The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
How is cardiac troponin released from injured myocardium?
Abstract
Cardiac troponin I and cardiac troponin T are nowadays the criterion biomarkers for the laboratory diagnosis of acute myocardial infarction due to their very high sensitivities and specificities for myocardial injury. However, still many aspects of their degradation, tissue release and elimination from the human circulation are incompletely understood. Myocardial injury may be caused by a variety of different mechanisms, for example, myocardial ischaemia, inflammatory and immunological processes, trauma, drugs and toxins, and myocardial necrosis is preceded by a substantial reversible prelethal phase. Recent experimental data in a pig model of myocardial ischaemia demonstrated cardiac troponin release into the circulation from apoptotic cardiomyocytes as an alternative explanation for clinical situations with increased cardiac troponin without any other evidence for myocardial necrosis. However, the comparably lower sensitivities of all currently available imaging modalities, including cardiac magnetic resonance imaging for the detection of particularly non-focal myocardial necrosis in patients, has to be considered for cardiac troponin test result interpretation in clinical settings without any other evidence for myocardial necrosis apart from increased cardiac troponin concentrations as well.
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Cites
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Cited by
Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T
du Fay de Lavallaz, J., Prepoudis, A., Wendebourg, M. J., Kesenheimer, E., Kyburz, D., Daikeler, T., Haaf, P., Wanschitz, J., Löscher, W. N., Schreiner, B., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.058489 · Cited by 121
Self-citation
Metadata
- Authors
- Mair, J., Lindahl, B., Hammarsten, O., Müller, C., Giannitsis, E., Huber, K., Möckel, M., Plebani, M., Thygesen, K., & Jaffe, A. S.
- Venue
- European Heart Journal: Acute Cardiovascular Care
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-12-27
- Volume
- 7
- Issue
- 6
- Pages
- 553-560
- ISSN
- 2048-8726 (ISSN-L)
- 2048-8734
- OpenAlex
- W2779110724
- Cited by
- 267
- References
- 42
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mair, J., Lindahl, B., Hammarsten, O., Müller, C., Giannitsis, E., Huber, K., Möckel, M., Plebani, M., Thygesen, K., & Jaffe, A. S. (2018). How is cardiac troponin released from injured myocardium? European Heart Journal: Acute Cardiovascular Care. https://doi.org/10.1177/2048872617748553
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
