Cited by 114Tissue Engineering and Regenerative Medicine3D Printing in Biomedical ResearchBone Tissue Engineering Materials

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Composite biomaterial scaffolds for cardiac tissue engineering

Shapira, A., Feiner, R., Dvir, T.·2016·International Materials Reviews

DOI 10.1179/1743280415y.0000000012

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Abstract

Coronary heart diseases result from the blockage of one of the coronary arteries, which nourishes the heart muscle. This process leads to ischaemia of a segment of the heart and death of the contractile tissue. As cardiac tissue is unable to regenerate itself, heart function is impaired. Tissue engineering (TE) is a field of science that integrates knowledge from biology, materials sciences, engineering and medicine to develop artificial, functional tissue constructs to replace defected tissues. In cardiac TE, contracting cells are seeded within supporting biomaterial scaffolds that provide them with the essential microenvironment for functional tissue assembly. Various strategies and methods for fabricating these scaffolds have been proposed and tested in the last decade, some of which combine multiple elements that altogether contribute to the formation of an improved functional tissue. This review summarises the unique properties of various composite biomaterial scaffolds and highlights their advantages over other pristine scaffolds for engineering functional three-dimensional cardiac patches.

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Authors: Shapira, A., Feiner, R., & Dvir, T.
Affiliations: Tel Aviv University (IL)
Corresponding author: Dvir, T.
ORCID: Shapira, A.
Feiner, R.
Dvir, T.
Venue: International Materials Reviews
Publisher: SAGE Publications
Published: 2016-01
Volume: 61
Issue: 1
Pages: 1-19
ISSN: 0950-6608 (ISSN-L)
1743-2804
DOI: 10.1179/1743280415y.0000000012
OpenAlex: W2170510199
Cited by: 114
References: 114
Citations by year: 2026: 3 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 5 · 2021: 24 · 2020: 14 · 2019: 20 · 2018: 12 · 2017: 9 · 2016: 3
FWCI: 8.08
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: International Materials Reviews (publishedVersion)
Funders: Moxie Foundation
Topics: Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords: cardiac tissue engineering, coronary artery disease, myocardial ischemia, cardiac regeneration, scaffold fabrication

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Composite biomaterial scaffolds for cardiac tissue engineering

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