Cited by 284T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisHematopoietic Stem Cell Transplantation

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Persistence of naive CD45RA+ regulatory T cells in adult life

Open access

Seddiki, Nabila, Santner-Nanan, Brigitte, Tangye, Stuart G., Alexander, Stephen I., Solomon, Michael, Lee, Soon, Nanan, Ralph, de Saint Groth, Barbara Fazekas·2006·Blood

DOI 10.1182/blood-2005-06-2403

Open this paper in CoChat — free account Open PDF

Abstract

Regulatory T cells (TREGs) constitutively expressing CD4, CD25, and the transcription factor Foxp3 can prevent a wide range of experimental and spontaneous autoimmune diseases in mice. In humans, CD4+CD25bright T cells, predominantly within the CD45RO+ activated/memory subset in adults and the CD45RA+ naive T-cell subset in infants, are considered to be the equivalent subset. Using novel combinations of monoclonal antibodies (mAbs), we examined expression of CD25 in human infant thymus, cord blood, adult peripheral blood, lymph node, and spleen. In addition to the CD4+CD25bright T cells, subfractionation on the basis of CD45 splice variants indicated that all samples contained a second distinct population of cells expressing a slightly lower level of CD25. In adult peripheral blood, this population expressed a naive CD45RA+ phenotype. The corresponding population in lymph node, spleen, and cord blood showed some evidence of activation, and expressed markers characteristic of TREGs, such as cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Sorted CD4+CD25+CD45RA+ T cells from both cord and adult blood expressed very high levels of mRNA for Foxp3 and manifested equivalent suppressive activity in vitro, indicating that they are bone fide members of the regulatory T-cell lineage. Targeting naive TREGs in adults may offer new means of preventing and treating autoimmune disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1182/blood-2005-06-2403

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
N aturally A rising CD4+R egulatory T C ells for I mmunologic S elf -T olerance and N egative C ontrol of I mmune R esponses
Sakaguchi, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,315
An essential role for Scurfin in CD4+CD25+ T regulatory cells
Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860
Immunol. Cell Biol.
Fitzgerald, M., Hayward, I. P., Thomas, A. C., Campbell, J. H., & CAMPBELL, G. R. (1995) · Cited by 2,552
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
Takahashi, T., Tagami, T., Yamazaki, S., Uede, T., Shimizu, J., Sakaguchi, N., Mak, T. W., & Sakaguchi, S. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.303 · Cited by 2,233
Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation
Read, S., Malmström, V., & Powrie, F. M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.295 · Cited by 2,206
CD4+CD25+ suppressor T cells: more questions than answers
Shevach, E. M. (2002) · Nature reviews. Immunology · doi:10.1038/nri821 · Cited by 2,097

Show all 50 references

Sorted by citations

FOXP3+ regulatory T cells in the human immune system
Sakaguchi, S., Miyara, M., Costantino, C. M., & Hafler, D. A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2785 · Cited by 2,524
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S. I., Nanan, R., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060468 · Cited by 1,512
Self-citation
Human T cell development, localization, and function throughout life
Kumar, B. V., Connors, T. J., & Farber, D. L. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.007 · Cited by 1,257
Regulatory T Cells and Human Disease
Sakaguchi, S., Mikami, N., Wing, J. B., Tanaka, A., Ichiyama, K., & Ohkura, N. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041717 · Cited by 1,163
Human CD25highFoxp3pos regulatory T cells differentiate into IL-17–producing cells
Koenen, H. J. P. M., Smeets, R. L., Vink, P. M., van Rijssen, E., Boots, A. M. H., & Joosten, I. (2008) · Blood · doi:10.1182/blood-2008-01-133967 · Cited by 754
Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
Wing, J. B., Tanaka, A., & Sakaguchi, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.020 · Cited by 726
Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery
Ito, T., Hanabuchi, S., Wang, Y.-H., Park, W. R., Arima, K., Bover, L. C., Qin, F. X.-F., Gilliet, M. F., & Liu, Y. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.018 · Cited by 565
Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
Hoffmann, P., Eder, R., Boeld, T. J., Doser, K., Piseshka, B., Andreesen, R., & Edinger, M. (2006) · Blood · doi:10.1182/blood-2006-06-027409 · Cited by 416
Successful and Maladaptive T Cell Aging
Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362
Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation
Hoffmann, P., Boeld, T. J., Eder, R., Huehn, J., Floess, S., Wieczorek, G., Olek, S., Dietmaier, W., Andreesen, R., & Edinger, M. (2009) · European Journal of Immunology · doi:10.1002/eji.200838904 · Cited by 356
Regulatory T cell memory
Rosenblum, M. D., Way, S. S., & Abbas, A. K. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.1 · Cited by 358
Transient regulatory T-cells: A state attained by all activated human T-cells
Pillai, V., Ortega, S. B., Wang, C. K., & Karandikar, N. J. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.10.014 · Cited by 344
Mesenchymal cells recruit and regulate T regulatory cells
Ianni, M. D., Papa, B. D., Ioanni, M. D., Moretti, L., Bonifacio, E., Cecchini, D., Sportoletti, P., Falzetti, F., & Tabilio, A. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2007.11.007 · Cited by 315
Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues
Thome, J. J. C., Bickham, K. L., Ohmura, Y., Kubota, M., Matsuoka, N., Gordon, C., Granot, T., Griesemer, A., Lerner, H., Kato, T., et al. (2016) · Nature Medicine · doi:10.1038/nm.4008 · Cited by 305
In vivo peripheral expansion of naive CD4+CD25highFoxP3+ regulatory T cells in patients with multiple myeloma
Beyer, M., Kochanek, M., Giese, T., Endl, E., Weihrauch, M. R., Knolle, P. A., Claßen, S., & Schultze, J. L. (2006) · Blood · doi:10.1182/blood-2005-09-3671 · Cited by 302
Natural Naive CD4+CD25+CD127low Regulatory T Cell (Treg) Development and Function Are Disturbed in Multiple Sclerosis Patients: Recovery of Memory Treg Homeostasis during Disease Progression
Venken, K., Hellings, N., Broekmans, T., Hensen, K., Rummens, J., & Stinissen, P. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.6411 · Cited by 272
Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells
Wang, R., Kozhaya, L., Mercer, F. K., Khaitan, A., Fujii, H., & Unutmaz, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901965106 · Cited by 252
Prevalence of Newly Generated Naive Regulatory T Cells (Treg) Is Critical for Treg Suppressive Function and Determines Treg Dysfunction in Multiple Sclerosis
Haas, J., Fritzsching, B., Trübswetter, P., Korporal, M., Milkova, L., Fritz, B., Vobis, D., Krammer, P. H., Suri‐Payer, E., & Wildemann, B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1322 · Cited by 253
Different Proliferative Potential and Migratory Characteristics of Human CD4+ Regulatory T Cells That Express either CD45RA or CD45RO
Booth, N. J., McQuaid, A. J., Sobande, T. O., Kissane, S., Agius, E., Jackson, S. E., Salmon, M., Falciani, F., Yong, K., Rustin, M. H. A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903781 · Cited by 232
The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery
Akbar, A. N., Vukmanovic‐Stejic, M., Taams, L. S., & Macallan, D. C. (2007) · Nature reviews. Immunology · doi:10.1038/nri2037 · Cited by 215
Co‐expression of TNFR2 and CD25 identifies more of the functional CD4 + FOXP3 + regulatory T cells in human peripheral blood
Chen, X., Subleski, J. J., Hamano, R., Howard, O. M. Z., Wiltrout, R. H., & Oppenheim, J. J. (2010) · European Journal of Immunology · doi:10.1002/eji.200940022 · Cited by 228
Circulating Naïve and CD4+CD25high Regulatory T Cells in Patients With Autoimmune Pancreatitis
Miyoshi, H., Uchida, K., Taniguchi, T., Yazumi, S., Matsushita, M., Takaoka, M., & Okazaki, K. (2008) · Pancreas · doi:10.1097/mpa.0b013e3181577553 · Cited by 187
A mathematical model of tumor–immune interactions
Robertson‐Tessi, M., El-Kareh, A. W., & Goriely, A. (2011) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2011.10.027 · Cited by 190
High Levels of Human Antigen-Specific CD4+ T Cells in Peripheral Blood Revealed by Stimulated Coexpression of CD25 and CD134 (OX40)
Zaunders, J. J., Munier, C. M. L., Seddiki, N., Pett, S. L., Ip, S., Bailey, M., Xu, Y., Brown, K., Dyer, W. B., Kim, M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803548 · Cited by 184
Self-citation
Human FoxP3+CD4+ regulatory T cells: their knowns and unknowns
Miyara, M., & Sakaguchi, S. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2010.137 · Cited by 181
FOXP3 and the regulation of Treg/Th17 differentiation
Ziegler, S. F., & Buckner, J. H. (2009) · Microbes and Infection · doi:10.1016/j.micinf.2009.04.002 · Cited by 177
Role of mi R ‐155 in the regulation of lymphocyte immune function and disease
Seddiki, N., Brezar, V., Ruffin, N., Lévy, Y., & Swaminathan, S. (2013) · Immunology · doi:10.1111/imm.12227 · Cited by 176
Self-citation
Functional defect of circulating regulatory CD4+ T cells in patients with Wegener's granulomatosis in remission
Abdulahad, W. H., Stegeman, C. A., van der Geld, Y. M., der Meer, B. D., Limburg, P. C., & Kallenberg, C. G. M. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22692 · Cited by 173
Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death
Fritzsching, B., Oberle, N., Pauly, E., Geffers, R., Buer, J., Pöschl, J. M. B., Krammer, P. H., Linderkamp, O., & Suri‐Payer, E. (2006) · Blood · doi:10.1182/blood-2006-02-005660 · Cited by 176
Phenotypical characterization of regulatory T cells in humans and rodents
Rodríguez-Perea, A. L., Arcia, D., Rueda, C. M., & Velilla, P. A. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12804 · Cited by 182
Safety and T Cell Modulating Effects of High Dose Vitamin D3 Supplementation in Multiple Sclerosis
Smolders, J., Peelen, E., Thewissen, M. M., Tervaert, J. W. C., Menheere, P. P. C. A., Hupperts, R., & Damoiseaux, J. G. M. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015235 · Cited by 166
Regulation of Trafficking Receptor Expression in Human Forkhead Box P3+ Regulatory T Cells
Lim, H. W., Broxmeyer, H. E., & Kim, C. H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.840 · Cited by 164
Identification of a Regulatory T Cell Specific Cell Surface Molecule that Mediates Suppressive Signals and Induces Foxp3 Expression
Wang, R., Wan, Q., Kozhaya, L., Fujii, H., & Unutmaz, D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002705 · Cited by 170
Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential
Wang, L., Liang, Y., Zhao, C., Ma, P., Zeng, S., Ju, D., Zhao, M., Yu, M., & Shi, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02326-4 · Cited by 186
Developmental Immunology and Role of Host Defenses in Fetal and Neonatal Susceptibility to Infection
Lewis, D. B., & Wilson, C. B. (2006) · Elsevier eBooks · doi:10.1016/b0-72-160537-0/50006-2 · Cited by 151
Disturbed regulatory T cell homeostasis in multiple sclerosis
Venken, K., Hellings, N., Liblau, R., & Stinissen, P. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.12.003 · Cited by 150
Pregnancy-associated diseases are characterized by the composition of the systemic regulatory T cell (Treg) pool with distinct subsets of Tregs
Steinborn, A., Schmitt, E., Kisielewicz, A., Rechenberg, S., Seissler, N., Mahnke, K., Schaier, M., Zeier, M. G., & Sohn, C. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04493.x · Cited by 142
Genome-Wide Identification of Human FOXP3 Target Genes in Natural Regulatory T Cells
Sadlon, T. J., Wilkinson, B. G., Pederson, S., Brown, C. Y., Bresatz, S., Gargett, T., Melville, E. L., Peng, K., D’Andrea, R. J., Glonek, G. G., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000082 · Cited by 146
Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation
Colamatteo, A., Carbone, F., Bruzzaniti, S., Galgani, M., Fusco, C., Maniscalco, G. T., Rella, F. D., de Candia, P., & Rosa, V. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03136 · Cited by 147
The Tolerogenic Function of Regulatory T Cells in Pregnancy and Cancer
Jørgensen, N., Persson, G., & Hviid, T. V. F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00911 · Cited by 137
Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome
Leiding, J. W., Vogel, T. P., Santarlas, V. G. J., Mhaskar, R. S., Smith, M. R., Carisey, A. F., Vargas‐Hernández, A., Silva‐Carmona, M., Heeg, M., Rensing‐Ehl, A., et al. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.09.002 · Cited by 136
Cell-surface IL-7 receptor expression facilitates the purification of FOXP3+ regulatory T cells
Banham, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.10.002 · Cited by 131
Impaired regulatory function in circulating CD4+CD25highCD127low/− T cells in patients with myasthenia gravis
Thiruppathi, M., Rowin, J., Ganesh, B. B., Sheng, J. R., Prabhakar, B. S., & Meriggioli, M. N. (2012) · Clinical Immunology · doi:10.1016/j.clim.2012.09.012 · Cited by 128
Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells
Chen, X., & Oppenheim, J. J. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.05.018 · Cited by 138
Aging and human CD4+ regulatory T cells
Hwang, K.-A., Kim, H., & Kang, I. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.06.003 · Cited by 125
Central Role of CD45RA− Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance
Braza, F., Dugast, E., Panov, I., Paul, C., Vogt, K., Pallier, A., Chesneau, M., Baron, D., Guérif, P., Lei, H., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014050480 · Cited by 121
Glatiramer acetate improves regulatory T-cell function by expansion of naive CD4+CD25+FOXP3+CD31+ T-cells in patients with multiple sclerosis
Haas, J., Korporal, M., Balint, B., Fritzsching, B., Schwarz, A., & Wildemann, B. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.06.011 · Cited by 119
Are regulatory T-cells linked with aging?
Dejaco, C., Duftner, C., & Schirmer, M. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.01.008 · Cited by 120
Treg activation defect in type 1 diabetes: correction with TNFR2 agonism
Okubo, Y., Torrey, H., Butterworth, J., Zheng, H., & Faustman, D. L. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2015.43 · Cited by 111
Enhanced formation and survival of CD4+CD25hiFoxp3+T-cells in chronic lymphocytic leukemia
Jak, M., Jak, M., Mous, R., Remmerswaal, E. B. M., Spijker, R., Jaspers, A., Yagüe, A., Eldering, E., van Lier, R. A. W., & van Oers, M. H. J. (2009) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190902803677 · Cited by 108
Dynamic Development of Homing Receptor Expression and Memory Cell Differentiation of Infant CD4+CD25high Regulatory T Cells
Grindebacke, H., Stenstad, H., Quiding‐Järbrink, M., Waldenström, J., Adlerberth, I., Wold, A. E., & Rudin, A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901091 · Cited by 106
Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis
Trzupek, D., Dunstan, M., Cutler, A. J., Lee, M., Godfrey, L., Jarvis, L., Rainbow, D. B., Aschenbrenner, D., Jones, J. L., Uhlig, H. H., et al. (2020) · Genome Medicine · doi:10.1186/s13073-020-00756-z · Cited by 105
Increased Frequency of Regulatory T Cells Accompanies Increased Immune Activation in Rectal Mucosae of HIV-Positive Noncontrollers
Shaw, J. M., Hunt, P. W., Critchfield, J. W., McConnell, D. H., Garcia, J. C., Pollard, R. B., Somsouk, M., Deeks, S. G., & Shacklett, B. L. (2011) · Journal of Virology · doi:10.1128/jvi.05608-11 · Cited by 104
Moving to tolerance: Clinical application of T regulatory cells
McMurchy, A. N., Bushell, A., Levings, M. K., & Wood, K. J. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.04.001 · Cited by 101
Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3+ precursors and impaired activated population
Laakso, S. M., Laurinolli, T.-T., Rossi, L. H., Lehtoviita, A., Sairanen, H. I., Perheentupa, J., Kekäläinen, E., & Arstila, T. P. (2010) · Journal of Autoimmunity · doi:10.1016/j.jaut.2010.07.008 · Cited by 105
The Impact of Aging on Regulatory T-Cells
Fessler, J., Ficjan, A., Duftner, C., & Dejaco, C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00231 · Cited by 88
Naive Precursors of Human Regulatory T Cells Require FoxP3 for Suppression and Are Susceptible to HIV Infection
Antons, A. K., Wang, R., Oswald-Richter, K. A., Tseng, M., Arendt, C., Kalams, S. A., & Unutmaz, D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.2.764 · Cited by 80
CD127low/- and FoxP3+ Expression Levels Characterize Different Regulatory T-Cell Populations in Human Peripheral Blood
Klein, S. M., Kretz, C. C., Krammer, P. H., & Kuhn, A. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.313 · Cited by 79
Involvement of Inducible Costimulator- and Interleukin 10-Positive Regulatory T Cells in the Development of IgG4-Related Autoimmune Pancreatitis
Kusuda, T., Uchida, K., Miyoshi, H., Koyabu, M., Satoi, S., Takaoka, M., Shikata, N., Uemura, Y., & Okazaki, K. (2011) · Pancreas · doi:10.1097/mpa.0b013e31821fc796 · Cited by 78
DNA damage, metabolism and aging in pro-inflammatory T cells
Li, Y., Goronzy, J. J., & Weyand, C. M. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.027 · Cited by 80
FOXP3 Expression Is Upregulated in CD4+T Cells in Progressive HIV-1 Infection and Is a Marker of Disease Severity
Suchard, M. S., Mayne, E. S., Green, V. A., Shalekoff, S., Donninger, S. L., Stevens, W. S., Gray, C. M., & Tiemessen, C. T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011762 · Cited by 76
The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer
Li, L., & Boussiotis, V. A. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.05.003 · Cited by 74
Regulatory T cells in HIV infection: pathogenic or protective participants in the immune response?
Groth, B. F. D. S., & LANDAY, A. L. (2008) · AIDS · doi:10.1097/qad.0b013e3282f466da · Cited by 73
Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states
Macaubas, C., Nguyen, K. D., Deshpande, C., Phillips, C. I., Peck, A., Lee, T. C., Park, J. L., Sandborg, C. I., & Mellins, E. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.09.010 · Cited by 73
High frequency and proliferation of CD4+FOXP3+ Treg in HIV‐1‐infected patients with low CD4 counts
Bi, X., Suzuki, Y., Gatanaga, H., & Oka, S. (2008) · European Journal of Immunology · doi:10.1002/eji.200838667 · Cited by 73
Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype
Santner-Nanan, B., Seddiki, N., Zhu, E., Quent, V., Kelleher, A., de St Groth, B. F., & Nanan, R. (2008) · International Immunology · doi:10.1093/intimm/dxm151 · Cited by 70
Self-citation
Mature T-Cell Leukemias Including T-Prolymphocytic Leukemia, Adult T-Cell Leukemia/Lymphoma, and Sézary Syndrome
Foucar, K. K. (2007) · American Journal of Clinical Pathology · doi:10.1309/k342-1w28-3805-633g · Cited by 70
Hepatocellular carcinoma cell supernatants increase expansion and function of CD4+CD25+ regulatory T cells
Cao, M., Cabrera, R., Xu, Y., Firpi, R. J., Zhu, H., Liu, C., & Nelson, D. R. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700540 · Cited by 69
FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer
Zhuo, C., Xu, Y., Ying, M., Li, Q., Huang, L., Li, D., Cai, S., & Li, B. (2015) · Immunologic Research · doi:10.1007/s12026-014-8616-y · Cited by 70
TGF-β–dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis
Wang, H., Peters, T., Sindrilaru, A., Keß, D., Oreshkova, T., Yu, X., Seier, A. M., Schreiber, H. A., Wlaschek, M., Blakytny, R., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34916 · Cited by 67
Multiple sclerosis patients have reduced resting and increased activated CD4+CD25+FOXP3+T regulatory cells
Verma, N. D., Lam, A. D., Chiu, C., Tran, G. T., Hall, B. M., & Hodgkinson, S. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-88448-5 · Cited by 75
Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis
Fessler, J., Raicht, A., Husic, R., Ficjan, A., Schwarz, C., Duftner, C., Schwinger, W., Graninger, W. B., Stradner, M. H., & Dejaco, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00300 · Cited by 65
CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation
Atanackovic, D., Cao, Y., Luetkens, T., Panse, J., Faltz, C., Arfsten, J., Bartels, K., Wolschke, C., EIERMANN, T. H., Zander, A. R., et al. (2008) · Haematologica · doi:10.3324/haematol.11897 · Cited by 63
Roles of Tregs in development of hepatocellular carcinoma: A meta-analysis
Zhao, H. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i24.7971 · Cited by 64
Promoting transplantation tolerance; adoptive regulatory T cell therapy
Safinia, N., Leech, J. M., Hernández-Fuentes, M. P., Lechler, R. I., & Lombardi, G. (2012) · Clinical & Experimental Immunology · doi:10.1111/cei.12052 · Cited by 64
CD44 expression positively correlates with Foxp3 expression and suppressive function of CD4+ Treg cells
Liu, T., Soong, L., Liu, G., König, R., & Chopra, A. K. (2009) · Biology Direct · doi:10.1186/1745-6150-4-40 · Cited by 63
Enhanced frequency and potential mechanism of B regulatory cells in patients with lung cancer
Zhou, J.-B., Min, Z., Zhang, D., Wang, W., Marincola, F., & Wang, X.-D. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0304-0 · Cited by 59
Dual Mechanism of Impairment of Interleukin-7 (IL-7) Responses in Human Immunodeficiency Virus Infection: Decreased IL-7 Binding and Abnormal Activation of the JAK/STAT5 Pathway
Juffroy, O., Bugault, F., Lambotte, O., Landires, I., Viard, J., Niel, L., Fontanet, A. L., Delfraissy, J., Thèze, J., & Chakrabarti, L. A. (2009) · Journal of Virology · doi:10.1128/jvi.01475-09 · Cited by 61
Post-chemotherapy T-cell recovery is a marker of improved survival in patients with advanced thoracic malignancies
McCoy, M. J., Lake, R., der Most, R. G. V., Dick, I. M., & Nowak, A. K. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.362 · Cited by 60
Essential and synergistic roles of IL1 and IL6 in human Th17 differentiation directed by TLR ligand-activated dendritic cells
Benwell, R. K., & Lee, D. R. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.09.013 · Cited by 61
Isolation strategies of regulatory T cells for clinical trials: Phenotype, function, stability, and expansion capacity
Ukena, S. N., Hoepting, M., Velaga, S., Ivanyi, P., Grosse, J., Baron, U., Ganser, A., & Franzke, A. (2011) · Experimental Hematology · doi:10.1016/j.exphem.2011.08.010 · Cited by 60
DRhigh+CD45RA−-Tregs Potentially Affect the Suppressive Activity of the Total Treg Pool in Renal Transplant Patients
Schaier, M., Seissler, N., Schmitt, E., Meuer, S. C., Hug, F., Zeier, M. G., & Steinborn, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034208 · Cited by 58
Regulatory T Cell Dysfunction in Autoimmune Diseases
Honing, D. Y., Luiten, R. M., & Matos, T. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137171 · Cited by 65
Monotherapy rapamycin allows an increase of CD4+ CD25bright+ FoxP3+T cells in renal recipients
Hendrikx, T. K., Velthuis, J. H. L., Klepper, M., van Gurp, E., Geel, A., Schoordijk, W., Baan, C. C., & Weimar, W. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00890.x · Cited by 57
Antibody Therapies for Acute Myeloid Leukemia: Unconjugated, Toxin-Conjugated, Radio-Conjugated and Multivalent Formats
Williams, B. A., Law, A., Hunyadkürti, J., Désilets, S., Leyton, J. V., & Keating, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081261 · Cited by 57
Developmental changes of FOXP3-expressing CD4+CD25+ regulatory T cells and their impairment in patients with FOXP3 gene mutations
Fuchizawa, T., Adachi, Y., Ito, Y., Higashiyama, H., Kanegane, H., Futatani, T., Kobayashi, I., Kamachi, Y., Sakamoto, T., Tsuge, I., et al. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.08.004 · Cited by 56
Human Regulatory T Cells: Understanding the Role of Tregs in Select Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers
Oparaugo, N. C., Ouyang, K., Nguyen, N. P. N., Nelson, A. M., & Agak, G. W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021527 · Cited by 60
The micro RNA ‐9/ B ‐lymphocyte‐induced maturation protein‐1/ IL ‐2 axis is differentially regulated in progressive HIV infection
Seddiki, N., Phetsouphanh, C., Swaminathan, S., Xu, Y., Rao, S., Li, J., Sutcliffe, E. L., Denyer, G. S., Finlayson, R. J., Gelgor, L., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201242695 · Cited by 55
Self-citation
CD4+FOXP3+ Regulatory T-Cell Subsets in Human Immunodeficiency Virus Infection
Simonetta, F., & Bourgeois, C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00215 · Cited by 57
Impaired Thymic Export and Increased Apoptosis Account for Regulatory T Cell Defects in Patients with Non-ST Segment Elevation Acute Coronary Syndrome
Zhang, W., Wang, J., Shu, Y., Tang, T., Zhu, Z., Xia, N., Nie, S., Liu, J., Zhou, S., Li, J., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.382978 · Cited by 55
Neonatal Cord Blood Subsets and Cytokine Response to Bacterial Antigens
Peoples, J., Cheung, S., Nesin, M., Lin, H., Tatad, A. M. F., Hoang, D., Perlman, J. M., & Cunningham–Rundles, S. (2009) · American Journal of Perinatology · doi:10.1055/s-0029-1220788 · Cited by 52
Regulatory T-cell therapy approaches
McCallion, O., Bilici, M., Hester, J., & Issa, F. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac078 · Cited by 52
Regulatory CAR-T cells in autoimmune diseases: Progress and current challenges
Riët, T., & Chmielewski, M. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.934343 · Cited by 57
Human Natural Regulatory T Cell Development, Suppressive Function, and Postthymic Maturation in a Humanized Mouse Model
Onoe, T., Kalscheuer, H., Danzl, N. M., Chittenden, M., Zhao, G., Yang, Y., & Sykes, M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100394 · Cited by 52
Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs
Tosello, V., Odunsi, K. O., Souleimanian, N. E., Lele, S., Shrikant, P. A., Old, L. J., Valmori, D., & Ayyoub, M. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.11.008 · Cited by 51
Comparative Study of Regulatory T Cell Function of Human CD25+ CD4+ T Cells from Thymocytes, Cord Blood, and Adult Peripheral Blood
Fujimaki, W., Takahashi, N., Ohnuma, K., Nagatsu, M., Kurosawa, H., Yoshida, S., Dang, N. H., Uchiyama, T., & Morimoto, C. (2008) · Clinical and Developmental Immunology · doi:10.1155/2008/305859 · Cited by 51
Current status of type 1 (IgG4-related) autoimmune pancreatitis
Uchida, K., & Okazaki, K. (2022) · Journal of Gastroenterology · doi:10.1007/s00535-022-01891-7 · Cited by 49
Differentiation of IL-17–Producing Effector and Regulatory Human T Cells from Lineage-Committed Naive Precursors
Mercer, F. K., Khaitan, A., Kozhaya, L., Aberg, J. A., & Unutmaz, D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302936 · Cited by 48
Increased levels of regulatory T cells (Tregs) in human immunodeficiency virus-infected patients after 5 years of highly active anti-retroviral therapy may be due to increased thymic production of naive Tregs
Kolte, L., Gaardbo, J. C., Skogstrand, K., Ryder, L. P., Ersbøll, A. K., & Nielsen, S. D. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03803.x · Cited by 46
Differentiation of human thymic regulatory T cells at the double positive stage
Nunes‐Cabaço, H., Caramalho, Í., Sepúlveda, N., & Sousa, A. E. (2011) · European Journal of Immunology · doi:10.1002/eji.201141614 · Cited by 47

Authors: Seddiki, N., Santner-Nanan, B., Tangye, S. G., Alexander, S. I., Solomon, M., Lee, S., Nanan, R., & de Saint Groth, B. F.
Affiliations: The University of Sydney (AU)
From the Centenary Institute of Cancer Medicine and Cell Biology, Faculty of Medicine, University of Sydney, NSW, Australia; Department of Pediatrics, University of Sydney, Western Clinical School, Penrith, NSW, Australia; The Childrens Hospital at Westmead, NSW, Australia; and the Departments of Gastroenterology and Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
ORCID: Seddiki, Nabila
Tangye, Stuart G.
Alexander, Stephen I.
Solomon, Michael
Lee, Soon
Nanan, Ralph
Venue: Blood
Publisher: American Society of Hematology
Published: 2006-04-01
Volume: 107
Issue: 7
Pages: 2830-2838
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2005-06-2403
OpenAlex: W2067263905
Cited by: 284
References: 50
Citations by year: 2026: 8 · 2025: 10 · 2024: 4 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 12 · 2019: 10 · 2018: 7 · 2017: 13 · 2016: 11 · 2015: 12 · 2014: 12 · 2013: 21 · 2012: 13
FWCI: 6.27
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Funders: Crohn's and Colitis Foundation of America
Cancer Australia
National Health and Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords: regulatory T cells, CD25 expression, Foxp3, CD45RO+ memory T cells, CTLA-4, Treg suppressive function, umbilical cord blood, thymus, peripheral blood, lymph nodes, spleen, autoimmune disease prevention
MeSH terms: Aging, Animals, Humans, Lymphocyte Activation, Mice, Inbred C57BL, T-Lymphocytes, CD4-Positive T-Lymphocytes, Leukocyte Common Antigens, Mice, Knockout, Homeodomain Proteins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Persistence of naive CD45RA+ regulatory T cells in adult life

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks