Altered Placental Function of 11β-Hydroxysteroid Dehydrogenase 2 Knockout Mice

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,114 · see citing works

Vascular Endothelial Growth Factor: Basic Science and Clinical Progress

Ferrara, N. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0027 · Cited by 3,707 · see citing works

Some new, simple and efficient stereological methods and their use in pathological research and diagnosis.

GUNDERSEN, H. J. G., BENDTSEN, T. F., KORBO, L., MARCUSSEN, N., MØLLER, A., NIELSEN, K., NYENGAARD, J. R., PAKKENBERG, B., SØRENSEN, F. B., VESTERBY, A., et al. (1988) · APMIS · doi:10.1111/j.1699-0463.1988.tb05320.x · Cited by 2,929 · see citing works

Postnatal disappearance of the pregnancy-associated reduced sensitivity of plasma cortisol to feedback inhibition

Owens, P. C., Smith, R., Brinsmead, M. W., Hall, C., Foureur, M. J., Hurt, D., Lovelock, M., Chan, E.-C., Cubis, J., & Lewin, T. J. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90603-5 · Cited by 958 · see citing works

Glucocorticoid exposure in utero: new model for adult hypertension

Benediktsson, R., Lindsay, R. S., Noble, J., Seckl, J. R., & Edwards, C. R. W. (1993) · The Lancet · doi:10.1016/0140-6736(93)90138-7 · Cited by 862 · see citing works

Mechanisms of Disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology

Seckl, J. R., & Holmes, M. C. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0515 · Cited by 754 · see citing works

Comparative Developmental Anatomy of the Murine and Human Definitive Placentae

Georgiades, P., Ferguson-Smith, A. C., & Burton, G. J. (2002) · Placenta · doi:10.1053/plac.2001.0738 · Cited by 641 · see citing works

Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring.

Nyirenda, M., Lindsay, R. S., Kenyon, C. J., Burchell, A. N., & Seckl, J. R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1567 · Cited by 574 · see citing works

The SLC2 family of facilitated hexose and polyol transporters

Uldry, M., & Thorens, B. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1085-0 · Cited by 494 · see citing works

Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour

Welberg, L., Seckl, J. R., & Holmes, M. C. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00065-3 · Cited by 420 · see citing works

Maternal stress alters endocrine function of the feto-placental unit in rats

Mairesse, J., Lesage, J., Breton, C., Bréant, B., Hahn, T., Darnaudéry, M., Dickson, S. L., Seckl, J., Blondeau, B., Vieau, D., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00574.2006 · Cited by 410 · see citing works

Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems

Constância, M., Angiolini, E., Sandovici, I., Smith, P., Smith, R., Kelsey, G., Dean, W., Ferguson-Smith, A., Sibley, C. P., Reik, W., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504468103 · Cited by 323 · see citing works

The ontogeny of 11 beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development

Brown, R. W., Diaz, R., Robson, A. C., Kotelevtsev, Y. V., Mullins, J. J., Kaufman, M. H., & Seckl, J. R. (1996) · Endocrinology · doi:10.1210/endo.137.2.8593833 · Cited by 307 · see citing works

Developmental Dynamics of the Definitive Mouse Placenta Assessed by Stereology1

Coan, P. M., Ferguson-Smith, A. C., & Burton, G. J. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.024166 · Cited by 296 · see citing works

Maternal Asthma Is Associated with Reduced Female Fetal Growth

Murphy, V. E., Gibson, P. G., Giles, W. B., Zakár, T., Smith, R., Bisits, A. M., Kessell, C. G., & Clifton, V. L. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200303-374oc · Cited by 295 · see citing works

Type 2 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid and activity in human placenta and fetal membranes: its relationship to birth weight and putative role in fetal adrenal steroidogenesis.

Stewart, P. M., Rogerson, F. M., & Mason, J. I. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.3.7883847 · Cited by 278 · see citing works

Umbilical uptake of amino acids in the unstressed fetal lamb.

Lemons, J. A., Adcock, E. W., Jones, M., Naughton, M. A., Meschia, G., & Battaglia, F. C. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108598 · Cited by 265 · see citing works

Mechanism of dexamethasone suppression of brain tumor-associated vascular permeability in rats. Involvement of the glucocorticoid receptor and vascular permeability factor.

Heiss, J. D., Papavassiliou, E. D., Merrill, M. J., Nieman, L. K., Knightly, J. J., Walbridge, S., Edwards, N. A., & Oldfield, E. H. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118927 · Cited by 256 · see citing works

Leptin Stimulates the Activity of the System A Amino Acid Transporter in Human Placental Villous Fragments

Jansson, N., Greenwood, S. L., Johansson, B. R., Powell, T. L., & Jansson, T. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021332 · Cited by 243 · see citing works

The Mother or the Fetus? 11β-Hydroxysteroid Dehydrogenase Type 2 Null Mice Provide Evidence for Direct Fetal Programming of Behavior by Endogenous Glucocorticoids

Holmes, M. C., Abrahamsen, C. T., French, K. L., Paterson, J. M., Mullins, J. J., & Seckl, J. R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4464-05.2006 · Cited by 200 · see citing works

Peroxisome Proliferator-Activated Receptor-γ Agonists Increase Vascular Endothelial Growth Factor Expression in Human Vascular Smooth Muscle Cells

Yamakawa, K., Hosoi, M., Koyama, H., Tanaka, S., Fukumoto, S., Morii, H., & Nishizawà, Y. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2665 · Cited by 136 · see citing works

Glucocorticoids Prevent the Normal Increase in Placental Vascular Endothelial Growth Factor Expression and Placental Vascularity during Late Pregnancy in the Rat

Hewitt, D. P., Mark, P. J., & Waddell, B. J. (2006) · Endocrinology · doi:10.1210/en.2006-0825 · Cited by 134 · see citing works

Reduced 11 -Hydroxysteroid Dehydrogenase Type 2 Activity Is Associated with Decreased Birth Weight Centile in Pregnancies Complicated by Asthma

Murphy, V. E., Zakár, T., Smith, R., Giles, W. B., Gibson, P. G., & Clifton, V. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8377 · Cited by 132 · see citing works

Placental glucose transporter gene expression and metabolism in the rat.

Zhou, J., & Bondy, C. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116305 · Cited by 125 · see citing works

Placental Glucose Transporter Expression Is Regulated by Glucocorticoids

Hahn, T. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.4.1445 · Cited by 119 · see citing works

Placental Glucose Transporter Expression Is Regulated by Glucocorticoids1

Hahn, T., Barth, S., Graf, R., Engelmann, M., Beslagic, D., Reul, J. M. H. M., Holsboer, F., Dohr, G., & Desoyé, G. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.4.5607 · Cited by 116 · see citing works

Glucose Transporter GLUT3 in the Rat Placental Barrier: A Possible Machinery for the Transplacental Transfer of Glucose

Shin, B., Fujikura, K., Suzuki, T., Tanaka, S., & Takata, K. (1997) · Endocrinology · doi:10.1210/endo.138.9.5369 · Cited by 99 · see citing works

Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation

LANGDOWN, M. L., & Sugden, M. C. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00629-3 · Cited by 92 · see citing works

Glucocorticoids inhibit vascular endothelial growth factor expression in growth plate chondrocytes.

Koedam, J., Smink, J. J., & van Buul-Offers, S. V. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00276-9 · Cited by 83 · see citing works

Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo)

Jones, H. N., Ashworth, C. J., Page, K., & McArdle, H. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00359.2005 · Cited by 83 · see citing works

Hormonal regulation of glucose and system A amino acid transport in first trimester placental villous fragments

Ericsson, A., Hamark, B., Jansson, N., Johansson, B. R., Powell, T. L., & Jansson, T. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00407.2004 · Cited by 81 · see citing works

Proinflammatory Cytokines Upregulate mRNA Expression and Secretion of Vascular Endothelial Growth Factor in Cultured Human Airway Smooth Muscle Cells

Alagappan, V. K. T., McKay, S., Widyastuti, A., Garrelds, I. M., Bogers, A. J. J. C., Hoogsteden, H. C., Hirst, S. J., & SHARMA, H. S. (2005) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:43:1:119 · Cited by 49 · see citing works

Placental Expression of Peroxisome Proliferator-Activated Receptors in Rat Pregnancy and the Effect of Increased Glucocorticoid Exposure1

Hewitt, D. P., Mark, P. J., & Waddell, B. J. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.045914 · Cited by 45 · see citing works

Hyperosmotic stimulus induces reversible angiogenesis within the hypothalamic magnocellular nuclei of the adult rat: a potential role for neuronal vascular endothelial growth factor

Alonso, G., Galibert, E., Duvoid, A., & Vincent, A. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-20 · Cited by 32 · see citing works

PPAR-γ ligands up-regulate basic fibroblast growth factor-induced VEGF release through amplifying SAPK/JNK activation in osteoblasts

Yasuda, E., Tokuda, H., Ishisaki, A., Hirade, K., Kanno, Y., Hanai, Y., Nakamura, N., Noda, T., Katagiri, Y., & Kozawa, O. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.163 · Cited by 25 · see citing works

Is knowledge of health behavior associated with low birth weight?

Mvula, M. M., & Miller, J. M. (1999) · The Journal of Maternal-Fetal Medicine · doi:10.1002/(sici)1520-6661(199905/06)8:3 · Cited by 1 · see citing works

11β-hydroxysteroid dehydrogenases: Intracellular gate-keepers of tissue glucocorticoid action

Chapman, K., Holmes, M., & Seckl, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00020.2012 · Cited by 887 · see citing works

Glucocorticoids, prenatal stress and the programming of disease

Harris, A., & Seckl, J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.007 · Cited by 871 · see citing works

Placental Origins of Chronic Disease

Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works

Prenatal stress, glucocorticoids and the programming of adult disease

Cottrell, E. C. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.019.2009 · Cited by 640 · see citing works

Placental efficiency and adaptation: endocrine regulation

Fowden, A. L., Sferruzzi-Perri, A. N., Coan, P. M., Constância, M., & Burton, G. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173013 · Cited by 359 · see citing works

The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming

Bronson, S. L., & Bale, T. L. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.231 · Cited by 285 · see citing works

Glucocorticoids, developmental ‘programming’ and the risk of affective dysfunction

Seckl, J. R. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67002-2 · Cited by 245 · see citing works

11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progress

Wyrwoll, C. S., Holmes, M. C., & Seckl, J. R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.12.001 · Cited by 244 · see citing works

Placental adaptations to the maternal–fetal environment: implications for fetal growth and developmental programming

Sandovici, I., Hoelle, K., Angiolini, E., & Constância, M. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.03.017 · Cited by 224 · see citing works

A Role for Glucocorticoids in Stress-Impaired Reproduction: Beyond the Hypothalamus and Pituitary

Whirledge, S., & Cidlowski, J. A. (2013) · Endocrinology · doi:10.1210/en.2013-1652 · Cited by 209 · see citing works

Early-life glucocorticoid exposure: the hypothalamic-pituitary-adrenal axis, placental function, and long-term disease risk

Braun, T., Challis, J. R., Newnham, J. P., & Sloboda, D. M. (2013) · Endocrine Reviews · doi:10.1210/er.2013-1012 · Cited by 196 · see citing works

Glucocorticoids and reproduction: Traffic control on the road to reproduction

Whirledge, S., & Cidlowski, J. A. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.02.005 · Cited by 178 · see citing works

Let's talk about placental sex, baby: understanding mechanisms that drive female- and male-specific fetal growth and developmental outcomes

Meakin, A. S., Cuffe, J. S. M., Darby, J. R. T., Morrison, J. L., & Clifton, V. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126386 · Cited by 158 · see citing works

Maternal Fructose Intake during Pregnancy and Lactation Alters Placental Growth and Leads to Sex-Specific Changes in Fetal and Neonatal Endocrine Function

Vickers, M. H., Clayton, Z. E., Yap, C., & Sloboda, D. M. (2011) · Endocrinology · doi:10.1210/en.2010-1093 · Cited by 157 · see citing works

Mechanisms of Glucocorticoid Action During Development

Busada, J. T., & Cidlowski, J. A. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.12.004 · Cited by 141 · see citing works

Regulation of Placental Amino Acid Transport and Fetal Growth

Vaughan, O. R., Rosario, F. J., Powell, T. L., & Jansson, T. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.008 · Cited by 130 · see citing works

Foetal and placental 11<i>β</i>‐<scp>HSD</scp>2: a hub for developmental programming

Cottrell, E. C., Seckl, J. R., Holmes, M. C., & Wyrwoll, C. S. (2014) · Acta Physiologica · doi:10.1111/apha.12187 · Cited by 123 · see citing works

Placental-Specific Igf2 Deficiency Alters Developmental Adaptations to Undernutrition in Mice

Sferruzzi-Perri, A. N., Vaughan, O. R., Coan, P. M., Suciu, M. C., Darbyshire, R., Constancia, M., Burton, G. J., & Fowden, A. L. (2011) · Endocrinology · doi:10.1210/en.2011-0240 · Cited by 115 · see citing works

The placenta as a window to the brain: A review on the role of placental markers in prenatal programming of neurodevelopment

Shallie, P. D., & Naicker, T. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.01.003 · Cited by 112 · see citing works

In Utero Origins of Hypertension: Mechanisms and Targets for Therapy

Morton, J. S., Cooke, C. M., & Davidge, S. T. (2016) · Physiological Reviews · doi:10.1152/physrev.00015.2015 · Cited by 106 · see citing works

Regulation of Placental Growth by Aldosterone and Cortisol

Gennari‐Moser, C., Khankin, E. V., Schüller, S. S., Escher, G., Frey, B. M., Portmann-Lanz, C. B., Baumann, M. U., Lehmann, A. D., Surbek, D., Karumanchi, S. A., et al. (2010) · Endocrinology · doi:10.1210/en.2010-0525 · Cited by 103 · see citing works

Reconciling the nutritional and glucocorticoid hypotheses of fetal programming

Cottrell, E. C., Holmes, M. C., Livingstone, D. E., Kenyon, C. J., & Seckl, J. R. (2012) · The FASEB Journal · doi:10.1096/fj.12-203489 · Cited by 102 · see citing works

Glucocorticoids as mediators of developmental programming effects

Khulan, B., & Drake, A. J. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.03.007 · Cited by 98 · see citing works

Environmental inhibitors of 11β-hydroxysteroid dehydrogenase type 2

Ma, X., Lian, Q.-Q., Dong, Q., & Ge, R.-S. (2011) · Toxicology · doi:10.1016/j.tox.2011.04.007 · Cited by 94 · see citing works

Review: Endocrine regulation of placental phenotype

Fowden, A. L., Forhead, A. J., Sferruzzi-Perri, A. N., Burton, G. J., & Vaughan, O. R. (2014) · Placenta · doi:10.1016/j.placenta.2014.11.018 · Cited by 96 · see citing works

Sex specific changes in placental growth and MAPK following short term maternal dexamethasone exposure in the mouse

Cuffe, J. S. M., Dickinson, H., Simmons, D. G., & Moritz, K. M. (2011) · Placenta · doi:10.1016/j.placenta.2011.09.009 · Cited by 86 · see citing works

Revisiting preeclampsia: a metabolic disorder of the placenta

Hu, M., Li, J., Baker, P. N., & Tong, C. (2021) · FEBS Journal · doi:10.1111/febs.15745 · Cited by 84 · see citing works

Altered placental development in undernourished rats: role of maternal glucocorticoids

Belkacemi, L., Jelks, A. T., Chen, C., Ross, M. G., & Desai, M. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-105 · Cited by 83 · see citing works

Hormonal and nutritional drivers of intrauterine growth

Sferruzzi-Perri, A. N., Vaughan, O. R., Forhead, A. J., & Fowden, A. L. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32835e3643 · Cited by 82 · see citing works

A rhythmic placenta? Circadian variation, clock genes and placental function

Waddell, B. J., Wharfe, M. D., Crew, R. C., & Mark, P. J. (2012) · Placenta · doi:10.1016/j.placenta.2012.03.008 · Cited by 78 · see citing works

Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation

Sferruzzi-Perri, A. N., López‐Tello, J., Fowden, A. L., & Constância, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602012113 · Cited by 73 · see citing works

Expression of eight glucocorticoid receptor isoforms in the human preterm placenta vary with fetal sex and birthweight

Saif, Z., Hodyl, N. A., Stark, M. J., Fuller, P. J., Cole, T. J., Lu, N. Z., & Clifton, V. L. (2015) · Placenta · doi:10.1016/j.placenta.2015.05.001 · Cited by 71 · see citing works

Environmental Pollutants and Hydroxysteroid Dehydrogenases

Ye, L., Guo, J., & Ge, R. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800095-3.00013-4 · Cited by 67 · see citing works

Dexamethasone stimulates placental system A transport and trophoblast differentiation in term villous explants

Audette, M. C., Greenwood, S. L., Sibley, C. P., Jones, C. J. P., Challis, J. R. G., Matthews, S. G., & Jones, R. L. (2010) · Placenta · doi:10.1016/j.placenta.2009.11.016 · Cited by 66 · see citing works

Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats

Napso, T., Hung, Y.-P., Davidge, S. T., Care, A. S., & Sferruzzi-Perri, A. N. (2019) · Scientific Reports · doi:10.1038/s41598-019-53199-x · Cited by 62 · see citing works

L-Citrulline Supplementation Enhances Fetal Growth and Protein Synthesis in Rats with Intrauterine Growth Restriction

Bourdon, A., Parnet, P., Nowak, C., Tran, N.-T., Winer, N., & Darmaun, D. (2016) · Journal of Nutrition · doi:10.3945/jn.115.221267 · Cited by 63 · see citing works

A maternal high-fat diet in rat pregnancy reduces growth of the fetus and the placental junctional zone, but not placental labyrinth zone growth

Mark, P. J., Sisala, C., Connor, K. L., Patel, R., Lewis, J. L., Vickers, M. H., Waddell, B. J., & Sloboda, D. M. (2011) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174410000681 · Cited by 61 · see citing works

Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity

Solano, M. E., Holmes, M. C., Mittelstadt, P. R., Chapman, K. E., & Tolosa, E. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0575-z · Cited by 63 · see citing works

Preeclampsia is associated with a deficiency of lipoxin A4, an endogenous anti-inflammatory mediator

Xu, Z., Zhao, F., Lin, F., Xiang, H., Wang, N., Ye, D., & Huang, Y. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.03.056 · Cited by 61 · see citing works

Metabolic Disease Programming: From Mitochondria to Epigenetics, Glucocorticoid Signalling and Beyond

Grilo, L. F., Tocantins, C., Diniz, M. S., Gomes, R. M., Oliveira, P. J., Matafome, P. N., & Pereira, S. P. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13625 · Cited by 62 · see citing works

Prenatal arsenic exposure alters the programming of the glucocorticoid signaling system during embryonic development

Caldwell, K. E., Labrecque, M. T., Solomon, B. R., Ali, A.-M. S., & Allan, A. M. (2014) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2014.11.006 · Cited by 60 · see citing works

Glucocorticoids, antenatal corticosteroid therapy and fetal heart maturation

Agnew, E. J., Ivy, J. R., Stock, S. J., & Chapman, K. E. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0077 · Cited by 61 · see citing works

Genomic and Non-Genomic Actions of Glucocorticoids on Adipose Tissue Lipid Metabolism

Mir, N., Chin, S. A., Riddell, M. C., & Beaudry, J. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168503 · Cited by 58 · see citing works

Inhibition of 11β-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole

Beck, K. R., Bächler, M., Vuorinen, A., Wagner, S., Akram, M., Griesser, U. J., Temml, V., Klusoňová, P., Yamaguchi, H., Schuster, D., et al. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.01.010 · Cited by 56 · see citing works

Bisphenol-A impairs cellular function and alters DNA methylation of stress pathway genes in first trimester trophoblast cells

Basak, S., Vilasagaram, S., & Duttaroy, A. K. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.10.009 · Cited by 55 · see citing works

Environmental regulation of placental phenotype: implications for fetal growth

Vaughan, O. R., Sferruzzi-Perri, A. N., Coan, P. M., & Fowden, A. L. (2011) · Reproduction Fertility and Development · doi:10.1071/rd11909 · Cited by 55 · see citing works

The inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by perfluoroalkylated substances

Zhao, B., Lian, Q., Chu, Y., Hardy, D. O., Li, X., & Ge, R. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.12.017 · Cited by 53 · see citing works

Vitamin D Deficiency in BALB/c Mouse Pregnancy Increases Placental Transfer of Glucocorticoids

Tesic, D., Hawes, J. E., Zosky, G. R., & Wyrwoll, C. S. (2015) · Endocrinology · doi:10.1210/en.2015-1377 · Cited by 53 · see citing works

Antenatal Dexamethasone Treatment in Midgestation Reduces System A-Mediated Transport in the Late-Gestation Murine Placenta

Audette, M. C., Challis, J. R. G., Jones, R. L., Sibley, C. P., & Matthews, S. G. (2011) · Endocrinology · doi:10.1210/en.2011-0104 · Cited by 47 · see citing works

In utero perfluorooctane sulfonate exposure causes low body weights of fetal rats: A mechanism study

Li, X., Ye, L., Ge, Y., Yuan, K., Zhang, Y., Liang, Y., Wei, J., Zhao, C., Lian, Q., Zhu, X., et al. (2016) · Placenta · doi:10.1016/j.placenta.2016.01.010 · Cited by 48 · see citing works

Dysregulation of 11beta-hydroxysteroid dehydrogenases: implications during pregnancy and beyond

Konstantakou, P., Mastorakos, G. P., Vrachnis, N., Tomlinson, J., & Valsamakis, G. (2016) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2016.1171308 · Cited by 48 · see citing works

A Role for the Placenta in Programming Maternal Mood and Childhood Behavioural Disorders

Janssen, A. B., Kertes, D. A., McNamara, G. I., Braithwaite, E., Creeth, H., Glover, V. A. S., & John, R. M. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12373 · Cited by 46 · see citing works

Maternal nutrition influences angiogenesis in the placenta through peroxisome proliferator activated receptors: A novel hypothesis

Meher, A. P., Sundrani, D. P., & Joshi, S. (2015) · Molecular Reproduction and Development · doi:10.1002/mrd.22518 · Cited by 45 · see citing works

Maternal obesity aggravates the abnormality of porcine placenta by increasing N6-methyladenosine

Song, T., Lü, J., Deng, Z., Xu, T., Yang, Y., Wei, H., Li, S., Jiang, S., & Peng, J. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0113-2 · Cited by 45 · see citing works

Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice

López‐Tello, J., Pérez-García, V., Khaira, J., Kusinski, L. C., Cooper, W. N., Andreani, A., Grant, I. D., de Liger, E. F., Lam, B., Hemberger, M., et al. (2019) · eLife · doi:10.7554/elife.45282 · Cited by 45 · see citing works

LPS alters placental inflammatory and endocrine mediators and inhibits fetal neurite growth in affected offspring during late gestation

Straley, M. E., Togher, K. L., Nolan, A. M., Kenny, L. C., & O’Keeffe, G. W. (2014) · Placenta · doi:10.1016/j.placenta.2014.06.001 · Cited by 43 · see citing works

Review: The role of multiple placental glucocorticoid receptor isoforms in adapting to the maternal environment and regulating fetal growth

Clifton, V. L., Cuffe, J. S. M., Moritz, K. M., Cole, T. J., Fuller, P. J., Lu, N. Z., Kumar, S., Chong, S., & Saif, Z. (2016) · Placenta · doi:10.1016/j.placenta.2016.12.017 · Cited by 43 · see citing works

Prenatal overexposure to glucocorticoids programs renal 11β-hydroxysteroid dehydrogenase type 2 expression and salt-sensitive hypertension in the rat

Tang, J. I.-S., Kenyon, C. R., Seckl, J. R., & Nyirenda, M. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e328340aa18 · Cited by 42 · see citing works

Dexamethasone Downregulates SLC7A5 Expression and Promotes Cell Cycle Arrest, Autophagy and Apoptosis in BeWo Cells

He, B., Zhang, N., & Zhao, R. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25076 · Cited by 42 · see citing works

Vitamin D deficiency and impaired placental function: potential regulation by glucocorticoids?

Yates, N. J., Crew, R. C., & Wyrwoll, C. S. (2017) · Reproduction · doi:10.1530/rep-16-0647 · Cited by 42 · see citing works

Differential expression of placental 11β-HSD2 induced by high maternal glucocorticoid exposure mediates sex differences in placental and fetal development

Yu, P., Zhou, J., Ge, C., Fang, M., Zhang, Y., & Wang, H. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.154396 · Cited by 42 · see citing works

Placental Size Is Associated with Mental Health in Children and Adolescents

Khalife, N., Glover, V. A. S., Hartikainen, A., Taanila, A. M., Ebeling, H. E., Järvelin, M., & Rodriguez, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040534 · Cited by 40 · see citing works

The human placenta and its role in reproductive outcomes revisited

Aye, I. L. M. H., Tong, S., Jones, D. S., & Smith, G. C. S. (2025) · Physiological Reviews · doi:10.1152/physrev.00039.2024 · Cited by 45 · see citing works

Pravastatin ameliorates placental vascular defects, fetal growth, and cardiac function in a model of glucocorticoid excess

Wyrwoll, C. S., Noble, J., Thomson, A. J. W., Tesic, D., Miller, M. R., Rog‐Zielinska, E. A., MORAN, C. M., Seckl, J. R., Chapman, K. E., & Holmes, M. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520356113 · Cited by 40 · see citing works

Effect of glucocorticoids on mechanisms of placental angiogenesis

Özmen, A., Ünek, G., & Korgun, E. T. (2017) · Placenta · doi:10.1016/j.placenta.2017.02.015 · Cited by 40 · see citing works

The effects of an obesogenic diet during pregnancy on fetal growth and placental gene expression are gestation dependent

King, V. M., Hibbert, N., Seckl, J. R., Norman, J. E., & Drake, A. J. (2013) · Placenta · doi:10.1016/j.placenta.2013.09.006 · Cited by 40 · see citing works

Modulation of fetoplacental growth, development and reproductive function by endocrine disrupters

Basak, S., Varma, S., & Duttaroy, A. K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1215353 · Cited by 39 · see citing works

Fetal brain 11β-hydroxysteroid dehydrogenase type 2 selectively determines programming of adult depressive-like behaviors and cognitive function, but not anxiety behaviors in male mice

Wyrwoll, C. S., Keith, M., Noble, J., Stevenson, P. L., Bombail, V., Crombie, S., Evans, L. C., Bailey, M. A., Wood, E. R., Seckl, J. R., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.05.003 · Cited by 39 · see citing works

Hypertrophy in the Distal Convoluted Tubule of an 11β-Hydroxysteroid Dehydrogenase Type 2 Knockout Model

Hunter, R. W., Ivy, J. R., Flatman, P. W., Kenyon, C. J., Craigie, E., Mullins, L. J., Bailey, M. A., & Mullins, J. J. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013060634 · Cited by 38 · see citing works

Maternal growth restriction and stress exposure in rats differentially alters expression of components of the placental glucocorticoid barrier and nutrient transporters

Briffa, J. F., Hosseini, S., Tran, M., Moritz, K. M., Cuffe, J. S. M., & Wlodek, M. E. (2017) · Placenta · doi:10.1016/j.placenta.2017.09.006 · Cited by 37 · see citing works

Antenatal Corticosteroids: A Risk Factor for the Development of Chronic Disease

Asztalos, E. V. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/930591 · Cited by 36 · see citing works

Metabolic Consequences of Glucocorticoid Exposure before Birth

Fowden, A. L., Vaughan, O. R., Murray, A. J., & Forhead, A. J. (2022) · Nutrients · doi:10.3390/nu14112304 · Cited by 40 · see citing works

Developmental programming of adult adrenal structure and steroidogenesis: effects of fetal glucocorticoid excess and postnatal dietary omega-3 fatty acids

Waddell, B. J., Bollen, M., Wyrwoll, C. S., Mori, T. A., & Mark, P. J. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0459 · Cited by 35 · see citing works

The p38 Mitogen-Activated Protein Kinase Regulates 11β-Hydroxysteroid Dehydrogenase Type 2 (11β-HSD2) Expression in Human Trophoblast Cells through Modulation of 11β-HSD2 Messenger Ribonucleic Acid Stability

Sharma, A., Guan, H., & Yang, K. (2009) · Endocrinology · doi:10.1210/en.2009-0479 · Cited by 34 · see citing works

Lipopolysaccharide Downregulates 11β-Hydroxysteroid Dehydrogenase 2 Expression through Inhibiting Peroxisome Proliferator–Activated Receptor-γ in Placental Trophoblasts

Fu, L., Chen, Y., Bo, Q., Song, Y., Ma, L., Wang, B., Xu, S., Zhang, C., Wang, H., & Xu, D. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900132 · Cited by 33 · see citing works

Spontaneous Miscarriages Are Explained by the Stress/Glucocorticoid/Lipoxin A4 Axis

Xu, Z., Zhao, J., Zhang, H., Tang, K., Xu, P., Cai, W., Katirai, F., Ye, D., Huang, Y., & Huang, B. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202807 · Cited by 32 · see citing works

Recent advances in the study of 11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2)Inhibitors

Zhou, C.-C., Ye, F., Wu, H., Ye, H., & Chen, Q. (2017) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2017.02.021 · Cited by 31 · see citing works

The structure-activity relationship (SAR) for phthalate-mediated developmental and reproductive toxicity in males.

Li, X., Mo, J., Zhu, Q., Ni, C., Wang, Y.-Y., Li, H.-T., Lin, Z.-K., & Ge, R. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.02.090 · Cited by 28 · see citing works

Developmental ORIgins of Healthy and Unhealthy AgeiNg: The Role of Maternal Obesity - Introduction to DORIAN

Iozzo, P., Holmes, M. C., Schmidt, M. V., Cirulli, F., Guzzardi, M. A., Berry, A., Balsevich, G., Andreassi, M. G., Wesselink, J., Liistro, T., et al. (2014) · Obesity Facts · doi:10.1159/000362656 · Cited by 30 · see citing works

nAChRs‐ERK1/2‐Egr‐1 signaling participates in the developmental toxicity of nicotine by epigenetically down‐regulating placental 11&bgr;‐HSD2

Zhou, J., Liu, F.-L., Yu, L., Xu, D., Li, B., Zhang, G.-H., Huang, W., Li, L., Zhang, Y.-Z., Zhang, W., et al. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.02.017 · Cited by 27 · see citing works

Species-specific differences in the inhibition of human and zebrafish 11β-hydroxysteroid dehydrogenase 2 by thiram and organotins.

Meyer, A., Strajhar, P., Murer, C., Cunha, T. D., & Odermatt, A. (2012) · Toxicology · doi:10.1016/j.tox.2012.07.001 · Cited by 24 · see citing works

Folic Acid Supplementation during Pregnancy Induces Sex-Specific Changes in Methylation and Expression of Placental 11β-Hydroxysteroid Dehydrogenase 2 in Rats

Peñailillo, R. S., Guajardo, A., Llanos, M. N., Hirsch, S., & Ronco, A. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121098 · Cited by 30 · see citing works

The Role of 11β-Hydroxy Steroid Dehydrogenase Type 2 in Glucocorticoid Programming of Affective and Cognitive Behaviours

Shearer, F. J. G., Wyrwoll, C. S., & Holmes, M. C. (2019) · Neuroendocrinology · doi:10.1159/000499660 · Cited by 29 · see citing works

The Role of Glucocorticoids in Pregnancy, Parturition, Lactation, and Nurturing in Melanocortin Receptor 2-Deficient Mice

Chida, D., Miyoshi, K., Sato, T., Yoda, T., Kikusui, T., & Iwakura, Y. (2011) · Endocrinology · doi:10.1210/en.2010-0935 · Cited by 29 · see citing works

Perinatal Programming of Circadian Clock-Stress Crosstalk

Astiz, M., & Oster, H. (2018) · Neural Plasticity · doi:10.1155/2018/5689165 · Cited by 28 · see citing works

The Effects of Glucocorticoids on Fetal and Placental Development

Korgun, E. T., Özmen, A., Ünek, G., & Mendilcioğlu, İ. (2012) · InTech eBooks · doi:10.5772/50103 · Cited by 28 · see citing works

Disruption of Slc52a3 gene causes neonatal lethality with riboflavin deficiency in mice

Yoshimatsu, H., Yonezawa, A., Yamanishi, K., Yao, Y., Sugano, K., Nakagawa, S., Imai, S., Omura, T., Nakagawa, T., Yano, I., et al. (2016) · Scientific Reports · doi:10.1038/srep27557 · Cited by 28 · see citing works

Adaptations in Placental Phenotype Depend on Route and Timing of Maternal Dexamethasone Administration in Mice1

Vaughan, O. R., Sferruzzi-Perri, A. N., Coan, P. M., & Fowden, A. L. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.109678 · Cited by 28 · see citing works

Mineralocorticoid Excess or Glucocorticoid Insufficiency

Mullins, L. J., Kenyon, C. J., Bailey, M. A., Conway, B. R., Díaz, M. E., & Mullins, J. J. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05262 · Cited by 27 · see citing works

How is prenatal stress transmitted from the mother to the fetus?

Sze, Y., & Brunton, P. J. (2024) · Journal of Experimental Biology · doi:10.1242/jeb.246073 · Cited by 29 · see citing works

Metallothionein-I- and -II-deficient mice display increased susceptibility to cadmium-induced fetal growth restriction

Selvaratnam, J. S., Guan, H., Koropatnick, J. D., & Yang, K. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00157.2013 · Cited by 25 · see citing works

Caffeine Reduces 11β-Hydroxysteroid Dehydrogenase Type 2 Expression in Human Trophoblast Cells through the Adenosine A2B Receptor

Sharmin, S., Guan, H., Williams, A. S., & Yang, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038082 · Cited by 24 · see citing works

Direct inhibition of bisphenols on human and rat 11β-hydroxysteroid dehydrogenase 2: Structure-activity relationship and docking analysis.

Zhang, B., Wang, S., Tang, Y.-B., Hu, Z., Shi, L., Lu, J., Li, H.-T., Wang, Y.-Y., Zhu, Y., Lin, H., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114715 · Cited by 19 · see citing works

Aldosterone and Cortisol Acutely Stimulate Na+/H+ Exchanger Activity in the Syncytiotrophoblast of the Human Placenta: Effect of Fetal Sex

Speake, P. F., Glazier, J. D., Greenwood, S. L., & Sibley, C. P. (2010) · Placenta · doi:10.1016/j.placenta.2009.12.025 · Cited by 21 · see citing works

The ERK1/2 Signaling Pathway Regulates 11beta-Hydroxysteroid Dehydrogenase Type 2 Expression in Human Trophoblast Cells Through a Transcriptional Mechanism1

Guan, H., Sun, K., & Yang, K. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.110924 · Cited by 22 · see citing works

Excess Maternal Glucocorticoids in Response to In Utero Undernutrition Inhibit Offspring Angiogenesis

Khorram, O., Ghazi, R., Chuang, T.-D., Han, G., Naghi, J., Ni, Y., & Pearce, W. J. (2014) · Reproductive Sciences · doi:10.1177/1933719113508819 · Cited by 22 · see citing works

Altered placental methyl donor transport in the dexamethasone programmed rat

Wyrwoll, C. S., Kerrigan, D., Holmes, M. C., Seckl, J. R., & Drake, A. J. (2012) · Placenta · doi:10.1016/j.placenta.2011.12.017 · Cited by 21 · see citing works

Progesterone partially recovers placental glucose transporters in dexamethasone-induced intrauterine growth restriction

Alawadhi, M. M., Mouihate, A., Kilarkaje, N., & Al‐Bader, M. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.10.016 · Cited by 20 · see citing works

Lack of Renal 11 Beta-Hydroxysteroid Dehydrogenase Type 2 at Birth, a Targeted Temporal Window for Neonatal Glucocorticoid Action in Human and Mice

Martinerie, L., Pussard, E., Méduri, G., Delezoide, A., Boileau, P., & Lombès, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031949 · Cited by 20 · see citing works

Prenatal Glucocorticoids: Short-Term Benefits and Long-Term Risks

Manojlovic-Stojanoski, M., Nestorovic, N., & Milosevic, V. (2012) · Glucocorticoids - New Recognition of Our Familiar Friend · doi:10.5772/51106 · Cited by 19 · see citing works

Foetal and placental 11<i>β</i>‐<scp>HSD</scp>2: a hub for developmental programming

Cottrell, E. C., Seckl, J. R., Holmes, M. C., & Wyrwoll, C. S. (2014) · Acta Physiologica · doi:10.1111/apha.12187 · Cited by 123 · see citing works

Glucocorticoids, feto-placental 11β-hydroxysteroid dehydrogenase type 2, and the early life origins of adult disease

Seckl, J. R. (1997) · Steroids · doi:10.1016/s0039-128x(96)00165-1 · Cited by 298 · see citing works

203. Partial progesterone withdrawal during late gestation increases placental expression of 11β-HSD1 in the rat

Mark, P. J., Augustus, S., Hewitt, D. P., & Waddell, B. J. (2008) · Reproduction Fertility and Development · doi:10.1071/srb08abs203

Influence of placental 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibition on glucose metabolism and 11β-HSD regulation in adult offspring of rats

Saegusa, H., Nakagawa, Y., Liu, Y., & Ohzeki, T. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90249-4 · Cited by 28 · see citing works

Maternal Malnutrition, Glucocorticoids, and Fetal Programming: A Role for Placental 11β-Hydroxysteroid Dehydrogenase Type 2

Chivers, E. K., & Wyrwoll, C. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-60289-9_39 · Cited by 1 · see citing works