Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells
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Forcing telomerase overexpression to lengthen telomeres in mouse HSCs does not restore their impaired function.
“the length of telomeres in HSC can be increased by enforced overexpression of telomerase, in mice this does not rescue functional impairment.”
From Aging of hematopoietic stem cells (2018) · cites this paper as [55]
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Cataldi, A., Zara, S., Rapino, M., Zingariello, M., di Giacomo, V., & Antonucci, A. T. (2009) · European Journal of Histochemistry · doi:10.4081/ejh.2009.e25 · Cited by 17 · see citing works
Functional Genomics Approach Using Mice
Sung, Y. H., Song, J., & Lee, H. (2004) · BMB Reports · doi:10.5483/bmbrep.2004.37.1.122 · Cited by 17 · see citing works
- Authors
- Allsopp, R. C., Morin, G. B., Horner, J. W., DePinho, R., Harley, C. B., & Weissman, I. L.
- Affiliations
- Stanford Medicine (US)
- Geron (United States) (US)
- Harvard University (US)
- Corresponding author
- Allsopp, Richard C.
- Venue
- Nature Medicine
- Published
- 2003-04
- Volume
- 9
- Issue
- 4
- Pages
- 369-371
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1992996777
- Cited by
- 155
- References
- 10
- Citations by year
- 2026: 3 · 2025: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 9
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r35ca042551-13)
- National Cancer Institute (CA 42551, CA76708, F32CA076708)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK053074, DK 53074)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- telomerase reverse transcriptase, hematopoietic stem cells, telomere length, cellular senescence, telomerase, stem cell aging, self-renewal, telomere shortening, serial transplantation, donor age, chromosome stability
- MeSH terms
- Animals, DNA-Binding Proteins, Mice, Transgenic, Gene Expression, Telomere, Cell Death, Hematopoietic Stem Cell Transplantation, Transgenes, Telomerase, Mice
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