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Cited by 298

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

A Single Ascending Dose Study of Epigallocatechin Gallate in Healthy Volunteers

Ullmann, U, Haller, J, Decourt, JP, Girault, N, Girault, J, Richard-Caudron, AS, Pineau, B, Weber, P·2003·Journal of International Medical Research
DOI 10.1177/147323000303100205
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Abstract

This randomized, double-blind, placebo-controlled study assessed the safety, tolerability and plasma kinetic behaviour of single oral doses of 94% pure crystalline bulk epigallocatechin gallate (EGCG) under fasting conditions in 60 healthy male volunteers. In each group of 10 subjects, eight received oral EGCG in single doses of 50 mg, 100 mg, 200 mg, 400 mg, 800 mg or 1600 mg, and two received placebo. Blood samples were taken at intervals until 26 h later. The area under the concentration-time curve from 0 h to infinity (AUC(0–∞)), the maximum plasma concentration ( C max) of EGCG, the time taken to reach the maximum concentration ( T max), and the terminal elimination half-life ( t 1/2z) of EGCG were determined. Safety and tolerability were assessed. In each dosage group, the kinetic profile revealed rapid absorption with a one-peak plasma concentration versus time course, followed by a multiphasic decrease consisting of a distribution phase and an elimination phase. The mean AUC(0– ∞) of total EGCG varied between 442 and 10368 ng·h/ml. The according mean C max values ranged from 130 to 3392 ng/ml and were observed after 1.3–2.2 h. The mean t 1/2z values were seen between 1.9 and 4.6 h. Single oral doses of EGCG up to 1600 mg were safe and very well tolerated.

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Metadata

Authors
Ullmann, U., Haller, J., Decourt, J., Girault, N., Girault, J., Richard-Caudron, A., Pineau, B., & Weber, P.
Venue
Journal of International Medical Research
Publisher
SAGE Publications
Published
2003-04
Volume
31
Issue
2
Pages
88-101
ISSN
  • 0300-0605 (ISSN-L)
  • 1473-2300
DOI
10.1177/147323000303100205
OpenAlex
W2003153226
Cited by
298
References
31
FWCI
5.82
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A Single Ascending Dose Study of Epigallocatechin Gallate in Healthy Volunteers. https://app.cochat.ai/papers/10.1177/147323000303100205
The paper
Ullmann, U., Haller, J., Decourt, J., Girault, N., Girault, J., Richard-Caudron, A., Pineau, B., & Weber, P. (2003). A Single Ascending Dose Study of Epigallocatechin Gallate in Healthy Volunteers. Journal of International Medical Research. https://doi.org/10.1177/147323000303100205

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.