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Effects of Transcranial Electrical Stimulation on Cognition
Open accessAbstract
Alterations of cortical excitability, oscillatory as well as non-oscillatory, are physiological derivates of cognitive processes, such as perception, working memory, learning, and long-term memory formation. Since noninvasive electrical brain stimulation is capable of inducing alterations in the human brain, these stimulation approaches might be attractive tools to modulate cognition. Transcranial direct current stimulation (tDCS) alters spontaneous cortical activity, while transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS) are presumed to induce or interfere with oscillations of cortical networks. Via these mechanisms, the respective stimulation techniques have indeed been shown to modulate cognitive processes in a multitude of studies conducted during the last years. In this review, we will gather knowledge about the potential of noninvasive electrical brain stimulation to study and modify cognitive processes in healthy humans and discuss directions of future research.
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“tDCS over cortical areas that mediate the cognitive function of interest combined with cognitive training of that specific function can improve task performance (Kuo and Nitsche, 2012)”
From Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation (2018) · cites this paper as Kuo and Nitsche, 2012
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BackgroundProgress of research and application of non-pharmacologic intervention in Alzheimer's disease
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“Dabei wirkt der meist kontinuierlich über ca. 20 min verabreichte Strom durch den Schädelknochen auf die Erregbarkeit kortikaler Hirnbereiche [20, 28].”
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“Die Autoren diskutieren, dass deshalb der linke DLPFC möglicherweise nicht die eigentliche Zielregion für Depressionsbehandlung sein könnte und unterlegen ihre Hypothese mit einer weiteren Studie an vier depressiven Patienten mit dem Vergleich bitemporaler zu extrazephaler Elektrodenpositionierung (16). tDCS, Kognitio…”
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Brain measurement and manipulation methods
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BackgroundZagonari, F. (2019) · Higher Education Quarterly · doi:10.1111/hequ.12201 · Cited by 4
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Self-citationChanging Brain Activity, Increasing Intelligence: Transcranial Electrical and Magnetic Stimulation
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“…al., 2003, 2004; Antal et al., 2007; Boros et al., 2008; Fritsch et al., 2010), behavioral (Wach et al., 2013; Hannah et al., 2019), and cognitive (Kuo and Nitsche, 2012; Fröhlich et al., 2015; Talsma et al., 2017; Green et al., 2020) performance. tESholdsimmense potential in the treatment of…”
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“Besides, another promising technique to promote learning and memory consolidation processes is transcranial Direct Current Stimulation (tDCS) that modulates cortical excitability (Brunoni et al., 2012; Huang et al., 2017; Kuo & Nitsche, 2012; Nitsche & Paulus, 2000).”
MethodSelf-citationEditorial: Modulating Cortical Dynamics in Language, Speech and Music
Hartwigsen, G., Scharinger, M., & Sammler, D. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00058 · Cited by 2
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NEUROMODULAÇÃO TRANSCRANIANA - REVISÃO SISTEMÁTICA
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“Furthermore, forms of transcranial electric stimulation have been used to alter the excitability of areas of the cortex to modulate behavioural performance in a range of experimental paradigms and with a variety of participants (Kuo and Nitsche, 2012).”
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“…is a safe and well-studied experimental manipulation that can modify the membrane potential of neurons via the application of a low-intensity electrical current to the scalp ( Brunoni et al. 2012) and has been found to influence cognitive processing when directed at the PFC ( Kuo and Nitsche 2012).”
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[Erratum] Brain Imaging and neurostimulation in health and disorders: status report
Baptista, A. F., Casali, A. G., Oda, A. L., Okano, A. H., Moreira, A., Santos, A. L. Y. D. S., Fernandes, A. M., Fontana, A. P., Brunoni, A. R., Fonseca, A. R. O., et al. (2024) · Brain Imaging and Stimulation · doi:10.17267/2965-3738bis.2024.e5952
Transparent electrode for neural electrical stimulation and synchronized optical imaging
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“TES is widely applied in clinical treatment, cognitive neuroscience, stroke rehabilitation, and other fields [2].”
Zakibakhsh, N., Basharpoor, S., Langroodi, H. G., Narimani, M., Nitsche, M., & Salehinejad, M. A. (2024) · medRxiv · doi:10.1101/2024.05.19.24306880
“…the potential to enhance the outcomes of pharmacological and physical interventions in MS by enhancing neuroplasticity and functional connectivity [41-43] and potentially have anti-inflammatory effects as observed in several noninvasive brain stimulation studies [44, 45], although the latter is…”
BackgroundSelf-citationMichael, L., Böke, A., & Ipczynski, H. (2022) · Brain Sciences · doi:10.3390/brainsci12060738 · Cited by 1
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“More specifically, tACS allows to exogenously interact with 97 ongoing oscillations, which can result in enhanced coherence within networks with the respective 98 behavioural impact [25,36,37].”
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“The brain region of interest varies by task; if a researcher is interested in improving fine motor control they will attach electrodes above the motor cortex[2]; if they are interested in improving working memory, sustained attention[3] and mood regulation[4], they will attach electrodes above the dorsolateral prefron…”
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Rodrigues, I. T. (2019) · Journal of Neurology & Stroke · doi:10.15406/jnsk.2019.09.00341
Scholarships vs. Training for Happiness Gained from Education in Creativity: An Analytical ModelPreprint
Zagonari, F. (2015) · SSRN Electronic Journal · doi:10.6092/unibo/amsacta/4225
“Finally, I will also not account for the effects of cannabis (Schafer et al., 2012), drugs (Muller et al., 2013; Reedijk et al., 2013), or electrical stimulation (Kuo & Nitsche, 2012) to improve creativity.”
BackgroundCosta, T. L., Boggio, P. S., & Ventura, D. S. F. (2014) · Temas em Psicologia · doi:10.9788/tp2014.3-02
Saiote, C. (2014) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4447
Vasquez, A., & Fregni, F. (2021) · Transcranial Direct Current Stimulation in Neuropsychiatric Disorders · doi:10.1007/978-3-030-76136-3_40
Cognitive Plasticity and Transcranial Electrical Stimulation
Byrne, E. M., Nord, C. L., & Holmes, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-39292-5_7
Advances in the Application of Non-Invasive Brain Stimulation in the Treatment of Depression
王, 晓. (2019) · Advances in Psychology · doi:10.12677/ap.2019.92038 · Cited by 1
“…DLPFC (Brunoni et al., 2013; Valiengo et al., 2013)。无 论是哪种刺激方式,tDCS 的治疗周期通常为 5~15 天。到目前为止,大量研究已经对 tDCS 治疗抑郁的 疗效进行了评估,并多以汉密尔顿量表得分下降 50%为有效标准(Berlim, Van den Eynde, & Daskalakis, 2013; Meron, Hedger, Garner, & Baldwin, 2015)。最近有研究者将这些分析结果整合后进行了二次评估,结 果表明:使用 tDCS…”
Metadata
- Authors
- Kuo, M.-F., & Nitsche, M. A.
- Affiliations
- University of Göttingen (DE)
- Corresponding author
- Nitsche, Michael A.
- Venue
- Clinical EEG and Neuroscience
- Publisher
- SAGE Publications
- Published
- 2012-07
- Volume
- 43
- Issue
- 3
- Pages
- 192-199
- ISSN
- 1550-0594 (ISSN-L)
- 2169-5202
- OpenAlex
- W1994130335
- Cited by
- 319
- References
- 77
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 20 · 2023: 18 · 2022: 23 · 2021: 21 · 2020: 23 · 2019: 33 · 2018: 25 · 2017: 17 · 2016: 44 · 2015: 30 · 2014: 24 · 2013: 22
- FWCI
- 12.25
- Type
- journal article
- Language
- en
- Open access
- Locations
- Clinical EEG and Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Keywords
- transcranial direct current stimulation, transcranial alternating current stimulation, transcranial random noise stimulation, non-invasive brain stimulation, cognitive modulation, cortical excitability, cortical oscillations, working memory, learning, long-term memory, perception
- MeSH terms
- Action Potentials, Brain, Cognition, Evoked Potentials, Humans, Nerve Net, Neuronal Plasticity, Transcranial Magnetic Stimulation
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