The role of CD40 and CD154/CD40L in dendritic cells

Ma, Daphne Y.; Clark, Edward A.

doi:10.1016/j.smim.2009.05.010

Cited by 446Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Response and Inflammation

The role of CD40 and CD154/CD40L in dendritic cells

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Ma, Daphne Y., Clark, Edward A.·2009·Seminars in Immunology

DOI 10.1016/j.smim.2009.05.010PMC PMC2749083

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Abstract

In this review, we focus on the function of CD40-CD40L (CD154) interactions in the regulation of dendritic cell (DC)-T cell and DC-B cell crosstalk. In addition, we examine differences and similarities between the CD40 signaling pathway in DCs and other innate immune cell receptors, and how these pathways integrate DC functions. As research into DC vaccines and immunotherapies progresses, further understanding of CD40 and DC function will advance the applicability of DCs in immunotherapy for human diseases.

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Engagement of CD40 with its ligand induces recruitment of TRAFs and initiates signaling cascades that activate genes involved in cytokine production, as well as upregulation of co-stimulatory molecules such as CD80 and CD86.
“Engagement of CD40 with its ligand induces recruitment of TNF receptor-associated factor family of proteins (TRAFs) and initiates signaling cascades that activate genes involved in cytokine production, as well as upregulation of co-stimulatory molecules such as CD80 and CD86 (37).”
From mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model (2022) · cites this paper as [37]

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The Tumor Microenvironment Innately Modulates Cancer Progression
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Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation
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Authors: Ma, D. Y., & Clark, E. A.
Corresponding author: Clark, Edward A.
ORCID: Clark, Edward A.
Venue: Seminars in Immunology
Publisher: Elsevier BV
Published: 2009-10
Volume: 21
Issue: 5
Pages: 265-272
ISSN: 1044-5323 (ISSN-L)
DOI: 10.1016/j.smim.2009.05.010
PMC: PMC2749083
OpenAlex: W1968783338
Cited by: 446
References: 131
Citations by year: 2026: 20 · 2025: 34 · 2024: 32 · 2023: 36 · 2022: 26 · 2021: 43 · 2020: 36 · 2019: 24 · 2018: 31 · 2017: 27 · 2016: 20 · 2015: 21 · 2014: 19 · 2013: 15 · 2012: 18
FWCI: 1.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Seminars in Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (R01GM037905)
National Institute of Allergy and Infectious Diseases (AI-52203, R37AI044257, R01AI052203)
National Institute of Dental and Craniofacial Research (DE16381, R01DE016381)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: CD40, dendritic cells, innate immune receptors, dendritic cell vaccine, immunotherapy
MeSH terms: Animals, B-Lymphocytes, Cell Communication, Dendritic Cells, Humans, T-Lymphocytes, Signal Transduction, CD40 Antigens, Receptor Cross-Talk, CD40 Ligand

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The role of CD40 and CD154/CD40L in dendritic cells

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