A prospective study of antibodies to β2‐glycoprotein I and prothrombin, and risk of thrombosis
Open accessAbstract
Antiphospholipid syndrome (APS) is a clinical autoimmune disorder characterized by thrombosis/pregnancy morbidity associated with the persistence of lupus anticoagulant (LA) and/or anticardiolipin (aCL) antibodies. We assessed the contribution of antibodies to beta2-glycoprotein I (anti-beta2GPI) and prothrombin (anti-PT) to the thrombotic risk in a cohort of 194 consecutive patients with persistent LA and/or aCL. Median follow-up was 45 months. A total of 39 patients (20.1%) had one documented episode of thrombosis during follow-up. Eleven of these patients had no previous thrombosis before enrollment in the study and 28 had recurrences of thrombosis. There were 21 venous and 18 arterial thrombotic events and the overall incidence of thrombosis was 5.6% per patient-year. After multivariate analysis, the male sex (P = 0.025), a previous thrombosis (P < 0.01), the presence of anti-beta2GPI (P = 0.001), and the presence of anti-PT (P = 0.03) remained as independent risk factors for recurrent thrombosis. Only IgG anti-beta2GPI and anti-PT were associated with an increased risk of thrombosis (P < 0.01 and P = 0.005). Patients testing positive for anti-beta2GPI had a higher rate of thrombosis than did antiphospholipid patients without anti-beta2GPI (8.0% vs. 3.1% per patient-year). Similarly, a higher rate of thrombosis was found in patients with positive anti-PT compared with patients without anti-PT (8.6% vs. 3.5% per patient-year). Considering only the group of 142 LA positive…
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In women with systemic lupus erythematosus and prior obstetric antiphospholipid syndrome, the protective effect of low-dose aspirin is supported by three retrospective studies that included a minority of patients with systemic lupus erythematosus.
“Studies of women with SLE and prior obstetric APS are scarce, but the protective effect of LDA was supported by three retrospective studies that included a minority of patients with SLE.18–20”
From EULAR recommendations for the management of antiphospholipid syndrome in adults (2019) · cites this paper as [19]
Some prospective studies have failed to produce reliable results because patients with vascular antiphospholipid syndrome and carriers of aPL were considered together.
“Some prospective studies have likewise failed to produce reliable results since patients with vascular antiphospholipid syndrome (APS) and carriers of aPL were considered together.[16][17][18]”
From Risk factors for a first thrombotic event in antiphospholipid antibody carriers: a prospective multicentre follow-up study. (2011) · cites this paper as [18]
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- Authors
- FORASTIERO, R., MARTINUZZO, M., POMBO, G., PUENTE, D., ROSSI, A., CELEBRIN, L., BONACCORSO, S., & AVERSA, L.
- Affiliations
- Favaloro University (AR)
- Hospital General de Agudos Dr. Enrique Tornú (AR)
- Hospital de Clínicas "José de San Martín" (AR)
- Hospital General de Niños Ricardo Gutierrez (AR)
- Corresponding author
- FORASTIERO, R.
- ORCID
- MARTINUZZO, M.
- Venue
- Journal of Thrombosis and Haemostasis
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 3
- Issue
- 6
- Pages
- 1231-1238
- ISSN
- 1538-7836 (ISSN-L)
- OpenAlex
- W1488742384
- Cited by
- 170
- References
- 3
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 9 · 2018: 2 · 2017: 7 · 2016: 17 · 2015: 9 · 2014: 11 · 2013: 14 · 2012: 10
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- antiphospholipid syndrome, anti-beta2-glycoprotein I antibodies, lupus anticoagulant, anticardiolipin antibodies, thrombosis risk, recurrent thrombosis, venous thrombosis, arterial thrombosis, IgG, risk factors
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Autoantibodies, Child, Child, Preschool, Female, Glycoproteins, Humans, Immunoglobulin G, Male, Middle Aged, Prospective Studies, Prothrombin, Recurrence, Thrombosis, Cohort Studies, Incidence, Lupus Coagulation Inhibitor, Antibodies, Anticardiolipin, beta 2-Glycoprotein I
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