The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells
Open accessAbstract
Myeloid-related protein 8 (MRP8) and MRP14, S100 proteins secreted by activated phagocytes, bind specifically to endothelial cells. The endothelial response to MRP8/MRP14, however, is unknown. Using oligonucleotide microarray analysis, we show for the first time that MRP8/MRP14 induce a thrombogenic, inflammatory response in human microvascular endothelial cells by increasing the transcription of proinflammatory chemokines and adhesion molecules and by decreasing the expression of cell junction proteins and molecules involved in monolayer integrity. All changes on the gene expression level could be confirmed using biochemical and functional assays. We demonstrated that the expression of MRP8/MRP14 closely correlated with the inflammatory activity in systemic vasculitis, confirming the important role of these proteins for distinct inflammatory reactions in endothelia. MRP8/MRP14 may represent novel targets for anti-inflammatory strategies.
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Cited by
Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., & Ma, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01298 · Cited by 1,450
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Self-citationS100A8 and S100A9 in inflammation and cancer
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Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells
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Metadata
- Authors
- Viemann, D., Strey, A., Janning, A., Jurk, K., Klimmek, K., Vogl, T., Hirono, K., Ichida, F., Foell, D., Kehrel, B., Gerke, V., Sorg, C., & Roth, J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-04-01
- Volume
- 105
- Issue
- 7
- Pages
- 2955-2962
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2130740394
- Cited by
- 316
- References
- 44
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. https://app.cochat.ai/papers/10.1182/blood-2004-07-2520
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- Viemann, D., Strey, A., Janning, A., Jurk, K., Klimmek, K., Vogl, T., Hirono, K., Ichida, F., Foell, D., Kehrel, B., Gerke, V., Sorg, C., & Roth, J. (2005). Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. Blood. https://doi.org/10.1182/blood-2004-07-2520
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