Endocrine and inflammatory markers as predictors of frailty
Open accessAbstract
Summary: Objective To examine the association of serum concentrations of 25‐hydroxyvitamin D [25(OH)D], interleukin‐6 (IL‐6), C‐reactive protein (CRP) and IGF‐1 with prevalent and incident frailty. Design The Longitudinal Aging Study Amsterdam (LASA), a prospective cohort study with 3‐yearly measurement cycles. Setting General population‐based sample. Participants The respondents were men and women aged 65 and over, who participated at T 1 (1995/1996, N = 1720) and T 2 (1998/1999, N = 1509). Blood samples were obtained at T 1 ( N = 1271). Measurements The presence of frailty at T 1 and 3‐year incidence of frailty. Frailty is defined as the presence of three out of nine frailty indicators. Results At T 1 , 242 (19·0%) of all respondents were frail. Those who were frail at T 1 had higher CRP and lower 25(OH)D levels. Serum 25(OH)D remained associated with frailty after adjustment for potential confounders with an odd ratios (OR) of 2·60 [95% confidence interval (95% CI) 1·60–4·21] for 25(OH)D < 25 nmol/l and 1·72 (95% CI 1·19–2·47) for 25(OH)D 25–50 nmol/l vs. high levels of 25(OH)D. Of the nonfrail at T 1 , 125 respondents (14·1%) became frail at T 2 . After adjustment, moderately elevated CRP levels (3–10 µg/ml) (OR 1·69, 95% CI 1·09–2·63) and low 25(OH)D (OR 2·04, 95% CI 1·01–4·13) were associated with incident frailty. No consistent associations were observed for IL‐6 and IGF‐1. Conclusion Low 25(OH)D levels were strongly associated with prevalent and incident frailty; moderately elevated levels of CRP were associated with incident frailty.
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Vitamin D prescription for older people who are deficient may reduce falls.
“vitamin D prescription for older people who are deficient may reduce falls (135)”
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- Authors
- Puts, M. T. E., Visser, M., Twisk, J. W. R., Deeg, D. J. H., & Lips, P.
- Affiliations
- Amsterdam Public Health (NL)
- Corresponding author
- Puts, Martine T. E.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2005-08-11
- Volume
- 63
- Issue
- 4
- Pages
- 403-411
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2155577996
- Cited by
- 316
- References
- 46
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 9 · 2023: 12 · 2022: 17 · 2021: 14 · 2020: 21 · 2019: 19 · 2018: 24 · 2017: 18 · 2016: 21 · 2015: 22 · 2014: 18 · 2013: 17 · 2012: 15
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (submittedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Koninklijke Nederlandse Akademie van Wetenschappen
- Vrije Universiteit Amsterdam
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Keywords
- frailty, 25-hydroxyvitamin D, vitamin D deficiency, C-reactive protein, interleukin-6, insulin-like growth factor I, inflammation, older adults, incident frailty, frailty risk factors
- MeSH terms
- Aged, Aged, 80 and over, Aging, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Insulin-Like Growth Factor I, Longitudinal Studies, Male, Predictive Value of Tests, Vitamin D, Biomarkers, Interleukin-6, Odds Ratio, Frail Elderly
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