Review: Therapeutic advances in functional gastrointestinal disease: irritable bowel syndrome
Open accessAbstract
Reported prevalence rates of irritable bowel syndrome (IBS) are between 8% to 20% in the US general population with an average medical expenditure of US$1.35 billion direct and US$205 million indirect costs. Current pathophysiologic theories are based on abnormalities of both the brain and gut, thus setting a new stage for current and future therapeutic approaches. There are numerous treatment options in IBS acting centrally and peripherally by influencing motility and visceral sensitivity. Clinical evidence is variable; however, newer emerging treatments are being evaluated using better-designed clinical trials. Accurate assessment of IBS drug efficacy is still hampered by heterogeneity of the IBS population. Novel methods such as pharmacogenomics or brain imaging may be helpful in the future to better understand and characterize IBS patient subtypes, and this in turn will lead to more specific and efficient therapeutic options. Patient subpopulation measurement of side effects is also a clinical challenge and further understanding could improve treatment efficacy by enhancing the patient compliance.
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A substantial proportion of patients with IBS do not attain adequate relief through conventional medical approaches.
“A substantial proportion of patients with IBS do not attain adequate relief through conventional medical approaches (5).”
From Mindfulness training reduces the severity of irritable bowel syndrome in women: Results of a randomized controlled trial (2011) · cites this paper as [5]
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Flagged first, then by citations
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Cited by
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- Authors
- Gaman, A., Bucur, M. C., & Kuo, B.
- Affiliations
- Harvard University (US)
- ORCID
- Kuo, Braden
- Venue
- Therapeutic Advances in Gastroenterology
- Publisher
- SAGE Publications
- Published
- 2009-04-28
- Volume
- 2
- Issue
- 3
- Pages
- 169-181
- ISSN
- 1756-283X (ISSN-L)
- 1756-2848
- PMC
- PMC2779541
- OpenAlex
- W2028601204
- Cited by
- 12
- References
- 99
- Citations by year
- 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Therapeutic Advances in Gastroenterology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K23DK069614)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, functional gastrointestinal disorders, IBS treatment, gut-brain axis, visceral sensitivity, gastrointestinal motility, pharmacogenomics, neuroimaging, IBS subtypes, drug efficacy, patient heterogeneity, adverse effects, medication adherence, health care costs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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