The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation
Abstract
Tissue factor (TF) is expressed on nonvascular cells and cells within the vessel wall and circulates in blood associated with microparticles. Although blood-borne TF accumulates into the developing thrombus during thrombus formation, the contribution of blood-borne TF and vessel wall TF to thrombin generation in vivo following vessel injury is unknown. To determine the source and role of blood-borne microparticle TF, we studied arterial thrombus formation in a living mouse using intravital microscopy. Platelet, TF, and fibrin accumulation in the developing thrombus was compared in wild-type and low TF mice. Compared to wild-type mice, low TF mice formed very small platelet thrombi lacking TF or fibrin. Wild-type and low TF mice received transplants of bone marrow from wild-type and low TF mice. Arterial thrombi in low TF bone marrow/wild-type chimeric mice had decreased size and decreased TF and fibrin levels. Arterial thrombi in wild-type bone marrow/low TF chimeric mice showed decreased platelet thrombus size but normal TF and fibrin levels. This demonstrates that blood-borne TF associated with hematopoietic cell-derived microparticles contributes to thrombus propagation.
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Cites
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Role of tissue factor in embryonic blood vessel development
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Self-citationCell-derived Microparticles Circulate in Healthy Humans and Support Low Grade Thrombin Generation
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Cited by
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Engelmann, B., & Massberg, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3345 · Cited by 1,989
Mechanisms of Thrombus Formation
Furie, B., & Furie, B. C. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0801082 · Cited by 1,926
Self-citationThe multifaceted functions of neutrophils
Mayadas, T. N., Cullere, X., & Lowell, C. A. (2014) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-164023 · Cited by 1,356
Microparticles in Hemostasis and Thrombosis
Owens, A. P., & Mackman, N. (2011) · Circulation Research · doi:10.1161/circresaha.110.233056 · Cited by 835
Self-citationEndothelial and Antithrombotic Actions of HDL
Mineo, C., Deguchi, H., Griffin, J. H., & Shaul, P. W. (2006) · Circulation Research · doi:10.1161/01.res.0000225982.01988.93 · Cited by 655
Metadata
- Authors
- Chou, J., Mackman, N., Merrill-Skoloff, G., Pedersen, B., Furie, B. C., & Furie, B.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2004-11-15
- Volume
- 104
- Issue
- 10
- Pages
- 3190-3197
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2056480338
- Cited by
- 347
- References
- 28
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- closed
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