Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes

Panigrahy, Suchitra Kumari; Bhatt, Renu; Kumar, Awanish

doi:10.1080/1061186x.2016.1207650

Cited by 103Advanced Glycation End Products researchNitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes

Panigrahy, Suchitra Kumari, Bhatt, Renu, Kumar, Awanish·2017·Journal of Drug Targeting

DOI 10.1080/1061186x.2016.1207650

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Abstract

Oxidative stress has been considered as a central mediator in the progression of diabetic complication. The intracellular reactive oxygen species (ROS) leads to oxidative stress and it is raised from the mitochondria as well as by activation of five major pathways: increased polyol pathway flux, activation of protein kinase C (PKC) pathway, increased formation of advanced glycation end products (AGEs), over activity of hexosamine pathway and increased production of angiotensin II. The increased ROS through these pathways leads to β-cell dysfunction and insulin resistance, responsible for cell damage and death. This review not only highlights the sources of ROS production and their involvement in the progression of diabetes, but also emphasizes on pharmacological interventions and targeting of ROS in type 2 diabetes. This review summarizes the ROS as potential therapeutic targets, based on a putative mechanism in the progression of the diabetes. It also summarizes current knowledge of ROS activation in type 2 diabetes as well as ROS as a possible target for its treatment. Eventually, it would be a promising target for various strategies and drugs to modulate ROS levels in diabetes.

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ROS is capable to directly damage β cells, promoting apoptosis, or it can indirectly regulate insulin signaling pathway to inhibit the function of β cells.
“Therefore, ROS is capable to directly damage β cells, promoting apoptosis, or it can indirectly regulate insulin signaling pathway to inhibit the function of β cells (82, 83).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [83]

1 retracted

RETRACTED: Epalrestat, an aldose reductase inhibitor, in diabetic neuropathy: An Indian perspective
Sharma, S., & Sharma, N. K. (2008) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.44558 · Cited by 42 · see citing works
Retracted
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works
Global and societal implications of the diabetes epidemic
Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883 · see citing works
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461 · see citing works
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802 · see citing works
Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714 · see citing works
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805193182007 · Cited by 2,512 · see citing works
Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes
Özcan, U., Yilmaz, E., Özcan, L., Furuhashi, M., Vaillancourt, E., Smith, R. O., Görgün, C. Z., & Hotamisligil, G. S. (2006) · Science · doi:10.1126/science.1128294 · Cited by 2,413 · see citing works
The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives
Chen, L., Magliano, D. J., & Zimmet, P. Z. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.183 · Cited by 2,227 · see citing works
Mitochondria, oxidative stress and cell death
Ott, M., Gogvadze, V. G., Orrenius, S., & Zhivotovsky, B. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0756-2 · Cited by 1,976 · see citing works
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728 · see citing works
Free radicals, reactive oxygen species, oxidative stress and its classification
Lushchak, V. I. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.10.016 · Cited by 1,665 · see citing works
Diabetes and Vascular Disease
Creager, M. A., Lüscher, T. F., of, P. W. T. A., Cosentino, F., & Beckman, J. A. (2003) · Circulation · doi:10.1161/01.cir.0000091257.27563.32 · Cited by 1,654 · see citing works
Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: Molecular and Pathophysiological Mechanisms
Kim, J.-A., Montagnani, M., Koh, K. K., & Quon, M. J. (2006) · Circulation · doi:10.1161/circulationaha.105.563213 · Cited by 1,652 · see citing works
Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction?
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482 · see citing works
Oxidative stress, insulin signaling, and diabetes
Rains, J., & Jain, S. K. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.006 · Cited by 1,444 · see citing works
Banting Lecture 2001
McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435 · see citing works
Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I
Paneni, F., Beckman, J. A., Creager, M. A., & Cosentino, F. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht149 · Cited by 1,420 · see citing works
Glucose autoxidation and protein modification. The potential role of ‘autoxidative glycosylation’ in diabetes
Wolff, S. P., & Dean, R. T. (1987) · Biochemical Journal · doi:10.1042/bj2450243 · Cited by 1,277 · see citing works
Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose
Thornalley, P. J., LANGBORG, A., & Minhas, H. S. (1999) · Biochemical Journal · doi:10.1042/bj3440109 · Cited by 1,209 · see citing works
Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus
Hink, U., Li, H., Mollnau, H., Oelze, M., Matheis, E., Hartmann, M., Skatchkov, M. P., Thaiss, F., Stahl, R. A. K., Warnholtz, A., et al. (2001) · Circulation Research · doi:10.1161/01.res.88.2.e14 · Cited by 1,176 · see citing works
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
Du, X.-L., Edelstein, D., Rossetti, L., Fantus, I. G., Goldberg, H. J., Ziyadeh, F. N., Wu, J., & Brownlee, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.22.12222 · Cited by 1,152 · see citing works
Hyperglycemic Pseudohypoxia and Diabetic Complications
Williamson, J. R., Chang, K. C., Frangos, M., Hasan, K. S., Ido, Y., Kawamura, T., Nyengaard, J. R., den Enden, M. V., Kilo, C., & Tilton, R. G. (1993) · Diabetes · doi:10.2337/diab.42.6.801 · Cited by 1,092 · see citing works
Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes
Robertson, R. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400019200 · Cited by 1,078 · see citing works
Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress
Rolo, A. P., & Palmeira, C. M. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.01.003 · Cited by 1,007 · see citing works
Indian herbs and herbal drugs used for the treatment of diabetes
Modak, M., Dixit, P., Londhe, J., Ghaskadbi, S., & Devasagayam, T. P. A. (2007) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.40.163 · Cited by 989 · see citing works
Beta Cell Dysfunction and Insulin Resistance
Cerf, M. E. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00037 · Cited by 964 · see citing works
Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection
Robertson, R. P., Harmon, J., Tran, P. O., Tanaka, Y., & Takahashi, H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.581 · Cited by 897 · see citing works
A review on the role of antioxidants in the management of diabetes and its complications
Rahimi, R., Nikfar, S., Larijani, B. A., & Abdollahi, M. R. (2005) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2005.07.002 · Cited by 890 · see citing works
Epidemiology of type 2 diabetes: Indian scenario.
Mohan, V., Sreedharan, S., Deepa, R., Shah, B., & Varghese, C. V. (2007) · PubMed · Cited by 841 · see citing works
New Insights on Oxidative Stress and Diabetic Complications May Lead to a “Causal” Antioxidant Therapy
Ceriello, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1589 · Cited by 734 · see citing works
Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.
Kaneto, H., Kajimoto, Y., Miyagawa, J., Matsuoka, T., Fujitani, Y., Umayahara, Y., Hanafusa, T., Matsuzawa, Y., Yamasaki, Y., & Hori, M. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2398 · Cited by 713 · see citing works
Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications
Domingueti, C. P., Dusse, L. M. S., Ferriani, M. D. G. C., Sousa, L. P., Gomes, K. B., & Fernandes, A. P. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.12.018 · Cited by 647 · see citing works
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
Soriano, F. G., Virág, L., Jagtap, P. G., Szabó, É., Mabley, J. G., Liaudet, L., Marton, A., Hoyt, D. G., Murthy, K. G. K., Salzman, A. L., et al. (2001) · Nature Medicine · doi:10.1038/83241 · Cited by 602 · see citing works
Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes
Shah, M. S., & Brownlee, M. (2016) · Circulation Research · doi:10.1161/circresaha.116.306923 · Cited by 601 · see citing works
Saturated Fatty Acids Synergize with Elevated Glucose to Cause Pancreatic β-Cell Death
El-Assaad, W., Buteau, J., Peyot, M., Nolan, C. J., Roduit, R., Hardy, S., Joly, E. C., Dbaibo, G. S., Rosenberg, L. C., & Prentki, M. (2003) · Endocrinology · doi:10.1210/en.2003-0410 · Cited by 586 · see citing works
Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis
Kaneto, H., Katakami, N., Matsuhisa, M., & Matsuoka, T. (2010) · Mediators of Inflammation · doi:10.1155/2010/453892 · Cited by 577 · see citing works
Maillard reaction products in tissue proteins: New products and new perspectives
Thorpe, S. R., & Baynes, J. (2003) · Amino Acids · doi:10.1007/s00726-003-0017-9 · Cited by 543 · see citing works
Increased oxidative stress precedes the onset of high-fat diet–induced insulin resistance and obesity
Nagata, N., Takamura, T., Ando, H., Nakamura, S., Kurita, S., Misu, H., Ota, T., Yokoyama, M., Honda, M., Miyamoto, K., et al. (2008) · Metabolism · doi:10.1016/j.metabol.2008.03.010 · Cited by 537 · see citing works
Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation
Eguchi, K., Manabe, I., Tanaka, Y., Ohsugi, M., Kono, N., Ogata, F., Yagi, N., Ohto, U., Kimoto, M., Miyake, K., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.023 · Cited by 519 · see citing works
Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy
Takemoto, M., Node, K., Hironori Nakagami, A., Liao, Y., Grimm, M. F., Takemoto, Y., Kitakaze, M., & Liao, J. K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13350 · Cited by 490 · see citing works
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diabetes.46.1.3 · Cited by 479 · see citing works
Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants
Tanaka, Y., Gleason, C. E., Tran, P. O. T., Harmon, J. S., & Robertson, R. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10857 · Cited by 460 · see citing works
An Unlikely Sugar Substrate Site in the 1.65 Å Structure of the Human Aldose Reductase Holoenzyme Implicated in Diabetic Complications
Wilson, D. K., Bohren, K. M., Gabbay, K. H., & Quiocho, F. A. (1992) · Science · doi:10.1126/science.1621098 · Cited by 434 · see citing works
Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity
Prentki, M., Joly, E. C., El-Assaad, W., & Roduit, R. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s405 · Cited by 428 · see citing works
The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
Marchetti, P., Bugliani, M., Lupi, R., Marselli, L., Masini, M., Boggi, U., Filipponi, F., Weir, G. C., Eizirik, D. L., & Cnop, M. (2007) · Diabetologia · doi:10.1007/s00125-007-0816-8 · Cited by 413 · see citing works
Proposed mechanisms for the induction of insulin resistance by oxidative stress
Bloch-Damti, A., & Bashan, N. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.1553 · Cited by 388 · see citing works
IGF-1 Overexpression Inhibits the Development of Diabetic Cardiomyopathy and Angiotensin II–Mediated Oxidative Stress
Kajstura, J., Fiordaliso, F., Andreoli, A. M., Li, B., Chimenti, S., Medow, M. S., Limana, F., Nadal‐Ginard, B., Leri, A., & Anversa, P. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1414 · Cited by 384 · see citing works
Effect of fatty acids on energy coupling processes in mitochondria
Wojtczak, L., & Schönfeld, P. (1993) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(93)90004-y · Cited by 363 · see citing works
The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes
Stitt, A. W., Gardiner, T. A., Anderson, N. L., Canning, P., Frizzell, N., Duffy, N., Boyle, C., Januszewski, A. S., Chachich, M. E., Baynes, J., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2826 · Cited by 355 · see citing works
Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells
Kaneto, H., Fujii, J., Seo, H. G., Suzuki, K., Matsuko, T.-A., Masahiro, N., Tatsumi, H., Yamasaki, Y., Kamada, T., & Taniguchi, N. (1995) · Diabetes · doi:10.2337/diab.44.7.733 · Cited by 342 · see citing works
High Glucose Causes Apoptosis in Cultured Human Pancreatic Islets of Langerhans
Federici, M., Hribal, M. L., Perego, L., Ranalli, M., Caradonna, Z., Perego, C., Usellini, L., Nano, R., Bonini, P., Bertuzzi, F., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1290 · Cited by 333 · see citing works
Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress
Kaneto, H., Xu, G., Song, K., Suzuma, K., Bonner‐Weir, S., Sharma, A., & Weir, G. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104115200 · Cited by 327 · see citing works
Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic β-cells
Sakai, K., Matsumoto, K., Nishikawa, T., Suefuji, M., Nakamaru, K., Hirashima, Y., Kawashima, J., Shirotani, T., Ichinose, K., Brownlee, M., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02832-2 · Cited by 323 · see citing works
Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats.
Rajasekaran, S., Sivagnanam, K., & Subramanian, S. P. (2005) · PubMed · Cited by 322 · see citing works
Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet β cell
Robertson, R. P., & Harmon, J. S. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.030 · Cited by 322 · see citing works
A role for glutathione peroxidase in protecting pancreatic β cells against oxidative stress in a model of glucose toxicity
Tanaka, Y., Tran, P. O. T., Harmon, J. S., & Robertson, R. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192445199 · Cited by 316 · see citing works
MafA Is a Glucose-regulated and Pancreatic β-Cell-specific Transcriptional Activator for the Insulin Gene
Kataoka, K., Han, S., Shioda, S., Hirai, M., Nishizawa, M., & Handa, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206796200 · Cited by 307 · see citing works
A Comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials
Xiang, Y., Shang, H., Gao, X., & Zhang, B. (2008) · Phytotherapy Research · doi:10.1002/ptr.2384 · Cited by 305 · see citing works
Members of the Large Maf Transcription Family Regulate Insulin Gene Transcription in Islet β Cells
Matsuoka, T., Zhao, L., Artner, I., Jarrett, H. W., Friedman, D., Means, A. L., & Stein, R. W. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.17.6049-6062.2003 · Cited by 293 · see citing works
Diabetes-induced Activation of Nuclear Transcriptional Factor in the Retina, and its Inhibition by Antioxidants
Kowluru, R. A., Koppolu, P., Chakrabarti, S., & Chen, S. (2003) · Free Radical Research · doi:10.1080/10715760310001604189 · Cited by 289 · see citing works
Role of nitric oxide in obesity-induced beta cell disease.
Shimabukuro, M., Ohneda, M., Lee, Y., & Unger, R. H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119534 · Cited by 282 · see citing works
Pharmacological Inhibition of Diabetic Retinopathy
Kern, T. S., & Engerman, R. L. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1636 · Cited by 277 · see citing works
Angiotensin II–Induced Insulin Resistance Is Associated With Enhanced Insulin Signaling
Ogihara, T., Asano, T., Ando, K., Chiba, Y., Sakoda, H., Anai, M., Shojima, N., Ono, H., Onishi, Y., Fujishiro, M., et al. (2002) · Hypertension · doi:10.1161/01.hyp.0000040262.48405.a8 · Cited by 274 · see citing works
Oxidative Stress in Diabetes
Piconi, L., Quagliaro, L., & Ceriello, A. (2003) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2003.177 · Cited by 255 · see citing works
Mechanisms decreasing glucose oxidation in diabetes and starvation: Role of lipid fuels and hormones
Randle, P. J., Kerbey, A. L., & Espinal, J. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040702 · Cited by 244 · see citing works
Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy
Kandhare, A. D., Raygude, K. S., Ghosh, P., Ghule, A. E., & Bodhankar, S. L. (2012) · Fitoterapia · doi:10.1016/j.fitote.2012.01.010 · Cited by 243 · see citing works
Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose
Thornalley, P. J., LANGBORG, A., & Minhas, H. S. (1999) · Biochemical Journal · doi:10.1042/0264-6021:3440109 · Cited by 243 · see citing works
Oxidative Stress-mediated, Post-translational Loss of MafA Protein as a Contributing Mechanism to Loss of Insulin Gene Expression in Glucotoxic Beta Cells
Harmon, J. S., Stein, R. W., & Robertson, R. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410345200 · Cited by 234 · see citing works
Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations.
Robertson, R. P., Zhang, H. J., Pyzdrowski, K. L., & Walseth, T. F. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115865 · Cited by 232 · see citing works
AT 1 Blockade Prevents Glucose-Induced Cardiac Dysfunction in Ventricular Myocytes
Privratsky, J. R., Wold, L. E., Sowers, J. R., Quinn, M. T., & Ren, J. T. (2003) · Hypertension · doi:10.1161/01.hyp.0000082814.62655.85 · Cited by 222 · see citing works
Cinnamon: Potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes
Qin, B., Panickar, K. S., & Anderson, R. A. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400324 · Cited by 220 · see citing works
Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain
Sharma, S., Kulkarni, S. K., Agrewala, J. N., & Chopra, K. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.03.006 · Cited by 219 · see citing works
Dominant Negative Pathogenesis by Mutant Proinsulin in the Akita Diabetic Mouse
Izumi, T., Yokota‐Hashimoto, H., Zhao, S., Wang, J., Halban, P. A., & Takeuchi, T. (2003) · Diabetes · doi:10.2337/diabetes.52.2.409 · Cited by 213 · see citing works
Amorfrutins are potent antidiabetic dietary natural products
Weidner, C., de Groot, J. C., Prasad, A., Freiwald, A., Quedenau, C., Kliem, M., Plauth, A., Kodelja, V., Han, T., Giegold, S., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116971109 · Cited by 212 · see citing works
Antidiabetic activity and toxicity of Zizyphus spina-christi leaves.
Abdel-Zaher, A. O., Salim, S. Y., Assaf, M., & Abdel-Hady, R. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.04.007 · Cited by 208 · see citing works
Caffeic acid as active principle from the fruit of Xanthium strumarium to lower plasma glucose in diabetic rats.
Hsu, F.-L., Chen, Y.-C., & Cheng, J.-T. (2000) · Planta Medica · doi:10.1055/s-2000-8561 · Cited by 207 · see citing works
Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage
Liu, Q., Wang, S., & Cai, L. (2014) · Journal of Diabetes Investigation · doi:10.1111/jdi.12250 · Cited by 206 · see citing works
Metformin Decreases Intracellular Production of Reactive Oxygen Species in Aortic Endothelial Cells
Ouslimani, N., Peynet, J., Bonnefont-Rousselot, D., Thérond, P., Legrand, A., & Beaudeux, J.-L. (2005) · Metabolism · doi:10.1016/j.metabol.2005.01.029 · Cited by 204 · see citing works
Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes
Kaneto, H., Matsuoka, T.-A., Nakatani, Y., Kawamori, D., Miyatsuka, T., Matsuhisa, M., & Yamasaki, Y. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0640-x · Cited by 193 · see citing works
Oxidative stress and cell death
Rumora, L., Petrik, J., & Žanić‐Grubišić, T. (2003) · Cited by 192 · see citing works
Protective Effects of Luteolin on Diabetic Nephropathy in STZ‐Induced Diabetic Rats
Wang, G., Lu, X. H., Li, W., Zhao, X., & Zhang, C. (2011) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2011/323171 · Cited by 181 · see citing works
Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes
Way, K. J., Isshiki, K., Suzuma, K., Yokota, T., Zvagelsky, D., Schöen, F. J., Sandusky, G. E., Pechous, P. A., Vlahos, C. J., Wakasaki, H., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2709 · Cited by 180 · see citing works
Increased glucose uptake promotes oxidative stress and PKC-δ activation in adipocytes of obese, insulin-resistant mice
Talior‐Volodarsky, I., Yarkoni, M., Bashan, N., & Eldar-Finkelman, H. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00044.2003 · Cited by 176 · see citing works
Critical Reduction in β-Cell Mass Results in Two Distinct Outcomes over Time
Laybutt, D. R., Glandt, M., Xu, G., Ahn, Y. B., Trivedi, N., Bonner‐Weir, S., & Weir, G. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210581200 · Cited by 156 · see citing works
Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression.
Olson, L. K., Sharma, A., Peshavaria, M., Wright, C. V. E., Towle, H. C., Rodertson, R. P., & Stein, R. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9127 · Cited by 149 · see citing works
Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats
Uzar, E., Alp, H., Çevik, M. U., Fırat, U., Evliyaoğlu, O., Tüfek, A., & Altun, Y. (2011) · Neurological Sciences · doi:10.1007/s10072-011-0775-1 · Cited by 146 · see citing works
Reduction of Diabetic Macular Edema by Oral Administration of the Kinase Inhibitor PKC412
Campochiaro, P. A. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0955 · Cited by 141 · see citing works
Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats.
Suryanarayana, P., Saraswat, M., Petrash, J. M., & Reddy, G. B. (2007) · PubMed · Cited by 130 · see citing works
Production of Reactive Oxygen Species in the Diabetic Heart
Teshima, Y., Takahashi, N., Nishio, S., Saito, S., Kondo, H., Fukui, A., Aoki, K., Yufu, K., Nakagawa, M., & Saikawa, T. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-1187 · Cited by 130 · see citing works
Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats
Baydaş, G., Reiter, R. J., Yaşar, A., Tuzcu, M., Akdemir, İ., & Nedzvetsky, V. S. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00408-8 · Cited by 129 · see citing works
A Selective Aldose Reductase Inhibitor of a New Structural Class Prevents or Reverses Early Retinal Abnormalities in Experimental Diabetic Retinopathy
Sun, W., Oates, P. J., Coutcher, J. B., Gerhardinger, C., & Lorenzi, M. (2006) · Diabetes · doi:10.2337/db06-0138 · Cited by 129 · see citing works
Probucol preserves pancreatic β-cell function through reduction of oxidative stress in type 2 diabetes
Gorogawa, S.-I., Kajimoto, Y., Umayahara, Y., Kaneto, H., Watada, H., Kuroda, A., Kawamori, D., Yasuda, T., Matsuhisa, M., Yamasaki, Y., et al. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(02)00005-0 · Cited by 115 · see citing works
PPARγ ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice
Shiojiri, T., Wada, K., Nakajima, A., Katayama, K., Shibuya, A., Kudo, C., Kadowaki, T., Mayumi, T., Yura, Y., & Kamisaki, Y. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01946-5 · Cited by 111 · see citing works
Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, from the Flowers of Chrysanthemum indicum L.
YOSHIKAWA, M., Morikawa, T., MURAKAMI, T., Toguchida, I., Harima, S., & Matsuda, H. (1999) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.47.340 · Cited by 108 · see citing works
Mitochondria-Targeted Antioxidants as Promising Drugs for Treatment of Age-Related Brain Diseases
Skulachev, V. P. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111391 · Cited by 106 · see citing works
Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase
Liu, W., Hei, Z., Nie, H., Tang, F., Huang, H., Li, X., Yan-hui, D. E. N. G., Chen, S., Guo, F., Huang, W., et al. (2008) · Chinese Medical Journal · doi:10.1097/00029330-200804020-00009 · Cited by 106 · see citing works
Amla ( Emblica officinalis Gaertn.) Extracts Reduce Oxidative Stress in Streptozotocin-Induced Diabetic Rats
Theertham Pradyumna, R. A. O., Sakaguchi, N., Juneja, L. R., Wada, E., & Yokozawa, T. (2005) · Journal of Medicinal Food · doi:10.1089/jmf.2005.8.362 · Cited by 100 · see citing works
Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, advanced glycation end products and oxidative stress in alloxan-induced diabetic rats
Sefi, M., Fetoui, H., Makni, M., & Zeghal, N. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.05.005 · Cited by 97 · see citing works
Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis
Drel, V. R., Pacher, P., Ali, T. K., Shin, J., Julius, U., El‐Remessy, A. B., & Obrosova, I. G. (2008) · International Journal of Molecular Medicine · doi:10.3892/ijmm.21.6.667 · Cited by 97 · see citing works
Therapeutic potential of anti-oxidants and diabetic retinopathy
Kowluru, R., & Kennedy, A. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.9.1665 · Cited by 96 · see citing works
ORAL PROTEIN KINASE C β INHIBITION USING RUBOXISTAURIN
Aiello, L. P., Vignati, L., Sheetz, M. J., Zhi, X., Girach, A., Davis, M. D., Wolka, A. M., Shahri, N., & Milton, R. C. (2011) · Retina · doi:10.1097/iae.0b013e3182111669 · Cited by 96 · see citing works
In vivo antioxidative effect of isoquercitrin on cadmium-induced oxidative damage to mouse liver and kidney
Li, R., Yuan, C., Dong, C., Shuang, S., & Choi, M. M. F. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-011-0613-2 · Cited by 93 · see citing works
New Insight into the Role of Reactive Oxygen Species (ROS) in Cellular Signal-Transduction Processes
Russell, E. G., & Cotter, T. G. (2015) · International review of cytology · doi:10.1016/bs.ircmb.2015.07.004 · Cited by 92 · see citing works
Effect of Ruboxistaurin on the Visual Acuity Decline Associated with Long-standing Diabetic Macular Edema
Davis, M. D., Sheetz, M. J., Aiello, L. P., Milton, R. C., Danis, R. P., Zhi, X., Girach, A., Jiménez, M. C. H., & Vignati, L. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2473 · Cited by 87 · see citing works
Eucommia ulmoides Oliver Leaf Extract Increases Endogenous Antioxidant Activity in Type 2 Diabetic Mice
Park, S. A., Choi, M., Jung, U. J., Kim, M., Kim, D. J., Park, H.-M., Park, Y. B., & Lee, M. (2006) · Journal of Medicinal Food · doi:10.1089/jmf.2006.9.474 · Cited by 87 · see citing works
Are reactive oxygen species still the basis for diabetic complications?
Marco, E. D., Jha, J. C., Sharma, A., Wilkinson‐Berka, J. L., Jandeleit-Dahm, K. A. M., & de Haan, J. B. (2015) · Clinical Science · doi:10.1042/cs20150093 · Cited by 86 · see citing works
Molecular Targets of Diabetic Cardiovascular Complications
Ahmad, F. K., He, Z., & King, G. L. (2005) · Current Drug Targets · doi:10.2174/1389450054021990 · Cited by 81 · see citing works
Incidence of Type 2 Diabetes Using Proposed HbA1c Diagnostic Criteria in the European Prospective Investigation of Cancer–Norfolk Cohort
Chamnan, P., Simmons, R. K., Forouhi, N. G., Luben, R., Khaw, K., Wareham, N. J., & Griffin, S. J. (2010) · Diabetes Care · doi:10.2337/dc09-2326 · Cited by 80 · see citing works
Hyperglycemia and the O-GlcNAc Transferase in Rat Aortic Smooth Muscle Cells: Elevated Expression and Altered Patterns of O-GlcNAcylation
Akimoto, Y., Kreppel, L. K., Hirano, H., & Hart, G. W. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2331 · Cited by 77 · see citing works
Statin-stimulated nitric oxide release from endothelium.
Dobrucki, L. W., Kalinowski, L., Dobrucki, I. T., & Maliñski, T. (2001) · PubMed · Cited by 76 · see citing works
Lipid Peroxidation and Activities of Antioxidant Enzymes in the Diabetic Kidney: Effect of Treatment with Angiotensin Convertase Inhibitors
Kędziora–Kornatowska, K., Luciak, M., & Paszkowski, J. (2000) · IUBMB Life · doi:10.1080/15216540050033177 · Cited by 70 · see citing works
Curcumin Analogs as Potent Aldose Reductase Inhibitors
Du, Z., Bao, Y., Liu, Z., Qiao, W., Ma, L., Huang, Z., Gu, L., & Chan, A. S. C. (2006) · Archiv der Pharmazie · doi:10.1002/ardp.200500205 · Cited by 67 · see citing works
Grape seed proanthocyanidins ameliorate pancreatic beta-cell dysfunction and death in low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats partially by regulating endoplasmic reticulum stress
Ding, Y., Zhang, Z., Dai, X., Jiang, Y., Bao, L., Li, Y., & Li, Y. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-51 · Cited by 67 · see citing works
50 years forward: mechanisms of hyperglycaemia-driven diabetic complications
Russell, N., & Cooper, M. E. (2015) · Diabetologia · doi:10.1007/s00125-015-3600-1 · Cited by 63 · see citing works
Inhibition of Aldose Reductase and Sorbitol Accumulation by Astilbin and Taxifolin Dihydroflavonols inEngelhardtia chrysolepis
Haraguchi, H., Ohmi, I., Fukuda, A., Tamura, Y., Mizutani, K., Tanaka, O., & Chou, W. (1997) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.61.651 · Cited by 61 · see citing works
Mechanism-based antidiabetic activity of Fructo- and isomalto-oligosaccharides: Validation by in vivo, in silico and in vitro interaction potential
Bharti, S. K., Krishnan, S., Kumar, A., Gupta, A. K., Ghosh, A. K., & Kumar, A. (2014) · Process Biochemistry · doi:10.1016/j.procbio.2014.10.014 · Cited by 60 · see citing works
Self-citation
Modulation of selenite cataract by the flavonoid fraction ofEmilia sonchifolia in experimental animal models
Lija, Y., Biju, P. G., Reeni, A., Cibin, T. R., Sahasranamam, V. I., & Abraham, A. (2006) · Phytotherapy Research · doi:10.1002/ptr.2005 · Cited by 59 · see citing works
Autophagy and the pancreatic beta-cell in human type 2 diabetes
Marchetti, P., & Masini, M. (2009) · Autophagy · doi:10.4161/auto.5.7.9511 · Cited by 56 · see citing works
Chard (Beta vulgaris L. var. cicla) extract ameliorates hyperglycemia by increasing GLUT2 through Akt2 and antioxidant defense in the liver of rats
Gezginci-Oktayoğlu, S., Saçan, Ö., Bolkent, Ş., İpçi, Y., Kabasakal, L., Şener, G., & Yanardağ, R. (2013) · Acta Histochemica · doi:10.1016/j.acthis.2013.04.016 · Cited by 55 · see citing works
Endothelial Nuclear Factor κB in Obesity and Aging
Kim, J. K. (2012) · Circulation · doi:10.1161/circulationaha.111.090134 · Cited by 55 · see citing works
Ruboxistaurin: PKC-β inhibition for complications of diabetes
Danis, R. P., & Sheetz, M. J. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560903401620 · Cited by 55 · see citing works
Stratified analyses for selecting appropriate target patients with diabetic peripheral neuropathy for long‐term treatment with an aldose reductase inhibitor, epalrestat
Hotta, N., Kawamori, R., Atsumi, Y., Baba, M., Kishikawa, H., Nakamura, J., Oikawa, S., Yamada, N., Yasuda, H., Shigeta, Y., et al. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02490.x · Cited by 49 · see citing works
Supplementation of Fenugreek Leaves Reduces Oxidative Stress in Streptozotocin-Induced Diabetic Rats
Annida, B., & Prince, P. S. M. (2005) · Journal of Medicinal Food · doi:10.1089/jmf.2005.8.382 · Cited by 47 · see citing works
The Role of Reactive Oxygen Species in Insulin Signaling in the Vasculature
Frank, G. D., Eguchi, S., & Motley, E. D. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1053 · Cited by 46 · see citing works
Diabetes: a pandemic, a development issue or both?
Colagiuri, R. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.10.12 · Cited by 46 · see citing works
Protective Effect of Rosemary (Rosmarinus Officinalis) Leaves Extract on Carbon Tetrachloride - Induced Nephrotoxicity in Albino Rats
Sakr, S. A., Lamfon, H. A., & Arabia, S. (2012) · Cited by 43 · see citing works
Role of metabolic programming in the pathogenesis of β-cell failure in postnatal life
Simmons, R. A. (2007) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-007-9045-1 · Cited by 41 · see citing works
Astilbin Attenuates Hyperuricemia and Ameliorates Nephropathy in Fructose-Induced Hyperuricemic Rats
Chen, L., Lan, Z., Zhou, Y., Li, F., Zhang, X., Zhang, C., Yang, Z., & Li, P. (2011) · Planta Medica · doi:10.1055/s-0030-1271135 · Cited by 41 · see citing works
Effective Control of Type 2 Diabetes through Antioxidant Defense by Edible Fruits of Diospyros peregrina
Dewanjee, S., Maiti, A., Sahu, R., Dua, T. K., & Mandal, V. (2009) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nep080 · Cited by 40 · see citing works
Type 2 Diabetes Mellitus: The Concerned Complications and Target Organs
Kumar, A., Bharti, S. K., & Kumar, A. (2014) · Apollo Medicine · doi:10.1016/j.apme.2014.01.009 · Cited by 34 · see citing works
Self-citation
Emerging drugs for diabetic retinopathy
Mohamed, Q. A., & Wong, T. Y. (2008) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210802584035 · Cited by 31 · see citing works
Chemistry and pharmacology of an ethanol extract of Bumelia sartorum
de Almeida, R. N., Barbosa‐Filho, J. M., & Suresh Ramnath, N. A. I. K. (1985) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(85)90085-6 · Cited by 30 · see citing works
Polyol accumulation in muscle and liver in a mouse model of type 2 diabetes
Gallagher, E. J., LeRoith, D., Stasinopoulos, M., Zelenko, Z., & Shiloach, J. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.04.019 · Cited by 28 · see citing works
Aldose Reductase Inhibitor Fidarestat Attenuates Leukocyte-Endothelial Interactions in Experimental Diabetic Rat RetinaIn Vivo
Hattori, T., Matsubara, A., Taniguchi, K., & Ogura, Y. (2010) · Current Eye Research · doi:10.3109/02713680903447918 · Cited by 27 · see citing works
Flavonoids with Anti-Cataract Activity from Brickellia arguta
Rosler, K.-H. A., Goodwin, R. S., Mabry, T. J., Varma, S. D., & Norris, J. A. (1984) · Journal of Natural Products · doi:10.1021/np50032a014 · Cited by 26 · see citing works
Histological changes in the pancreas following administration of ethanolic extract of Alchornea cordifolia leaf in alloxan-induced diabetic wistar rats.
Eliakim-Ikechukwu, C. F., & Obri, A. I. (2010) · Nigerian Journal of Physiological Sciences · doi:10.4314/njps.v24i2.52927 · Cited by 23 · see citing works
From Single Cells to Engineered and Explanted Tissues
Bergmann, S., & Steinert, M. (2015) · International review of cytology · doi:10.1016/bs.ircmb.2015.06.003 · Cited by 17 · see citing works
Effect of Bauhinia variegate Bark Extract on Blood Glucose Level in Normal and Alloxanised Diabetic Rats
Koti, B., Biradar, S. M., Karadi, R. V., Taranalli, A. D., & Benade, V. S. (2009) · Journal of Natural Remedies · doi:10.18311/jnr/2009/217 · Cited by 16 · see citing works
Curcumin Analogues as Potent Aldose Reductase Inhibitors.
Du, Z., Bao, Y., Liu, Z., Qiao, W., Ma, L., Huang, Z., Gu, L., & Chan, A. S. C. (2006) · ChemInform · doi:10.1002/chin.200627213 · Cited by 12 · see citing works

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SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection
D’Onofrio, N., Servillo, L., & Balestrieri, M. L. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7178 · Cited by 389 · see citing works
“The metabolic milieu in diabetes, including hyperglycemia, dyslipidemia, insulin resistance, and hyperinsulinemia, induces a vicious circle of events in the vascular wall and causes overactivation of several biochemical pathways, contributing to increased oxidative stress, apoptosis and vascular permeability, and a lo…”
Background
The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes
Eguchi, N., Vaziri, N. D., Dafoe, D. C., & Ichii, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041509 · Cited by 354 · see citing works
Oxidative stress: Roles in skeletal muscle atrophy
Zhang, H., Qi, G., Wang, K., Yang, J., Shen, Y., Yang, X., Chen, X., Yao, X., Gu, X., Qi, L., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115664 · Cited by 319 · see citing works
Redox Signaling in Diabetic Wound Healing Regulates Extracellular Matrix Deposition
Kunkemoeller, B. H., & Kyriakides, T. R. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7263 · Cited by 236 · see citing works
“PKC phosphorylates the p47 phox subunit of Nox, which induces its translocation to the cell membrane and assembly of the functional Nox complex (133).”
Influential
Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Wang, M., Tan, Y., Shi, Y., Wang, X., Liao, Z., & Wei, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00568 · Cited by 231 · see citing works
Antidiabetic phytoconstituents and their mode of action on metabolic pathways
Bharti, S. K., Krishnan, S., Kumar, A., & Kumar, A. (2018) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018818755019 · Cited by 222 · see citing works
Self-citation
Nrf2: The Master and Captain of Beta Cell Fate
Baumel-Alterzon, S., Katz, L. S., Brill, G., Garcı́a-Ocaña, A., & Scott, D. K. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.11.002 · Cited by 105 · see citing works
Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies
Shen, Y., Li, M., Wang, K., Qi, G., Liu, H., Wang, W., Ji, Y., Chang, M., Deng, C., Xu, F., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.917113 · Cited by 103 · see citing works
RETRACTED: The effects of vitamin D and probiotic co-supplementation on glucose homeostasis, inflammation, oxidative stress and pregnancy outcomes in gestational diabetes: A randomized, double-blind, placebo-controlled trial
Jamilian, M., Amirani, E., & Asemi, Z. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.10.028 · Cited by 95 · see citing works
“Existing experimental studies have shown that antioxidant supplementationmay improve insulin sensitivity and decrease GDM complications [48].”
Retracted
Redox imbalance and mitochondrial abnormalities in the diabetic lung
Wu, J., Jin, Z. H., & Yan, L. (2016) · Redox Biology · doi:10.1016/j.redox.2016.11.003 · Cited by 88 · see citing works
Targeting type II diabetes with plant terpenes: the new and promising antidiabetic therapeutics
Panigrahy, S. K., Bhatt, R., & Kumar, A. (2020) · Biologia · doi:10.2478/s11756-020-00575-y · Cited by 86 · see citing works
Self-citation
Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory Diseases
Kim, M., & Jeon, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052846 · Cited by 79 · see citing works
“A major factor contributing to pancreatic β-cell dysfunction is oxidative stress-mediated mitochondrial damage [205].”
Background
Targeting oxidative stress through antioxidants in diabetes mellitus
Thakur, P., Kumar, A., & Kumar, A. (2017) · Journal of drug targeting · doi:10.1080/1061186x.2017.1419478 · Cited by 79 · see citing works
Self-citation
A Review on Cellular and Molecular Mechanisms Linked to the Development of Diabetes Complications
Babel, R. A., & Dandekar, M. P. (2020) · Current Diabetes Reviews · doi:10.2174/1573399816666201103143818 · Cited by 76 · see citing works
Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus
You, S., Zheng, J., Chen, Y., & Huang, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.976465 · Cited by 68 · see citing works
Secreted protein acidic and rich in cysteine and bioenergetics: Extracellular matrix, adipocytes remodeling and skeletal muscle metabolism
Ghanemi, A., Melouane, A., Yoshioka, M., & St‐Amand, J. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.105627 · Cited by 57 · see citing works
Recent progress in bone-repair strategies in diabetic conditions
Sheng, N., Xing, F., Wang, J., Zhang, Q., Nie, R., Li‐Ling, J., Duan, X., & Xie, H. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100835 · Cited by 52 · see citing works
“…of ROS is associated with hyperactivation of multiple molecular pathways resulting from hyperglycemia, including the mitochondrial pathway, polyol pathway, protein kinase C (PKC) pathway, hexosamine pathway, in addition to AGE formation and increased production of angiotensin II [99 – 101].”
Background
Antidiabetic, Antihyperlipidemic, Antioxidant, Anti-inflammatory Activities of Ethanolic Seed Extract of Annona reticulata L. in Streptozotocin Induced Diabetic Rats
Wen, W., Lin, Y., & Ti, Z. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00716 · Cited by 52 · see citing works
Arginase: Biological and Therapeutic Implications in Diabetes Mellitus and Its Complications
Ren, Y., Li, Z., Li, W., Fan, X., Han, F., Huang, Y., Yu, Y., Lü, Q., & Xiong, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2419412 · Cited by 50 · see citing works
“Reactive oxygen species (ROS) is thought to be one of the culprits to the induction and progression of DM and its complications, owing to an excess of ROS that causes oxidative stress, which promotes β-cell dysfunction, IR, and vascular dysfunction by activating multiple cellular stress-sensitive signaling pathways [6…”
Health promoting potential of herbal teas and tinctures from Artemisia campestris subsp. maritima: from traditional remedies to prospective products
Pereira, C. G., Barreira, L. A., Bijttebier, S., Pieters, L. A. C., Marques, C. F., Santos, T., Rodrigues, M. J., Varela, J. C. S., & Custódio, L. M. B. (2018) · Scientific Reports · doi:10.1038/s41598-018-23038-6 · Cited by 45 · see citing works
Effects of reactive oxygen species and antioxidant strategies on wound healing in diabetes
Yu, Q., Zheng, Z., Zhang, H., Xie, E., Chen, L., Jiang, Z., Gao, Y., Ma, J., & Yang, L. (2025) · Interdisciplinary medicine · doi:10.1002/inmd.20240062 · Cited by 44 · see citing works
Ergothioneine products derived by superoxide oxidation in endothelial cells exposed to high-glucose
Servillo, L., D’Onofrio, N., Casale, R., Cautela, D., Giovane, A., Castaldo, D., & Balestrieri, M. L. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.03.009 · Cited by 42 · see citing works
Mechanistic analysis of viscosity-sensitive fluorescent probes for applications in diabetes detection
Sreejaya, M. M., Pillai, V. M., Ayesha, A., Baby, M., Bera, M., & Gangopadhyay, M. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02697c · Cited by 41 · see citing works
Vitamin D deficiency causes insulin resistance by provoking oxidative stress in hepatocytes
Tao, S., Yuan, Q., Mao, L., Chen, F., Ji, F., & Cui, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.18754 · Cited by 41 · see citing works
Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus
Azarova, I. E., Polonikov, A., & Klyosova, E. Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054738 · Cited by 37 · see citing works
Screening and characterisation of potential antioxidant, hypoglycemic and hypolipidemic components revealed in Portulaca oleracea via multi‐target affinity ultrafiltration LC–MS and molecular docking
Zhang, H., Chen, G., Yang, J., Yang, C., & Guo, M. (2021) · Phytochemical Analysis · doi:10.1002/pca.3086 · Cited by 29 · see citing works
Protein Mediated Oxidative Stress in Patients with Diabetes and its Associated Neuropathy: Correlation with Protein Carbonylation and Disease Activity Markers
Almogbel, E. S. (2017) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2017/23789.9417 · Cited by 29 · see citing works
RETRACTED ARTICLE: Vitamin D regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin-induced diabetes
Fathi, F. E. Z. M., Sadek, K. M., Khafaga, A. F., Alsenosy, A. A., Ghoniem, H. A., Fayez, S., & Zeweil, M. F. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-22064-2 · Cited by 28 · see citing works
“Panigrahy et al. (2017) reported that hyperglycemia disrupts electron transfer and activation in the mitochondria and causes an excessive production of reactive oxygen species (ROS) via the polyol pathway.”
Retracted
Unravelling the potential of the medicinal halophyte Eryngium maritimum L.: In vitro inhibition of diabetes-related enzymes, antioxidant potential, polyphenolic profile and mineral composition
Pereira, C. G., Locatelli, M., Innosa, D., Cacciagrano, F., Polesna, L., Santos, T., Rodrigues, M. J., & Custódio, L. M. B. (2018) · South African Journal of Botany · doi:10.1016/j.sajb.2018.06.013 · Cited by 26 · see citing works
Serum free thiols in type 2 diabetes mellitus: A prospective study
Schillern, E. E. M., Pasch, A., Feelisch, M., Waanders, F., Hendriks, S. H., Mencke, R., Harms, G., Groenier, K. H., Bilo, H. J. G., Hillebrands, J., et al. (2019) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2019.100182 · Cited by 25 · see citing works
“Given the antioxidant properties of R-SH and the possibility of supplementation affecting circulating thiol concentrations, this may have implications for future therapeutic interventions [16].”
Background
Reactive Oxygen Species, Glucose Metabolism, and Lipid Metabolism
Yang, Y., Wu, Y., Sun, X., & Zhang, Y. (2021) · Springer eBooks · doi:10.1007/978-981-16-0522-2_9 · Cited by 25 · see citing works
Alpha-Lipoic Acid as a Means of Influence on Systemic Inflammation in Type 2 Diabetes Mellitus Patients with Prior Myocardial Infarction
Алтуніна, Н. В., Lizogub, V. G., & Bondarchuk, O. M. (2020) · Journal of Medicine and Life · doi:10.25122/jml-2020-0018 · Cited by 22 · see citing works
“Activation of the polyol pathway leads to enhanced formation of reactive oxygen species, triggering oxidative stress (OS), which plays a key role in inducing smooth muscle cell apoptosis and cardiac remodeling [5-7].”
Background
Recent Progress in Fluorescent Probes for Diabetes Visualization and Drug Therapy
Jia, T.-T., Li, Y., & Niu, H. (2022) · Chemosensors · doi:10.3390/chemosensors10070280 · Cited by 21 · see citing works
Improvement of glucolipid metabolism and oxidative stress via modulating PI3K/Akt pathway in insulin resistance HepG2 cells by chickpea flavonoids
Zhou, K., Xiao, S., Cao, S., Zhao, C., Zhang, M., & Ying-hua, F. (2024) · Food Chemistry X · doi:10.1016/j.fochx.2024.101630 · Cited by 21 · see citing works
“Oxidative stress is considered as a primary contributor to the development of IR (Panigrahy et al., 2017).”
Tomato ( Solanum lycopersicum L.) and type 2 diabetes
Banihani, S. A. (2018) · International Journal of Food Properties · doi:10.1080/10942912.2018.1439959 · Cited by 20 · see citing works
“The nonenzymatic glycosylation of proteins (glycation reaction), which occurs more rapidly in diabetic conditions, generates reactive oxygen species, such as superoxide ions, leading to cellular oxidative stress.([25,26]) This state may occur in the pancreas, resulting in β-cell destruction and shifting the progress o…”
Background
DIABETES MELLITUS: THE MODERN STATE OF THE ISSUE (PART 1)
Sharofova, M. U., Самаровна, С. Ш., & Yusufi, S. J. (2019) · Avicenna Bulletin · doi:10.25005/2074-0581-2019-21-3-502-512 · Cited by 19 · see citing works
“Повышенный уровень окислительного стресса [59], высокое содержание циркулирующих свободных жирных кислот и нарушение метаболизма липидов вызывают повреждения структуры сердца, что также может привести к диабетической кардиомиопатии [63].”
RETRACTED: A review on network pharmacology based phytotherapy in treating diabetes- An environmental perspective
Venkateswaran, M. R., Vadivel, T. E., Jayabal, S., Murugesan, S., Rajasekaran, S., & Periyasamy, S. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111656 · Cited by 18 · see citing works
Retracted
Effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on podocytes, inflammation, and oxidative stress in patients with diabetic nephropathy (DN)
Liu, J., Guo, S., Li, H., & Liu, X.-Y. (2022) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.38.5.4719 · Cited by 20 · see citing works
Fluorescence Imaging of Mitochondrial Redox State to Assess Diabetic Wounds
Mehrvar, S., Rymut, K. T., Foomani, F. H., Mostaghimi, S., Eells, J. T., Ranji, M., & Gopalakrishnan, S. (2019) · IEEE Journal of Translational Engineering in Health and Medicine · doi:10.1109/jtehm.2019.2945323 · Cited by 17 · see citing works
“oxidative stress [20], [21].”
Pyridoxamine Treatment of HK-2 Human Proximal Tubular Epithelial Cells Reduces Oxidative Stress and the Inhibition of Autophagy Induced by High Glucose Levels
Wang, Y., Li, Y., Yang, Z., Wang, Z., Chang, J., Zhang, T., Chi, Y., Han, N., & Zhao, K. (2019) · Medical Science Monitor · doi:10.12659/msm.914799 · Cited by 15 · see citing works
“Oxidative stress caused by overproduction of mitochondrial ROS is often deemed to be of importance to diabetic complications [30], which closely related to mitochondrial energy generation.”
Background
Resistance of nepetin and its analogs on the fibril formation of human islet amyloid polypeptide
Xu, J., Zheng, T., Zhao, C., Huang, X., & Du, W. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.202 · Cited by 14 · see citing works
Identification of key lipid metabolites during metabolic dysregulation in the diabetic retinopathy disease mouse model and efficacy of Keluoxin capsule using an UHPLC-MS-based non-targeted lipidomics approach
Ge, N., Kong, L. D., Zhang, A., Sun, Y., Zhao, M.-Q., Zhang, B., Xu, L., Ke, X., Sun, H. J., & Wang, X. (2021) · RSC Advances · doi:10.1039/d0ra00343c · Cited by 13 · see citing works
Ameliorative effects of chickpea flavonoids on redox imbalance and mitochondrial complex I dysfunction in type 2 diabetic rats
Ying-hua, F., Li, Z., Xiao, S., Zhao, C., Zhou, K., & Cao, S. (2022) · Food & Function · doi:10.1039/d2fo00753c · Cited by 13 · see citing works
Antioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependent enzyme activities in tissues of aged diabetic rats
Ulusu, N. N., Gök, M., Şakul, A., Arı, N., Štefek, M., & Karasu, Ç. (2017) · Interdisciplinary Toxicology · doi:10.1515/intox-2017-0021 · Cited by 13 · see citing works
“A decrease in endogenous antioxidant mechanisms with aging or diabetes increases the vulnerability of the tissues to oxidative damage (Shakeel, 2015; Panigrahy et al., 2017).”
New Advances on Pathophysiology of Diabetes Neuropathy and Pain Management: Potential Role of Melatonin and DPP-4 Inhibitors
Busa, P., Kuthati, Y., Huang, N.-C., & Wong, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.864088 · Cited by 13 · see citing works
“retinopathy and neuropathic complications in DM (Rolo & Palmeira, 2006; Kizub, Klymenko, & Soloviev, 2014; Karunakaran et al., 2015; Panigrahy et al., 2017).”
Background
Insulin resistance in vitamin D-deficient mice is alleviated by n-acetylcysteine
Cui, Z., Yuan, Q., Mao, L., Chen, F., Ji, F., & Tao, S. (2017) · Oncotarget · doi:10.18632/oncotarget.18793 · Cited by 12 · see citing works
Antioxidant and Anti-inflammatory Properties of Yttrium Oxide Nanoparticles: New Insights into Alleviating Diabetes
Tang, K. S. (2020) · Current Diabetes Reviews · doi:10.2174/1573399816999201012201111 · Cited by 12 · see citing works
Telmisartan Mitigates High-Glucose-Induced Injury in Renal Glomerular Endothelial Cells (rGECs) and Albuminuria in Diabetes Mice
Zhan, X., Chen, W., Chen, J., Lei, C., & Wei, L. (2021) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.1c00159 · Cited by 12 · see citing works
Evaluation of Lipid Peroxidation in the Saliva of Diabetes Mellitus Type 2 Patients with Periodontal Disease
Mirnić, J., Djuric, M., Veljović, T., Gušić, I., Katanić, J., Vukoje, K., Ramić, B. D., Tadić, A., & Brkic, S. V. (2022) · Biomedicines · doi:10.3390/biomedicines10123147 · Cited by 11 · see citing works
“Moreover, extant research shows that interactions between AGEs and their receptors on inflammatory cells result in increased proinflammatory cytokine production, leading to enhanced oxidative stress and accelerated tissue damage [33,34], as shown in experimental animal studies involving diabetic rats [35,36].”
Background
Ameliorative Effect of Oxytocin on FBN1 and PEPCK Gene Expression, and Behavioral Patterns in Rats' Obesity-Induced Diabetes
Elnagar, A., El-Dawy, K., El‐Belbasi, H. I., Rehan, I. F., Embark, H. M., Al‐Amgad, Z., Shanab, O., Mickdam, E., Batiha, G. E., Alamery, S. F., et al. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.777129 · Cited by 11 · see citing works
In Vitro and In Vivo Anti-diabetic Activity of Fractions Obtained from the Unexplored Hedychium coronarium Rhizome
Panigrahy, S. K., Kumar, A., & Bhatt, R. (2019) · Proceedings of the National Academy of Sciences India Section B Biological Sciences · doi:10.1007/s40011-019-01125-6 · Cited by 11 · see citing works
Self-citation
Comparative cytotoxicity and mitochondrial disruption in H9c2 cardiomyocytes induced by common pesticides
Ma, Y., Tao, Q. F., Huang, L., & Wang, Q. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.143627 · Cited by 10 · see citing works
Biopolymeric nanocarrier: an auspicious system for oral delivery of insulin
Panigrahy, S. K., & Kumar, A. (2022) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2022.2096527 · Cited by 10 · see citing works
Self-citation
Treatment Effect of Type 2 Diabetes Patients in Outpatient Department Based on Blockchain Electronic Mobile Medical App
Liu, Y., Yu, Z., & Sun, H. (2021) · Journal of Healthcare Engineering · doi:10.1155/2021/6693810 · Cited by 10 · see citing works
“Although he proposed a speculative mechanism based on the development of diabetes, he did not summarize ROS as a potential therapeutic target [3].”
Background
Retracted
Sestrin2 in diabetes and diabetic complications
Zhang, X., Luo, Z., Li, J., Lin, Y., Yu, L., & Li, W. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1274686 · Cited by 9 · see citing works
Epidermal growth factor receptor (EGFR) as a key regulator in type 2 diabetes: Drug discovery insights
Ochoa, R. R., & Rojas, C. A. C. (2025) · Human Gene · doi:10.1016/j.humgen.2025.201390 · Cited by 9 · see citing works
The role of gut dysbiosis and mitochondrial dysfunction in type 2 diabetes: Insights on pathogenesis, intervention and future perspective
Yu, X., Li, M., & Li, H. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118846 · Cited by 11 · see citing works
Phytochemical activators of Nrf2: a review of therapeutic strategy in diabetes
Qin, S., Chen, Z., Wen, Y., Yi, Y., Lv, C., Zeng, C., Chen, L., & Shi, M. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022192 · Cited by 9 · see citing works
“…damage, including the activation of protein kinase C (PKC) isoforms via denovosynthesis of the lipid second messenger DAG, increased hexosamine pathway flux, increased advanced glycation end product (AGE) formation, increased polyol pathway flux, and increased production of angiotensin [13].”
Molecular docking and ADMET-based mining of terpenoids against targets of type-II diabetes
Panigrahy, S. K., Jha, A., Bhatt, R., & Kumar, A. (2020) · Network Modeling Analysis in Health Informatics and Bioinformatics · doi:10.1007/s13721-020-00229-8 · Cited by 9 · see citing works
Self-citation
Therapeutic effects of mesenchymal stem cell conditioned media on streptozotocin-induced diabetes in Wistar rats
Shalaby, M. S., Abdel-Reheim, E. S., Almanaa, T. N., Alhaber, L. A. A., Nabil, A., Ahmed, O. M., Elwan, M., & Abdel‐Moneim, A. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.11.004 · Cited by 7 · see citing works
Valorisation of the industrial waste of Chukrasia tabularis A.Juss.: Characterization of the leaves phenolic constituents and antidiabetic-like effects
Andrade, C., Ferreres, F., Gomes, N. G. M., Gil‐Izquierdo, Á., Duangsrisai, S., Pereira, D. M., Andrade, P. B., & Valentão, P. (2022) · Industrial Crops and Products · doi:10.1016/j.indcrop.2022.115100 · Cited by 7 · see citing works
Chronic Antihyperglycemic Effect Exerted by Traditional Extracts of Three Mexican Medicinal Plants
Espinoza-Hernández, F. A., & Adolfo Andrade-cetto, A. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/5970358 · Cited by 7 · see citing works
“noncanonical pathways, such as polyols, that initially cause osmotic stress and fnally damage cells by oxidative stress and abnormal stimulation of protein kinase C [5, 6].”
Background
Assessment of Serum Level of Protein Carbonyl as a Marker of Protein Oxidation in Patients with Type 2 Diabetes Mellitus
Yaas, A. A., Al-Shakour, A. A., & Mansour, A. A. (2022) · AL-Kindy College Medical Journal · doi:10.47723/kcmj.v18i3.827 · Cited by 7 · see citing works
“According to several studies, DM has been linked to an increase in the formation of ROS or RNS as well as a decrease in anti-oxidant potential (7).”
Background
Chlorogenic acid, a dietary phenolic acid ameliorates hepatorenal injury in streptozotocin-induced diabetic rats through regulation of oxidative stress and inflammation
Singh, A. K., Rana, H. K., Sharma, R., & Pandey, A. K. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106244 · Cited by 6 · see citing works
Probiotic therapy as a promising strategy for gestational diabetes mellitus management
Lemos, D. E. D. A., Alves, J. L. D. B., & de Souza, E. L. (2024) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2024.2409880 · Cited by 7 · see citing works
“…receptor; GLP-1 - glucagon-like peptide-1; ROS – reactive oxygen species; PPAR-γ - peroxisome proliferator-activated receptor gamma; VLDL – very low-density lipoprotein; TC – total cholesterol; TG – triglycerides. be a strategy to reduce oxidative stress and cellular damage in pregnancy [128–130].”
Biomaterial-mediated strategies for accurate and convenient diagnosis, and effective treatment of diabetes: advantages, current progress and future perspectives
Xie, B., Wang, K., Li, B., Huang, R., Xu, Z., & Li, X. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb00034f · Cited by 6 · see citing works
Aging: An evolutionary competition between host cells and mitochondria
Tan, D. X. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.04.007 · Cited by 6 · see citing works
An insight into paper-based microfluidic devices for diabetes diagnosis: Fabrication, detection, and applications
Panigrahy, S. K., Nandha, A., & Kumar, A. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.114475 · Cited by 5 · see citing works
Self-citation
A fluorescence probe with targeted mitochondria for detecting hydrogen peroxide in vitro and in diabetic mice
Wang, Y., Qiao, F.-Q., Tan, Y.-W., Hu, J., Zhang, A.-H., Liang, T., Liu, X., Song, H., & Kang, Y. (2024) · Analytical Methods · doi:10.1039/d4ay00653d · Cited by 5 · see citing works
Preliminary studies on in vitro antioxidant and retardation of essential carbohydrate hydrolysing enzymes by some indigenous South African medicinal plants
Ogbe, A. A., Gupta, S., Finnie, J. F., & Staden, J. V. (2023) · South African Journal of Botany · doi:10.1016/j.sajb.2023.05.030 · Cited by 5 · see citing works
Glycemic management is inversely related to skeletal muscle microvascular endothelial function in patients with type 2 diabetes
Bock, J. M., Hughes, W. E., Ueda, K., Feider, A. J., Hanada, S., & Casey, D. P. (2021) · Physiological Reports · doi:10.14814/phy2.14764 · Cited by 5 · see citing works
“, superoxide) (Panigrahy et al., 2017), or advanced glycation end products (Vlassara & Uribarri, 2014) attenuated NO bioavailability that promotes a pathologic milieu.”
Background
The susceptibility to autoxidation of erythrocytes in diabetic mice: Effects of melatonin and pentoxifylline
Şekeroğlu, M. R., Huyut, Z., Çokluk, E., Özbek, H., & Hakan, H. (2017) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21976 · Cited by 4 · see citing works
Spilanthes filicaulis (Schumach. & Thonn.) C. D Adam leaf extract prevents assault of streptozotocin on liver cells via inhibition of oxidative stress and activation of the NrF2/Keap1, PPARγ, and PTP1B signaling pathways
Ojo, O. A., Oladepo, F. S., Ogunlakin, A. D., Ayokunle, D. I., Odugbemi, A. I., Babatunde, D. E., Ojo, A. B., Ajayi-Odoko, O. A., Ajiboye, B. O., & Dahunsi, S. O. (2024) · PLoS ONE · doi:10.1371/journal.pone.0306039 · Cited by 4 · see citing works
Oxidative Stress and Antioxidant Interventions in Type 2 Diabetes
Sohail, A., Hasnain, M. M., Haq, M. E. U., Nasir, I., Sufyan, R., Khan, M., & Ullah, I. (2024) · Biochemistry · doi:10.5772/intechopen.1006081 · Cited by 4 · see citing works
The Positive Relationship Between the Low-Density Lipoprotein Cholesterol/Apoprotein B Ratio and Bone Turnover Markers in Patients With Type 2 Diabetes
Lu, C., Liu, W., Huang, H., Ge, X., Hua, L.-Y., Wang, X., & Su, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.903336 · Cited by 4 · see citing works
Effect of Ethanol Extract of Jamblang Aceh (Syzygium cumini) in Diabetic Mice (Mus musculus) and Its Potential As Anti-Diabetic Agent
Sari, A. N., Januardi, J., & Diningrat, D. S. (2020) · Elkawnie · doi:10.22373/ekw.v6i1.5496 · Cited by 4 · see citing works
“Antioxidants have been proven to prevent the destruction of β-cells by inhibiting peroxidation chain reactions so that they can provide protection against the development of diabetes (Volpe et al., 2018; Panigrahy et al., 2017).”
Background
Antidiabetic, antihyperlipidemic and protective effects of Gladiolus psittacinus on hyperglycemia-mediated oxidative stress in streptozotocin-induced diabetic rats
Karigidi, K. O., Akintimehin, E. S., Karigidi, M. E., & Adetuyi, F. O. (2023) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2023-0018 · Cited by 3 · see citing works
l-norleucine on high glucose-induced insulin sensitivity and mitochondrial function in skeletal muscle cells
Ding, B., Fan, Y., Zhu, T., Bai, G., Liang, B., Tian, X., & Xie, X. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149742 · Cited by 3 · see citing works
Hierarchically Targeting and ROS-Responsive Platform for Diabetic Periodontitis Treatment through Mitochondrial Repair in M1 Macrophages
Xie, W., Wang, Y., Wu, J., Wang, X., Wu, J., Cheng, B., Feng, H., Huang, X., Cheng, X., Chen, J., et al. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c20136 · Cited by 2 · see citing works
Vascular actions of Ang 1–7 and Ang 1–8 through EDRFs and EDHFs in non-diabetes and diabetes mellitus
Mahmood, N. M. S., Mahmud, A. M. R., & Maulood, I. M. (2025) · Nitric Oxide · doi:10.1016/j.niox.2025.02.003 · Cited by 2 · see citing works
Cerebral ischemia in diabetics and oxidative stress
Cho, S., Fuchs, P., Sarmah, D., Kaur, H., Bhattacharya, P., & Dave, K. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815776-3.00006-1 · Cited by 2 · see citing works
Dietary inclusion of coconut and date palm fruit blend attenuate hyperglycemia, insulin insensitivity and diabetes-induced complications in vivo
Mohammed, A., & Liman, M. L. (2023) · Food and Humanity · doi:10.1016/j.foohum.2023.10.002 · Cited by 1 · see citing works
Comparative efficacy of four potent bioactive molecules of fenugreek seed in holistic management of type 1 diabetes
Majumdar, J., Chatterjee, A., Chakraborty, S. B., Chakraborty, P., & Sarkar, S. (2024) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-024-00774-x · Cited by 1 · see citing works
“Both conditions trigger excessive reactive oxygen species (ROS) production leading to tissue damage in important organs (Takayanagi et al. 2010; Panigrahy et al. 2017) Glucagon-like peptide-1 (GLP-1) is an incretin hormone, secreted postprandially by intestinal enteroendocrine L-cells which…”
Recent Developments in Triazole Derivatives as α-Glucoside Inhibitors for the Treatment of Diabetes
Devi, P., Maity, S., Gupta, S., Singh, A., Verma, S. K., & Asati, V. (2025) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575371876250429175826 · Cited by 1 · see citing works
Unraveling the Antioxidant, Antihyperlipidemic, and Antidiabetic Potential of Jatropha integerrima in Streptozotocin-Induced Diabetic Rats
Bharati, D., Pualsa, D., Mayekar, S., Nadar, J., Mohite, P. B., Kumar, A. A. A. A., & Singh, S. K. (2026) · Life · doi:10.3390/life16020246 · Cited by 1 · see citing works
Self-citation
Predicting HbA1c Target Achievement in Type 2 Diabetes: A Retrospective Single-Centre Nomogram Derived From National MMC-Standardised Management
Lu, M., Zhou, H., Liu, Y., Song, J., Lü, X., & Liu, Y. (2025) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s535766 · Cited by 1 · see citing works
The Role of Galectin 3 in the Pathogenesis of Diabetes Mellitus: Focus on β-Cell Function and Survival
Marinković, M., & Petrović, I. (2022) · EABR. Experimental and Applied Biomedical Research · doi:10.2478/sjecr-2022-0008 · Cited by 1 · see citing works
A Network Pharmacology-Based Strategy for Predicting Active Ingredients and Potential Targets of Shuilu Erxian Dan in Treating Diabetic Kidney DiseasePreprint
Wu, T., Yue, R., & He, M. (2020) · Research Square · doi:10.21203/rs.3.rs-54579/v1 · Cited by 1 · see citing works
Preliminary in Vitro Antioxidant and Retardation of Essential Carbohydrate Hydrolysing Enzymes by Some Indigenous South African Medicinal PlantPreprint
Ogbe, A. A., Gupta, S., Finnie, J. F., & van Staden, J. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4188476 · Cited by 1 · see citing works
A demographic study on relation between uric acid and diabetes parameters in the Chhattisgarh State of India
Kumar, A., Thakur, P., Kumar, A., & Patra, P. K. (2017) · Advances in Human Biology · doi:10.4103/aihb.aihb_34_17
Self-citation
Evaluation of wound healing effects of ginsenoside Rg1 and red ginseng extract in STZ-induced diabetic wound model: an in vivo pilot studyPreprint
Lim, J. Y., Choi, Y. S., Lee, H. R., An, H. M., & Lee, Y. K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.05.442721
Relationships among the Hexosamine Biosynthetic Pathway, Sleep Disturbance, and Cognition in Obstructive Sleep Apnea
Lee, H. Y., Oh, S. M., Lee, M. H., Jeon, J. E., Lee, K. H., Jung, S., Han, I., Hwang, G., & Lee, Y. J. (2021) · Chronobiology in Medicine · doi:10.33069/cim.2021.0013
“ROS increase insulin resistance and decrease intracellular glucose levels, leading to reduction of HBP activation and O-GlcNAcylation [17].”
BackgroundInfluential
The current state of diabetes treatment
Danquah, M. K., & Jeevanandam, J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85396-5.00007-5
Association of Thiol–disulfide Homeostasis with Retinal Layer Thickness in Patients with Diabetes MellitusPreprint
Bilginer, M. C., Tam, A. A., Ogmen, B. E., Güler, B. Y., Uğurlu, N., Yülek, F., Erel, Ö., Topaloğlu, O., Ersoy, R., & Çakır, B. (2021) · Research Square · doi:10.21203/rs.3.rs-791653/v1
Investigation Into the Antidiabetic Effects of a Developed Polyherbal Nanosuspension and Its Assessment
Raheena, K. A., Kv, A., Panicker, P. S., Chandran, A., Aswathy, C. A., Naseena, U., Lameesa Banu, P., Shafin, P., & Swathi, H. (2023) · Journal Of Advanced Zoology · doi:10.17762/jaz.v44is-3.765
ALDOSE REDUCTASE ENZYME'S CLINICAL AND THERMODYNAMIC CHARACTERISTICS IN THE SERUM OF IRAQI DIABETIC PATIENTS
ABASS, H. A. (2023) · MINAR International Journal of Applied Sciences and Technology · doi:10.47832/2717-8234.17.2
Age-related aspects of redox signaling cascades of wound healing
Kumari, G., Padhiary, M., & Pal, A. (2024) · Advances in biogerontology · doi:10.1016/bs.abger.2024.05.002
Elucidating the Type 2 Diabetes Regulatory Network: Identification of EGFR as a Key Hub and Novel Drug CandidatesPreprint
Romero, R. C., & Rojas, C. A. C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.08.602441
“Some studies have reported elevated EGFR levels in T2D patients, particularly in adipose tissue of obese individuals at high risk for T2D[38].”
Background
Study the role of GLP-1 receptor agonist (Liraglutide) on experimentally induced diabetic nephropathy in male albino rats
Elraey, S. G. E., Shebl, M. M., Abdelfattah, A. E., & Elsawy, S. A. (2025) · International Journal of Health Sciences · doi:10.53730/ijhs.v9ns1.15674
Beyond traditional medicine: Erythrophyleum suaveolens (Guill. & Perr.) Brenan shows promising antidiabetic activity in experimentally induced type II diabetes
Ojo, O. A., Nwafor-Ezeh, P. I., Ojo, A. B., Rotimi, D. E., Ogunlakin, A. D., Akanbi, C. A., Adeyemi, P., & Molehin, O. R. (2026) · Kuwait Journal of Science · doi:10.1016/j.kjs.2026.100594

Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives.
Bhatti, J. S., Sehrawat, A., Mishra, J., Sidhu, I. S., Navik, U., Khullar, N., Kumar, S., Bhatti, G. K., & Reddy, P. (2022) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2022.03.019 · Cited by 649 · see citing works
Roles Of Reactive Oxygen Species In The Pathogenesis Of Type 2 Diabetes Mellitus
Subhajit Mandal, S. P. (2022) · Journal of Pharmaceutical Negative Results · doi:10.47750/pnr.2022.13.s10.636
Diabetes, oxidative stress and therapeutic strategies
Rochette, L., Zeller, M., Cottin, Y., & Vergely, C. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.05.017 · Cited by 530 · see citing works
Oxidative stress and type 2 diabetes
Meng, Y. (2008) · Basic & Clinical Medicine · Cited by 3 · see citing works
Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage
Elbatreek, M. H., Pachado, M. P., Cuadrado, A., Jandeleit-Dahm, K. A. M., & Schmidt, H. H. H. W. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.02.006 · Cited by 69 · see citing works

Authors: Panigrahy, S. K., Bhatt, R., & Kumar, A.
Affiliations: Guru Ghasidas Vishwavidyalaya (IN)
National Institute of Technology Raipur (IN)
Corresponding author: Bhatt, Renu
Kumar, Awanish
ORCID: Bhatt, Renu
Kumar, Awanish
Venue: Journal of Drug Targeting
Publisher: Informa UK Limited
Published: 2016-07-19
Volume: 25
Issue: 2
Pages: 93-101
ISSN: 1026-7158 (ISSN-L)
1061-186X
1029-2330
DOI: 10.1080/1061186x.2016.1207650
OpenAlex: W2468238510
Cited by: 103
References: 142
Citations by year: 2026: 3 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 20 · 2021: 11 · 2020: 11 · 2019: 8 · 2018: 6 · 2017: 11 · 2016: 1
FWCI: 0.89
Type: journal article
Language: en
Open access: closed
Locations: Journal of drug targeting (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: reactive oxygen species, oxidative stress, type 2 diabetes, polyol pathway, protein kinase C, advanced glycation end products, hexosamine biosynthetic pathway, angiotensin II, beta-cell dysfunction, insulin resistance, diabetes complications, antioxidant therapy
MeSH terms: Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Reactive Oxygen Species

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Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes

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