Effect of Withania somnifera (Ashwagandha) on the Development of Chemotherapy-Induced Fatigue and Quality of Life in Breast Cancer Patients
Open accessAbstract
UNLABELLED: Hypothesis. Withania somnifera is an herb with antioxidant, anti-inflammatory, anticancer, antistress, and adaptogenic properties. Previous studies have shown its antistress effects in animals. Traditional Indian medicine has used it for centuries to alleviate fatigue and improve general well-being. METHODS: This is an open-label prospective nonrandomized comparative trial on 100 patients with breast cancer in all stages undergoing either a combination of chemotherapy with oral Withania somnifera or chemotherapy alone. The chemotherapy regimens were either taxotere, adriamycin, and cyclophosphamide or 5-fluorouracil, epirubicin, and cyclophosphamide. Withania somnifera root extract was administered to patients in the study group at a dose of 2 g every 8 hours, throughout the course of chemotherapy. The quality-of-life and fatigue scores were evaluated before, during, and on the last cycles of chemotherapy using the EORTC QLQ-C30 (Version 3), Piper Fatigue Scale (PFS), and Schwartz Cancer Fatigue Scale (SCFS-6). RESULTS: The median age distributions in the study and control arm were 51 years (range = 36-70) and 50.5 years (range = 32-71), respectively. The majority (77%) of patients had stage II and III disease. Patients in the control arm experienced statistically significant higher estimated marginal means of fatigue score compared with the study group (P < .001 PFS, P < .003 SCFS-6). Furthermore, various symptom scales of the EORTC QLQ-C30 were statistically significant in 7 out of 18 symptoms in the intervention group compared with the control group (P < .001). The 24-month overall survival for all stages in study and control group patients were 72% versus 56%, respectively; however, the result was not significant (P = .176), at a median follow-up duration of 26 months. CONCLUSIONS: Withania somnifera has potential against cancer-related fatigue, in addition to improving the quality of life. However, further study with a larger sample size in a randomized trial is warranted to validate our findings.
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Ethanolic root extract of WS showed neuroprotective activity in bisphenol A (BPA)-induced loss of spatial learning and working memory in Swiss albino mice.
“The ethanolic root extract of WS showed neuroprotective activity in bisphenol A (BPA) induced loss of spatial learning and working memory in Swiss albino mice [57].”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [57]
Ethanolic root extract restored the level of N-methyl-D-aspartate receptor (NMDAR) in BPA-intoxicated mice.
“Restoring the level of N-”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [57]
Ethanol root extract increases antioxidant property in Swiss albino mice.
“| Ethanol root extract | BPA induced cognitive dysfunction | Swiss albino mice | Increase in antioxidant property, NMDAR | [57] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [57]
Ethanol root extract increases NMDAR in Swiss albino mice.
“| Ethanol root extract | BPA induced cognitive dysfunction | Swiss albino mice | Increase in antioxidant property, NMDAR | [57] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [57]
Ethanol root extract reduces BPA induced cognitive dysfunction in Swiss albino mice.
“| Ethanol root extract | BPA induced cognitive dysfunction | Swiss albino mice | Increase in antioxidant property, NMDAR | [57] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [57]
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- Authors
- Biswal, B. M., Sulaiman, S. A., Ismail, H. C., Zakaria, H., & Musa, K. I.
- Affiliations
- Universiti Sains Malaysia (MY)
- Venue
- Integrative Cancer Therapies
- Publisher
- SAGE Publications
- Published
- 2012-11-09
- Volume
- 12
- Issue
- 4
- Pages
- 312-322
- ISSN
- 1534-7354 (ISSN-L)
- 1552-695X
- OpenAlex
- W1986443532
- Cited by
- 131
- References
- 33
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 10 · 2023: 7 · 2022: 13 · 2021: 13 · 2020: 12 · 2019: 8 · 2018: 6 · 2017: 12 · 2016: 2 · 2015: 8 · 2014: 7 · 2013: 2
- FWCI
- 13.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Integrative Cancer Therapies (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Keywords
- Withania somnifera, breast cancer, chemotherapy-induced fatigue, cancer-related fatigue, quality of life, complementary and alternative medicine, root extract, EORTC QLQ-C30, Piper Fatigue Scale, overall survival
- MeSH terms
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Fatigue, Female, Humans, Phytotherapy, Middle Aged, Plant Extracts, Quality of Life, Treatment Outcome, Withania, Medication Adherence
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