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Modulation of Endocrine Systems and Food Intake by Green Tea Epigallocatechin Gallate

Kao, Y.-H.·2000·Endocrinology
DOI 10.1210/en.141.3.980
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Abstract

Green tea polyphenols, especially the catechin, (-)-epigallocatechin gallate (EGCG), have been proposed as a cancer chemopreventative based on a variety of laboratory studies. For clear assessment of the possible physiological effects of green tea consumption, we injected pure green tea catechins ip into rats and studied their acute effects on endocrine systems. We found that EGCG, but not related catechins, significantly reduced food intake; body weight; blood levels of testosterone, estradiol, leptin, insulin, insulin-like growth factor I, LH, glucose, cholesterol, and triglyceride; as well as growth of the prostate, uterus, and ovary. Similar effects were observed in lean and obese male Zucker rats, suggesting that the effect of EGCG was independent of an intact leptin receptor. EGCG may interact specifically with a component of a leptin-independent appetite control pathway. Endocrine changes induced by parenteral administration of EGCG may relate to the observed growth inhibition and regression of human prostate and breast tumors in athymic mice treated with EGCG as well as play a role in the mechanism by which EGCG inhibits cancer initiation and promotion in various animal models of cancer.

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Metadata

Authors
Kao, Y.-H.
Venue
Endocrinology
Publisher
The Endocrine Society
Published
2000-03-01
Volume
141
Issue
3
Pages
980-987
ISSN
0013-7227 (ISSN-L)
DOI
10.1210/en.141.3.980
OpenAlex
W1999108312
Cited by
545
References
1
FWCI
9.14
Type
journal article
Language
en
Open access
closed

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Kao, Y.-H. (2000). Modulation of Endocrine Systems and Food Intake by Green Tea Epigallocatechin Gallate. Endocrinology. https://doi.org/10.1210/en.141.3.980

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