Cited by 892Salivary Gland Disorders and FunctionsClinical Laboratory Practices and Quality ControlHIV/AIDS oral health manifestations

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T he D iagnostic A pplications of S aliva — A R eview

Kaufman, Eliaz, Lamster, Ira B.·2002·Critical Reviews in Oral Biology & Medicine

DOI 10.1177/154411130201300209

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Abstract

This review examines the diagnostic application of saliva for systemic diseases. As a diagnostic fluid, saliva offers distinctive advantages over serum because it can be collected non-invasively by individuals with modest training. Furthermore, saliva may provide a cost-effective approach for the screening of large populations. Gland-specific saliva can be used for diagnosis of pathology specific to one of the major salivary glands. Whole saliva, however, is most frequently used for diagnosis of systemic diseases, since it is readily collected and contains serum constituents. These constituents are derived from the local vasculature of the salivary glands and also reach the oral cavity via the flow of gingival fluid. Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use.

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Authors: Kaufman, E., & Lamster, I. B.
Affiliations: Columbia University (US)
ORCID: Lamster, Ira B.
Venue: Critical Reviews in Oral Biology & Medicine
Publisher: SAGE Publications
Published: 2002-03
Volume: 13
Issue: 2
Pages: 197-212
ISSN: 1045-4411 (ISSN-L)
1544-1113
DOI: 10.1177/154411130201300209
OpenAlex: W2084107384
Cited by: 887
References: 212
Citations by year: 2026: 39 · 2025: 32 · 2024: 52 · 2023: 61 · 2022: 39 · 2021: 40 · 2020: 47 · 2019: 43 · 2018: 34 · 2017: 36 · 2016: 38 · 2015: 56 · 2014: 57 · 2013: 52 · 2012: 55
FWCI: 0.98
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Critical Reviews in Oral Biology & Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Salivary Gland Disorders and Functions
Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
Health Sciences › Dentistry › General Dentistry › HIV/AIDS oral health manifestations
Keywords: saliva diagnostics, whole saliva, non-invasive biomarkers, systemic disease diagnosis, salivary gland pathology, autoimmune disease, genetic disorders, cancer, infectious diseases, endocrine disorders, therapeutic drug monitoring, mass screening
MeSH terms: Animals, Autoimmune Diseases, Communicable Diseases, Hormones, Humans, Mouth Diseases, Saliva, Biomarkers, Drug Monitoring, Clinical Chemistry Tests, Genetic Diseases, Inborn

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