A new method for CHD prediction and prevention based on regional risk scores and randomized clinical trials; PRECARD(R) and the Copenhagen Risk Score

Thomsen, T. F.; Davidsen, M.; Ibsen, H.; Jorgensen, T.; Jensen, G.; Borch-Johnsen, K.

doi:10.1177/174182670100800508

Cited by 127Health Promotion and Cardiovascular PreventionLipoproteins and Cardiovascular HealthCardiovascular Health and Risk Factors

A new method for CHD prediction and prevention based on regional risk scores and randomized clinical trials; PRECARD(R) and the Copenhagen Risk Score

Thomsen, T. F., Davidsen, M., Ibsen, H., Jorgensen, T., Jensen, G., Borch-Johnsen, K.·2001·European Journal of Cardiovascular Prevention & Rehabilitation

DOI 10.1177/174182670100800508

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Abstract

BACKGROUND: There is a considerable gap between the recommended prevention of coronary heart disease (CHD) in the guidelines from the European Society of Cardiology and the actually conducted clinical practice in preventive cardiology. A new method for implementing the recommended clinical practice in preventive cardiology is described. AIM: To develop a comprehensive and flexible health educational computer program (the PRECARD program) for individual coronary risk prediction and multifactorial prevention. MATERIAL AND METHODS: The PRECARD program contains a new coronary risk score (the Copenhagen Risk Score) for myocardial infarction and a model for calculating the effect of intervention. Two Danish population studies (n = 11,765) with 10 years of follow up were used to establish the risk score. The included risk factors were: age, sex, cholesterol (incl. HDL), systolic blood pressure, smoking, body mass index, diabetes, familial predisposition and previous heart disease. Nine randomized clinical trials were used to estimate the effect of intervention. RESULTS: The findings in the Copenhagen Risk Score and the estimated effect of intervention deducted from the clinical trials were comparable to other similar studies. The PRECARD program gives a graphical or numerical presentation of absolute coronary risk, the potential benefit of intervention, the relative impact of modifiable risk factors and numbers needed to treat. The program compiles individually tailored health messages in print for the patient. The program can easily be adjusted to different regional risk scores, other end-points and languages. CONCLUSION: The PRECARD program may promote the recommended clinical practice in preventive cardiology by serving as an integrated part of the lifestyle consultation.

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The primary outcome used the Copenhagen risk score, which is recommended by the European Society of Cardiology for screening of cardiovascular risk.
“We used the Copenhagen risk score, which is based on data from two large epidemiological studies in the Copenhagen area 16 and is recommended by the European Society of Cardiology for screening of cardiovascular risk 29 .”
From The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity (2016) · cites this paper as [16]
Composite surrogate outcomes assessing the risk of cardiovascular disease have been proposed.
“To overcome this, composite surrogate outcomes assessing the risk of cardiovascular disease have been proposed 16 .”
From The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesity (2016) · cites this paper as [16]

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Authors: Thomsen, T. F., Davidsen, M., Ibsen, H., Jorgensen, T., Jensen, G., & Borch-Johnsen, K.
Affiliations: Glostrup Hospital (DK)
Bispebjerg Hospital (DK)
Corresponding author: Thomsen, T. F.
ORCID: Davidsen, M.
Jensen, G.
Venue: European Journal of Cardiovascular Prevention & Rehabilitation
Publisher: Oxford University Press (OUP)
Published: 2001-10-01
Volume: 8
Issue: 5
Pages: 291-297
ISSN: 1741-8267 (ISSN-L)
1741-8275
DOI: 10.1177/174182670100800508
OpenAlex: W2110061973
Cited by: 127
References: 37
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 10 · 2014: 3 · 2013: 7 · 2012: 8
FWCI: 9.64
Type: journal article
Language: en
Open access: closed
Locations: European Journal of Cardiovascular Prevention & Rehabilitation (publishedVersion)
PubMed (publishedVersion)
Funders: Hjerteforeningen
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: coronary artery disease, cardiovascular risk prediction, multifactorial prevention, myocardial infarction risk, intervention effect estimation, number needed to treat, modifiable risk factors, preventive cardiology
MeSH terms: Adult, Age Factors, Aged, Aged, 80 and over, Blood Pressure, Cholesterol, Coronary Disease, Denmark, Female, Follow-Up Studies, Humans, Lipoproteins, HDL, Male, Middle Aged, Myocardial Infarction, Predictive Value of Tests, Risk Factors, Software, Cohort Studies, Suburban Health

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A new method for CHD prediction and prevention based on regional risk scores and randomized clinical trials; PRECARD(R) and the Copenhagen Risk Score

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