Cited by 672Oral microbiology and periodontitis researchMicrobial Community Ecology and PhysiologyGut microbiota and health

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Pyrosequencing analysis of the Oral Microflora of healthy adults

Keijser, B.J.F., Zaura, E., Huse, S.M., van der Vossen, J.M.B.M., Schuren, F.H.J., Montijn, R.C., ten Cate, J.M., Crielaard, W.·2008·Journal of Dental Research

DOI 10.1177/154405910808701104

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Abstract

A good definition of commensal microflora and an understanding of its relation to health are essential in preventing and combating disease. We hypothesized that the species richness of human oral microflora is underestimated. Saliva and supragingival plaque were sampled from 71 and 98 healthy adults, respectively. Amplicons from the V6 hypervariable region of the small-subunit ribosomal RNA gene were generated by PCR, pooled into saliva and plaque pools, and sequenced by means of the Genome Sequencer 20 system at 454 Life Sciences. Data were evaluated by taxonomic and rarefaction analyses. The 197,600 sequences generated yielded about 29,000 unique sequences, representing 22 taxonomic phyla. Grouping the sequences in operational taxonomic units (6%) yielded 3621 and 6888 species-level phylotypes in saliva and plaque, respectively. This work gives a radically new insight into the diversity of human oral microflora, which, with an estimated number of 19,000 phylotypes, is considerably higher than previously reported.

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“Recent studies where cloning and sequencing approaches of microbial 16S rDNA were applied to the oral microflora have identified still more new species (Aas et al., 2008; Preza et al., 2008; Riggio et al., 2008).”
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Authors: Keijser, B. J. F., Zaura, E., Huse, S. M., van der Vossen, J. M. B. M., Schuren, F. H. J., Montijn, R. C., ten Cate, J. M., & Crielaard, W.
Affiliations: Marine Biological Laboratory (US)
TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Zeist, The Netherlands;
ORCID: Keijser, B.J.F.
Zaura, E.
Schuren, F.H.J.
Venue: Journal of Dental Research
Publisher: SAGE Publications
Published: 2008-11
Volume: 87
Issue: 11
Pages: 1016-1020
ISSN: 0022-0345 (ISSN-L)
1544-0591
DOI: 10.1177/154405910808701104
OpenAlex: W2103805072
Cited by: 669
References: 27
Citations by year: 2026: 6 · 2025: 14 · 2024: 33 · 2023: 16 · 2022: 39 · 2021: 26 · 2020: 30 · 2019: 24 · 2018: 47 · 2017: 45 · 2016: 41 · 2015: 42 · 2014: 49 · 2013: 50 · 2012: 65
FWCI: 53.33
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Dental Research (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (publishedVersion)
UvA-DARE (University of Amsterdam) (submittedVersion)
VU Research Portal (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: oral microbiota, species richness, saliva, supragingival plaque, 16S rRNA gene, operational taxonomic units, phylotypes, microbial diversity, healthy adults
MeSH terms: Adult, Dental Plaque, DNA, Bacterial, Humans, RNA, Bacterial, RNA, Ribosomal, 16S, Saliva, Bacterial Typing Techniques, Sequence Analysis, DNA

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Pyrosequencing analysis of the Oral Microflora of healthy adults

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