The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation
Open accessAbstract
Jagged1-mediated Notch signaling has been suggested to be critically involved in hematopoietic stem cell (HSC) self-renewal. Unexpectedly, we report here that inducible Cre-loxP–mediated inactivation of the Jagged1 gene in bone marrow progenitors and/or bone marrow (BM) stromal cells does not impair HSC self-renewal or differentiation in all blood lineages. Mice with simultaneous inactivation of Jagged1 and Notch1 in the BM compartment survived normally following a 5FU-based in vivo challenge. In addition, Notch1-deficient HSCs were able to reconstitute mice with inactivated Jagged1 in the BM stroma even under competitive conditions. In contrast to earlier reports, these data exclude an essential role for Jagged1-mediated Notch signaling during hematopoiesis.
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Citations
Cites
Notch regulation of lymphocyte development and function
Radtke, F., Wilson, A., Mancini, S. J. C., & MacDonald, H. R. (2004) · Nature Immunology · doi:10.1038/ni1045 · Cited by 539
Self-citation
Cited by
Hypoxia-Inducible Factors, Stem Cells, and Cancer
Keith, B., & Simon, M. C. (2007) · Cell · doi:10.1016/j.cell.2007.04.019 · Cited by 1,179
Butler, J. M., Nolan, D. J., Vertes, E. L., Varnum-Finney, B., Kobayashi, H., Hooper, A. T., Seandel, M., Shido, K., White, I. A., Kobayashi, M., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.02.001 · Cited by 688
Koch, U., Fiorini, E., Benedito, R., Besseyrias, V., Schuster-Gossler, K., Pierres, M., Manley, N. R., Duarte, A., MacDonald, H. R., & Radtke, F. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080829 · Cited by 464
Self-citationSignaling pathways governing stem-cell fate
Blank, U., Karlsson, G., & Karlsson, S. (2008) · Blood · doi:10.1182/blood-2007-07-075168 · Cited by 355
Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells
Maillard, I., Koch, U., Dumortier, A., Shestova, O., Xu, L., Sai, H., Pross, S. E., Aster, J. C., Bhandoola, A., Radtke, F., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.02.011 · Cited by 317
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Metadata
- Authors
- Mancini, S. J. C., Mantei, N., Dumortier, A., Suter, U., MacDonald, H. R., & Radtke, F.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-03-15
- Volume
- 105
- Issue
- 6
- Pages
- 2340-2342
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2017625115
- Cited by
- 300
- References
- 1
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Mancini, S. J. C., Mantei, N., Dumortier, A., Suter, U., MacDonald, H. R., & Radtke, F. (2005). Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood. https://doi.org/10.1182/blood-2004-08-3207
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