The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease Prevalence
Abstract
Low vitamin D status has been implicated in the etiology of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, insulin-dependent diabetes mellitus, and inflammatory bowel disease. The optimal level of vitamin D intake required to support optimal immune function is not known but is likely to be at least that required for healthy bones. Experimentally, vitamin D deficiency results in the increased incidence of autoimmune disease. Mechanistically, the data point to a role for vitamin D in the development of self-tolerance. The vitamin D hormone (1,25-dihydroxy vitamin D 3) regulates T helper cell (Th1) and dendritic cell function while inducing regulatory T-cell function. The net result is a decrease in the Th1-driven autoimmune response and decreased severity of symptoms. This review discusses the accumulating evidence pointing to a link between vitamin D and autoimmunity. Increased vitamin D intakes might decrease the incidence and severity of autoimmune diseases and the rate of bone fracture.
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Holick, M. F., MacLaughlin, J. A., & Doppelt, S. H. (1981) · Science · doi:10.1126/science.6256855 · Cited by 558
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Epidemiology and risk factors for IBD
Ananthakrishnan, A. N. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.34 · Cited by 1,741
Vitamin D for health: a global perspective
Hossein-nezhad, A., & Holick, M. F. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.05.011 · Cited by 1,298
Malformation syndromes caused by disorders of cholesterol synthesis
Porter, F. D., & Herman, G. E. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r009548 · Cited by 473
Endocrine and inflammatory markers as predictors of frailty
Puts, M. T. E., Visser, M., Twisk, J. W. R., Deeg, D. J. H., & Lips, P. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02355.x · Cited by 316
Yamshchikov, A. V., Desai, N. S., Blumberg, H. M., Ziegler, T. R., & Tangpricha, V. (2009) · Endocrine Practice · doi:10.4158/ep09101.orr · Cited by 307
Calder, P. C. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113001286 · Cited by 283
Juran, B. D., Hirschfield, G. M., Invernizzi, P., Atkinson, E. J., Li, Y., Xie, G., Kosoy, R., Ransom, M., Sun, Y., Bianchi, I., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds359 · Cited by 150
“Finally, the 11q13 locus is associated with population differences in levels of vitamin D (20,21), a molecule with integral roles in immunity (44).”
BackgroundStubbs, G., Henley, K., & Green, J. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.01.015 · Cited by 107
Hamilton, S. A., McNeil, R., Hollis, B. W., Davis, D. J., Winkler, J., Cook, C., Warner, G., Bivens, B., McShane, P., & Wagner, C. L. (2010) · International Journal of Endocrinology · doi:10.1155/2010/917428 · Cited by 105
Metadata
- Authors
- Cantorna, M. T., & Mahon, B. D.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 2004-12
- Volume
- 229
- Issue
- 11
- Pages
- 1136-1142
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W1902194990
- Cited by
- 526
- References
- 1
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- closed
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