Cited by 284T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisHematopoietic Stem Cell Transplantation

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Persistence of naive CD45RA+ regulatory T cells in adult life

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Seddiki, Nabila, Santner-Nanan, Brigitte, Tangye, Stuart G., Alexander, Stephen I., Solomon, Michael, Lee, Soon, Nanan, Ralph, de Saint Groth, Barbara Fazekas·2006·Blood

DOI 10.1182/blood-2005-06-2403

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Abstract

Regulatory T cells (TREGs) constitutively expressing CD4, CD25, and the transcription factor Foxp3 can prevent a wide range of experimental and spontaneous autoimmune diseases in mice. In humans, CD4+CD25bright T cells, predominantly within the CD45RO+ activated/memory subset in adults and the CD45RA+ naive T-cell subset in infants, are considered to be the equivalent subset. Using novel combinations of monoclonal antibodies (mAbs), we examined expression of CD25 in human infant thymus, cord blood, adult peripheral blood, lymph node, and spleen. In addition to the CD4+CD25bright T cells, subfractionation on the basis of CD45 splice variants indicated that all samples contained a second distinct population of cells expressing a slightly lower level of CD25. In adult peripheral blood, this population expressed a naive CD45RA+ phenotype. The corresponding population in lymph node, spleen, and cord blood showed some evidence of activation, and expressed markers characteristic of TREGs, such as cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Sorted CD4+CD25+CD45RA+ T cells from both cord and adult blood expressed very high levels of mRNA for Foxp3 and manifested equivalent suppressive activity in vitro, indicating that they are bone fide members of the regulatory T-cell lineage. Targeting naive TREGs in adults may offer new means of preventing and treating autoimmune disease.

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Authors: Seddiki, N., Santner-Nanan, B., Tangye, S. G., Alexander, S. I., Solomon, M., Lee, S., Nanan, R., & de Saint Groth, B. F.
Affiliations: The University of Sydney (AU)
From the Centenary Institute of Cancer Medicine and Cell Biology, Faculty of Medicine, University of Sydney, NSW, Australia; Department of Pediatrics, University of Sydney, Western Clinical School, Penrith, NSW, Australia; The Childrens Hospital at Westmead, NSW, Australia; and the Departments of Gastroenterology and Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
ORCID: Seddiki, Nabila
Tangye, Stuart G.
Alexander, Stephen I.
Solomon, Michael
Lee, Soon
Nanan, Ralph
Venue: Blood
Publisher: American Society of Hematology
Published: 2006-04-01
Volume: 107
Issue: 7
Pages: 2830-2838
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2005-06-2403
OpenAlex: W2067263905
Cited by: 284
References: 50
Citations by year: 2026: 8 · 2025: 10 · 2024: 4 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 12 · 2019: 10 · 2018: 7 · 2017: 13 · 2016: 11 · 2015: 12 · 2014: 12 · 2013: 21 · 2012: 13
FWCI: 6.27
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Funders: Crohn's and Colitis Foundation of America
Cancer Australia
National Health and Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords: regulatory T cells, CD25 expression, Foxp3, CD45RO+ memory T cells, CTLA-4, Treg suppressive function, umbilical cord blood, thymus, peripheral blood, lymph nodes, spleen, autoimmune disease prevention
MeSH terms: Aging, Animals, Humans, Lymphocyte Activation, Mice, Inbred C57BL, T-Lymphocytes, CD4-Positive T-Lymphocytes, Leukocyte Common Antigens, Mice, Knockout, Homeodomain Proteins, Mice

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Persistence of naive CD45RA+ regulatory T cells in adult life

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