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Cited by 85Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Response and Inflammation

Long-lived immature dendritic cells mediated by TRANCE-RANK interaction

Open access
Cremer, Isabelle, Dieu-Nosjean, Marie-Caroline, Maréchal, Sylvie, Dezutter-Dambuyant, Colette, Goddard, Sarah, Adams, David, Winter, Nathalie, Menetrier-Caux, Christine +3 more·2002·Blood
DOI 10.1182/blood-2002-01-0312
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Abstract

Immature dendritic cells (DCs) reside in interstitial tissues (int-DC) or in the epidermis, where they capture antigen and, thereafter, mature and migrate to draining lymph nodes (LNs), where they present processed antigen to T cells. We have identified int-DCs that express both TRANCE (tumor necrosis factor–related activation-induced cytokine) and RANK (receptor activator of NF-κB) and have generated these cells from CD34+ human progenitor cells using macrophage colony-stimulating factor (M-CSF). These CD34+-derived int-DCs, which are related to macrophages, are long-lived, but addition of soluble RANK leads to significant reduction of cell viability and Bcl-2 expression. This suggests that constitutive TRANCE-RANK interaction is responsible for CD34+-derived int-DC longevity. Conversely, CD1a+ DCs express only RANK and are short-lived. However, they can be rescued from cell death either by recombinant soluble TRANCE or by CD34+-derived int-DCs. CD34+-derived int-DCs mature in response to lipopolysaccharide (LPS) plus CD40 ligand (L) and become capable of CCL21/CCL19-mediated chemotaxis and naive T-cell activation. Upon maturation, they lose TRANCE, making them, like CD1a+DCs, dependent on exogenous TRANCE for survival. These findings provide evidence that TRANCE and RANK play important roles in the homeostasis of DCs.

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  • RANK activation of Langerhans cells by UV can induce pro-survival and anti-apoptotic signals due to upregulation of Bcl-xL, leading to generation of regulatory T cells.

    “Intriguingly, receptor activator of NF-κB (RANK) activation of LCs by UV can induce the pro-survival and anti-apoptotic signals due to the upregulation of Bcl-xL, leading to the generation of regulatory T cells.”

    From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [68]

    The section on rescuing Langerhans-type dendritic cells from cell death reports that TRANCE–RANK engagement supports their viability and is associated with Bcl-2 expression (page unavailable). The paper does not report UV-induced RANK activation, Bcl-xL upregulation, or regulatory T-cell generation by those cells. Its Introduction mentions regulatory T cells only in connection with a mouse diabetes model. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • A well-characterized consequence of RANK activation on Langerhans cells is an anti-apoptotic signal caused by the upregulation of Bcl-xL.

    “A well-characterized consequence of RANK activation on LCs is an anti-apoptotic signal caused by the upregulation of Bcl-xL [67–69].”

    From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [68]

    In the section “CD34+-derived int-DCs can rescue L-DCs from cell death” (page unavailable), TRANCE–RANK engagement is associated with improved survival of cultured Langerhans-type dendritic cells. The paper measures Bcl-2 expression in those cells, not Bcl-xL upregulation, so it does not support the claimed molecular mechanism. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

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Authors
Cremer, I., Dieu-Nosjean, M.-C., Maréchal, S., Dezutter-Dambuyant, C., Goddard, S., Adams, D., Winter, N., Menetrier-Caux, C., Sautès-Fridman, C., Fridman, W. H., & Mueller, C. G. F.
Affiliations
  • Inserm (FR)
  • From the Institut National de la Santé et de la Recherche Médicale (INSERM) U255, Centre de Recherches Biomédicales des Cordeliers, and Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France; INSERM U346, Hôpital Edouard Herriot, and INSERM U453, Centre Léon Bérard, Lyon, France; and Liver Unit Laboratories, Queen Elizabeth Hospital, Birmingham, Great Britain.
ORCID
Venue
Blood
Publisher
American Society of Hematology
Published
2002-11-15
Volume
100
Issue
10
Pages
3646-3655
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2002-01-0312
OpenAlex
W2111759218
Cited by
85
References
2
Citations by year
2025: 2 · 2024: 2 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 1
FWCI
2.52
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders
  • University of Pennsylvania
  • Institut National de la Santé et de la Recherche Médicale
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
immature dendritic cells, trance, RANK, dendritic cell homeostasis, CD34+ cells, macrophage colony-stimulating factor, Bcl-2, CD1a+ dendritic cells, dendritic cell survival, dendritic cell maturation, naive T cell activation, CD40 ligand, lipopolysaccharide, lymph node migration
MeSH terms
Carrier Proteins, Cell Differentiation, Cell Movement, Cell Survival, Cells, Cultured, Dendritic Cells, Glycoproteins, Humans, Lymphocyte Culture Test, Mixed, Lipopolysaccharides, Membrane Glycoproteins, Protein Binding, Skin, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Cell Lineage, CD40 Ligand, Osteoprotegerin, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B

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