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Cited by 347Gastrointestinal motility and disordersInfant Health and DevelopmentGastroesophageal reflux and treatments

Colonic Motility Abnormality in Patients With Irritable Bowel Syndrome Exhibiting Abdominal Pain and Diarrhea

Chey, William Y., Jin, Hai Ou, Lee, Mun Ho, Sun, Sung Wu, Lee, Kae Yol·2001·American Journal of Gastroenterology
DOI 10.1111/j.1572-0241.2001.03804.x
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Abstract

OBJECTIVES: Although colon dysmotility is recognized as a pathophysiological factor in irritable bowel syndrome (IBS), it has not been characterized. We have investigated motility patterns in IBS patients with abdominal pain and frequent defecation or diarrhea and in healthy volunteers. METHODS: A recording catheter that had six polyvinyl tubes with infusion ports was placed in the transverse, descending, and sigmoid colon under fluoroscopy. After 2-h basal recordings, motility responses to cholecystokinin octapeptide (CCK-8) and a meal were studied for 3 h. The motility index (MI) and number of high amplitude propagating contractions (HAPCs) in 10 IBS patients were compared with those of 10 controls. HAPCs were correlated with abdominal pain, and colon transit time using radio-opaque markers was determined. Using human colon muscle strips, the effect of CCK-8 on muscle contractions was also studied. RESULTS: The MI and mean number and peak amplitude of HAPCs in IBS patients were significantly greater than in controls. These abnormalities paralleled markedly shortened colonic transit time. Abdominal pain coincided with >90% of HAPCs. Dose-dependent muscle contraction by CCK-8 was profoundly suppressed both by loxiglumide and atropine. CONCLUSIONS: The dysmotility in this subset of IBS patients was characterized by significantly increased occurrences of powerful HAPCs that paralleled rapid colon transit and were accompanied by abdominal pain. Thus, it is suggested that this powerful contraction is one of the causes of abdominal pain. The action of CCK-8 seems to be mediated via the colon enteric nervous system.

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  • Pain responses in functional bowel disorders of the gut-brain axis such as IBS are associated with altered parasympathetic activity.

    “pain responses in functional bowel disorders of the gutbrain axis such as IBS are associated with altered parasympathetic activity (Chey et al., 2001).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Chey et al., 2001

  • The microbially-modulated metabolite 4-ethylphenylsulfate is sufficient to induce anxiety-like behavior in mice.

    “Multiple research groups (Chey et al., 2001;Hsiao et al., 2013;Lyte, 2013;Sokol and Adolph, 2018;Wall et al., 2014) have demonstrated that the microbially-modulated metabolite 4-ethylphenylsulfate is sufficient to induce anxiety-like behavior in mice.”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Chey et al., 2001

  • Accelerated intestinal transit, with an increased number of giant migrating contractions, is seen in many diarrheal states, including diarrhea-predominant IBS.

    “while accelerated intestinal transit, with an increased number of giant, migrating contractions, is seen in many diarrheal states, including diarrhea-predominant IBS.22”

    From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [22]

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Authors
Chey, W. Y., Jin, H. O., Lee, M. H., Sun, S. W., & Lee, K. Y.
Affiliations
University of Rochester Medicine (US)
Corresponding author
Chey, William Y.
Venue
American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-05
Volume
96
Issue
5
Pages
1499-1506
ISSN
0002-9270 (ISSN-L)
DOI
10.1111/j.1572-0241.2001.03804.x
OpenAlex
W2028184380
Cited by
347
References
24
Citations by year
2026: 6 · 2025: 9 · 2024: 9 · 2023: 13 · 2022: 13 · 2021: 12 · 2020: 5 · 2019: 11 · 2018: 12 · 2017: 7 · 2016: 17 · 2015: 16 · 2014: 20 · 2013: 7 · 2012: 19
FWCI
13.31
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Health Professions › Pharmacy › Infant Health and Development
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords
irritable bowel syndrome, colonic motility, abdominal pain, diarrhea, colonic transit time, cholecystokinin octapeptide, CCK-8, enteric nervous system, loxiglumide, atropine
MeSH terms
Adult, Aged, Colon, Colonic Diseases, Functional, Diarrhea, Fasting, Female, Gastrointestinal Motility, Gastrointestinal Transit, Humans, Male, Middle Aged, Muscle, Smooth, Reference Values, Sincalide, Abdominal Pain, Postprandial Period, In Vitro Techniques

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