Reduced Levels of Serum Pigment Epithelium-Derived Factor in Women With Endometriosis
Abstract
The authors previously demonstrated decreased levels of pigment epithelium-derived factor (PEDF) in peritoneal fluid of women with endometriosis compared to women without endometriosis. Here, the authors determine whether women with endometriosis have altered levels of PEDF in serum. Peripheral blood samples were collected from 71 women with and without endometriosis (n = 43 and 28, respectively) before laparoscopic surgery. Concentrations of serum PEDF were measured by enzyme-linked immunosorbent assay. We detected lower levels of serum PEDF in women with endometriosis (16.3 ± 6.6 ng/mL) than in those without endometriosis (24.5 ± 7.3 ng/mL; P < .001). In women with endometriosis, the concentrations of serum PEDF were significantly lower in women with pain (n = 11, 12.6 ± 7.1 ng/mL) compared to women without pain (n = 32, 17.5 ± 6.0 ng/mL; P < .05). However, the concentrations of serum PEDF did not correlate with disease stage or site or infertility. In addition, the concentrations of serum PEDF did not show any difference in the phase of the cycle in either group. Our results suggest that reduced levels of serum PEDF in women with endometriosis and disease-related pain may play a role in the pathogenesis of this disease.
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PEDF was significantly decreased in women with endometriosis (n=43) compared with women without endometriosis (n=28), independent of the phase of the cycle and correlated with pain symptoms.
“In a study by Chen et al., PEDF was significantly decreased in women with endometriosis (n = 43) compared with women without endometriosis (n = 28), independent of the phase of the cycle and correlated with pain symptoms [71].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [71]
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- Authors
- Chen, L., Fan, R., Huang, X., Xu, H., & Zhang, X.
- Affiliations
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Corresponding author
- Zhang, Xinmei
- Venue
- Reproductive Sciences
- Published
- 2012-01
- Volume
- 19
- Issue
- 1
- Pages
- 64-69
- ISSN
- 1933-7191 (ISSN-L)
- 1933-7205
- OpenAlex
- W2012106487
- Cited by
- 26
- References
- 53
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, pigment epithelium-derived factor, endometriosis-associated pain, biomarkers, endometriosis pathogenesis, menstrual cycle phases
- MeSH terms
- Pigment Epithelium-Derived Factor, Adult, Endometriosis, Eye Proteins, Female, Humans, Nerve Growth Factors, Biomarkers, Serpins, Case-Control Studies
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