Low salivary resolvin D1 to leukotriene B 4 ratio predicts carotid intima media thickness: A novel biomarker of non-resolving vascular inflammation
Abstract
Different lipid mediators may have opposing effects on vascular inflammation. For example, whereas leukotriene B4 (LTB4) transduces inflammation, resolvin D1 (RvD1), which is synthesized from the omega-3 fatty acid docosahexaenoic acid, facilitates the resolution of inflammation. The aim of this study was to determine the association of the RvD1/LTB4 ratio with subclinical atherosclerosis. Saliva samples and ultrasound measurements of the intima media thickness of the carotid artery was obtained for 254 participants. The lipid mediators RvD1 and LTB4 were measured by enzyme-linked immunosorbent assay. Participants with a salivary RvD1/LTB4 ratio >1 had a significantly lower intima media thickness than those in whom LTB4 prevailed. The salivary RvD1/LTB4 ratio independently predicted carotid intima media thickness. The ratio between the proresolving and proinflammatory salivary lipid mediators RvD1 and LTB4 may serve as a biomarker of non-resolving inflammation and its relation to intima media thickness in cardiovascular disease.
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A low resolvin D1 to leukotriene B4 ratio in saliva can predict carotid intimal thickness in humans.
“a low resolvin D1 (RvD1):leukotriene B4 ratio in saliva can predict carotid intimal thickness in humans37.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [37]
Advanced atherosclerotic lesions in mice are deficient in pro-resolving lipid mediators.
“in mice, the advanced atherosclerotic lesions are deficient in pro-resolving lipid mediators37,38.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [37]
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Pro-resolving lipid mediators are leads for resolution physiology
Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041 · see citing works
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Authors/Task Force Members, Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M. T., Corrà, U., Cosyns, B., et al. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487316653709 · Cited by 1,409 · see citing works
Bénétos, A., Adamopoulos, C., Bureau, J.-M., Temmar, M., Labat, C., Bean, K., Thomas, F., Pannier, B., Asmar, R. G., Zureik, M., et al. (2002) · Circulation · doi:10.1161/hc1002.105135 · Cited by 590 · see citing works
Self-citationBäck, M., Bu, D.-X., Bränström, R., Sheikine, Y., Yan, Z.-Q., & Hansson, G. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505845102 · Cited by 227 · see citing works
Self-citationHo, K. J., Spite, M., Owens, C. D., Lancero, H., Kroemer, A. H. K., Pande, R., Creager, M. A., Serhan, C. N., & Conte, M. S. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.091082 · Cited by 204 · see citing works
Angioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy.
Brezinski, D. A., Nesto, R. W., & Serhan, C. N. (1992) · Circulation · doi:10.1161/01.cir.86.1.56 · Cited by 193 · see citing works
Miyahara, T., Runge, S. J., Chatterjee, A., Chen, M., Mottola, G., Fitzgerald, J. M., Serhan, C. N., & Conte, M. S. (2013) · The FASEB Journal · doi:10.1096/fj.12-225615 · Cited by 134 · see citing works
Chiang, N., Shinohara, M., Dalli, J., Mirakaj, V., Kibi, M., Choi, A. M. K., & Serhan, C. N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202969 · Cited by 117 · see citing works
Elabdeen, H. R. Z., Mustafa, M., Szklenár, M., Rühl, R., Ali, R. W., & Bolstad, A. I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070838 · Cited by 77 · see citing works
Inflammatory mediators in saliva associated with arterial stiffness and subclinical atherosclerosis
Labat, C., Temmar, M., Nagy, E., Bean, K., Brink, C., Bénétos, A., & Bäck, M. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328363dccc · Cited by 67 · see citing works
Self-citationPetri, M. H., Laguna-Fernandez, A., Tseng, C.-N., Hedin, U., Perretti, M., & Bäck, M. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.11.010 · Cited by 60 · see citing works
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Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works
Self-citationThe lipid paradox in neuroprogressive disorders: Causes and consequences
Morris, G., Berk, M., Walder, K., O’Neil, A., Maes, M., & Puri, B. K. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.017 · Cited by 17 · see citing works
- Authors
- Thul, S., Labat, C., Temmar, M., Benetos, A., & Bäck, M.
- Affiliations
- Karolinska Institutet (SE)
- Inserm (FR)
- Telomere Cardiology Center, Algeria
- INSERM U1116, Université de Lorraine Nancy, France
- Karolinska University Hospital (SE)
- Corresponding author
- Bäck, Magnus
- Venue
- European Journal of Preventive Cardiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-02-14
- Volume
- 24
- Issue
- 9
- Pages
- 903-906
- ISSN
- 2047-4873 (ISSN-L)
- 2047-4881
- OpenAlex
- W2588734186
- Cited by
- 81
- References
- 11
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 21 · 2021: 10 · 2020: 8 · 2019: 10 · 2018: 5 · 2017: 8
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Preventive Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- resolvin D1, leukotriene B4, carotid intima-media thickness, subclinical atherosclerosis, salivary biomarkers, docosahexaenoic acid, omega-3 fatty acids, lipid mediators, cardiovascular disease
- MeSH terms
- Aged, Carotid Artery Diseases, Docosahexaenoic Acids, Enzyme-Linked Immunosorbent Assay, Female, Humans, Leukotriene B4, Male, Middle Aged, Predictive Value of Tests, Saliva, Biomarkers, Inflammation Mediators, Carotid Intima-Media Thickness
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