Cited by 892Salivary Gland Disorders and FunctionsClinical Laboratory Practices and Quality ControlHIV/AIDS oral health manifestations

The DOI matches its Crossref record; 212 of the 212 references it cites were found in a registry or an index.

T he D iagnostic A pplications of S aliva — A R eview

Kaufman, Eliaz, Lamster, Ira B.·2002·Critical Reviews in Oral Biology & Medicine

DOI 10.1177/154411130201300209

Open this paper in CoChat — free account

Abstract

This review examines the diagnostic application of saliva for systemic diseases. As a diagnostic fluid, saliva offers distinctive advantages over serum because it can be collected non-invasively by individuals with modest training. Furthermore, saliva may provide a cost-effective approach for the screening of large populations. Gland-specific saliva can be used for diagnosis of pathology specific to one of the major salivary glands. Whole saliva, however, is most frequently used for diagnosis of systemic diseases, since it is readily collected and contains serum constituents. These constituents are derived from the local vasculature of the salivary glands and also reach the oral cavity via the flow of gingival fluid. Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use.

Integrity signals

Registry

Crossref · 10.1177/154411130201300209

Cites

212 of 212 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Antinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell Biology
Tan, E. M. (1989) · Advances in immunology · doi:10.1016/s0065-2776(08)60641-0 · Cited by 1,506
Methods for Collecting Saliva
Navazesh, M. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb18343.x · Cited by 1,449
A Prospective Study of Dengue Infections in Bangkok
Burke, D. S., Nisalak, A., Johnson, D. E., & Scott, R. M. (1988) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1988.38.172 · Cited by 827
Salivary cortisol: a better measure of adrenal cortical function than serum cortisol
Vining, R. F., McGinley, R. A., Maksvytis, J. J., & Ho, K. Y. (1983) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456328302000601 · Cited by 684
Labial salivary gland biopsy in sjögren's syndrome
Daniels, T. E. (1984) · Arthritis & Rheumatism · doi:10.1002/art.1780270205 · Cited by 605
Potential Pathogenic Mechanisms of Periodontitis‐Associated Pregnancy Complications
Offenbacher, S., Jared, H., O'Reilly, P. G., Wells, S. R., Salvi, G. E., Lawrence, H. P., Socransky, S. S., & Beck, J. D. (1998) · Annals of Periodontology · doi:10.1902/annals.1998.3.1.233 · Cited by 570
The Functions of Saliva
Mandel, I. D. (1987) · Journal of Dental Research · doi:10.1177/00220345870660s203 · Cited by 495
The role of saliva in maintaining oral homeostasis
Mandel, I. D. (1989) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1989.0211 · Cited by 434
A reference guide to drugs and dry mouth – 2nd edition
Sreebny, L. M., & Schwartz, S. S. (1997) · Gerodontology · doi:10.1111/j.1741-2358.1997.00033.x · Cited by 434

Show all 212 references

Research works printed but not linked: 2

Gaudette D, North L, Hindahl M, Griffin K, Klimkow N, Thieme T (1994). Stability of clinically significant antibodies in saliva and oral fluid. J Clin Immunoassay 17:171–175.
Young JA, Van Lennep EW (1978). The process of secretion of organic products. In: The morphology of salivary glands. London, UK: Academic Press, pp. 124-144.

Sorted by citations

Wearable biosensors for healthcare monitoring
Kim, J., Campbell, A. S., de Ávila, B. E.-F., & Wang, J. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0045-y · Cited by 3,373
Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017
Hiemke, C., Bergemann, N., Clement, H. ‐., Conca, A., Deckert, J., Domschke, K., Eckermann, G., Egberts, K. M., Gerlach, M., Greiner, C., et al. (2017) · Pharmacopsychiatry · doi:10.1055/s-0043-116492 · Cited by 1,494
Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: Current state of research
Nater, U. M., & Rohleder, N. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.014 · Cited by 1,370
The human volatilome: volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva
Amann, A., Costello, B. D. L., Miekisch, W., Schubert, J., Buszewski, B., Pleil, J., Ratcliffe, N., & Risby, T. (2014) · Journal of Breath Research · doi:10.1088/1752-7155/8/3/034001 · Cited by 804
Diagnostic Potential of Saliva: Current State and Future Applications
Pfaffe, T., Cooper-White, J. J., Beyerlein, P., Kostner, K., & Punyadeera, C. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.153767 · Cited by 805
Non-invasive matrices in human biomonitoring: A review
Esteban, M., & Castaño, A. (2008) · Environment International · doi:10.1016/j.envint.2008.09.003 · Cited by 589
The role of natural salivary defences in maintaining a healthy oral microbiota
Pedersen, A. M. L., & Belstrøm, D. (2019) · Journal of Dentistry · doi:10.1016/j.jdent.2018.08.010 · Cited by 496
Microfluidic Chips for Point‐of‐Care Immunodiagnostics
Gervais, L., de Rooij, N., & Delamarche, E. (2011) · Advanced Materials · doi:10.1002/adma.201100464 · Cited by 500
Saliva diagnostics – Current views and directions
Kaczor‐Urbanowicz, K. E., Carreras‐Presas, C. M., Aro, K. L. S., Tu, M. K., Garcı́a-Godoy, F., & Wong, D. T. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216681550 · Cited by 501
Testosterone-mediated immune functions and male life histories
Muehlenbein, M. P., & Bribiescas, R. G. (2005) · American Journal of Human Biology · doi:10.1002/ajhb.20419 · Cited by 449
Comparative Human Salivary and Plasma Proteomes
Loo, J. A., Yan, W., Ramachandran, P., & Wong, D. T. (2010) · Journal of Dental Research · doi:10.1177/0022034510380414 · Cited by 446
Advances and challenges in biosensor-based diagnosis of infectious diseases
Sin, M. L. Y., Mach, K. E., Wong, P. K., & Liao, J. C. (2014) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2014.888313 · Cited by 458
Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted?
McCullough, M. E., Churchland, P. S., & Mendez, A. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.018 · Cited by 416
Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring
Wang, B., Zhao, C., Wang, Z., Yang, K.-A., Cheng, X., Liu, W., Yu, W., Lin, S., Zhao, Y., Cheung, K. M., et al. (2022) · Science Advances · doi:10.1126/sciadv.abk0967 · Cited by 411
Current Developments in Salivary Diagnostics
Miller, C. S., Foley, J. D., Bailey, A. L., Campell, C. L., Humphries, R. L., Christodoulides, N. J., Floriano, P. N., Simmons, G. W., Bhagwandin, B., Jacobson, J. W., et al. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.09.68 · Cited by 403
Saliva: potential diagnostic value and transmission of 2019-nCoV
Xu, R., Cui, B., Duan, X., Zhang, P., Zhou, X., & Yuan, Q. (2020) · International Journal of Oral Science · doi:10.1038/s41368-020-0080-z · Cited by 400
Salivary biomarkers of existing periodontal disease
Miller, C. S., King, C. P., Langub, M. C., Kryscio, R. J., & Thomas, M. V. (2006) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2006.0181 · Cited by 362
Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: a systematic review
Soares Nunes, L. A., Mussavira, S., & Sukumaran Bindhu, O. (2015) · Biochemia Medica · doi:10.11613/bm.2015.018 · Cited by 333
Analysis of matrix metalloproteinases, especially MMP‐8, in gingival crevicular fluid, mouthrinse and saliva for monitoring periodontal diseases
Sorsa, T. A., Gürsoy, U. K., Nwhator, S. O., Hernández, M., Tervahartiala, T. I., Leppilahti, J. M., Gürsoy, M., Könönen, E., Emingil, G., Pussinen, P. J., et al. (2015) · Periodontology 2000 · doi:10.1111/prd.12101 · Cited by 319
Identification of human whole saliva protein components using proteomics
Vitorino, R. M. P., Calheiros‐Lobo, M. J., Ferrer‐Correira, A. J., Dubin, J. R., Tomer, K. B., Domingues, P. M., & Amado, F. M. L. (2004) · PROTEOMICS · doi:10.1002/pmic.200300638 · Cited by 295
Medication effects on salivary cortisol: Tactics and strategy to minimize impact in behavioral and developmental science
Granger, D. A., Hibel, L. C., Fortunato, C., & Kapelewski, C. H. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.017 · Cited by 295
Hybrid Volatolomics and Disease Detection
Broza, Y. Y., Mochalski, P., Ruzsányi, V., Amann, A., & Haick, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201500153 · Cited by 302
Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans
Walsh, M. C., Brennan, L., Malthouse, J. P. G., Roche, H. M., & Gibney, M. J. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.3.531 · Cited by 297
The rôle of saliva in maintaining oral health and as an aid to diagnosis.
Llena, C. (2006) · PubMed · Cited by 285
The human saliva metabolome
Dame, Z. T., Aziat, F., Mandal, R., Krishnamurthy, R., Bouatra, S., Borzouie, S., Guo, A. C., Sajed, T., Deng, L., Lin, H., et al. (2015) · Metabolomics · doi:10.1007/s11306-015-0840-5 · Cited by 275
Discovery and Preclinical Validation of Salivary Transcriptomic and Proteomic Biomarkers for the Non-Invasive Detection of Breast Cancer
Zhang, L., Xiao, H., Karlan, S. R., Zhou, H., Gross, J., Elashoff, D. A., Akin, D., Yan, X., Chia, D., Karlan, B. Y., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015573 · Cited by 278
Salivary markers of inflammation in response to acute stress
Slavish, D. C., Graham‐Engeland, J. E., Smyth, J. M., & Engeland, C. G. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.08.008 · Cited by 274
Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics
Malon, R. S. P., Sadir, S., Balakrishnan, M., & Córcoles, E. P. (2014) · BioMed Research International · doi:10.1155/2014/962903 · Cited by 260
Salivary Biomarkers of Stress, Anxiety and Depression
Chojnowska, S., Ptaszyńska-Sarosiek, I., Kępka, A., Knaś, M., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030517 · Cited by 251
Exploiting salivary miR‐31 as a clinical biomarker of oral squamous cell carcinoma
Liu, C., Lin, S., Yang, C., Cheng, H., & Chang, K. (2011) · Head & Neck · doi:10.1002/hed.21713 · Cited by 236
Salivary Biomarkers of Periodontal Disease in Response to Treatment
Sexton, W. M., Lin, Y.-S., Kryscio, R., Dawson, D. R., Ebersole, J., & Miller, C. (2011) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01706.x · Cited by 226
Evaluation and comparison of in vitro degradation kinetics of DNA in serum, urine and saliva: A qualitative study
Wang, Y., Chen, M. Y., Nan, X., & Liu, H. (2016) · Gene · doi:10.1016/j.gene.2016.06.033 · Cited by 232
Salivary markers of oxidative stress in oral diseases
Tóthová, Ľ., Kamodyová, N., Červenka, T., & Celec, P. (2015) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00073 · Cited by 222
An update: salivary hormones and physical exercise
Gatti, R., & De Palo, E. F. (2011) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2010.01252.x · Cited by 213
Identification of N-Linked Glycoproteins in Human Saliva by Glycoprotein Capture and Mass Spectrometry
Ramachandran, P., Boontheung, P., Xie, Y., Sondej, M. A., Wong, D. T., & Loo, J. A. (2006) · Journal of Proteome Research · doi:10.1021/pr050492k · Cited by 213
Characterization of RNA in Saliva
Park, N. J., Li, Y., Yu, T., Brinkman, B. M. N., & Wong, D. T. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.063206 · Cited by 213
Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices
Pullano, S. A., Greco, M., Bianco, M. G., Foti, D., Brunetti, A., & Fiorillo, A. S. (2022) · Theranostics · doi:10.7150/thno.64035 · Cited by 210
Salivary gland function, development, and regeneration
Chibly, A. M., Aure, M. H., Patel, V. N., & Hoffman, M. P. (2022) · Physiological Reviews · doi:10.1152/physrev.00015.2021 · Cited by 219
Trends in Nanomaterial-Based Non-Invasive Diabetes Sensing Technologies
Makaram, P., Owens, D., & Aceros, J. C. (2014) · Diagnostics · doi:10.3390/diagnostics4020027 · Cited by 209
Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment
Hemadi, A. S., Huang, R., Zhou, Y., & Zou, J. (2017) · International Journal of Oral Science · doi:10.1038/ijos.2017.35 · Cited by 210
Salivary Biomarkers for Oral Squamous Cell Carcinoma Diagnosis and Follow-Up: Current Status and Perspectives
Cristaldi, M., Mauceri, R., Fede, O. D., Giuliana, G., Campisi, G., & Panzarella, V. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01476 · Cited by 202
Nanoscale Sensor Technologies for Disease Detection via Volatolomics
Vishinkin, R., & Haick, H. (2015) · Small · doi:10.1002/smll.201501904 · Cited by 202
Salivary Exosomes: Emerging Roles in Systemic Disease
Han, Y., Jia, L., Zheng, Y., & Li, W. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.25018 · Cited by 196
Proteomic Analysis of Human Saliva From Lung Cancer Patients Using Two-Dimensional Difference Gel Electrophoresis and Mass Spectrometry
Xiao, H., Zhang, L., Zhou, H., Lee, J. M., Garon, E. B., & Wong, D. T. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.012112 · Cited by 192
Salivary Biomarkers for Detection of Systemic Diseases
Rathnayake, N., Åkerman, S., Klinge, B., Lundegren, N., Jansson, H., Tryselius, Y., Sorsa, T. A., & Gustafsson, A. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061356 · Cited by 191
Use of Saliva-Based Nano-Biochip Tests for Acute Myocardial Infarction at the Point of Care: A Feasibility Study
Floriano, P. N., Christodoulides, N. J., Miller, C. S., Ebersole, J. L., Spertus, J. A., Rose, B. G., Kinane, D. F., Novak, M. J., Steinhubl, S. R., Acosta, S., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.117713 · Cited by 188
Host-to-Host Airborne Transmission As a Multiphase Flow Problem For Science-Based Social Distance Guidelines
Balachandar, S., Zaleski, S., Soldati, A., Ahmadi, G., & Bourouiba, L. (2020) · International Journal of Multiphase Flow · doi:10.1016/j.ijmultiphaseflow.2020.103439 · Cited by 195
Lipid Peroxidation Levels and Total Oxidant/Antioxidant Status in Serum and Saliva From Patients With Chronic and Aggressive Periodontitis. Oxidative Stress Index: A New Biomarker for Periodontal Disease?
Baltacıoğlu, E., Yuva, P., Aydın, G., Alver, A., Kahraman, C., Karabulut, E., & Akalın, F. A. (2014) · Journal of Periodontology · doi:10.1902/jop.2014.130654 · Cited by 182
Salivary biomarkers of oral health – a cross‐sectional study
Rathnayake, N., Åkerman, S., Klinge, B., Lundegren, N., Jansson, H., Tryselius, Y., Sorsa, T. A., & Gustafsson, A. K. (2012) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12038 · Cited by 180
Association Between Obesity, Flow Rate of Whole Saliva, and Dental Caries in Adolescents
Modéer, T., Blomberg, C., Wondimu, B., Julihn, A., & Marcus, C. (2010) · Obesity · doi:10.1038/oby.2010.63 · Cited by 185
Effects of diabetes mellitus on salivary secretion and its composition in the human
Mata, A., Marques, D. N. D. S., Rocha, S., Francisco, H., Santos, C., de Mesquita, M. F., & Singh, J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000028748.40917.6f · Cited by 179
Validation of a high-sensitivity assay for C-reactive protein in human saliva
Ouellet‐Morin, I., Danese, A., Williams, B. S., & Arseneault, L. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.020 · Cited by 176
Salivary steroid assays – research or routine?
Wood, P. J. (2009) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2008.008208 · Cited by 175
A comparison of the pro-inflammatory, NF-κB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients
Rhodus, N. L., Cheng, B., Myers, S. L., Bowles, W. R., Ho, V., & Ondrey, F. G. (2005) · Clinical Immunology · doi:10.1016/j.clim.2004.12.003 · Cited by 171
Human saliva as a diagnostic material
Chojnowska, S., Baran, T., Wilińska, I., Sienicka, P., Cabaj-Wiater, I., & Knaś, M. (2017) · Advances in Medical Sciences · doi:10.1016/j.advms.2017.11.002 · Cited by 170
Toward Defining the Human Parotid Gland Salivary Proteome and Peptidome: Identification and Characterization Using 2D SDS−PAGE, Ultrafiltration, HPLC, and Mass Spectrometry
Hardt, M., Thomas, L. R., Dixon, S. E., Newport, G., Agabian, N. M., Prakobphol, A., Hall, S. C., Witkowska, H. E., & Fisher, S. J. (2005) · Biochemistry · doi:10.1021/bi048176r · Cited by 167
Saliva--a diagnostic window to the body, both in health and in disease.
Greabu, M., Battino, M. A., Mohora, M., Totan, A., Didilescu, A. C., Spînu, T. C., Totan, C., Miricescu, D., & Rădulescu, R. (2009) · PubMed Central · Cited by 163
Salivary infectious agents and periodontal disease status
Saygun, I., Nizam, N., Keskiner, İ., Bal, M. V., Kubar, A., Açıkel, C., Serdar, M. A., & Slots, J. (2011) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2010.01335.x · Cited by 162
Saliva as a non-invasive diagnostic tool for inflammation and insulin-resistance.
Desai, G. S., & Mathews, S. T. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i6.730 · Cited by 144
Oral-fluid samples for surveillance of commercial growing pigs for porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 infections
Prickett, J., Kim, W., Simer, R., Yoon, K. J., & Zimmerman, J. J. (2008) · Journal of Swine Health and Production · doi:10.54846/jshap/565 · Cited by 156
Systematic comparison of exosomal proteomes from human saliva and serum for the detection of lung cancer
Sun, Y., Liu, S., Qiao, Z., Shang, Z., Xia, Z., Niu, X., Qian, L., Zhang, Y., Fan, L.-Y., Cao, C., et al. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.06.005 · Cited by 155
A Review of Selected Studies That Determine the Physical and Chemical Properties of Saliva in the Field of Dental Treatment
Kubala, E., Strzelecka, P. M., Grzegocka, M., Lietz–Kijak, D., Gronwald, H., Skomro, P., & Kijak, E. (2018) · BioMed Research International · doi:10.1155/2018/6572381 · Cited by 165
Serum, plasma and saliva biomarkers for head and neck cancer
Arantes, L. M. R. B., de Carvalho, A. C., Melendez, M. E., & Carvalho, A. L. (2017) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2017.1404906 · Cited by 153
Characterization of the Human Salivary Proteome by Capillary Isoelectric Focusing/Nanoreversed-Phase Liquid Chromatography Coupled with ESI-Tandem MS
Guo, T., Rudnick, P. A., Wang, W., Lee, C. S., DeVoe, D. L., & Balgley, B. M. (2006) · Journal of Proteome Research · doi:10.1021/pr060065m · Cited by 150
Salivary Biomarkers for Caries Risk Assessment
Guo, L., & Wenyuan, S. (2013) · Journal of the California Dental Association · doi:10.1080/19424396.2013.12222284 · Cited by 149
Proteome analysis of glandular parotid and submandibular‐sublingual saliva in comparison to whole human saliva by two‐dimensional gel electrophoresis
Walz, A., Stühler, K., Wattenberg, A., Hawranke, E., Meyer, H. E., Schmalz, G., Blüggel, M., & Rühl, S. (2006) · PROTEOMICS · doi:10.1002/pmic.200500125 · Cited by 146
Saliva-based microfluidic point-of-care diagnostic
Pittman, T. W., Decsi, D. B., Punyadeera, C., & Henry, C. S. (2023) · Theranostics · doi:10.7150/thno.78872 · Cited by 146
Two-Dimensional Liquid Chromatography Study of the Human Whole Saliva Proteome
Wilmarth, P. A., Riviere, M. A., Rustvold, D. L., Lauten, J. D., Madden, T., & David, L. L. (2004) · Journal of Proteome Research · doi:10.1021/pr049911o · Cited by 144
Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone
Rhodus, N., Cheng, B., Bowles, W. R., Myers, S. L., Miller, L., & Ondrey, F. G. (2005) · Oral Diseases · doi:10.1111/j.1601-0825.2005.01165.x · Cited by 139
Non-invasive wearable chemical sensors in real-life applications
Promphet, N., Ummartyotin, S., Ngeontae, W., Puthongkham, P., & Rodthongkum, N. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.338643 · Cited by 141
Salivary biomarkers detection: Analytical and immunological methods overview
Gug, I., Tertiş, M., Hosu, O., & Cristea, C. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.02.020 · Cited by 136
Saliva as a potential non-invasive liquid biopsy for early and easy diagnosis/prognosis of head and neck cancer
Kumar, P., Gupta, S., & Das, B. C. (2023) · Translational Oncology · doi:10.1016/j.tranon.2023.101827 · Cited by 136
Bone Remodeling Biomarkers of Periodontal Disease in Saliva
Frodge, B. D., Ebersole, J. L., Kryscio, R. J., Thomas, M. V., & Miller, C. S. (2008) · Journal of Periodontology · doi:10.1902/jop.2008.080070 · Cited by 134
Comparison of Salivary and Serum Glucose Levels in Diabetic Patients
Gupta, S., Sandhu, S. V., Bansal, H., & Sharma, D. (2014) · Journal of Diabetes Science and Technology · doi:10.1177/1932296814552673 · Cited by 131
Rheumatoid arthritis and salivary biomarkers of periodontal disease
Mirrielees, J., Crofford, L. J., Lin, Y., Kryscio, R. J., Dawson, D. R., Ebersole, J. L., & Miller, C. S. (2010) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01625.x · Cited by 131
Salivary Genomics, Transcriptomics and Proteomics: The Emerging Concept of the Oral Ecosystem and their Use in the Early Diagnosis of Cancer and other Diseases
Fábián, T., Fejérdy, P., & Csermely, P. (2008) · Current Genomics · doi:10.2174/138920208783884900 · Cited by 129
Analysis of the saliva proteome from patients with head and neck squamous cell carcinoma reveals differences in abundance levels of proteins associated with tumour progression and metastasis
Dowling, P., Wormald, R. N., Meleady, P., Henry, M. A., Curran, A. J., & CLYNES, M. M. (2008) · Journal of Proteomics · doi:10.1016/j.jprot.2008.04.004 · Cited by 127
Modern creatinine (Bio)sensing: Challenges of point-of-care platforms
Cánovas, R., Cuartero, M., & Crespo, G. A. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.01.048 · Cited by 127
Quantitative analysis of estradiol and six other steroid hormones in human saliva using a high throughput liquid chromatography–tandem mass spectrometry assay
Gao, W., Tobias Stalder, A., & Kirschbaum, C. (2015) · Talanta · doi:10.1016/j.talanta.2015.05.004 · Cited by 127
Emerging 0D, 1D, 2D, and 3D nanostructures for efficient point-of-care biosensing
Byakodi, M., Shrikrishna, N. S., Sharma, R., Bhansali, S., Mishra, Y. K., Kaushik, A. K., & Gandhi, S. (2022) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2022.100284 · Cited by 127
Detection of bacterial quorum sensing N-acyl homoserine lactones in clinical samples
Kumari, A., Pasini, P., & Daunert, S. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2002-3 · Cited by 122
Analysis of the human saliva proteome
Amado, F. M. L., Vitorino, R. M. P., Domingues, P. M., Calheiros‐Lobo, M. J., & Duarte, J. A. (2005) · Expert Review of Proteomics · doi:10.1586/14789450.2.4.521 · Cited by 122
Saliva as a matrix for human biomonitoring in occupational and environmental medicine
Michalke, B., Roßbach, B., Göen, T., Schäferhenrich, A., & Scherer, G. (2014) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-014-0938-5 · Cited by 121
The physics of respiratory particle generation, fate in the air, and inhalation
Morawska, L., Buonanno, G., Mikszewski, A., & Stabile, L. (2022) · Nature Reviews Physics · doi:10.1038/s42254-022-00506-7 · Cited by 130
Vibration spectroscopy and body biofluids: Literature review for clinical applications
Leal, L. B., Nogueira, M. S., Canevari, R. D. A., & Carvalho, L. F. C. S. (2018) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2018.09.008 · Cited by 119
Lung Cancer Biomarkers
Hoseok, I., & Cho, J. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2015.07.003 · Cited by 121
Bacterial and viral pathogens in saliva: disease relationship and infectious risk
Slots, J., & Slots, H. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2010.00361.x · Cited by 119
Saliva: A Fluid of Study for OMICS
Cuevas-Córdoba, B., & Santiago-Garcı́a, J. (2014) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2013.0064 · Cited by 118
Electrochemical sensors for cortisol detections: Almost there
Zea, M., Bellagambi, F. G., Halima, H. B., Zine, N., Jaffrezic-Renault, N. J., Villa, R., Gabriel, G., & Errachid, A. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116058 · Cited by 122
Non-blood circulating tumor DNA detection in cancer
Peng, M., Chen, C., Hulbert, A., Brock, M. V., & Yu, F. (2017) · Oncotarget · doi:10.18632/oncotarget.19942 · Cited by 119
Biosensing Systems for the Detection of Bacterial Quorum Signaling Molecules
Kumari, A., Pasini, P., Deo, S. K., Flomenhoft, D. R., Shashidhar, H., & Daunert, S. (2006) · Analytical Chemistry · doi:10.1021/ac061421n · Cited by 117
Saliva proteomics as an emerging, non-invasive tool to study livestock physiology, nutrition and diseases
Lamy, E., & Mau, M. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.05.007 · Cited by 120
Validated toxicological determination of 30 drugs of abuse as optimized derivatives in oral fluid by long column fast gas chromatography/electron impact mass spectrometry
Gunnar, T., Ariniemi, K., & Lillsunde, P. M. (2005) · Journal of Mass Spectrometry · doi:10.1002/jms.846 · Cited by 117
Biomarkers in the Clinical Diagnosis and Management of Traumatic Brain Injury
Hergenroeder, G. W., Redell, J. B., Moore, A. N., & Dash, P. K. (2008) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256301 · Cited by 120
Detection of Influenza a Virus in Porcine Oral Fluid Samples
Detmer, S. E., Patnayak, D. P., Jiang, Y., Gramer, M. R., & Goyal, S. M. (2011) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/104063871102300207 · Cited by 116
Salivary Markers for Oral Cancer Detection
Markopoulos, A. K., Michailidou, E. Z., & Tzimagiorgis, G. (2010) · The Open Dentistry Journal · doi:10.2174/1874210601004010172 · Cited by 117
Saliva: Physiology and Diagnostic Potential in Health and Disease
Farnaud, S., Kosti, O., Getting, S. J., & Renshaw, D. W. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.38 · Cited by 117
Dental erosive wear and salivary flow rate in physically active young adults
Mulic, A., Tveit, A. B., Songe, D., Sivertsen, H., & Skaare, A. B. (2012) · BMC Oral Health · doi:10.1186/1472-6831-12-8 · Cited by 114
Salivary Biomarkers for Clinical Applications
Zhang, L., Xiao, H., & Wong, D. T. (2009) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256330 · Cited by 114
Salivary Diagnostics—Point-of-Care diagnostics of MMP-8 in dentistry and medicine
Rathnayake, N., Gieselmann, D., Heikkinen, A. M., Tervahartiala, T. I., & Sorsa, T. A. (2017) · Diagnostics · doi:10.3390/diagnostics7010007 · Cited by 112

Authors: Kaufman, E., & Lamster, I. B.
Affiliations: Columbia University (US)
ORCID: Lamster, Ira B.
Venue: Critical Reviews in Oral Biology & Medicine
Publisher: SAGE Publications
Published: 2002-03
Volume: 13
Issue: 2
Pages: 197-212
ISSN: 1045-4411 (ISSN-L)
1544-1113
DOI: 10.1177/154411130201300209
OpenAlex: W2084107384
Cited by: 887
References: 212
Citations by year: 2026: 39 · 2025: 32 · 2024: 52 · 2023: 61 · 2022: 39 · 2021: 40 · 2020: 47 · 2019: 43 · 2018: 34 · 2017: 36 · 2016: 38 · 2015: 56 · 2014: 57 · 2013: 52 · 2012: 55
FWCI: 0.98
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Critical Reviews in Oral Biology & Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Salivary Gland Disorders and Functions
Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
Health Sciences › Dentistry › General Dentistry › HIV/AIDS oral health manifestations
Keywords: saliva diagnostics, whole saliva, non-invasive biomarkers, systemic disease diagnosis, salivary gland pathology, autoimmune disease, genetic disorders, cancer, infectious diseases, endocrine disorders, therapeutic drug monitoring, mass screening
MeSH terms: Animals, Autoimmune Diseases, Communicable Diseases, Hormones, Humans, Mouth Diseases, Saliva, Biomarkers, Drug Monitoring, Clinical Chemistry Tests, Genetic Diseases, Inborn

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

T he D iagnostic A pplications of S aliva — A R eview

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks