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Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells
Open accessAbstract
Coupling of ovalbumin (OVA) to anti–DEC-205 monoclonal antibody (mAb) (αDEC) induced the proliferation of OVA-specific T cells in vivo. Expansion was short-lived, caused by dendritic cells (DCs), and rendered T cells anergic thereafter. Phenotypic analysis revealed the induction of CD25+/CTLA-4+ T cells suppressing proliferation and interleukin-2 (IL-2) production of effector CD4+ T cells. The findings were supported by 2 disease models: (1) CD4+ T-cell–mediated hypersensitivity reactions were suppressed by the injection of αDEC-OVA and (2) the application of hapten-coupled αDEC-205 reduced CD8+ T-cell–mediated allergic reactions. Thus, targeting of antigens to immature DCs through αDEC antibodies led to the induction of regulatory T cells, providing the basis for novel strategies to induce regulatory T cells in vivo.
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Citations
Cited by
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Bilate, A. M., & Lafaille, J. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075043 · Cited by 569
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells
Loser, K., Mehling, A., Loeser, S., Apelt, J., Kuhn, A., Grabbe, S., Schwarz, T., Penninger, J. M., & Beissert, S. (2006) · Nature Medicine · doi:10.1038/nm1518 · Cited by 402
Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications
Rutella, S., & Lemoli, R. M. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.04.015 · Cited by 147
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Adema, G. J., de Vries, I. J. M., Punt, C. J., & Figdor, C. G. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.01.004 · Cited by 134
Metadata
- Authors
- Mahnke, K., Qian, Y., Knop, J., & Enk, A. H.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-06-15
- Volume
- 101
- Issue
- 12
- Pages
- 4862-4869
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2073694191
- Cited by
- 388
- References
- 0
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mahnke, K., Qian, Y., Knop, J., & Enk, A. H. (2003). Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells. Blood. https://doi.org/10.1182/blood-2002-10-3229
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