Guillemin, Gilles J.

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature

Tryptophan and brain disordersToxic Organic Pollutants Impact

Cited by 1,898

Quinolinic acid, the inescapable neurotoxin

Guillemin, G. J. (2012) · The FEBS Journal

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 595

Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats

Braidy, N., Guillemin, G. J., Mansour, H., Chan-Ling, T., Poljak, A., & Grant, R. (2011) · PLoS ONE

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 594

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

Steiner, J., Walter, M., Gos, T., Guillemin, G. J., Bernstein, H.-G., Sarnyai, Z., Mawrin, C., Brisch, R., Bielau, H., zu Schwabedissen, L., et al. (2011) · Journal of Neuroinflammation

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 568

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012) · PLoS ONE

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 545

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

Manoharan, S., Guillemin, G. J., Abiramasundari, R. S., Essa, M. M., Akbar, M., & Akbar, M. D. (2016) · Oxidative Medicine and Cellular Longevity

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 523

Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons

Guillemin, G. J., Smythe, G., Takikawa, O., & Brew, B. J. (2005) · Glia

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 497

Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases

Lovelace, M. D., Varney, B., Sundaram, G., Lennon, M. J., Lim, C. K., Jacobs, K., Guillemin, G. J., & Brew, B. J. (2017) · Neuropharmacology

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 393

Connecting inflammation with glutamate agonism in suicidality

Erhardt, S., Lim, C. K., Linderholm, K. R., Janelidze, S., Lindqvist, D., Samuelsson, M., Lundberg, K., Postolache, T. T., Träskman-Bendz, L., Guillemin, G. J., et al. (2013) · Neuropsychopharmacology

Tryptophan and brain disordersSuicide and Self-Harm Studies

Cited by 345

A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality

Bay-Richter, C., Linderholm, K. R., Lim, C. K., Samuelsson, M., Träskman-Bendz, L., Guillemin, G. J., Erhardt, S., & Brundin, L. (2015) · Brain, Behavior, and Immunity

Tryptophan and brain disordersTreatment of Major Depression

Cited by 304

Neuroprotective effect of natural products against Alzheimer’s disease

Essa, M. M., Vijayan, R. K., Castellano-Gonzalez, G., Memon, M. A., Braidy, N., & Guillemin, G. J. (2012) · Neurochemical Research

Medicinal Plants and NeuroprotectionAlzheimer's disease research and treatments

Cited by 278

The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons

Rahman, A., Ting, K., Cullen, K. M., Braidy, N., Brew, B. J., & Guillemin, G. J. (2009) · PLoS ONE

Alzheimer's disease research and treatmentsTryptophan and brain disorders

Cited by 257

NAD Deficiency, Congenital Malformations, and Niacin Supplementation

Shi, H., Enriquez, A., Rapadas, M., Martin, E. M. M. A., Wang, R., Moreau, J., Lim, C. K., Szot, J. O., Ip, E., Hughes, J. N., et al. (2017) · New England Journal of Medicine

Metabolism and Genetic DisordersGenomics and Rare Diseases

Cited by 246

Expression of The Kynurenine Pathway Enzymes in Human Microglia and Macrophages

Guillemin, G. J., Smith, D. G., Smythe, G. A., Armati, P. J., & Brew, G. J. (2003) · Advances in Experimental Medicine and Biology

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 229

An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation

Brundin, L., Sellgren, C. M., Lim, C. K., Grit, J., Pålsson, E., Landén, M., Samuelsson, M., Lundgren, K., Brundin, P., Fuchs, D., et al. (2016) · Translational Psychiatry

Tryptophan and brain disordersSuicide and Self-Harm Studies

Cited by 195

Role of ABCG1 and ABCA1 in Regulation of Neuronal Cholesterol Efflux to Apolipoprotein E Discs and Suppression of Amyloid-β Peptide Generation

Kim, W. S., Rahmanto, A. S., Kamili, A., Rye, K.-A., Guillemin, G. J., Gelissen, I. C., Jessup, W., Hill, A. F., & Garner, B. (2007) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismAlzheimer's disease research and treatments

Cited by 191

Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease

Ting, K. K., Brew, B. J., & Guillemin, G. J. (2009) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 166

Involvement of the kynurenine pathway in the pathogenesis of Parkinson's disease

Lim, C. K., Fernández-Gomez, F. J., Braidy, N., Estrada, C., Costa, C., Costa, S., Bessede, A., Fernandez-Villalba, E., Zinger, A., Herrero, M. T., et al. (2017) · Progress in Neurobiology

Tryptophan and brain disordersParkinson's Disease Mechanisms and Treatments

Cited by 159

NAD+metabolism and oxidative stress: the golden nucleotide on a crown of thorns

Massudi, H., Grant, R., Guillemin, G. J., & Braidy, N. (2012) · Redox Report

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 158

The kynurenine pathway and inflammation in amyotrophic lateral sclerosis

Chen, Y., Stankovic, R., Cullen, K. M., Meininger, V., Garner, B., Coggan, S., Grant, R., Brew, B. J., & Guillemin, G. J. (2010) · Neurotoxicity Research

Tryptophan and brain disordersAmyotrophic Lateral Sclerosis Research

Cited by 141

Characterisation of kynurenine pathway metabolism in human astrocytes and implications in neuropathogenesis

Guillemin, G. J., Smith, D. G., Kerr, S. J., Smythe, G. A., Kapoor, V., Armati, P. J., & Brew, B. J. (2000) · Redox Report

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 108

Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis

Guillemin, G. J., Meininger, V., & Brew, B. J. (2005) · Neurodegenerative Diseases

Tryptophan and brain disordersAmyotrophic Lateral Sclerosis Research

Cited by 105

M. tuberculosis Induces Potent Activation of IDO-1, but This Is Not Essential for the Immunological Control of Infection

Blumenthal, A., Nagalingam, G., Huch, J. H., Walker, L., Guillemin, G. J., Smythe, G. A., Ehrt, S., Britton, W. J., & Saunders, B. M. (2012) · PLoS ONE

Tuberculosis Research and EpidemiologyImmune responses and vaccinations

Cited by 105

Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation

Vieira, B. D. M., Radford, R. A., Chung, R. S., Guillemin, G. J., & Pountney, D. L. (2015) · Frontiers in Cellular Neuroscience

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 93