Long-term effects of a community-based lifestyle intervention to prevent type 2 diabetes: the DEPLOY extension pilot study
Abstract
OBJECTIVE: The US Diabetes Prevention Program (DPP) and other large trials internationally have shown that an intensive lifestyle intervention can reduce the development of type 2 diabetes. We evaluated long-term effects of a lower cost, group-based adaption of the DPP lifestyle intervention offered by the YMCA. METHODS: Participants were adults with BMI ≥24 kg/m(2) and random capillary blood glucose 6.1-11.1 mmol/L who had been previously enrolled in a cluster-randomized trial comparing a group-based DPP lifestyle intervention versus brief advice alone. Four to 12 months after completion of the initial trial, 72% of 92 participants enrolled in an extension study, and all were offered a group lifestyle maintenance program at the YMCA. Paired t-tests were used to assess within-group changes; ANCOVA with adjustment was used for between-group comparisons. RESULTS: At 28 months, after both arms were offered the same 8-month lifestyle maintenance intervention, both arms had statistically significant weight losses compared to baseline (brief advice controls: -3.6%; 95% CI: -5.8 to -1.4; intensive lifestyle: -6.0%; 95% CI: -8.8 to -3.2). Participants initially assigned to the DPP also experienced significant improvements in blood pressure and total cholesterol. DISCUSSION: The YMCA is a promising channel for dissemination of a low-cost model for lifestyle diabetes prevention. Future studies are needed to verify these findings.
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Fourteen articles were not included in the meta-analysis because they provided insufficient data for analyses or because they reported outcomes from a trial already included in the analysis but with data from other follow-up times.
“Fourteen articles were not included in the meta-analysis because they provided insufficient data for analyses (i.e., did not report SEs for outcomes and authors did not respond to requests for these data) (23–27) or because these articles reported outcomes from a trial already included in the analysis but with data from other follow-up times (28–36).”
From Global diabetes prevention interventions: A systematic review and network meta-analysis of the real-world impact on incidence, weight, and glucose (2018) · cites this paper as [30]
An extension study of DEPLOY found that both control and intervention arms maintained weight changes compared with baseline, and those in the initial intervention group lost a further 1.5% of body weight, with significant decreases in total cholesterol and systolic blood pressure.
“An extension study in which both the control and intervention arms were offered an 8-month lifestyle maintenance program found that both groups maintained weight changes compared with baseline, and those in the initial intervention group lost a further 1.5% of body weight, with significant decreases in total cholesterol and systolic blood pressure (79).”
From The CardioMetabolic Health Alliance (2015) · cites this paper as [79]
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Translation of the diabetes prevention program to the community: evaluation of implementation issues
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- Authors
- Ackermann, R. T., Finch, E. A., Caffrey, H. M., Lipscomb, E. R., Hays, L. M., & Saha, C.
- Affiliations
- Indiana University Indianapolis (US)
- Corresponding author
- Ackermann, Ronald T
- Venue
- Chronic Illness
- Publisher
- SAGE Publications
- Published
- 2011-08-12
- Volume
- 7
- Issue
- 4
- Pages
- 279-290
- ISSN
- 1742-3953 (ISSN-L)
- 1745-9206
- OpenAlex
- W2112829586
- Cited by
- 58
- References
- 21
- Citations by year
- 2025: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 10 · 2014: 8 · 2013: 7 · 2012: 2
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chronic Illness (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R34 DK70702-S1, R34DK070702)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- type 2 diabetes prevention, lifestyle intervention, Diabetes Prevention Program, YMCA, weight loss, prediabetes, blood pressure, total cholesterol, community-based intervention, long-term follow-up
- MeSH terms
- Aged, Blood Pressure, Cholesterol, Diabetes Mellitus, Type 2, Female, Humans, Indiana, Life Style, Male, Middle Aged, Pilot Projects, Psychotherapy, Group, Weight Loss, Community Networks, Risk Reduction Behavior
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