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Cited by 9Neurotransmitter Receptor Influence on BehaviorMultiple Sclerosis Research StudiesGenetic Associations and Epidemiology

Polymorphism in the serotonin transporter gene polymorphisms ( 5-HTTLPR ) modifies the association between significant life events and depression in people with multiple sclerosis

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Saul, Alice, Taylor, Bruce, Simpson, Steve, Ponsonby, Anne-Louise, Blizzard, Leigh, Dwyer, Terence, McMorran, Brendan, Wood, Brenda +1 more·2019·Multiple Sclerosis Journal
DOI 10.1177/1352458518770021
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Abstract

Background: In the general population, variation in the serotonin-transporter-linked polymorphic region ( 5-HTTLPR) has been shown to modify the association between stressful events and depression/anxiety. This has not been examined in people with multiple sclerosis (MS). Objective: We examined the interaction between significant life events (SLE), 5-HTTLPR and depression/anxiety. Methods: A population-based longitudinal cohort of 198 people with MS was followed biannually for 2.5 years. Depression and anxiety symptoms were measured at each review using the Hospital Anxiety and Depression Scale (HADS). SLEs were assessed using a questionnaire based on the Social Readjustment Rating Scale. Results: We found an interaction between SLE load in the previous 12 months and functional variation in the 5-HTTLPR allele type in predicting depression, with the association between SLE load and depression being stronger for those with S/S allele type (β = 0.21 (95% confidence interval (CI): 0.09–0.33) per 10-unit increase) and S/L (β = 0.14 (95% CI: 0.05–0.24)) compared to L/L allele type (β = 0.04 (95% CI: −0.05 to 0.24); p interaction < 0.001). No convincing evidence of an interaction was found with anxiety. Conclusion: We found that the association between SLE load and MS depression severity was stronger among those with one or two copies of the short allele of the 5-HTTLPR. The identification of a gene–environment interaction between SLEs and depression in a population where depression is partly disease-driven is novel.

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  • Significant life events interact with functional variation in the 5-HTTLPR allele type to influence depression in the context of multiple sclerosis.

    “A study reported an interaction of significant life events with functional variation in the serotonin-transporter-linked polymorphic region (5-HTTLPR) allele type (in the context of multiple sclerosis) and linked this to depression [361]”

    From Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature (2021) · cites this paper as [361]

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Authors
Saul, A., Taylor, B., Simpson, S., Ponsonby, A.-L., Blizzard, L., Dwyer, T., McMorran, B., Wood, B., & van der Mei, I. A.
Affiliations
  • Menzies Institute for Medical Research (AU)
  • Murdoch Children's Research Institute (AU)
  • The George Institute for Global Health (GB)
  • Australian National University (AU)
  • Menzies Institute for Medical Research, Hobart, TAS, Australia
ORCID
Venue
Multiple Sclerosis Journal
Publisher
SAGE Publications
Published
2018-04-23
Volume
25
Issue
6
Pages
848-855
ISSN
  • 1352-4585 (ISSN-L)
  • 1477-0970
DOI
10.1177/1352458518770021
OpenAlex
W2800283862
Cited by
9
References
35
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 2
FWCI
0.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Multiple Sclerosis Journal (publishedVersion)
  • PubMed (publishedVersion)
  • eCite Digital Repository (University of Tasmania) (submittedVersion)
  • UTAS Research Repository (submittedVersion)
  • Figshare (submittedVersion, cc-by)
Funders
University of Tasmania (V0027334, BT000001)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
5-HTTLPR, serotonin transporter gene, multiple sclerosis, depression, anxiety, major life events, gene-environment interaction, short allele, social readjustment, life events, genetic polymorphism
MeSH terms
Adult, Aged, Depression, Female, Humans, Life Change Events, Longitudinal Studies, Male, Middle Aged, Multiple Sclerosis, Severity of Illness Index, Polymorphism, Single Nucleotide, Serotonin Plasma Membrane Transport Proteins, Young Adult, Gene-Environment Interaction

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