The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Anti–β2-glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphospholipid syndrome
Abstract
The association of antiphospholipid antibodies with thrombosis and obstetric events defines the antiphospholipid syndrome. A recent systematic review of the literature showed lupus anticoagulants to be risk factors of thrombosis, independent of the type and site of the event, the presence of
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This contention is supported by meta-analyses showing that the presence of aCL and ab2GPI alone are poorly associated with thromboembolic events [6,7].”
From Clinical course of high‐risk patients diagnosed with antiphospholipid syndrome (2010) · cites this paper as [7]
In the citing paper
“which implies that aCL are generally regarded as less symptomatic than their conventional aPL counterparts.”
From Single or triple positivity for antiphospholipid antibodies in “carriers” or symptomatic patients: Untangling the knot (2021) · cites this paper as [8]
In the citing paper
“In the literature, 5- 8 among the aPL, isolated LA and aB2GPI are generally found to be associated with higher thrombotic risk than aCL.”
From Single or triple positivity for antiphospholipid antibodies in “carriers” or symptomatic patients: Untangling the knot (2021) · cites this paper as [8]
Citations
Cites
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
The Hazards of Scoring the Quality of Clinical Trials for Meta-analysis
Jüni, P. (1999) · JAMA · doi:10.1001/jama.282.11.1054 · Cited by 1,981
McNeil, H. P., Simpson, R. J., Chesterman, C. N., & Krilis, S. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4120 · Cited by 1,595
Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor
Galli, M., Barbui, T., Comfurius, P., Maassen, C., Hemker, H. C., Zwaal, R. F. A., Bevers, E. M., Baets, M. H. D., & Vriesman, P. J. C. V. B. (1990) · The Lancet · doi:10.1016/0140-6736(90)91374-j · Cited by 1,266
Self-citationBrandt, J. T., Triplett, D. A., Alving, B. M., & Scharrer, I. (1995) · PubMed · Cited by 1,164
Brandt, J. T., Triplett, D. A., Alving, B., & Scharrer, I. (1995) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649901 · Cited by 993
Galli, M., Luciani, D., Bertolini, G., & Barbui, T. (2003) · Blood · doi:10.1182/blood-2002-02-0441 · Cited by 972
Self-citationThe “Primary” Antiphospholipid Syndrome
Asherson, R. A., Khamashta, M. A., Ordi, J., Derksen, R. H. W. M., Machin, S. J., Barquinero, J., OUTT, H. H., Harris, E. N., Vilardell, M., & Hughes, G. R. V. (1989) · Medicine · doi:10.1097/00005792-198911000-00004 · Cited by 963
The "primary" antiphospholipid syndrome: major clinical and serological features.
Asherson, R. A., Khamashta, M. A., Ordi‐Ros, J., Derksen, R. H. W. M., Machin, S. J., Barquinero, J., OUTT, H. H., Harris, E. N., Vilardell, M., & Hughes, G. R. V. (1989) · PubMed · Cited by 892
Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease
Matsuura, E., Igarashi, Y., Fujimoto, M., Ichikawa, K., & Koike, T. (1990) · The Lancet · doi:10.1016/0140-6736(90)91697-9 · Cited by 718
Alarcón-Segovia, D., Delezé, M., Oria, C. V., Sánchez‐Guerrero, J., Gómez-Pacheco, L., Cabiedes, J., Fernández, L. A. N., & de León, S. P. (1989) · Medicine · doi:10.1097/00005792-198911000-00003 · Cited by 635
Bevers, E. M., Galli, M., Barbui, T., Comfurius, P., & Zwaal, R. F. A. (1991) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646476 · Cited by 575
Self-citationOosting, J. D., Derksen, R. H. W. M., Bobbink, I. W. G., Hackeng, T. M., Bouma, B. N., & de Groot, P. G. (1993) · Blood · doi:10.1182/blood.v81.10.2618.2618 · Cited by 487
Vaarala, O., Aho, K., Palosuo, T., Alfthan, G., Jauhiainen, M., & Leirisalo‐Repo, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)91213-6 · Cited by 409
Viard, J., Amoura, Z., & Bach, J. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90049-h · Cited by 266
Brey, R. L., Abbott, R. D., Curb, J. D., Sharp, D. S., Ross, G. W., Stallworth, C. L., & Kittner, S. J. (2001) · Stroke · doi:10.1161/01.str.32.8.1701 · Cited by 250
Horbach, D. A., van Oort, E., Donders, R. C. J. M., Derksen, R. H. W. M., & de Groot, P. G. (1996) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1650686 · Cited by 246
Heterogeneity in Meta-analysis of Data from Epidemiologic Studies: A Commentary
Colditz, G. A., Burdick, E., & Mosteller, F. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117644 · Cited by 245
Bias in meta-analytic research
Felson, D. T. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90072-u · Cited by 231
Anticardiolipin response in acute infections
Vaarala, O., Palosuo, T., Kleemola, M., & Aho, K. (1986) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(86)90046-2 · Cited by 231
Cabiedes, J., Cabral, A. R., & Alarcón-Segovia, D. (1995) · PubMed · Cited by 222
Arvieux, J., Darnige, L., Caron, C., Reber, G., Bensa, J., & Colomb, M. G. (1995) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649891 · Cited by 210
Tsutsumi, A., Matsuura, E., Ichikawa, K., Fujisaku, A., Mukai, M., Kobayashi, S., & Koike, T. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390905 · Cited by 192
Amengual, O. (1996) · British journal of rheumatology · doi:10.1093/rheumatology/35.12.1239 · Cited by 192
Galli, M., Beretta, G., Daldossi, M., Bevers, E. M., & Barbui, T. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1655994 · Cited by 168
Self-citationAnti β2 glycoprotein I antibodies: detection and association with thrombosis
Martinuzzo, M. E., Forastiero, R. R., & Carreras, L. O. (1995) · British Journal of Haematology · doi:10.1111/j.1365-2141.1995.tb03317.x · Cited by 163
Pengo, V., Biasiolo, A., Brocco, T., Tonetto, S., & Ruffatti, A. (1996) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1650355 · Cited by 159
Anti-beta 2-glycoprotein I antibodies: a marker of antiphospholipid syndrome?
Balestrieri, G., Tincani, A., Spatola, L., Allegri, F., Prati, E., Cattaneo, R., Valesini, G., Papa, N. D., & Meroni, P. L. (1995) · Lupus · doi:10.1177/096120339500400208 · Cited by 153
Antiprothrombin Antibodies: Detection and Clinical Significance in the Antiphospholipid Syndrome
Galli, M., & Barbui, T. (1999) · Blood · doi:10.1182/blood.v93.7.2149.407a33_2149_2157 · Cited by 151
Self-citationAntiprothrombin Antibodies: Detection and Clinical Significance in the Antiphospholipid Syndrome
Galli, M., & Barbui, T. (1999) · Blood · doi:10.1182/blood.v93.7.2149 · Cited by 147
Self-citationForastiero, R. R., Martinuzzo, M. E., Cerrato, G. S., Kordich, L., & Carreras, L. O. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657678 · Cited by 146
Matsuda, J., Saitoh, N., Gohchi, K., Gotoh, M., & Tsukamoto, A. M. (1994) · American Journal of Hematology · doi:10.1002/ajh.2830470112 · Cited by 137
Autoantibodies to phosphatidylethanolamine (PE) recognize a kininogen- PE complex
Sugi, T., & McIntyre, J. (1995) · Blood · doi:10.1182/blood.v86.8.3083.3083 · Cited by 133
Antibodies to Prothrombin Imply a Risk of Myocardial Infarction in Middle-Aged Men
Vaarala, O., Puurunen, M. K., Mänttäri, M., Manninen, V., Aho, K., & Palosuo, T. (1996) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1650296 · Cited by 130
Antiphospholipid Syndrome: Diagnostic Aspects of Lupus Anticoagulants
Arnout, J. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1616204 · Cited by 121
Reber, G., Schousboe, I., Tincani, A., Sanmarco, M., Kveder, T., de Moerloose, P., Boffa, M., & Arvieux, J. (2002) · PubMed · Cited by 119
Autoantibodies to phosphatidylethanolamine (PE) recognize a kininogen- PE complex
Sugi, T., & McIntyre, J. (1995) · Blood · doi:10.1182/blood.v86.8.3083.bloodjournal8683083 · Cited by 119
Day, H. M., Thiagarajan, P., Ahn, C. W., Reveille, J. D., Tinker, K. F., & Arnett, F. C. (1998) · PubMed · Cited by 96
Cabral, A. R., Cabiedes, J., & Alarcón-Segovia, D. (1995) · PubMed · Cited by 95
The antiphospholipid syndrome II : autoimmune thrombosis
Asherson, R. A. (2002) · Cited by 91
Antibodies to β2-glycoprotein I—a specific marker for the antiphospholipid syndrome
Guerin, J., Feighery, C., Sim, R. B., & Jackson, J. (1997) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1997.4601357.x · Cited by 91
Inter-laboratory Variability of Anti-β2-glycoprotein I Measurement
Schousboe, I., Tincani, A., Sanmarco, M., Kveder, T., de Moerloose, P., Boffa, M., Arvieux, J., & Reber, G. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613156 · Cited by 90
Bertolaccini, M. L., Atsumi, T., Khamashta, M. A., Amengual, O., & Hughes, G. R. V. (1998) · PubMed · Cited by 89
Roubey, R. A. S., Maldonado, M. A., & Byrd, S. N. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390922 · Cited by 86
Puurunen, M. K., Vaarala, O., Julkunen, H. A., Aho, K., & Palosuo, T. (1996) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1996.0089 · Cited by 84
Palosuo, T., Virtamo, J. R. K., Haukka, J. K., Taylor, P. R., Aho, K., Puurunen, M. K., & Vaarala, O. (1997) · PubMed · Cited by 77
(1998) · PubMed · Cited by 75
Palosuo, T., Virtamo, J. R. K., Haukka, J. K., Taylor, P. R., Aho, K., Puurunen, M. K., & Vaarala, O. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657711 · Cited by 71
Swadźba, J., Clerck, L. S. D., Stevens, W. J., Bridts, C. H., Cotthem, K. A. V., Musiał, J., Jankowski, M., & Szczeklik, A. (1997) · PubMed · Cited by 71
Sanmarco, M., Soler, C., Christides, C., Raoult, D., Weiller, P. J., Gérolami, V., & Bernard, D. J. (1997) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(97)90004-4 · Cited by 67
Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar.
Santiago, M., Martinelli, R. P., Ko, A. I., Reis, E. A., Fontes, R. D., Nascimento, E. G., Pierangeli, S. S., Espinola, R. G., & Gharavi, A. E. (2001) · PubMed · Cited by 60
Lakos, G., Kiss, E. V., Regéczy, N., Tarján, P., Soltész, P., Zeher, M., Bodolay, E., Szűcs, G., Szakony, S., Sipka, S., et al. (2000) · PubMed · Cited by 60
Muñoz, F. J., Reverter, J. C., Font, J., Tàssies, D., Cervera, R., Espinosa, G., Carmona, F., Balasch, J., Ordinas, A., & Ingelmo, M. (2000) · PubMed · Cited by 56
Nojima, J., Kuratsune, H., Suehisa, E., Futsukaichi, Y., Yamanishi, H., Machii, T., Kitani, T., Iwatani, Y., & Kanakura, Y. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.02950.x · Cited by 54
Bruce, I. N., Clark-Soloninka, C. A., Spitzer, K. A., Gladman, D. D., Urowitz, M. B., & Laskin, C. A. (2000) · PubMed · Cited by 52
Antibodies to Factor XII Associated with Lupus Anticoagulant
Gallimore, M. J., Harris, S. L., Winter, M., & Jones, D. W. (1999) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614483 · Cited by 51
Lupus anticoagulant, anticardiolipin antibodies and hepatitis C virus infection in thalassaemia
Giordano, P., Galli, M., Vecchio, G., Altomare, M., Norbis, F., Ruggeri, L., Petronelli, M., & Mattia, D. D. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00853.x · Cited by 51
Self-citationFactor VII/VIIa: a new antigen in the anti‐phospholipid antibody syndrome
Bidot, C., Jy, W., Horstman, L. L., Huisheng, H., Jimenez, J. J., Yaniz, M., & Ahn, Y. S. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04161.x · Cited by 51
Dlott, J., Norbis, F., Ruggeri, L., Cler, L., Triplett, D., Barbui, T., & Galli, M. (2000) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614164 · Cited by 48
Self-citationLee, S., Cho, M. L., Joo, Y.-S., Kim, W. U., Hong, Y. S., Min, J., Lee, S. H., Park, S. H., Cho, C. S., & Kim, H. (2001) · PubMed · Cited by 41
Martinuzzo, M. E., Pombo, G., Forastiero, R. R., Cerrato, G. S., Colorio, C. C., & Carreras, L. (1998) · PubMed · Cited by 39
Cugno, M., Domínguez, M., Cabibbe, M., Bisiani, G., Galli, M., Anglés‐Cano, E., & Agostoni, A. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.01948.x · Cited by 39
Self-citationAnti-β2-Glycoprotein I Antibodies in Patients with Acute Venous Thromboembolism
Zanon, E., Prandoni, P., Vianello, F., Saggiorato, G., Carraro, G., Bagatella, P., & Girolami, A. (1999) · Thrombosis Research · doi:10.1016/s0049-3848(99)00105-x · Cited by 38
Donohoe, S., Mackie, I. J., Isenberg, D. A., & Machin, S. J. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.02716.x · Cited by 38
Rampazzo, P., Biasiolo, A., Garin, J., Rosato, A., Betterle, C., Ruffatti, A., & Pengo, V. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1612904 · Cited by 34
Amiral, J., Martin, L. D. S., Mottier, D., & Pasquier, É. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1616083 · Cited by 25
Sorice, M., Pittoni, V., Circella, A., Misasi, R., Conti, F., Longo, A., Pontieri, G. M., & Valesini, G. (1998) · PubMed · Cited by 25
The Antiphospholipid Syndrome II
Bijl, M., & Kallenberg, C. G. M. (2002) · Elsevier eBooks · doi:10.1016/b978-0-444-50987-1.x5000-1 · Cited by 23
Previtali, S., Barbui, T., & Galli, M. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613293 · Cited by 19
Self-citationPriori, R., Conti, F., Pittoni, V., Garofalo, T., Sorice, M., & Valesini, G. (2000) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613776 · Cited by 13
Oosting, J., Derksen, R. H. W. M., Bobbink, I., et al. (1993) · Blood · doi:10.1182/blood.v81.10.2618.bloodjournal81102618 · Cited by 12
Antibodies to Cardiolipin and other Phospholipids
Pierangeli, S. S., & Harris, E. N. (2002) · Elsevier eBooks · doi:10.1016/b978-044450987-1/50006-1 · Cited by 3
β2-glycoprotein-I and Anti-β2-glycoprotein-I Antibodies
de Groot, P. G., Bouma, B., Lutters, B. C. H., & Derksen, R. H. W. M. (2002) · Elsevier eBooks · doi:10.1016/b978-044450987-1/50007-3 · Cited by 3
Wilson (1999) · doi:10.1002/1529-0131(199907)42:7
Atsumi (2000) · doi:10.1002/1529-0131(200009)43:9
Research works printed but not linked: 2
- Galli M, Bevers EM, Barbui T. Immunologic properties and anticoagulant activity of antiphospholipid antibodies. In: Levine SR, Brey RL, eds. Clinical Approach to Antiphospolipid Antibodies. Boston, MA: Butterworth; 2000: 19-31.
- Arvieux J, Darnige L, Caron C, Reber G, Bensa JC, Colomb MG. Development of an ELISA for autoantibodies to prothrombin showing their prevalence in patients with lupus anticoagulants. Thromb Haemost.1995;74: 1120-1125. · DOI
Cited by
Sorted by citations
MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203
Meschia, J. F., Bushnell, C., Boden-Albala, B., Braun, L. T., Bravata, D. M., Chaturvedi, S., Creager, M. A., Eckel, R. H., Elkind, M. S. V., Fornage, M., et al. (2014) · Stroke · doi:10.1161/str.0000000000000046 · Cited by 2,650
Goldstein, L. B., Bushnell, C. D., Adams, R. J., Appel, L. J., Braun, L. T., Chaturvedi, S., Creager, M. A., Culebras, A., Eckel, R. H., Hart, R. G., et al. (2011) · Stroke · doi:10.1161/str.0b013e3181fcb238 · Cited by 1,306
Ruiz‐Irastorza, G., Crowther, M. A., Branch, W. D., & Khamashta, M. A. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60709-x · Cited by 875
Guidelines on the investigation and management of antiphospholipid syndrome
Keeling, D., Mackie, I., Moore, G. W., Greer, I. A., Greaves, M., & British Committee for Standards in Haematology (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09037.x · Cited by 740
Metadata
- Authors
- Galli, M., Luciani, D., Bertolini, G., & Barbui, T.
- Affiliations
- From the Division of Hematology, Ospedali Riuniti, Bergamo, Italy; and the Laboratory of Clinical Epidemiology, Istituto “Mario Negri,” Ranica Bergamo (BG), Italy.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-10-15
- Volume
- 102
- Issue
- 8
- Pages
- 2717-2723
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2069794594
- Cited by
- 413
- References
- 72
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 11 · 2017: 13 · 2016: 16 · 2015: 20 · 2014: 17 · 2013: 27 · 2012: 26
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
- Keywords
- antiphospholipid syndrome, anti-beta2-glycoprotein I antibodies, anti-prothrombin antibodies, lupus anticoagulant, thrombosis risk, thrombosis risk factors, pregnancy complications
- MeSH terms
- Antibodies, Cardiolipins, Female, Glycoproteins, Humans, Pregnancy, Pregnancy Complications, Hematologic, Prothrombin, Retrospective Studies, Thrombosis, Odds Ratio, Antiphospholipid Syndrome, beta 2-Glycoprotein I
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review