The DOI matches its Crossref record; 113 of the 114 references it cites were found in a registry or an index.
Composite biomaterial scaffolds for cardiac tissue engineering
Abstract
Coronary heart diseases result from the blockage of one of the coronary arteries, which nourishes the heart muscle. This process leads to ischaemia of a segment of the heart and death of the contractile tissue. As cardiac tissue is unable to regenerate itself, heart function is impaired. Tissue engineering (TE) is a field of science that integrates knowledge from biology, materials sciences, engineering and medicine to develop artificial, functional tissue constructs to replace defected tissues. In cardiac TE, contracting cells are seeded within supporting biomaterial scaffolds that provide them with the essential microenvironment for functional tissue assembly. Various strategies and methods for fabricating these scaffolds have been proposed and tested in the last decade, some of which combine multiple elements that altogether contribute to the formation of an improved functional tissue. This review summarises the unique properties of various composite biomaterial scaffolds and highlights their advantages over other pristine scaffolds for engineering functional three-dimensional cardiac patches.
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“the patch should also have certain biological functions, which can simulate the microstructure and biological function of natural heart tissue, and provide a suitable extracellular matrix environment [164].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [164]
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Metadata
- Authors
- Shapira, A., Feiner, R., & Dvir, T.
- Affiliations
- Tel Aviv University (IL)
- Corresponding author
- Dvir, T.
- Venue
- International Materials Reviews
- Publisher
- SAGE Publications
- Published
- 2016-01
- Volume
- 61
- Issue
- 1
- Pages
- 1-19
- ISSN
- 0950-6608 (ISSN-L)
- 1743-2804
- OpenAlex
- W2170510199
- Cited by
- 114
- References
- 114
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 5 · 2021: 24 · 2020: 14 · 2019: 20 · 2018: 12 · 2017: 9 · 2016: 3
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Materials Reviews (publishedVersion)
- Funders
- Moxie Foundation
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- cardiac tissue engineering, coronary artery disease, myocardial ischemia, cardiac regeneration, scaffold fabrication
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