Cited by 672Oral microbiology and periodontitis researchMicrobial Community Ecology and PhysiologyGut microbiota and health

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Pyrosequencing analysis of the Oral Microflora of healthy adults

Keijser, B.J.F., Zaura, E., Huse, S.M., van der Vossen, J.M.B.M., Schuren, F.H.J., Montijn, R.C., ten Cate, J.M., Crielaard, W.·2008·Journal of Dental Research

DOI 10.1177/154405910808701104

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Abstract

A good definition of commensal microflora and an understanding of its relation to health are essential in preventing and combating disease. We hypothesized that the species richness of human oral microflora is underestimated. Saliva and supragingival plaque were sampled from 71 and 98 healthy adults, respectively. Amplicons from the V6 hypervariable region of the small-subunit ribosomal RNA gene were generated by PCR, pooled into saliva and plaque pools, and sequenced by means of the Genome Sequencer 20 system at 454 Life Sciences. Data were evaluated by taxonomic and rarefaction analyses. The 197,600 sequences generated yielded about 29,000 unique sequences, representing 22 taxonomic phyla. Grouping the sequences in operational taxonomic units (6%) yielded 3621 and 6888 species-level phylotypes in saliva and plaque, respectively. This work gives a radically new insight into the diversity of human oral microflora, which, with an estimated number of 19,000 phylotypes, is considerably higher than previously reported.

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Pruesse, E., Quast, C., Knittel, K., Fuchs, B. M., Ludwig, W., Peplies, J., & Glöckner, F. O. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm864 · Cited by 6,682
Microbial diversity in the deep sea and the underexplored “rare biosphere”
Sogin, M. L., Morrison, H. G., Huber, J. A., Welch, D. B. M., Huse, S. M., Neal, P. R., Arrieta, J. M., & Herndl, G. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605127103 · Cited by 3,803
Defining the normal bacterial flora of the oral cavity
Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I., & Dewhirst, F. E. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.11.5721-5732.2005 · Cited by 3,092
Introducing DOTUR, a Computer Program for Defining Operational Taxonomic Units and Estimating Species Richness
Schloss, P. D., & Handelsman, J. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.3.1501-1506.2005 · Cited by 2,529
Review and re-analysis of domain-specific 16S primers
Baker, G. C., Smith, J. J., & Cowan, D. A. (2003) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2003.08.009 · Cited by 1,934
Pyrosequencing enumerates and contrasts soil microbial diversity
Roesch, L. F. W., Fulthorpe, R. R., Riva, A., Casella, G., Hadwin, A. K. M., Kent, A. D., Daroub, S. H., Camargo, F. A. D. O., Farmerie, W. G., & Triplett, E. W. (2007) · The ISME Journal · doi:10.1038/ismej.2007.53 · Cited by 1,891
A Sequencing Method Based on Real-Time Pyrophosphate
Ronaghi, M., Uhlén, M., & Nyrén, P. (1998) · Science · doi:10.1126/science.281.5375.363 · Cited by 1,630
The Ribosomal Database Project (RDP-II): sequences and tools for high-throughput rRNA analysis
Cole, J. R. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki038 · Cited by 1,478
Accuracy and quality of massively parallel DNA pyrosequencing
Huse, S. M., Huber, J. A., Morrison, H. G., Sogin, M. L., & Welch, D. B. M. (2007) · Genome biology · doi:10.1186/gb-2007-8-7-r143 · Cited by 1,280
Bacteria of Dental Caries in Primary and Permanent Teeth in Children and Young Adults
Aas, J. A., Griffen, A. L., Dardis, S. R., Lee, A. M., Olsen, I., Dewhirst, F. E., Leys, E. J., & Paster, B. J. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.01410-07 · Cited by 952 · cited 1×
“Recent studies where cloning and sequencing approaches of microbial 16S rDNA were applied to the oral microflora have identified still more new species (Aas et al., 2008; Preza et al., 2008; Riggio et al., 2008).”
Background

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Identification of key markers of normal and pathogenic microbiota determining health of periodontium by NGS-sequencing 16S-rDNA libraries of periodontal swabs
Зорина, О. А., Petrukhina, N. B., Basovа, А. А., Shibaeva, A. V., Трубникова, Е. В., & Shevelev, A. B. (2014) · Stomatology · doi:10.17116/stomat201493625-31 · Cited by 4
“Помимо высокой вариабельности, участок V6 16S pДНК удобен тем, что он уже использовался во многих исследованиях [14, 15, 26].”
Subgingival Biofilms as Etiological Factors of Periodontal Disease
Thurnheer, T., Bao, K., & Belibasakis, G. N. (2017) · Springer eBooks · doi:10.1007/978-3-319-53737-5_3 · Cited by 4
Genomics of Infectious Diseases and Private Industry
Vernet, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-799942-5.00018-4 · Cited by 4
“The technology has found applications in metagenomics, such as identification of a new arenavirus in transplantation patients (Palacios et al., 2008) or the characterization of microflora in oral cavity or guts (Keijser et al., 2008; Turnbaugh et al., 2009) .”
Exopolysaccharide Productivity and Biofilm Phenotype on Oral Commensal Bacteria as Pathogenesis of Chronic Periodontitis
Yamanaka, T., Yamane, K., Mashimo, C., Nambu, T., Maruyama, H., Leung, K., & Fukushim, H. (2012) · InTech eBooks · doi:10.5772/31034 · Cited by 4
“A recent study using pyrosequencing technique showed that dental plaque harbors nearly 7000 species-level phylotypes (Keijser et al., 2008).”
Background
Oral pathogens in children with respiratory disease
Endo, Y., Ooka, T., Hironaka, S., Sugiyama, T., Matsuhashi, K., Abe, Y., Tatsuno, M., Mukai, Y., & Inoue, M. (2014) · Pediatric Dental Journal · doi:10.1016/j.pdj.2014.09.002 · Cited by 4
A survey of the oral cavity microbiome of New Zealand fur seal pups (Arctocephalus forsteri)
Emami‐Khoyi, A., Benmazouz, I., Ross, J. G., Boren, L. J., Murphy, E., van Vuuren, B. J., Teske, P. R., & Paterson, A. M. (2019) · Marine Mammal Science · doi:10.1111/mms.12639 · Cited by 4
Lactic Acid Bacteria in Oral Health
Meurman, J. H., & Stamatova, I. (2011) · CRC Press eBooks · doi:10.1201/b11503-24 · Cited by 4
Community and genomic analysis of the human small intestine microbiota
van den Bogert, B. (2013) · doi:10.18174/274416 · Cited by 4
Probiotic activity of Lactobacillus delbrueckii subsp. bulgaricus in the oral cavity
Stamatova, I. (2010) · Työväentutkimus Vuosikirja · Cited by 4
Analysis of the oral microbiome composition of healthy individuals and the in vitro antibacterial activity of platelet-rich fibrin from these individuals against oral pathogenic bacteria
Popowski, W., Domanowska, D., Koseski, D., Ostrowski, R., Zalewska, M., Małecka‐Giełdowska, M., Łasica, A. M., & Popowska, M. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1691046 · Cited by 3
Oral Care Across Ages: A Review
Ashford, J. R. (2012) · Perspectives on Swallowing and Swallowing Disorders (Dysphagia) · doi:10.1044/sasd21.1.3 · Cited by 3
“Over 600 species of bacteria, either floating free in oral secretions or attached to surfaces as plaque, struggle for survival (Keijser et al., 2008).”
Background
Major changes in the normal periodontal microbiome associated with chronic generalized periodontitis as detected by metagenomic sequencing
Зорина, О. А., Аймадинова, Н. К., Boriskina, O. A., Basovа, А. А., & Rebrikov, D. V. (2017) · Russian Journal of Stomatology · doi:10.17116/rosstomat201710241-48 · Cited by 3
Application of fluorescent In situ hybridization for rapid detection of aggregatibacter actinomycetemcomitans in patients with chronic periodontitis
Bhat, K., Chhatre, A., Kumbar, V. M., Kugaji, M. S., & Patil, S. (2018) · Journal of the International Clinical Dental Research Organization · doi:10.4103/jicdro.jicdro_28_17 · Cited by 3
Gut Microbiota Role in Liver Regeneration:Evidences and Novel Insights
Frumento, D. (2018) · CINECA IRIS Institutial Research Information System (University of Genoa) · Cited by 3
Le poumon est sensible aux effets locaux et à distance des microbiotes
Mathieu, E., Marquant, Q., Descamps, D., Riffault, S., Saint‐Criq, V., & Thomas, M. (2021) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2021.04.002 · Cited by 5
Modulation of Systemic Immune Responses Through Genital, Skin, and oral Microbiota: Unveiling the Fundamentals of Human Microbiomes
Sanapala, P., & Pola, S. (2021) · Springer eBooks · doi:10.1007/978-981-16-3156-6_2 · Cited by 3
Sonication versus the conventional method for evaluation of the dental microbiome: a prospective pilot study
Wagendorf, O., Menzel, P., Schwarzer, R., Neckel, N., Preißner, S., Heiland, M., & Nahles, S. (2022) · BMC Oral Health · doi:10.1186/s12903-022-02374-0 · Cited by 3
“The microbial composition reported is similar to earlier studies focusing on the oral bacterial composition [30, 32, 33, 36].”
BackgroundResult
Oral Flora Composition and Its Connection to Oral Health
Yamashita, Y., & Takeshita, T. (2011) · Journal of Oral Biosciences · doi:10.1016/s1349-0079(11)80003-4 · Cited by 3
Lactobacillus characterization and effects on oral biofilm composition
Vestman, N. R. (2013) · Cited by 3
Biomarkers of Human Decomposition Ecology and the Relationship to Postmortem Interval
Damann, F. E. (2012) · Cited by 3
New Approaches to Cultivation of Human Microbiota
Epstein, S. S., Sizova, M. V., & Hazen, A. (2013) · Wiley eBooks · doi:10.1002/9781118409855.ch13 · Cited by 3
[Impact of the recent advances in the analysis of microbial communities on the control of the wastewater treatment process].
Erijman, L., Figuerola, E. L. M., Guerrero, L. D., & Ayarza, J. M. (2011) · PubMed · doi:10.1590/s0325-75412011000200011 · Cited by 2
Metagenomics of the human microbiome
Shestakov, S. (2011) · Biology Bulletin Reviews · doi:10.1134/s2079086411020095 · Cited by 2
Oral Infection, Carcinogenesis and Cancer
Meurman, J. H., & Martínez, A. B. (2015) · Springer eBooks · doi:10.1007/978-3-319-20669-1_11 · Cited by 2
Oral Biofilms and Their Implication in Oral Diseases
Belibasakis, G. N., & Bostancı, N. (2017) · CRC Press eBooks · doi:10.4324/9781315120119-3 · Cited by 2
Agents of inflammatory diseases of the maxillofacial region in regional hospitals of Belarus
Кabanova, А. А. (2017) · Medical news of the North Caucasus · doi:10.14300/mnnc.2017.12119 · Cited by 2
Development, Characterization and Ecological Implications of a Smooth Colony Variant of Biofilm-forming Cariogenic Streptococcus mutans
Narisawa, N. (2010) · Journal of Oral Biosciences · doi:10.1016/s1349-0079(10)80028-3 · Cited by 2
Oral antibacterial effect of chlorhexidine treatments and professional prophylaxis in children
Cruvinel, T., de Oliveira, T. M., Sakai, V. T., Tessarolli, V., & Machado, M. A. D. A. M. (2013) · Brazilian journal of oral sciences/Brazilian Journal of Oral Sciences · doi:10.1590/s1677-32252013000200012 · Cited by 2
Oral Bacteria Transmissible by Saliva and Kissing
Posse, J. L., Dios, P. D., & Scully, C. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-813681-2.00002-0 · Cited by 2
Microbiomics of Oral Biofilms: Driving The Future of Dental Research
Seneviratne, C., & Suriyanarayanan, T. (2017) · Scientific Dental Journal · doi:10.26912/sdj.2017.01.01-05 · Cited by 2
“Pyrosequencing methods are able to provide a holistic view of the diversity and composition of oral biofilms revealing the remarkable diversity of oral microbiome.(31,32).”
Background
Bacterial spectrum of orofacial infections and their antibiotic resistance in Belarus
Кabanova, А. А. (2018) · Medical Research Journal · doi:10.5603/mrj.2017.0021 · Cited by 2
“Nowadays more than 600 species of oral microorganisms were isolated and identified [3].”
Background
Identification of biofilm producing bacterial species causing dental caries and their sensitivity to zoocin A and clove hydroalcoholic extract
Khalili, H., Sisakhtpour, R., & Abdollahzadeh, S. (2018) · Immunopathologia Persa · doi:10.15171/ipp.2018.27 · Cited by 2
“In one person, the number of bacterial species present in the oral cavity may be much less than these numbers, but these bacteria form a composite and complex biofilm (16,17).”
Analysis of gut bacterial community composition in obese and lean Indian participants by denaturing gradient gel electrophoresis
Chaudhry, R., Bahadur, T., Bamola, V. D., Chutani, A. M., Verma, A., & Paul, J. (2021) · Indian Journal of Health Sciences and Biomedical Research (KLEU) · doi:10.4103/kleuhsj.kleuhsj_273_20 · Cited by 2
The Top 200 Cited Articles in Restorative Dentistry Between 1945-2019: Bibliometric Analysis Study
Demırcı, M., Karabay, F., Tuncer, S., Tekçe, N., & Berkman, M. (2022) · Turkiye Klinikleri Journal of Dental Sciences · doi:10.5336/dentalsci.2021-81540 · Cited by 2
Could oral hygiene prevent cases of at-home-acquired Legionnaires’ disease? – Results of a comprehensive case–control study on infection sources, risk, and protective behaviors
Lehfeld, A.-S., Reber, F., Lewandowsky, M., Jahn, H. J., Lück, C., Petzold, M., Schaefer, B., Germelmann, A.-R., Lorenz, K., & Buchholz, U. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1199572 · Cited by 2
“, 1984) with an estimated 19,000 phylotypes (Keijser et al., 2008) it is biologically plausible that Legionella may be present in dentures and/or dental plaque.”
Background
Genomics of Infectious Diseases and Private Industry
Vernet, G. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-384890-1.00019-4 · Cited by 2
“The technology has found applications in metagenomics, such as identification of a new arenavirus in transplantation patients (Palacios et al., 2008) or the characterization of microflora in oral cavity or guts (Keijser et al., 2008; Turnbaugh et al., 2009).”
BackgroundMethod
Oral health and menopause
Tarkkila, L. (2011) · Työväentutkimus Vuosikirja · Cited by 2
Characterisation of mixed microbial populations in white mineral dispersions
Maiuta, N. D. (2026) · OpenGrey (Institut de l'Information Scientifique et Technique) · doi:10.82444/warw.33490585 · Cited by 2
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Chong, C. (2016) · ScholarlyCommons (University of Pennsylvania) · Cited by 2
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Sturgeon, A. (2014) · The Atrium (University of Guelph) · Cited by 2
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Ma, M. (2019) · UA Campus Repository (The University of Arizona) · Cited by 2
Functional and metagenomic analysis of the human tongue dorsum using phage display
Easton, S. (2009) · UCL Discovery (University College London) · Cited by 3
The Oral Microbiome
Boonanantanasarn, K., & Gill, S. R. (2011) · doi:10.1128/9781555817107.ch2 · Cited by 2
Multi-omics in Study of Oral Microbiome
Nguyen, D. H., & Chu, D. (2024) · Springer eBooks · doi:10.1007/978-981-97-1844-3_11 · Cited by 1
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Alashkar, S., & Alajlani, M. M. (2024) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2024.00792 · Cited by 2
“Studies such as Keijser et al. (2018) and Xu et al. (2015) showcase the potential of these technologies in unraveling the hidden intricacies of the oral microbial world, guiding our understanding of its impact on health and disease.”
Salivary immune alteration persists after caries treatment
Huerta-Garcia, E. X., Camargo-Ayala, P. A., Días, N. B., Nachtigall, F. M., Santos, L. S., Rivera, C., & Botelho, J. N. (2026) · Scientific Reports · doi:10.1038/s41598-026-43748-6 · Cited by 1
“A considerable fraction of the salivary microbiota has been reported to originate from the tongue, with genera such as Prevotella and Streptococcus predominating 78 , contributing to the heterogeneity and stability of the microbial profile.”
Metagenome and Metabolic Pathways in Plaque Biofilms of Thai ELANE-Associated Neutropenic Patients: An Original Study and Scoping Review
Chetruengchai, W., Sriwattanapong, K., Manaspon, C., Fakhruddin, K. S., Samaranayake, L. P., Shotelersuk, V., & Porntaveetus, T. (2026) · European Journal of Dentistry · doi:10.1055/s-0046-1818559 · Cited by 1
“36 Both taxa are considered as a bridging species within developing bio ﬁ lms due to their distinct coaggregation interactions and abilities to stimulate the growth of other bio ﬁ lm colonizers.”
Put your money where your mouth is: surveillance of antibiotic resistance within the commensal Neisseria
Regan, M. R., McDevitt, C. J., Robinson, L. R., Issifou, S., & Wadsworth, C. B. (2026) · Microbiology Spectrum · doi:10.1128/spectrum.00725-26 · Cited by 1
“These species are universally carried by healthy human adults and make up the most abundant genera within Proteobacteria in oral and pharyngeal samples (approximately 10% of operational taxonomic units) (6, 7).”
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Scholz, M. (2012) · Cited by 1
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Barbosa, P., Dias, Ó., Arrais, J. P., & Rocha, M. (2014) · Advances in intelligent systems and computing · doi:10.1007/978-3-319-07581-5_23 · Cited by 1
“Furthermore, previous studies of the oral flora at the genus level reveal a diverse microbiome composition [22], which is in agreement with the pattern observed here.”
Result
The Oral Microbiome and Its Relationship to Genomics and Oral Disease
Glurich, I., Shukla, S. K., Acharya, A., Ginsburg, G. S., & Brilliant, M. H. (2015) · Springer eBooks · doi:10.1007/978-3-319-17942-1_3 · Cited by 1
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Davis, E. M. (2015) · Cited by 1
PROBIOTICS - FRIENDLY BACTERIAL SUPPLEMENT 'A MODERN OPINION'
Anand, V., Gulati, M., Anand, M. D. B., Anand, M. D. A., Singh, M. D. A., Daing, M. D. A., & Mds-, M. (2012) · Cited by 1
Peri-implant Disease: Etiological Factors and Microbiological Approaches
Kim, H. J., Kim, K.-H., Lee, Y., Ku, Y., Rhyu, I., & Seol, Y. (2018) · The Korean Academy of Oral and Maxillofacial Implantology · doi:10.32542/implantology.20180015 · Cited by 1
Dysbiosis of the Oral Microbiome: Association with and Prevention of Human Diseases
Zhang, Z., Yang, W., & Omaye, S. T. (2019) · Food and Nutrition Sciences · doi:10.4236/fns.2019.107058 · Cited by 1
“Researchers found 318 genera of oral microbes covering 22 taxonomic phyla [7].”
Background
The value of the microbiological examination in the diagnosis and monitoring of periodontitis
Disciplina de Pedodonţie, U. D. M. Ş. F. „. H., Lupșe, I., Roman, A., Disciplina de Parodontologie, U. D. M. Ş. F. „. H., Micu, I. C., Disciplina de Parodontologie, U. D. M. Ş. F. „. H., Șoancă, A., & Disciplina de Parodontologie, U. D. M. Ş. F. „. H. (2018) · Romanian Journal of Stomatology · doi:10.37897/rjs.2018.1.5 · Cited by 1
“Aproximativ 20-30 de specii predominante au fost izolate din fiecare situs de prelevare (mucoasă sau placă dentară) (9,10).”
Background
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Frumento, D. (2018) · Current Trends in Biomedical Engineering & Biosciences · doi:10.19080/ctbeb.2018.13.555852 · Cited by 1
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Cleatus, B., Thirunavukkarasu, R., Subramanian, K., & John, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22348-8.00008-8 · Cited by 1
Cohort, Longitudinal and Cross-Sectional Studies: Periodontal Diseases
Teles, F., Feres, M., & Retamal‐Valdes, B. (2025) · Springer series on biofilms · doi:10.1007/978-3-031-82202-5_20 · Cited by 1
Oral Microbes in Health and Disease
Bachrach, G., Faerman, M., Ginesin, O., Eini, A., Sol, A., & Coppenhagen‐Glazer, S. (2011) · Springer eBooks · doi:10.1007/978-3-642-21680-0_13 · Cited by 1
Metagenomic analysis of the gastric microbiota cultivable from a patient with gastritis concomitant with Barrett's esophagus.
Gutiérrez-Escobar, A. J., Bayona, M. A., Barragan-Vidal, C., Lara, S. R., & Oliveros, R. (2014) · PubMed · doi:10.47892/rgp.2014.343.158 · Cited by 1
Molecular Microecological Techniques
Ling, Z., & Xiang, C. (2014) · Advanced topics in science and technology in China · doi:10.1007/978-3-662-43883-1_7 · Cited by 1
Microbiota and HCV Infection Interplay
Frumento, D. (2018) · Current Trends in Biomedical Engineering & Biosciences · doi:10.19080/ctbeb.2018.12.555852 · Cited by 1
“Human physiological status greatly depends on microbiota, in fact it presence is necessary for a normal development, as well as for supporting immune system in the protection of the host from pathogens [4,5].”
Background
Probiotics: An End to Caries?
Joseph, V. S., Babu, A. S., Narayanankutty, S. K., & Anupama, S. (2016) · Conservative Dentistry and Endodontic Journal · doi:10.5005/jp-journals-10048-0002 · Cited by 1
Maladies bulleuses auto-immunes à expression gingivale: rôle du microbiote parodontal
Pantchenko, C., Bisson, C., Bellakhdar, F., Gagnot, G., Oro, S., Gaultier, F., & Dridi, S. (2021) · Annales de Dermatologie et de Vénéréologie - FMC · doi:10.1016/j.fander.2020.06.008 · Cited by 1
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Zorba, Μ., Patsatsi, A., & Andreadis, D. (2022) · Springer eBooks · doi:10.1007/978-981-19-1946-6_12 · Cited by 1
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Gustavo, M. (2022) · Scholarly Journal of Otolaryngology · doi:10.32474/sjo.2022.08.000282 · Cited by 1
Estudo dos efeitos da terapia fotodinâmica sobre Streptococcus mutans
da Silva, T. C. (2010) · doi:10.11606/t.25.2010.tde-18082010-104126 · Cited by 1
Proatherogenic effects of common pathogens on liver, adipose tissue and coronary artery disease
Hyvärinen, K. (2013) · Työväentutkimus Vuosikirja · Cited by 1
A Multi-Faceted Diagnostic Approach to Lung Infections in Patients with Cystic Fibrosis
Doud, M. S. (2010) · doi:10.25148/etd.fi10041609 · Cited by 1
“The Haemophilus sequences, present in all samples but H3, were most likely from species that live in the oral cavity (Keijser et al., 2008; Kraut et al., 1972; Sixou et al., 1991).”
BackgroundInfluential
Taxonomic and functional analysis of metagenomes
Barbosa, P. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 1
Lipopolysaccharide: a Link between Periodontitis and Cardiometabolic Disorders
Kallio, E. (2014) · Työväentutkimus Vuosikirja · Cited by 1
Chlorhexidine compounds in cosmetic products Risk assessment of antimicrobial and antibiotic resistance development in microorganisms. Opinion of the Panel on Biological Hazards of the Norwegian Scientific Committee for Food Safety
Lunestad, B. T., Møretrø, T., Hegstad, K., Langsrud, S., Scheie, A. A., Kapperud, G., Lassen, J. F., Nygård, K. M., Robertson, L. J., Nesbakken, T., et al. (2010) · BIBSYS Brage (BIBSYS (Norway)) · Cited by 1
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Almeida-Santos, A. C., Martins‐Mendes, D., Gayà‐Vidal, M., Pérez-Pardal, L., & Beja‐Pereira, A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.07.031070 · Cited by 1
“(24) study on healthy adults 242 reported that Prevotella, Streptococcus, and Veillonella genera were responsible for about 243 50% of the total salivary microbiome, which is similar to our findings.”
Result
Biofilms Around Dental Implants
Herrera, D., Bermejo, P., Sánchez, M. C., Figuero, E., & Sanz, M. (2020) · doi:10.1002/9781119427926.ch24 · Cited by 1
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Le, A. (2020) · UA Campus Repository (The University of Arizona) · Cited by 1
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Awang, R. A. (2014) · Enlighten: Theses (The University of Glasgow) · Cited by 1
Microbial Community Assembly found with Sponge Orange Band Disease in Xestospongia muta (Giant Barrel Sponge)
Mulheron, R. (2014) · NSUWorks (Nova Southeastern University) · Cited by 2
16S rRNA-Based Tag Pyrosequencing of Complex Food and Wastewater Environments: Microbial Diversity and Dynamics
McElhany, K. G. (2012) · OakTrust (Texas A&M University Libraries)
Microbiome Diversity in Human Saliva
Nasidze, I., & Stoneking, M. (2011) · Wiley eBooks · doi:10.1002/9781118010549.ch33
Otiorhynchus spp. (Coleoptera: Curculionidae) as pests in horticulture: genetics and management options with entomopathogenic fungi
Hirsch, J. (2012) · University writing server of the University of Hohenheim (Universität Hohenheim)
ESPRIT: Estimating Species Richness Using Large Collections of 16S rRNA Data
Sun, Y., Cai, Y., Liu, L., Yu, F., & Farmerie, W. G. (2011) · doi:10.1002/9781118010518.ch53
The Responses of Dental Plaque Microcosms to Experimental Environmental Changes
Wall-Manning, G. M. (2012) · Otago University Research Archive (University of Otago)
The Human Gastric Microbiota in Health and Disease
Lindberg, M. (2010) · Figshare
Asepsie-antisepsie en endodontie
Pérard, M., Clerc, J. L., Gautier, T., Pérez, F., Vulcain, J.-M., Dautel-Morazin, A., & Goff, A. L. (2014)
The Application of 16SrRNA Sequences Analysis in Oral Microbial Community
李, 春. (2014) · QianRen Biology · doi:10.12677/qrb.2014.12007
Exploring the Effect of Surgical Operations on the Oral Microflora of Human Oral Carcinoma
Hua, L., Rui, H., Xinying, Z., Li, Q., & Ning, G. (2013) · Journal of Hard Tissue Biology · doi:10.2485/jhtb.22.267
Bacterial diversity in children's dental caries
Kim, E., Baik, K. S., & Ha, M.-O. (2013) · Journal of Korean society of Dental Hygiene · doi:10.13065/jksdh.2013.13.05.889
Storage Stability and Folate Requirements of a Commercial Probiotic Bifidobacteria and Bifidobacterium longum DJO10A
Çelik, Ö. (2013) · University of Minnesota Digital Conservancy (University of Minnesota)
Zoocin A and lauricidin in combination selectively inhibit Streptococcus mutans in a biofilm model
Lester, K. (2011) · Otago University Research Archive (University of Otago)
The Immunogenetics of Dental Caries
McCarlie, V. W. (2010) · doi:10.7912/c2/1554
d iversity of e ndodontic Microbiota r evisited
Siqueira, J. F., Jr., & Rôças, I. N. (2010)
Chirality: The Key to Specific Bacterial Protease-Based Diagnosis?
Kaman, W. E. (2014) · RePub (Erasmus University Rotterdam)
17 Microbiologie van parodontale infecties
Winkelhoff, A. J. V., & van der Reijden, W. A. (2009) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-6887-7_17
Towards in vivo editing of the human microbiome
Yaung, S. J. (2015) · DSpace@MIT (Massachusetts Institute of Technology)
Bacterial Characterization in Health and Periodontal Diseases During Induced Gingival Inflammation
da Silva, A. P. B. (2012)
A report of 26 unrecorded bacterial species in Korea, belonging to the Bacteroidetes and Firmicutes
Kim, H., Yoon, J., Cha, C., Seong, C. N., Im, W., Jahng, K., Jeon, C. O., Kim, S. B., & Joh, K. (2016) · Journal of Species Research · doi:10.12651/jsr.2016.5.1.166
“, 2000) and normal microbiota of the oral cavity, either in the saliva or dental plaque (Keijser et al., 2008; Nasidze et al., 2009a, 2009b).”
BackgroundInfluential
Association Between Oral Infections and Cancer Risk
Meurman, J. H. (2015) · Springer eBooks · doi:10.1007/978-3-319-25091-5_7
Correlation between DMFT index andoccurrence of Lactobacillus spp. in the oral cavity
Khajeh, M., & Baserisalehi, M. (2015) · International journal of molecular and clinical microbiology
A new probiotic approach for the prevention and/or treatment of dental caries, oral candidiasis and periodontal diseases
Saha, S. (2015) · eScholarship@McGill (McGill) · doi:10.82308/7943

Authors: Keijser, B. J. F., Zaura, E., Huse, S. M., van der Vossen, J. M. B. M., Schuren, F. H. J., Montijn, R. C., ten Cate, J. M., & Crielaard, W.
Affiliations: Marine Biological Laboratory (US)
TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Zeist, The Netherlands;
ORCID: Keijser, B.J.F.
Zaura, E.
Schuren, F.H.J.
Venue: Journal of Dental Research
Publisher: SAGE Publications
Published: 2008-11
Volume: 87
Issue: 11
Pages: 1016-1020
ISSN: 0022-0345 (ISSN-L)
1544-0591
DOI: 10.1177/154405910808701104
OpenAlex: W2103805072
Cited by: 669
References: 27
Citations by year: 2026: 6 · 2025: 14 · 2024: 33 · 2023: 16 · 2022: 39 · 2021: 26 · 2020: 30 · 2019: 24 · 2018: 47 · 2017: 45 · 2016: 41 · 2015: 42 · 2014: 49 · 2013: 50 · 2012: 65
FWCI: 53.33
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Dental Research (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (publishedVersion)
UvA-DARE (University of Amsterdam) (submittedVersion)
VU Research Portal (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: oral microbiota, species richness, saliva, supragingival plaque, 16S rRNA gene, operational taxonomic units, phylotypes, microbial diversity, healthy adults
MeSH terms: Adult, Dental Plaque, DNA, Bacterial, Humans, RNA, Bacterial, RNA, Ribosomal, 16S, Saliva, Bacterial Typing Techniques, Sequence Analysis, DNA

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Pyrosequencing analysis of the Oral Microflora of healthy adults

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