Contribution of Mitochondrial Dysfunction and Oxidative Stress to Cellular Premature Senescence Induced by Antiretroviral Thymidine Analogues

Caron, Martine; Auclair, Martine; Vissian, Anais; Vigouroux, Corinne; Capeau, Jacqueline

doi:10.1177/135965350801300103

Cited by 114HIV-related health complications and treatmentsMitochondrial Function and PathologyHIV/AIDS drug development and treatment

Contribution of Mitochondrial Dysfunction and Oxidative Stress to Cellular Premature Senescence Induced by Antiretroviral Thymidine Analogues

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Caron, Martine, Auclair, Martine, Vissian, Anais, Vigouroux, Corinne, Capeau, Jacqueline·2008·Antiviral Therapy

DOI 10.1177/135965350801300103

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Abstract

Objectives: Treatment of HIV-infected patients is associated with early onset of aging-related comorbidities. Some of the adverse effects of antiretroviral therapy have been attributed to the mitochondrial toxicity of nucleoside reverse transcriptase inhibitors (NRTI), and it is of note that mitochondrial dysfunction and oxidative stress are involved in the aging processes. In this regard, we examined whether NRTIs could accelerate the senescence of cultured cells. Methods: Human fibroblasts were exposed to NRTIs from culture passage 1 to 14. Cytochrome c-oxidase (COX) subunits 2 and 4, mitochondrial potential and mass, and reactive oxygen species (ROS) were quantified at each passage. Proliferation, cell-cycle arrest, senescence-associated β-galactosidase activity, and morphology were assessed in parallel. Mitochondrial and senescence markers were assessed in cultured murine preadipocytes and in fat samples from lipodystrophic HIV-infected patients. Results: Stavudine and zidovudine induced mitochondrial dysfunction and increased ROS levels in fibroblasts at early culture passages, while cell division gradually slowed. At passages 8–12, fibroblasts exposed to stavudine or zidovudine but not abacavir, didanosine, lamivudine and tenofovir were senescent, on the basis of p16 INK4 and p21 WAF-1 protein expression, cell morphology and senescence-associated-β-galactosidase activity. Senescence markers and COX2 underexpression were also found in 3T3-F442A preadipocytes exposed for 7 weeks to stavudine or zidovudine, but not lamivudine, and in adipose tissue samples from lipodystrophic HIV-infected patients on antiretroviral regimens containing stavudine or zidovudine. Conclusions: Mitochondrial changes and oxidative damage could partly explain the premature senescence of fibroblasts and adipose cells induced by stavudine and zidovudine. This suggests that thymidine analogues might be involved in the early aging-related diseases observed in some HIV-infected patients taking antiretroviral drugs.

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Protease inhibitors and NRTIs can induce p16 and p21 expression in human adipose tissue.
“To our knowledge, no evidence yet exists on whether antiretroviral compounds can induce senescence in adipocytes in vitro, but it has been demonstrated that protease inhibitors and NRTIs can induce p16 and p21 expression in human adipose tissue (Caron et al, 2007, 2008).”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Caron et al, 2008

The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works
Adverse effects of antiretroviral therapy
Carr, A. D., & Cooper, D. A. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02854-3 · Cited by 1,062 · see citing works
The signals and pathways activating cellular senescence
Ben-Porath, I., & Weinberg, R. A. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.013 · Cited by 1,046 · see citing works
Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy
Brinkman, K., Smeitink, J. A. M., Romijn, J. A., & Reiss, P. (1999) · The Lancet · doi:10.1016/s0140-6736(99)06102-4 · Cited by 863 · see citing works
Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective
Lewis, W., Day, B. J., & Copeland, W. C. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1201 · Cited by 496 · see citing works
Assessment of Mitochondrial Toxicity in Human Cells Treated with Tenofovir: Comparison with Other Nucleoside Reverse Transcriptase Inhibitors
Birkuš, G., Hitchcock, M. J. M., & Cihlář, T. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.3.716-723.2002 · Cited by 436 · see citing works
Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance
Bastard, J., Caron, M., Vidal, H., Jan, V., Auclair, M., Vigouroux, C., Luboinski, J., Laville, M., Maachi, M., Girard, P., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08094-7 · Cited by 405 · see citing works
Self-citation
The HIV Protease Inhibitor Indinavir Impairs Sterol Regulatory Element-Binding Protein-1 Intranuclear Localization, Inhibits Preadipocyte Differentiation, and Induces Insulin Resistance
Caron, M., Auclair, M., Vigouroux, C., Glorian, M., Forest, C. D., & Capeau, J. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1378 · Cited by 310 · see citing works
Self-citation
Accumulation of Short Telomeres in Human Fibroblasts Prior to Replicative Senescence
Martens, U. M., Chavez, E. A., Poon, S. S. S., Schmoor, C., & Lansdorp, P. M. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4823 · Cited by 263 · cited 1× · see citing works
“Population doubling level The population doubling level (PDL) was calculated as previously described [39] as log2 (D/D0), where D0 and D are the numbers of cells at seeding and harvesting, respectively.”
Method
Lipodystrophy-associated morphological, cholesterol and triglyceride abnormalities in a population-based HIV/AIDS treatment database
Heath, K., Hogg, R. S., Chan, K., Harris, M., Montessori, V., O’Shaughnessy, M. V., & Montaner, J. S. G. (2001) · AIDS · doi:10.1097/00002030-200101260-00013 · Cited by 250 · see citing works
Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence
Caron, M., Auclair, M., Donadille, B., Béréziat, V, Guerci, B., Laville, M., Narbonne, H., Bodemer, C., Lascols, O., Capeau, J., et al. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402197 · Cited by 226 · cited 2× · see citing works
“Accordingly, we recently reported that some protease inhibitors can trigger premature senescence via a mitochondrial oxidative stress, in vitro, in cultured fibroblasts, and in vivo at the fat tissue level of HIV-infected patients [37].”
BackgroundSelf-citation
Care of patients with hepatitis C and HIV co-infection
Soriano, V., Puoti, M., Sulkowski, M., Mauss, S., Cacoub, P., Cargnel, A., Dieterich, D. T., Hatzakis, A. E., & Rockstroh, J. K. (2004) · AIDS · doi:10.1097/00002030-200401020-00001 · Cited by 222 · see citing works
HIV lipodystrophy: prevalence, severity and correlates of risk in Australia
Miller, J., Carr, A. D., Emery, S., Law, M. G., Mallal, S. A., Baker, D. A., Smith, D. E., Kaldor, J. M., & Cooper, D. (2003) · HIV Medicine · doi:10.1046/j.1468-1293.2003.00159.x · Cited by 214 · see citing works
Mitochondrial Alterations with Mitochondrial DNA Depletion in the Nerves of AIDS Patients with Peripheral Neuropathy Induced by 2′3′-Dideoxycytidine (ddC)
Dalakas, M. C., Semino‐Mora, C., & Leon‐Monzon, M. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780367 · Cited by 211 · see citing works
Some HIV Antiretrovirals Increase Oxidative Stress and Alter Chemokine, Cytokine or Adiponectin Production in Human Adipocytes and Macrophages
Lagathu, C., Eustace, B. K., Prot, M., Frantz, D., Gu, Y., Bastard, J., Maachi, M., Azoulay, S., Briggs, M., Caron, M., et al. (2007) · Antiviral Therapy · doi:10.1177/135965350701200407 · Cited by 185 · see citing works
Self-citation
Premature ageing of the immune system: the cause of AIDS?
Appay, V., & Rowland-Jones, S. L. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02338-4 · Cited by 173 · see citing works
Depletion of mitochondrial DNA in liver under antiretroviral therapy with didanosine, stavudine, or zalcitabine
Walker, U. A., Bäuerle, J., Laguno, M., Murillas, J., Mauss, S., Schmutz, G., Setzer, B., Miquel, R., Gatell, J. M., & Mallolas, J. (2004) · Hepatology · doi:10.1002/hep.20074 · Cited by 171 · see citing works
In Vivo, Nucleoside Reverse‐Transcriptase Inhibitors Alter Expression of Both Mitochondrial and Lipid Metabolism Genes in the Absence of Depletion of Mitochondrial DNA
Mallon, P. W. G., Unemori, P., Sedwell, R., Morey, A. L., Rafferty, M., Williams, K., Chisholm, D. J., Samaras, K., Emery, S., Kelleher, A. D., et al. (2005) · The Journal of Infectious Diseases · doi:10.1086/429697 · Cited by 170 · see citing works
Altered Fat Differentiation and Adipocytokine Expression are Inter-Related and Linked to Morphological Changes and Insulin Resistance in HIV-1-Infected Lipodystrophic Patients
Jan, V., Cervera, P., Maachi, M., Baudrimont, M., Kim, M. J., Vidal, H., Girard, P., Levan, P., Rozenbaum, W., Lombès, A., et al. (2004) · Antiviral Therapy · doi:10.1177/135965350400900412 · Cited by 169 · see citing works
Self-citation
Mitochondrial DNA and aging
ALEXEYEV, M. F., LeDoux, S. P., & Wilson, G. L. (2004) · Clinical Science · doi:10.1042/cs20040148 · Cited by 149 · see citing works
Antiretroviral nucleoside and nucleotide analogues and mitochondria
Cossarizza, A., & Moyle, G. J. (2004) · AIDS · doi:10.1097/00002030-200401230-00002 · Cited by 143 · see citing works
Contribution of p16 INK4a and p21 CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53
Chen, J., Huang, X., Halicka, D., Brodsky, S., Avram, A., Eskander, J., Bloomgarden, N. A., Darzynkiewicz, Z., & Goligorsky, M. S. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00364.2005 · Cited by 142 · see citing works
HIV Infection and Bone Mineral Density in Middle-Aged Women
Arnsten, J. H., Freeman, R., Howard, A. A., Floris-Moore, M., Santoro, N. F., & Schoenbaum, E. E. (2006) · Clinical Infectious Diseases · doi:10.1086/501015 · Cited by 137 · see citing works
Insights into the Molecular Mechanism of Mitochondrial Toxicity by AIDS Drugs
Feng, J. Y., Johnson, A. A., Johnson, K. A., & Anderson, K. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101156200 · Cited by 130 · see citing works
Oxidant Stress Is Increased during Treatment of Human Immunodeficiency Virus Infection
Hulgan, T., Morrow, J. D., D’Aquila, R. T., Raffanti, S. P., Morgan, M., Rebeiro, P. F., & Haas, D. W. (2003) · Clinical Infectious Diseases · doi:10.1086/379776 · Cited by 110 · see citing works
The HIV-1 nucleoside reverse transcriptase inhibitors stavudine and zidovudine alter adipocyte functions in vitro
Caron, M., Auclair, M., Lagathu, C., Lombès, A., Walker, U. A., Kornprobst, M., & Capeau, J. (2004) · AIDS · doi:10.1097/00002030-200411050-00004 · Cited by 107 · see citing works
Self-citation
Redox signalling involving NADPH oxidase-derived reactive oxygen species
Dworakowski, R., Anilkumar, N., Zhang, M., & Shah, A. M. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340960 · Cited by 105 · see citing works
Decreased antioxidant defence in individuals infected by the human immunodeficiency virus
Treitinger, Spada, Verdi, Miranda, Oliveira, Silveira, Moriel, P., & Abdalla, A. (2000) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2000.00642.x · Cited by 105 · see citing works
Anti-HIV drugs and the mitochondria
Pinti, M., Salomoni, P., & Cossarizza, A. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.001 · Cited by 102 · see citing works
Understanding aging: revealing order out of chaos
Dufour, É., & Larsson, N. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.04.020 · Cited by 101 · see citing works
Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: the adipocyte as a target of anti-retroviral-induced mitochondrial toxicity
Villarroya, F., Domingo, P., & Giralt, M. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.12.005 · Cited by 86 · see citing works
Uridine Abrogates the Adverse Effects of Antiretroviral Pyrimidine Analogues on Adipose Cell Functions
Walker, U. A., Auclair, M., Lebrecht, D., Kornprobst, M., Capeau, J., & Caron, M. (2006) · Antiviral Therapy · doi:10.1177/135965350601100109 · Cited by 86 · see citing works
Self-citation
Contribution of p16INK4a to replicative senescence of human fibroblasts
Brookes, S., Rowe, J., del Arroyo, A. G., BOND, J. A., & Peters, G. G. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.035 · Cited by 83 · see citing works
Mitochondrial Proliferation, Dna Depletion and Adipocyte Differentiation in Subcutaneous Adipose Tissue of HIV-Positive Haart Recipients
Pace, C. S., Martin, A. M., Hammond, E., Mamotte, C. D. S., Nolan, D. A., & Mallal, S. A. (2003) · Antiviral Therapy · doi:10.1177/135965350300800409 · Cited by 82 · see citing works
Apoptosis in mitochondrial myopathies is linked to mitochondrial proliferation
Auré, K., Fayet, G., Leroy, J. P., Lacène, E., Romero, N. B., & Lombès, A. (2006) · Brain · doi:10.1093/brain/awl061 · Cited by 79 · see citing works
Mitochondrial dysfunction in AIDS and its treatment
Gerschenson, M., & Brinkman, K. (2004) · Mitochondrion · doi:10.1016/j.mito.2004.07.025 · Cited by 78 · see citing works
Mitochondrial oxidative stress in human hepatoma cells exposed to stavudine
Velsor, L. W., Kovacevic, M., Goldstein, M., Leitner, H., Lewis, W., & Day, B. J. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.03.005 · Cited by 72 · see citing works
Mitochondria as Cell Targets of AZT (Zidovudine)
Barile, M., Valenti, D., Quagliariello, E., & Passarella, S. (1998) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(98)00041-x · Cited by 68 · see citing works
Reduction of mitochondrial DNA content and respiratory chain activity occurs in adipocytes within 6–12 months of commencing nucleoside reverse transcriptase inhibitor therapy
Hammond, E., Nolan, D. A., JAMES, I. R., Metcalf, C., & Mallal, S. A. (2004) · AIDS · doi:10.1097/00002030-200403260-00015 · Cited by 57 · see citing works
Tissue-Specific Associations Between Mitochondrial DNA Levels and Current Treatment Status in HIV-Infected Individuals
Cherry, C. L., Nolan, D. A., JAMES, I. R., McKinnon, E., Mallal, S. A., Gahan, M. E., Lal, L., McArthur, J. C., & Wesselingh, S. L. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000224974.67962.ce · Cited by 56 · see citing works
Assessment of Adipokine Expression and Mitochondrial Toxicity in HIV Patients With Lipoatrophy on Stavudine- and Zidovudine-Containing Regimens
Jones, S. P., Qazi, N. A., Morelese, J., Lebrecht, D., Sutinen, J., Yki‐Järvinen, H., Back, D. J., Pirmohamed, M., Gazzard, B., Walker, U. A., et al. (2005) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000187443.30838.3e · Cited by 55 · see citing works
Aging and HIV Infection
Kohli, R., Klein, R. S., Schoenbaum, E. E., Anastos, K., MINKOFF, H. L., & Sacks, H. S. (2006) · Journal of Urban Health · doi:10.1007/s11524-005-9005-6 · Cited by 54 · see citing works
Oxidative Stress in NRTI-Induced Toxicity: Evidence From Clinical Experience and Experiments In Vitro and In Vivo
Day, B. J., & Lewis, W. (2004) · Cardiovascular Toxicology · doi:10.1385/ct:4:3:207 · Cited by 53 · see citing works
The low dose dexamethasone suppression test: Effect of time of administration and dose
Barton, C., March, S., & Wittert, G. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344008 · Cited by 48 · see citing works
A-type nuclear lamins, progerias and other degenerative disorders
Smith, E. D., Kudlow, B. A., Frock, R. L., & Kennedy, B. K. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.10.006 · Cited by 47 · see citing works
Changes in Body Composition and Mitochondrial Nucleic Acid Content in Patients Switched from Failed Nucleoside Analogue Therapy to Ritonavir‐Boosted Indinavir and Efavirenz
Boyd, M. A., Carr, A. D., Ruxrungtham, K., Srasuebkul, P., Bien, D. D., Law, M. G., Wangsuphachart, S., Krisanachinda, A., Lerdlum, S., Lange, J. M. A., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/505709 · Cited by 32 · see citing works
Effects of HIV-1 infection and aging on neurobehavioral functioning
Cherner, M., Ellis, R. J., Lazzaretto, D., Young, C., Mindt, M. R., Atkinson, J. H., Grant, I., & Heaton, R. K. (2004) · AIDS · doi:10.1097/00002030-200418001-00005 · Cited by 20 · see citing works
Growing old with HIV
Senior, K. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70279-6 · Cited by 13 · see citing works

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Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094 · see citing works
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Barrera, G. (2012) · ISRN Oncology · doi:10.5402/2012/137289 · Cited by 822 · see citing works
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Triant, V. A., Brown, T. T., Lee, H., & Grinspoon, S. K. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0828 · Cited by 489 · see citing works
The Absence of CD4+ T Cell Count Recovery Despite Receipt of Virologically Suppressive Highly Active Antiretroviral Therapy: Clinical Risk, Immunological Gaps, and Therapeutic Options
Gazzola, L., Tincati, C., Bellistrì, G. M., Monforte, A. D., & Marchetti, G. C. (2009) · Clinical Infectious Diseases · doi:10.1086/595851 · Cited by 236 · see citing works
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The struggle of a good friend getting old: cellular senescence in viral responses and therapy
Kohli, J., Veenstra, I., & Demaria, M. (2021) · The EMBO Reports · doi:10.15252/embr.202052243 · Cited by 52 · see citing works
The protease inhibitor atazanavir triggers autophagy and mitophagy in human preadipocytes
Gibellini, L., Biasi, S. D., Pinti, M., Nasi, M., Riccio, M., Carnevale, G., Cavallini, G. M., de Oyanguren, F. S., O’Connor, J., Mussini, C., et al. (2012) · AIDS · doi:10.1097/qad.0b013e328359b8be · Cited by 50 · see citing works
HIV-Associated Lipodystrophy: Impact of Antiretroviral Therapy
Guaraldi, G., Stentarelli, C., Zona, S., & Santoro, A. (2013) · Drugs · doi:10.1007/s40265-013-0108-1 · Cited by 50 · see citing works
Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation
Stankov, M. V., Panayotova‐Dimitrova, D., Leverkus, M., Vondran, F. W. R., Bauerfeind, R., Binz, A., & Behrens, G. M. N. (2012) · AIDS · doi:10.1097/qad.0b013e32835804f9 · Cited by 49 · see citing works
Adipose Tissue in HIV Infection
Koethe, J. R. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160028 · Cited by 49 · see citing works
Major health impact of accelerated aging in young HIV-infected individuals on antiretroviral therapy
Rajasuriar, R., Chong, M. L., Bashah, N. S. A., Aziz, S. A. A., McStea, M., Lee, E. C. Y., Wong, P. L., Azwa, I., Omar, S. F. S., Lai, P. S. M., et al. (2017) · AIDS · doi:10.1097/qad.0000000000001475 · Cited by 47 · see citing works
Abacavir and didanosine induce the interaction between human leukocytes and endothelial cells through Mac-1 upregulation
Pablo, C. D., Orden, S., Apostolova, N., Blanquer, A., Esplugues, J. V., & Álvarez, Á. (2010) · AIDS · doi:10.1097/qad.0b013e32833a2b02 · Cited by 46 · see citing works
HIV-1, reactive oxygen species, and vascular complications
Porter, K. M., & Sutliff, R. L. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.019 · Cited by 45 · see citing works
Mitochondrial DNA Depletion and Respiratory Chain Activity in Primary Human Subcutaneous Adipocytes Treated with Nucleoside Analogue Reverse Transcriptase Inhibitors
Stankov, M. V., Lücke, T., Das, A. M., Schmidt, R. E., & Behrens, G. M. N. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00914-09 · Cited by 44 · see citing works
Epidemiology, pathophysiology, and prevention of heart failure in people with HIV
Sinha, A., & Feinstein, M. J. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.01.002 · Cited by 43 · see citing works
Oxydative stress alters nuclear shape through lamins dysregulation
Barascu, A., Chalony, C. L., Pennarun, G., Genet, D., Zaarour, N., & Bertrand, P. (2012) · Nucleus · doi:10.4161/nucl.21674 · Cited by 42 · see citing works
Senescent cells at the crossroads of aging, disease, and tissue homeostasis
Kuehnemann, C., & Wiley, C. D. (2023) · Aging Cell · doi:10.1111/acel.13988 · Cited by 41 · see citing works
Impact of HIV/simian immunodeficiency virus infection and viral proteins on adipose tissue fibrosis and adipogenesis
Gorwood, J., Bourgeois, C., Mantecon, M., Atlan, M., Pourcher, V., Pourcher, G., Grand, R. L., Desjardins, D., Fève, B., Lambotte, O., et al. (2019) · AIDS · doi:10.1097/qad.0000000000002168 · Cited by 41 · see citing works
Self-citation
Nutrition and the HIV-associated lipodystrophy syndrome
Loonam, C., & Mullen, A. (2012) · Nutrition Research Reviews · doi:10.1017/s0954422411000138 · Cited by 40 · see citing works
Oxidants and Antioxidants in the Pathogenesis of HIV/AIDS
Agarwal, A. (2011) · The Open Reproductive Science Journal · doi:10.2174/1874255601103010154 · Cited by 39 · see citing works
SIV Infection and the HIV Proteins Tat and Nef Induce Senescence in Adipose Tissue and Human Adipose Stem Cells, Resulting in Adipocyte Dysfunction
Gorwood, J., Ejlalmanesh, T., Bourgeois, C., Mantecon, M., Rose, C., Atlan, M., Desjardins, D., Grand, R. L., Fève, B., Lambotte, O., et al. (2020) · Cells · doi:10.3390/cells9040854 · Cited by 38 · see citing works
Self-citation
Adipose Tissue is Enriched for Activated and Late-Differentiated CD8+ T Cells and Shows Distinct CD8+ Receptor Usage, Compared With Blood in HIV-Infected Persons
Koethe, J. R., McDonnell, W. J., Kennedy, A. J., Abana, C. O., Pilkinton, M. A., Setliff, I., Georgiev, I. S., Barnett, L. D., Hager, C. C., Smith, R. M., et al. (2017) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001573 · Cited by 36 · see citing works
The role of TEMRA cell-mediated immune senescence in the development and treatment of HIV disease
Guo, L., Liu, X., & Su, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1284293 · Cited by 34 · see citing works
Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes
Terelius, Y., Figler, R. A., Marukian, S., Collado, M. S., Lawson, M. J., Mackey, A. J., Manka, D., Qualls, C. W., Blackman, B. R., Wamhoff, B. R., et al. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.11.023 · Cited by 33 · see citing works
Probing the Interface of HIV and Inflammaging
Sieg, S. F., Shive, C. L., Panigrahi, S., & Freeman, M. L. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-021-00547-0 · Cited by 33 · see citing works
HIV infection and aging of the innate immune system
Hearps, A. C., Angelovich, T. A., Jaworowski, A., MILLS, J. S., LANDAY, A. L., & Crowe, S. M. (2011) · Sexual Health · doi:10.1071/sh11028 · Cited by 33 · see citing works
Tumor cell redox state and mitochondria at the center of the non-canonical activity of telomerase reverse transcriptase
Indran, I. R., Hande, M. P., & Pervaiz, S. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.12.001 · Cited by 33 · see citing works
Parallel high throughput neuronal toxicity assays demonstrate uncoupling between loss of mitochondrial membrane potential and neuronal damage in a model of HIV-induced neurodegeneration
White, M. G., Wáng, Y., Akay, C., Lindl, K. A., Kolson, D. L., & Jordan‐Sciutto, K. L. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.01.013 · Cited by 32 · see citing works
Antiretroviral‐Related Adipocyte Dysfunction and Lipodystrophy in HIV‐Infected Patients: Alteration of the PPARγ‐Dependent Pathways
Caron, M., Vigouroux, C., Bastard, J., & Capeau, J. (2008) · PPAR Research · doi:10.1155/2009/507141 · Cited by 32 · see citing works
Self-citation
HIV antiretroviral therapy drugs induce premature senescence and altered physiology in HUVECs
Cohen, J., D’Agostino, L., Tüzer, F., & Torres, C. A. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.07.008 · Cited by 31 · see citing works
The far-reaching HAND of cART: cART effects on astrocytes
Gonzalez, H., Podany, A. T., Al‐Harthi, L., & Wallace, J. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09907-w · Cited by 31 · see citing works
HIV patients presenting common adverse drug events caused by highly active antiretroviral therapy in Tanzania
Minzi, O., Irunde, H., & Moshiro, C. S. (2009) · Tanzania journal of health research/Tanzania Journal of Health Research · doi:10.4314/thrb.v11i1.43243 · Cited by 30 · see citing works
Zidovudine Induces Downregulation of Mitochondrial Deoxynucleoside Kinases: Implications for Mitochondrial Toxicity of Antiviral Nucleoside Analogs
Sun, R., Eriksson, S., & Wang, L. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03613-14 · Cited by 30 · see citing works
Adipocyte Differentiation, Mitochondrial Gene Expression and Fat Distribution: Differences between Zidovudine and Tenofovir after 6 Months
Boothby, M., McGee, K. C., Tomlinson, J., Gathercole, L., McTernan, P. G., Shojaee‐Moradie, F., Umpleby, A. M., Nightingale, P., & Shahmanesh, M. (2009) · Antiviral Therapy · doi:10.3851/imp1457 · Cited by 28 · see citing works
Effects of Switching from Stavudine to Raltegravir on Subcutaneous Adipose Tissue in HIV-Infected Patients with HIV/HAART-Associated Lipodystrophy Syndrome (HALS). A Clinical and Molecular Study
Domingo, P., Gutiérrez, M. D. M., Gallego-Escuredo, J. M., Torres, F., Mateo, G. M., Villarroya, J., Santos, I. D. L., Domingo, J. C., Villarroya, F., del Río, L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089088 · Cited by 28 · see citing works
Oxidative Stress Associated to Disease Progression and Toxicity during Antiretroviral Therapy in Human Immunodeficiency Virus Infection
Valle, L., Hernández, R., & Ávila, J. (2013) · Journal of Virology and Microbiology · doi:10.5171/2013.279685 · Cited by 28 · see citing works
Increased pericardial fat accumulation is associated with increased intramyocardial lipid content and duration of highly active antiretroviral therapy exposure in patients infected with human immunodeficiency virus: a 3T cardiovascular magnetic resonance feasibility study
Díaz‐Zamudio, M., Dey, D., Labounty, T. M., Nelson, M. D., Fan, Z., Szczepaniak, L. S., Hsieh, B. P. C., Rajani, R., Berman, D. S., Li, D., et al. (2015) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-015-0193-2 · Cited by 25 · see citing works
Thymidine Analogues Suppress Autophagy and Adipogenesis in Cultured Adipocytes
Stankov, M. V., Panayotova‐Dimitrova, D., Leverkus, M., Schmidt, R. E., & Behrens, G. M. N. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01560-12 · Cited by 24 · see citing works
Relationship between plasma bilirubin level and oxidative stress markers in HIV ‐infected patients on atazanavir‐ vs. efavirenz‐based antiretroviral therapy
Estrada, V., Monge, S., Gómez‐Garré, D., Sobrino‐Vegas, P., Masiá, M., Berenguer, J., Portilla, J., Viladés, C., Martínez, E., & Blanco, J. R. (2016) · HIV Medicine · doi:10.1111/hiv.12368 · Cited by 23 · see citing works
Chronic Nucleoside Reverse Transcriptase Inhibitors Disrupt Mitochondrial Homeostasis and Promote Premature Endothelial Senescence
Chen, Y., Stampley, J., Irving, B. A., & Dugas, T. R. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz203 · Cited by 22 · see citing works
Etiology and pathophysiology of heart failure in people with HIV
Choi, H., Dey, A. K., Sharma, G., Bhoite, R. R., Burkholder, G., Fedson, S., & Jneid, H. M. (2021) · Heart Failure Reviews · doi:10.1007/s10741-020-10048-8 · Cited by 22 · see citing works
Down-regulation of mitochondrial thymidine kinase 2 and deoxyguanosine kinase by didanosine: Implication for mitochondrial toxicities of anti-HIV nucleoside analogs
Sun, R., Eriksson, S., & Wang, L. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.06.098 · Cited by 18 · see citing works
Systemic Dysfunction of Osteoblast Differentiation in Adipose-Derived Stem Cells from Patients with Multiple Myeloma
Béréziat, V., Mazurier, C., Auclair, M., Ferrand, N., Jolly, S., Marie, T., Kobari, L., Toillon, I., Delhommeau, F., Fève, B., et al. (2019) · Cells · doi:10.3390/cells8050441 · Cited by 17 · see citing works
Self-citation
Endothelial mitochondrial senescence accelerates cardiovascular disease in antiretroviral-receiving HIV patients
Chen, Y.-F., & Dugas, T. R. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.09.018 · Cited by 16 · see citing works
Telomere Length Shortening in Microglia: Implication for Accelerated Senescence and Neurocognitive Deficits in HIV
Hsiao, C.-B., Bedi, H., Gomez, R., Khan, A., Meciszewski, T., Aalinkeel, R., Khoo, T. C., Sharikova, A. V., Khmaladze, A. T., & Mahajan, S. D. (2021) · Vaccines · doi:10.3390/vaccines9070721 · Cited by 16 · see citing works
3D Spheroids of Human Primary Urine-Derived Stem Cells in the Assessment of Drug-Induced Mitochondrial Toxicity
Ding, H., Jambunathan, K., Jiang, G., Margolis, D. M., Leng, I., Ihnat, M. A., Ma, J., Mirsalis, J. C., & Zhang, Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051042 · Cited by 15 · see citing works
Reciprocal Effects of Antiretroviral Drugs Used To Treat HIV Infection on the Fibroblast Growth Factor 21/β-Klotho System
Moure, R., Domingo, P., Villarroya, J., Gasa, L., Gallego-Escuredo, J. M., Quesada‐López, T., Morón‐Ros, S., Maroto, A. F., Mateo, G. M., Domingo, J. C., et al. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00029-18 · Cited by 15 · see citing works
Dynamics of leukocyte telomere length in pregnant women living with HIV, and HIV-negative pregnant women: A longitudinal observational study
Saberi, S., Kalloger, S. E., Zhu, M. M. T., Sattha, B., Maan, E. J., van Schalkwyk, J., Money, D., Côté, H. C. F., & the CIHR Team in Cellular Aging and HIV Comorbidities in Women and Children (CARMA) (2019) · PLoS ONE · doi:10.1371/journal.pone.0212273 · Cited by 14 · see citing works
Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells
Kobari, L., Auclair, M., Piau, O., Ferrand, N., Zaoui, M., Delhommeau, F., Fève, B., Sabbah, M., & Garderet, L. (2021) · Leukemia · doi:10.1038/s41375-021-01428-6 · Cited by 14 · see citing works
Self-citation
Antiretroviral molecules and cardiovascular diseases.
Gibellini, D., Borderi, M., Clò, A., Morini, S., Miserocchi, A., Bon, I., & Re, M. C. (2012) · PubMed · Cited by 13 · see citing works
Efficacy and safety of ritonavir-boosted dual protease inhibitor therapy in antiretroviral-naive HIV-1-infected patients: the 2IP ANRS 127 study
Landman, R., Capitant, C., Descamps, D., Chazallon, C., Peytavin, G., Katlama, C., Pialoux, G., Bentata, M., Brun‐Vézinet, F., Aboulker, J.-P., et al. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp146 · Cited by 13 · see citing works
Evidence for a Shift to Anaerobic Metabolism in Adipose Tissue in Efavirenz-Containing Regimens for HIV with Different Nucleoside Backbones
McGee, K. C., Shahmanesh, M., Boothby, M., Nightingale, P., Gathercole, L., Tripathi, G., Harte, A. L., Shojaee‐Moradie, F., Umpleby, A. M., Das, S., et al. (2011) · Antiviral Therapy · doi:10.3851/imp2017 · Cited by 11 · see citing works
Dolutegravir-containing HIV therapy reversibly alters mitochondrial health and morphology in cultured human fibroblasts and peripheral blood mononuclear cells
Ajaykumar, A., Caloren, L. C., Povshedna, T., Hsieh, A. Y. Y., Zakaria, A., Cai, R., Smith, M.-S. R., Thompson, C. A. H., Becquart, P., Uday, P., et al. (2022) · AIDS · doi:10.1097/qad.0000000000003369 · Cited by 11 · see citing works
Lipodystrophy: beyond generalization?
Freitas, P., & Carvalho, D. M. (2013) · PubMed · Cited by 11 · see citing works
Immune Dysregulation in Myocardial Fibrosis, Steatosis, and Heart Failure: Current Insights from HIV and the General Population
Sinha, A., & Feinstein, M. J. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-020-00536-9 · Cited by 11 · see citing works
Coenzyme Q10 Alleviates Chronic Nucleoside Reverse Transcriptase Inhibitor-Induced Premature Endothelial Senescence
Chen, Y.-F., Hebert, V. Y., Stadler, K., Xue, S. Y., Slaybaugh, K., Luttrell-Williams, E., Glover, M. C., Krzywanski, D. M., & Dugas, T. R. (2019) · Cardiovascular Toxicology · doi:10.1007/s12012-019-09520-1 · Cited by 10 · see citing works
The Potential of Moringa oleifera to Ameliorate HAART-Induced Pathophysiological Complications
Ndlovu, S. S., Ghazi, T., & Chuturgoon, A. A. (2022) · Cells · doi:10.3390/cells11192981 · Cited by 9 · see citing works
Mitochondrial Reactive Oxygen Species in Cellular Senescence
Nacarelli, T., Torres, C. A., & Sell, C. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-26239-0_10 · Cited by 8 · see citing works
Role of Mitochondria in Adipose Tissues Metabolism and Plasticity
Carrière, A., & Casteilla, L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00007-9 · Cited by 7 · see citing works
Heightened levels of plasma growth differentiation factor 15 in men living with HIV
Agarwal, N., Ramirez, C. E., Wu, H., Armamento‐Villareal, R., Lake, J. E., Balasubramanyam, A., & Hartig, S. M. (2022) · Physiological Reports · doi:10.14814/phy2.15293 · Cited by 7 · see citing works
DNMT1 modulation in chronic hepatitis B patients and hypothetic influence on mitochondrial DNA methylation status during long‐term nucleo(t)side analogs therapy
Madeddu, G., Ortu, S., Garrucciu, G., Maida, I. R., Melis, M., Muredda, A. A., Mura, M. S., & Babudieri, S. (2016) · Journal of Medical Virology · doi:10.1002/jmv.24742 · Cited by 7 · see citing works
Tenofovir-induced renal tubular dysfunction among human immunodeficiency virus patients on antiretroviral therapy in Nigeria: Prospects for early detection of presymptomatic nephrotoxicity
Obiebi, I. P., & Nwannadi, E. A. (2018) · Kidney Research and Clinical Practice · doi:10.23876/j.krcp.2018.37.3.230 · Cited by 7 · see citing works
Mitral Annular and Coronary Artery Calcification Are Associated with Mortality in HIV-Infected Individuals
Lange, D. C., Glidden, D. V., Secemsky, E. A., Ordovas, K. G., Deeks, S. G., Martin, J. N., Bolger, A. F., & Hsue, P. Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130592 · Cited by 6 · see citing works
Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence
Moreno‐Navarrete, J. M., Liñares‐Pose, L., Sabater, M., Rial‐Pensado, E., Comas, F., Jové, M., Latorre, J., Ortega, F. J., Ricart, W., Portero‐Otín, M., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495170 · Cited by 5 · see citing works
Bone Mineral Content Estimation in People Living with HIV: Prediction and Validation of Sex-Specific Anthropometric Models
Correia, I. M., Navarro, A. M., Cordeiro, J. F. C., Gomide, E. B. G., Mazzonetto, L. F., Oliveira, A. D. S., Sebastião, É., Aguilar, B. A., de Andrade, D., Machado, D. R. L., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912336 · Cited by 5 · see citing works
HIV and Aging: Parallels and Synergistic Mechanisms Leading to Premature Disease and Functional Decline
Hearps, A. C., Schafer, K. R., High, K. P., & LANDAY, A. L. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_17 · Cited by 5 · see citing works
Antioxidant Effect of Hederagenin 3-O-b-D-Glucopyranosyl(1→3)-a-L-Rhamnopyranosyl(1→2)-a-L-Arabinopyranoside (HDL) Isolated from Root Bark of Ulmus davidiana
Bong, J.-G., & Park, Y.-Y. (2010) · Journal of Life Science · doi:10.5352/jls.2010.20.2.281 · Cited by 5 · see citing works
Factors Associated With Hospitalizations Among HIV-Infected Adults in the United States
Price, V., Swanson, B. A., Phillips, J. M., Swartwout, K. D., Fog, L., & Jegier, B. J. (2014) · Western Journal of Nursing Research · doi:10.1177/0193945914546202 · Cited by 4 · see citing works
A Multicenter, Open Labeled, Randomized, Phase III Study Comparing Lopinavir/Ritonavir Plus Atazanavir to Lopinavir/Ritonavir Plus Zidovudine and Lamivudine in Naive HIV-1-Infected Patients: 48-Week Analysis of the LORAN Trial
Ulbricht, K. U., Behrens, G. M., Stoll, M., Salzberger, B., Jessen, H., Jessen, A. B., Kuhlmann, B., Heiken, H., Trein, A., & Schmidt, R. E. (2011) · The Open AIDS Journal · doi:10.2174/1874613601105010044 · Cited by 4 · see citing works
Absence of Mitochondrial Toxicity in Hearts of Transgenic Mice Treated with Abacavir
Kohler, J. J., Hosseini, S. H., Green, E., Fields, E. J., Abuin, A., Ludaway, T., Russ, R. B., & Lewis, W. (2010) · Cardiovascular Toxicology · doi:10.1007/s12012-010-9070-2 · Cited by 4 · see citing works
Premature Onset of Cardiovascular Disease in HIV-Infected Individuals: The Drugs and the Virus
Maisa, A., Westhorpe, C. L. V., Elliott, J., Jaworowski, A., Hearps, A. C., Dart, A. M., Hoy, J., & Crowe, S. M. (2010) · HIV Therapy · doi:10.2217/hiv.10.53 · Cited by 4 · see citing works
The Patient With the Human Immunodeficiency Virus-1 in the Cardiovascular Operative Setting
Conte, A. H., Esmailian, F., Labounty, T. M., Lubin, L. N., Hardy, W. D., & Yumul, R. (2012) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2012.06.029 · Cited by 3 · see citing works
HIV inhibits Warburg metabolism in human macrophages infected with Mycobacterium tuberculosis
Brown, K. E., Walsh, A. M., Yennemadi, A. S., Murphy, D. M., Connolly, S. A., Jameson, G., O’Sullivan, M. P., Basdeo, S. A., O’Leary, S. M., Leisching, G. R., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-50059-3 · Cited by 2 · see citing works
Ageing with HIV-1: immunological challenges for effective vaccination
Saint-Charles, P., Didierlaurent, A. M., & Appay, V. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00544-6 · Cited by 2 · see citing works
The Role of Nutrition in HIV-Associated Neurocognitive Disorders: Mechanisms, Risks, and Interventions
Siddi, C., Balla, J., Agbey, C., Fadda, P., & Dedoni, S. (2025) · Life · doi:10.3390/life15060982 · Cited by 1 · see citing works
Altered Redox Regulation as Cofactor in Comorbidities and Accelerated Aging in HIV Infection Evolution and Antiretroviral Treatment
del Valle, L. G. (2014) · Epidemiology Open Access · doi:10.4172/2161-1165.1000171 · Cited by 1 · see citing works
Green Tea (Camellia sinensis) Ameliorate Non-alcoholic Fatty Liver Disease Induced by Highly Active Antiretroviral Therapy
Wondimnew, T., Genet, S., & Gnanasekaran, N. (2021) · Free Radicals and Antioxidants · doi:10.5530/fra.2020.2.14 · Cited by 1 · see citing works
Chronic Nucleoside Reverse Transcriptase Inhibitors Disrupt Mitochondrial Homeostasis and Promote Premature Endothelial Senescence
Chen, Y. (2019) · doi:10.31390/gradschool_dissertations.4974 · Cited by 1 · see citing works
Studies of enzymes in mitochondrial DNA precursor synthesis
Sun, R. (2013) · Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))
CAVEOLIN-1 MEDIATED P53 ACTIVATION IN STRESS INDUCED PREMATURE SENESCENCE AND ITS ANTAGONISTIC PLEIOTROPIC IMPLICATIONS IN CANCER
Bartholomew, J. N. (2009) · D-Scholarship@Pitt (University of Pittsburgh)

ANTIRETROVIRAL THERAPY DRIVES MITOCHONDRIAL DYSFUNCTION-ASSOCIATED SENESCENCE, PROMOTING LIPOATROPHY
Wiley, C. D., Kuehnemann, C., & Campisi, J. (2017) · Innovation in Aging · doi:10.1093/geroni/igx004.4453 · Cited by 1 · see citing works
Uncovering Mechanisms of NRTI Induced Cellular Senescence
Kura, N., Kuehnemann, C., Constantino, G., & Wiley, C. D. (2025) · Innovation in Aging · doi:10.1093/geroni/igaf122.3865
Premature and accelerated aging: HIV or HAART?
Smith, R. L., de Boer, R., Brul, S., Budovskaya, Y. V., & van der Spek, H. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2012.00328 · Cited by 138 · see citing works
The Impact of HIV- and ART-Induced Mitochondrial Dysfunction in Cellular Senescence and Aging
Schank, M., Zhao, J., Moorman, J. P., & Yao, Z. Q. (2021) · Cells · doi:10.3390/cells10010174 · Cited by 151 · see citing works
Mitochondrial and Oxidative Stress Response in HepG2 Cells Following Acute and Prolonged Exposure to Antiretroviral Drugs
Nagiah, S., Phulukdaree, A., & Chuturgoon, A. A. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25149 · Cited by 51 · see citing works

Authors: Caron, M., Auclair, M., Vissian, A., Vigouroux, C., & Capeau, J.
Affiliations: Inserm (FR)
Inserm, U680, Paris, 75012 France
ORCID: Auclair, Martine
Vigouroux, Corinne
Capeau, Jacqueline
Venue: Antiviral Therapy
Publisher: SAGE Publications
Published: 2008-01
Volume: 13
Issue: 1
Pages: 27-38
ISSN: 1359-6535 (ISSN-L)
2040-2058
DOI: 10.1177/135965350801300103
OpenAlex: W56705576
Cited by: 114
References: 50
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 3 · 2019: 10 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 5 · 2014: 8 · 2013: 8 · 2012: 10
FWCI: 12.08
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Antiviral Therapy (publishedVersion)
PubMed (publishedVersion)
Funders: Styrelsen för Internationellt Utvecklingssamarbete
Sidaction
European Commission (LSHM-CT-2005-018690, 018690)
Institut National de la Santé et de la Recherche Médicale
Topics: Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords: mitochondrial dysfunction, oxidative stress, thymidine analogs, nucleoside reverse transcriptase inhibitors, stavudine, zidovudine, antiretroviral therapy, lipodystrophy, cytochrome c oxidase, reactive oxygen species, senescence-associated β-galactosidase, p16INK4, p21WAF-1, fibroblasts, preadipocytes, adipose tissue
MeSH terms: Adipose Tissue, Cells, Cultured, Fibroblasts, Gene Expression Regulation, Humans, Mitochondria, Thymidine, Biomarkers, HIV Infections, Cellular Senescence, Oxidative Stress, Reverse Transcriptase Inhibitors, Anti-HIV Agents, Cell Proliferation

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Contribution of Mitochondrial Dysfunction and Oxidative Stress to Cellular Premature Senescence Induced by Antiretroviral Thymidine Analogues

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