongoing demyelination and is a hallmark of disease progression in MS [175–177].”

    From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [177]

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Authors
Maarouf, A., Ferré, J.-C., Zaaraoui, W., Le Troter, A., Bannier, E., Berry, I., Guye, M., Pierot, L., Barillot, C., Pelletier, J., Tourbah, A., Edan, G., Audoin, B., & Ranjeva, J.-P.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Institut national de recherche en sciences et technologies du numérique (FR)
  • Aix-Marseille Université, CNRS, CRMBM UMR 7339, Marseille, France
  • INRIA Rennes - VisAGeS Team, Rennes, France
  • Hôpital Rangueil (FR)
  • Centre Hospitalier Universitaire de Reims (FR)
  • Hôpital Pontchaillou (FR)
Corresponding author
Maarouf, Adil
ORCID
Venue
Multiple Sclerosis Journal
Publisher
SAGE Publications
Published
2015-10-09
Volume
22
Issue
8
Pages
1032-1039
ISSN
  • 1352-4585 (ISSN-L)
  • 1477-0970
DOI
10.1177/1352458515607649
OpenAlex
W2401931296
Cited by
22
References
32
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 3
FWCI
2.64
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Multiple Sclerosis Journal (publishedVersion)
  • PubMed (publishedVersion)
  • HAL Portal Artxiker (Hindustan Aeronautics Limited (India)) (submittedVersion)
  • HAL AMU (submittedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
clinically isolated syndrome, multiple sclerosis, macrophage infiltration, axonal loss, magnetization transfer ratio, gadolinium-enhancing lesions, brain tissue injury, lesion progression, tissue recovery
MeSH terms
Adult, Brain, Contrast Media, Demyelinating Diseases, Dextrans, Female, France, Humans, Longitudinal Studies, Macrophage Activation, Macrophages, Magnetic Resonance Imaging, Male, Nerve Degeneration, Predictive Value of Tests, Prognosis, Prospective Studies, Time Factors, Disease Progression, Young Adult, Magnetite Nanoparticles

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