Anti-Apoptosis and Autophagy Effects of Melatonin Protect Rat Chondrocytes against Oxidative Stress via Regulation of AMPK/Foxo3 Pathways

ROS, mitochondria and the regulation of autophagy

Scherz-Shouval, R., & Elazar, Z. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.009 · Cited by 954 · see citing works

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

Salminen, A., Hyttinen, J. M. T., & Kaarniranta, K. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0748-0 · Cited by 866 · see citing works

The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor

Greer, E. L., Oskoui, P. R., Banko, M. R., Maniar, J. M., Gygi, M. P., Gygi, S. P., & Brunet, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705325200 · Cited by 820 · see citing works

AMP-activated protein kinase: the current landscape for drug development

Steinberg, G. R., & Carling, D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0019-2 · Cited by 757 · see citing works

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

Zhao, Y., Hu, X., Liu, Y., Dong, S., Wen, Z., He, W., Zhang, S., Huang, Q., & Shi, M. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0648-1 · Cited by 735 · see citing works

The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis.

Zheng, L.-L., Zhang, Z.-J., Sheng, P., & Mobasheri, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101249 · Cited by 717 · see citing works

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

Venegas, C., García, J. A. G., Escames, G., Ortiz, F., López, A., Doerrier, C., García‐Corzo, L., López, L. C., Reiter, R. J., & Acuña-Castroviejo, D. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00931.x · Cited by 580 · see citing works

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

Shin, H. R., Kim, H.-K., Oh, S., Lee, J.-G., Kee, M., Ko, H., Kweon, M., Won, K., & Baek, S. H. (2016) · Nature · doi:10.1038/nature18014 · Cited by 441 · see citing works

ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration

Feng, C., Yang, M., Lan, M., Liu, C., Zhang, Y., Huang, B., Liu, H., & Zhou, Y. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5601593 · Cited by 384 · see citing works

Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin

Hosseinzadeh, A., Kamrava, S. K., Joghataei, M. T., Darabi, R., Shakeri‐Zadeh, A., Shahriari, M., Reiter, R. J., Ghaznavi, H., & Mehrzadi, S. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12362 · Cited by 345 · see citing works

Quercetin attenuates oxidative stress‐induced apoptosis via SIRT1/AMPK‐mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model

Feng, K., Chen, Z., Liu, P., Zhang, S., & Wang, X. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28452 · Cited by 254 · see citing works

AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis

Liu, D., Ma, Z., Di, S., Yang, Y., Yang, J., Xu, L., Reiter, R. J., Qiao, S., & Yuan, J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.032 · Cited by 225 · see citing works

FoxO Transcription Factors Support Oxidative Stress Resistance in Human Chondrocytes

Akasaki, Y., Álvarez-García, Ó., Saito, M., Caramés, B., Iwamoto, Y., & Lotz, M. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38868 · Cited by 223 · see citing works

NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation

Kim, S. R., Kim, D. I., Kim, S. H., Lee, H. J., Lee, K. S., Cho, S., & Lee, Y. C. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.460 · Cited by 208 · see citing works

Osteoarthritis year in review 2020: biology

van den Bosch, M. H. J. (2020) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2020.10.006 · Cited by 192 · see citing works

Neurological Enhancement Effects of Melatonin against Brain Injury-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration via AMPK/CREB Signaling

Rehman, S. U., Ikram, M. A., Ullah, N., Alam, S. I., Park, H. Y., Badshah, H., Choe, K., & Kim, M. O. (2019) · Cells · doi:10.3390/cells8070760 · Cited by 187 · see citing works

Glioma-Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK

Sato, A., Sunayama, J., Okada, M., Watanabe, E., Seino, S., Shibuya, K., Suzuki, K., Narita, Y., Shibui, S., Kayama, T., et al. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2012-0058 · Cited by 184 · see citing works

AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes

Matzinger, M., Fischhuber, K., Pölöske, D., Mechtler, K., & Heiß, E. H. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101393 · Cited by 145 · see citing works

KCNQ1OT1 promotes autophagy by regulating miR‐200a/FOXO3/ATG7 pathway in cerebral ischemic stroke

Yu, S., Yu, M., He, X., Wen, L., Bu, Z., & Feng, J. (2019) · Aging Cell · doi:10.1111/acel.12940 · Cited by 123 · see citing works

Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis

Álvarez-García, Ó., Matsuzaki, T., Olmer, M., Plate, L., Kelly, J. W., & Lotz, M. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40104 · Cited by 101 · see citing works

SIRT1 inhibits chemoresistance and cancer stemness of gastric cancer by initiating an AMPK/FOXO3 positive feedback loop

An, Y., Wang, B., Wang, X., Dong, G., Jia, J., & Yang, Q. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2308-4 · Cited by 93 · see citing works

Melatonin Enhances Autophagy and Reduces Apoptosis to Promote Locomotor Recovery in Spinal Cord Injury via the PI3K/AKT/mTOR Signaling Pathway

Li, Y., Guo, Y., Fan, Y., Tian, H., Li, K., & Mei, X. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02838-w · Cited by 91 · see citing works

FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis

Lee, K., Choi, S., Matsuzaki, T., Álvarez-García, Ó., Olmer, M., Grogan, S. P., DʼLima, D. D., & Lotz, M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918673117 · Cited by 83 · see citing works

Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate

Dávila, D., Connolly, N. M. C., Bonner, H. P., Weisová, P., Düßmann, H., Concannon, C. G., Huber, H. J., & Prehn, J. H. M. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.49 · Cited by 74 · see citing works

Activation of the AMP-related kinase (AMPK) induces renal vasodilatation and downregulates Nox-derived reactive oxygen species (ROS) generation

Rodríguez, C., Contreras, C., Medina, J. S., Muñoz, M., Corbacho, C., Carballido, J., García‐Sacristán, A., Hernández, M., López, M., Rivera, L., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101575 · Cited by 68 · see citing works

Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2

Hua, W., Li, S., Luo, R., Wu, X., Zhang, Y., Liao, Z., Song, Y., Wang, K., Zhao, K., Yang, S., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165575 · Cited by 63 · see citing works

Melatonin protects spermatogonia from the stress of chemotherapy and oxidation via eliminating reactive oxidative species

Zhang, X., Qin, X., Wei, R., Song, H., Mi, J., Lin, Z., Yang, Y., Sun, Z., & Zou, K. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.04.009 · Cited by 61 · see citing works

Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway

Lu, Y., Chen, D.-L., Wang, D., Chen, L.-Z., Mo, H., Sheng, H., Bai, L., Wu, Q.-N., Yu, H., Xie, D., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.330 · Cited by 57 · see citing works

Activation of AMPK/Sirt3 pathway by phloretin reduces mitochondrial ROS in vascular endothelium by increasing the activity of MnSOD via deacetylation

Han, L., Li, J., Li, J., Pan, C., Xiao, Y., Lan, X., & Wang, M. (2020) · Food & Function · doi:10.1039/c9fo02334h · Cited by 52 · see citing works

Activation of AMPK is neuroprotective in the oxidative stress by advanced glycosylation end products in human neural stem cells

Lin, C., Cheng, Y., Nicol, C. J. B., Lin, K., Yen, C., & Chiang, M. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.08.019 · Cited by 46 · see citing works

Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage

Fan, C., Feng, J., Tang, C., Zhang, Z., Feng, Y., Duan, W., Zhai, M., Yan, Z., Zhu, L., Feng, L., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01948-5 · Cited by 45 · see citing works

Marein protects human nucleus pulposus cells against high glucose-induced injury and extracellular matrix degradation at least partly by inhibition of ROS/NF-κB pathway

Yao, M., Zhang, J., Li, Z., Guo, S., Zhou, X., & Zhang, W. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106126 · Cited by 40 · see citing works

PKR Promotes Oxidative Stress and Apoptosis of Human Articular Chondrocytes by Causing Mitochondrial Dysfunction through p38 MAPK Activation—PKR Activation Causes Apoptosis in Human Chondrocytes

Ma, C.-H., Wu, C.-H., Jou, I., Tu, Y., Hung, C.-H., Chou, W.-C., Chang, Y., Hsieh, P., & Tsai, K. (2019) · Antioxidants · doi:10.3390/antiox8090370 · Cited by 35 · see citing works

Lower range of molecular weight of xanthan gum inhibits cartilage matrix destruction via intrinsic bax-mitochondria cytochrome c-caspase pathway

Shao, X., Chen, Q., Dou, X., Chen, L., Wu, J., Zhang, W., Shao, H., Ling, P., Liu, F., & Wang, F. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.06.108 · Cited by 29 · see citing works

Role of Forkhead Box O Transcription Factors in Oxidative Stress-Induced Chondrocyte Dysfunction: Possible Therapeutic Target for Osteoarthritis?

Wang, R., Zhang, S., Previn, R., Chen, D., Jin, Y., & Zhou, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123794 · Cited by 28 · see citing works

Angiotensin‐(1‐7) prevents T3‐induced cardiomyocyte hypertrophy by upregulating FOXO3/SOD1/catalase and downregulating NF‐ĸB

Senger, N., Parletta, A. C., Marques, B. V. D., Akamine, E. H., Diniz, G. P., Campagnole‐Santos, M. J., Santos, R. A. S., & Barreto‐Chaves, M. L. M. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30069 · Cited by 22 · see citing works

Melatonin Attenuates AlCl3-Induced Apoptosis and Osteoblastic Differentiation Suppression by Inhibiting Oxidative Stress in MC3T3-E1 Cells

Cao, Z., Geng, X. H., Jiang, X., Gao, X., Liu, K., & Li, Y. (2019) · Biological Trace Element Research · doi:10.1007/s12011-019-01893-2 · Cited by 15 · see citing works

Mito–managing ROS & redox to reboot the immune system: Tapping mitochondria & redox management to extend the reach of hematopoietic stem cell transplantation

Mohrin, M. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.01.034 · Cited by 9 · see citing works

Roles of reactive oxygen species in inflammation and cancer

Yu, Y., Liu, S., Yang, L., Song, P., Liu, Z., Liu, X., Yan, X., & Dong, Q. (2024) · MedComm · doi:10.1002/mco2.519 · Cited by 170 · see citing works

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works

Beyond mechanical loading: The metabolic contribution of obesity in osteoarthritis unveils novel therapeutic targets

Sobieh, B. H., EL-Mesallamy, H. O., & Kassem, D. H. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15700 · Cited by 49 · see citing works

Melatonin and bone-related diseases: an updated mechanistic overview of current evidence and future prospects

Bagherifard, A., Hosseinzadeh, A., Koosha, F., Sheibani, M., Behnagh, A. K., Reiter, R. J., & Mehrzadi, S. (2023) · Osteoporosis International · doi:10.1007/s00198-023-06836-1 · Cited by 39 · see citing works

Melatonin Prevents Chondrocyte Matrix Degradation in Rats with Experimentally Induced Osteoarthritis by Inhibiting Nuclear Factor-κB via SIRT1

Zhao, M., Song, X., Chen, H., Ma, T., Tang, J., Wang, X., Yu, Y., Liangyu, L., Jia, L., & Gao, L. (2022) · Nutrients · doi:10.3390/nu14193966 · Cited by 28 · see citing works

Melatonin alleviates oxidative stress damage in mouse testes induced by bisphenol A

Qi, Q., Yang, J., Li, S., Liu, J., Xu, D., Wang, G., Feng, L., & Pan, X. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1338828 · Cited by 27 · see citing works

Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway

Ma, T., Wang, X., Qu, W., Yang, L., Jing, C., Zhu, B., Zhang, Y., & Xie, W. (2022) · Molecules · doi:10.3390/molecules27238624 · Cited by 25 · see citing works

Alpha‐ketoglutarate ameliorates age‐related and surgery induced temporomandibular joint osteoarthritis via regulating IKK / NF ‐ κB signaling

Ye, X., Li, X., Qiu, J. F., Kuang, Y., Hua, B., & Liu, X. (2024) · Aging Cell · doi:10.1111/acel.14269 · Cited by 25 · see citing works

Bufei Yishen formula protects the airway epithelial barrier and ameliorates COPD by enhancing autophagy through the Sirt1/AMPK/Foxo3 signaling pathway

Jia, L., Liu, X., Liu, X., Guan, Q., Tian, Y., Li, J., & Zhao, P. (2024) · Chinese Medicine · doi:10.1186/s13020-024-00905-1 · Cited by 22 · see citing works

The role of chondrocyte senescence in osteoarthritis pathogenesis and therapeutic implications

Huang, K., & Cai, H. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112828 · Cited by 26 · see citing works

Melatonin pretreatment on exosomes: Heterogeneity, therapeutic effects, and usage

Zhou, Z., Wang, R., Wang, J., Hao, Y., Xie, Q., Wang, L., & Wang, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.933736 · Cited by 21 · see citing works

The Role and Interactive Mechanism of Endoplasmic Reticulum Stress and Ferroptosis in Musculoskeletal Disorders

Guo, Z., Chi, R., Peng, Y., Sun, K., Liu, H., Guo, F., & Guo, J. (2024) · Biomolecules · doi:10.3390/biom14111369 · Cited by 17 · see citing works

Melatonin Delays Arthritis Inflammation and Reduces Cartilage Matrix Degradation through the SIRT1-Mediated NF-κB/Nrf2/TGF-β/BMPs Pathway

Zhao, M., Qiu, D., Miao, X., Yang, W., Li, S., Cheng, X., Tang, J., Chen, H., Ruan, H., Liu, Y., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116202 · Cited by 17 · see citing works

Aberrant Tryptophan Metabolism Manipulates Osteochondral Homeostasis

Xiang, T., Yang, C., Xie, L., Xiao, S., Tang, Y., Huang, G., Sun, D., Chen, Y., & Luo, F. (2025) · Research · doi:10.34133/research.0728 · Cited by 17 · see citing works

Melatonin ameliorates glyphosate- and hard water-induced renal tubular epithelial cell senescence via PINK1-Parkin-dependent mitophagy

Zhang, L., Ding, F., Wu, X., Wang, R., Wan, Y., Hu, J., Zhang, X., & Wu, Q. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114719 · Cited by 18 · see citing works

Programmed cell death and melatonin: A comprehensive review

Rafiyan, M., Reiter, R. J., Manesh, S. M. R., Asemi, R., Sharifi, M., Mohammadi, S., Mansournia, M. A., & Asemi, Z. (2024) · Functional & Integrative Genomics · doi:10.1007/s10142-024-01454-4 · Cited by 14 · see citing works

Therapeutic targets and potential delivery systems of melatonin in osteoarthritis

Xiong, Z., Peng, G., Deng, J., Liu, M., Ning, X., Zhuang, Y., Yang, H., & Sun, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1331934 · Cited by 10 · see citing works

Potential role of gut-related factors in the pathology of cartilage in osteoarthritis

Ning, P., Lin, S., Shi, Y., & Liu, T. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1515806 · Cited by 10 · see citing works

Strontium ion attenuates osteoarthritis through inhibiting senescence and enhancing autophagy in fibroblast-like synoviocytes

Liao, B., Ding, M. L., Wang, Y., Xu, H., & Shangguan, L. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-08112-7 · Cited by 10 · see citing works

Programmed cell death in osteoarthritis

Li, H., Chen, P., Cheng, W., Zhang, Z., Yang, J., Zhang, H. F., Jin, F., Kan, L., Chen, L., & Wang, H. (2026) · APOPTOSIS · doi:10.1007/s10495-025-02210-0 · Cited by 9 · see citing works

Forkhead box O proteins in chondrocyte aging and diseases

He, Y., Zhu, W., Alexander, P. G., Hines, S. E., Bartholomew, O., Zhao, C., Liu, Q., & Lin, H. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.07.011 · Cited by 8 · see citing works

Melatonin Alleviates the Impairment of Muscle Bioenergetics and Protein Quality Control Systems in Leptin-Deficiency-Induced Obesity

Potes, Y., Díaz-Luis, A., Bermejo-Millo, J. C., Pérez-Martínez, Z., de Luxán-Delgado, B., Rubio-González, A., Menéndez-Valle, I., Gutiérrez-Rodríguez, J., Solano, J. J., Caballero, B., et al. (2023) · Antioxidants · doi:10.3390/antiox12111962 · Cited by 8 · see citing works

Relationship between autophagy and NLRP3 inflammasome during articular cartilage degradation in oestrogen-deficient rats with streptozotocin-induced diabetes

Florencio‐Silva, R., Sasso, G. R. D. S., Sasso‐Cerri, E., Cerri, P. S., Gil, C. D., & Simões, M. D. J. (2024) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2024.152318 · Cited by 6 · see citing works

The therapeutic effect and mechanism of melatonin on osteoarthritis: From the perspective of non-coding RNAs

Li, S., Si, H., Xu, J., Liu, Y., & Shen, B. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.968919 · Cited by 6 · see citing works

Chlorogenic acid attenuates oxidative damage in rat lacrimal gland epithelial cells via PI3K/AKT/FoxO3 signaling: network pharmacology and experimental evidence

Tang, Y., Zhong, Y., Shi, J., Chen, L., Chen, H., Peng, Q., & Yao, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-02788-0 · Cited by 5 · see citing works

Comprehensive analysis of femoral head necrosis based on machine learning and bioinformatics analysis

Chen, Z., Jiang, Y., Wu, S., & Dang, M. (2023) · Medicine · doi:10.1097/md.0000000000033963 · Cited by 5 · see citing works

RNA binding protein PUM2 promotes IL-1β-induced apoptosis of chondrocytes via regulating FOXO3 expression

Wang, D., Zhang, Z., Li, X., & He, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25080 · Cited by 4 · see citing works

Therapeutic potential of melatonin in musculoskeletal medicine

Migliorini, F., Schäfer, L., Simeone, F., Memminger, M. K., Eschweiler, J., & Vaishya, R. (2025) · Journal of Orthopaedics · doi:10.1016/j.jor.2025.11.011 · Cited by 3 · see citing works

Protective effects of betulinic acid on oxidative stress-induced apoptosis and DNA damage in C2C12 myoblasts

Kim, D. H., Hong, S. H., & Choi, Y. H. (2025) · Journal of Nutrition and Health · doi:10.4163/jnh.2025.58.3.287 · Cited by 2 · see citing works

Clinical and biochemical changes and their correction in patients with metabolic phenotype of osteoarthritis and insomnia

Рахимович, Ш. Д., Zvyagina, V. I., Николаевна, Р. М., & Николаевна, Д. М. (2023) · Obesity and metabolism · doi:10.14341/omet12888 · Cited by 2 · see citing works

FOXO3 Protects Lens Epithelial Cells From UVB ‐Induced Oxidative Stress via the AMPK / FOXO3 Signaling Pathway

Sun, Y., Hong, Y., Ning, L., Xiao, B., Ainiwaer, M., Jiang, Y., & Ji, Y. (2025) · The FASEB Journal · doi:10.1096/fj.202501265rr · Cited by 2 · see citing works

Melatonin’s Role in Redox Homeostasis: A Preclinical and Clinical Perspective

Torres, F. F., Bernardo, V., Zucão, A. C. A., Gazarini, L., Reiter, R. J., & da Silva, D. G. H. (2025) · Pharmacological Research · doi:10.1016/j.prenap.2025.100147 · Cited by 2 · see citing works

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K / AKT / FoxO3 ‐Mediated Mitophagy

Huang, C., Zhang, G., Ma, Y., Ma, X., & Lv, S. (2025) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.70131 · Cited by 1 · see citing works

Melatonin Improves Diabetic‐Accelerated Experimental Osteoarthritis by Inhibiting NLRP3‐Mediated Chondrocyte Pyroptosis via PKG/Nrf2

Yang, W., Chen, H., Zhang, Y., Wang, S., Miao, X., Qiu, Z., Qiu, D., Gu, B., Zhang, L., Zhang, J., et al. (2026) · Journal of Pineal Research · doi:10.1111/jpi.70113 · Cited by 1 · see citing works

Sleep Hormone Melatonin, Inflammation and Aging

Xia, Y., Wu, X., Yin, Z., Li, Y., & He, F. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-22468-3_13 · Cited by 1 · see citing works

Melatonin and Cancer: New Insights

Solà, E., Ramos, E., Gil‐Martín, E., García, J. M., & Romero, A. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_231

Mechanistic insights into non-coding RNAs regulate autophagy in chondrocytes and their contribution to osteoarthritis

Wang, B., & Wang, Z. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2025.1735826

Mesenchymal stem cell-derived exosomes mitigate myocardial ischemia-reperfusion injury by inhibiting ferroptosis via the AMPK/FOXO3 signaling pathway

Qiu, Z., Han, B. J., Zhang, J. K., Cao, Y., Kuang, C., Cai, W., Fu, Y., Chen, W., Liu, L., Jiang, M., et al. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153919

Dysregulated autophagy in osteoarthritis: Mechanisms, regulation by non-coding RNAs, and therapeutic implications.

Liu, L., Wang, J., Liu, L., Shi, W.-L., Gao, H.-J., & Liu, L. (2026) · Pathology, Research and Practice · doi:10.1016/j.prp.2026.156695

The therapeutic potential of melatonin: Focus on the SIRT1 signaling pathway

Vahidinia, Z., Behdarvandy, M., Tameh, A. A., Barati, S., & Yasamian, A. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12815-6

Melatonin in Musculoskeletal and Spine-Related Conditions: A Systematic Review of Preclinical and Clinical Evidence

Bisaccia, M., Bifarini, B., Ripani, U., Lucchetta, L., Bonanno, E., Siragusano, M., Mitri, D. D., Bronzini, F., & Rinonapoli, G. (2026) · Medicina · doi:10.3390/medicina62101946

Melatonin Enhances Chondrocytes Survival Through Hyaluronic Acid Production and Mitochondria Protection

Liu, Z., Wang, J., Thapa, A., Xie, Y., Guo, J. R., Li, X., Jiang, H., Wang, Y., Peng, Z., Wang, S., et al. (2021) · Archives of Medical Science · doi:10.5114/aoms/136343 · Cited by 1 · see citing works

Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin

Hosseinzadeh, A., Kamrava, S. K., Joghataei, M. T., Darabi, R., Shakeri‐Zadeh, A., Shahriari, M., Reiter, R. J., Ghaznavi, H., & Mehrzadi, S. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12362 · Cited by 345 · see citing works

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K / AKT / FoxO3 ‐Mediated Mitophagy

Huang, C., Zhang, G., Ma, Y., Ma, X., & Lv, S. (2025) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.70131 · Cited by 1 · see citing works

Melatonin Prevents Cartilage Degradation in Early-Stage Osteoarthritis Through Activation of miR-146a/NRF2/HO-1 Axis

Zhou, X., Zhang, Y., Hou, M., Liu, H., Yang, H., Chen, X., Liu, T., He, F., & Zhu, X. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4527 · Cited by 64 · see citing works

Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis

Zhang, Y., Hou, M., Liu, Y., Liu, T., Chen, X., Shi, Q., Geng, D., Yang, H., He, F., & Zhu, X. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12815 · Cited by 48 · see citing works